1,840
Views
15
CrossRef citations to date
0
Altmetric
Original Article

Potent protein tyrosine phosphatase 1B (PTP1B) inhibiting constituents from Anoectochilus chapaensis and molecular docking studies

, &
Pages 1030-1034 | Received 13 Nov 2013, Accepted 11 Aug 2014, Published online: 22 Jan 2015

References

  • Anonymous. (1999). Editorial Committee of the Flore of China of Chinese Academy of Science. Flora Republicae Popularis Sinicae, vol. 17. Peking: Science Press
  • Barr AJ. (2010). Protein tyrosine phosphatases as drug targets: Strategies and challenges of inhibitor development. Future Med Chem 2:1563–76
  • Elchebly M, Payette P, Michaliszyn E, et al. (1999). Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283:1544–8
  • Feldhammer M, Uetani N, Miranda-Saavedra D, Tremblay ML. (2013). PTP1B: A simple enzyme for a complex world. Crit Rev Biochem Mol Biol 5:430–45
  • Klaman LD, Boss O, Peroni OD, et al. (2000). Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 20:5479–89
  • McCain DF, Wu L, Nickel P, et al. (2004). Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases. J Biol Chem 279:14713–25
  • Morris GM, Huey R, Lindstrom W, et al. (2009). AutoDock 4 and AutoDock-Tools 4: Automated docking with selective receptor flexibility. J Comput Chem 30:2785–91
  • Panzhinskiy E, Ren J, Nair S. (2013). Pharmacological inhibition of protein tyrosine phosphatase 1B: A promising strategy for the treatment of obesity and type 2 diabetes mellitus. Curr Med Chem 21:2609–25
  • Park H, Bhattarai BR, Ham SW, Cho H. (2009). Structure based virtual screening approach to identify novel classes of PTP1B inhibitors. Eur J Med Chem 44:3280–4
  • Popov D. (2011). Novel protein tyrosine phosphatase 1B inhibitors: Interaction requirements for improved intracellular efficacy in type 2 diabetes mellitus and obesity control. Biochem Biophys Res Co 410:377–81
  • Sun JP, Fedorov AA, Lee SY, et al. (2003). Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. J Biol Chem 14:12406–14
  • Szczepankiewicz BG, Liu G, Hajduk PJ, et al. (2003). Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy. J Am Chem Soc 125:4087–96
  • Trott O, Olson AJ. (2010). AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading. J Comput Chem 31:455–61
  • Wang JF, Gong K, Wei DQ, et al. (2009). Molecular dynamics studies on the interactions of PTP1B with inhibitors: From the first phosphate-binding site to the second one. Protein Eng Des Sel 6:349–55
  • Zhang S, Zhang ZY. (2007). PTP1B as a drug target: Recent developments in PTP1B inhibitor discovery. Drug Discov Today 10:373–81

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.