Free radical scavenging actions of three Trifolium species in the protection of blood plasma antioxidant capacity in vitro

References

• Arlorio M, Locatelli M, Travagilia F, et al. (2008). Roasting impact on the contents of clovamide (N-caffeoyl-l-DOPA) and the antioxidant activity of cocoa beans (Theobroma cacao L.). Food Chem 106:967–75
   Web of Science ®Google Scholar
• Arts MJ, Haenen GR, Wilms LC, et al. (2002). Interactions between flavonoids and proteins: Effect on the total antioxidant capacity. J Agric Food Chem 27:1184–7
   Google Scholar
• Asgary S, Moshtaghian J, Naderi G, et al. (2007). Effects of dietary red clover on blood factors and cardiovascular fatty streak formation in hypercholesterolemic rabbits. Phytother Res 21:768–70
   PubMedGoogle Scholar
• Benzie IFF, Strain JJ. (1996). The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: The FRAP assay. Anal Biochem 239:70–76
   PubMed Web of Science ®Google Scholar
• Booth NL, Overk CR, Yao P, et al. (2006). The chemical and biological profile of a red clover (Trifolium pratense) phase II clinical extract. J Altern Complement Med 12:133–9
   PubMed Web of Science ®Google Scholar
• Coon JT, Pittler MH, Ernst E. (2007). Trifolium pratense isoflavones in the treatment of menopausal hot flushes: A systematic review and meta-analysis. Phytomedicine 14:153–9
   PubMed Web of Science ®Google Scholar
• Engelmann NJ, Reppert A, Yousef G, et al. (2009). In vitro production of radiolabeled red clover (Trifolium pratense) isoflavones. Plant Cell Tiss Organ Cult 98:147–56
   PubMed Web of Science ®Google Scholar
• Gencel VB, Benjamin MM, Bahou SN, Khalil RA. (2011). Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease. Mini Rev Med Chem 12:149–74
   Google Scholar
• Heijnen CG, Haenen GR, van Acker FA, et al. (2001a). Flavonoids as peroxynitrite scavengers: The role of the hydroxyl groups. Toxicol In Vitro 15:3–6
   PubMed Web of Science ®Google Scholar
• Heijnen CG, Haenen GR, Vekemans JA, Bast A. (2001b). Peroxynitrite scavenging of flavonoids: Structure activity relationship. Environ Toxicol Pharmacol 10:199–206
   PubMed Web of Science ®Google Scholar
• Hollman PC, Cassidy A, Comte B, et al. (2011). The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established. J Nutr 141:989–1009
   PubMed Web of Science ®Google Scholar
• Janaszewska A, Bartosz G. (2002). Assay of total antioxidant capacity: Comparison of four methods as applied to human blood plasma. Scand J Clin Lab Invest 62:231–6
   PubMed Web of Science ®Google Scholar
• Kolodziejczyk-Czepas J. (2012). Trifolium species-derived substances and extracts – Biological activity and prospects for medicinal applications. J Ethnopharmacol 143:14–23
   PubMed Web of Science ®Google Scholar
• Kolodziejczyk J, Olas B, Wachowicz B, et al. (2011). Clovamide-rich extract from Trifolium pallidum reduces oxidative stress-induced damage to blood platelets and plasma. J Physiol Biochem 67:391–9
   PubMed Web of Science ®Google Scholar
• Kolodziejczyk-Czepas J, Nowak P, Moniuszko-Szajwaj B, et al. (2014). Biological activity of clovers – Free radical scavenging ability and antioxidant action of six Trifolium species. Pharm Biol 52:1308–14
   PubMed Web of Science ®Google Scholar
• Kolodziejczyk-Czepas J, Olas B, Malinowska J, et al. (2013a). Trifolium pallidum and Trifolium scabrum extracts in the protection of human plasma components. J Thromb Thrombol 35:193–9
   PubMed Web of Science ®Google Scholar
• Kolodziejczyk-Czepas J, Wachowicz B, Moniuszko-Szajwaj B, et al. (2013b). Antioxidative effects of extracts from Trifolium species on blood platelets exposed to oxidative stress. J Physiol Biochem 69:879–87
   PubMed Web of Science ®Google Scholar
• Kowalska I, Jedrejek D, Ciesla L, et al. (2013). Isolation, chemical and free radical scavenging characterization of phenolics from Trifolium scabrum L. aerial parts. J Agric Food Chem 61:4417–23
   PubMedGoogle Scholar
• Krenn L, Paper DH. (2009). Inhibition of angiogenesis and inflammation by an extract of red clover (Trifolium pratense L.). Phytomedicine 16:1083–8
   PubMed Web of Science ®Google Scholar
• Lipovac M, Chedraui P, Gruenhut C, et al. (2010). Improvement of postmenopausal depressive and anxiety symptoms after treatment with isoflavones derived from red clover extracts. Maturitas 65:258–61
   PubMed Web of Science ®Google Scholar
• Maul R, Kulling SE. (2010). Absorption of red clover isoflavones in human subjects: Results from a pilot study. Br J Nutr 103:1569–72
   PubMedGoogle Scholar
• Nowak P, Wachowicz B. (2001). Studies on pig blood platelet responses to peroxynitrite action. Platelets 12:376–81
   PubMed Web of Science ®Google Scholar
• Olas B, Nowak P, Kolodziejczyk J, Wachowicz B. (2004). The effects of antioxidants on peroxynitrite-induced changes in platelet proteins. Thromb Res 113:399–406
   PubMed Web of Science ®Google Scholar
• Oleszek W, Stochmal A, Janda B. (2007). Concentration of isoflavones and other phenolics in the aerial parts of Trifolium species. J Agric Food Chem 55:8095–100
   PubMed Web of Science ®Google Scholar
• Re R, Pellegrini N, Proteggente A, et al. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26:1231–7
   PubMed Web of Science ®Google Scholar
• Renda G, Yalçın FN, Nemutlu E, et al. (2013). Comparative assessment of dermal wound healing potentials of various Trifolium L. extracts and determination of their isoflavone contents as potential active ingredients. J Ethnopharmacol 148:423–32
   PubMed Web of Science ®Google Scholar
• Rossouw J, Anderson GL, Prentice RL, et al. ( Writing Group for the Women’s Health Initiative Investigators). (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women’s Health Initiative Randomized Controlled Trial. JAMA 288:321–33
   PubMedGoogle Scholar
• Ruiz-Larrea MB, Mohan AR, Paganga G, et al. (1997). Antioxidant activity of phytoestrogenic isoflavones. Free Radic Res 26:63–70
   PubMed Web of Science ®Google Scholar
• Sabudak T, Guler N. (2009). Trifolium L. – a review on its phytochemical and pharmacological profile. Phytother Res 23:439–46
   PubMed Web of Science ®Google Scholar
• Schulz E, Gori T, Münzel T. (2011). Oxidative stress and endothelial dysfunction in hypertension. Hypertens Res 3:665–73
   Google Scholar
• Setchell KD. (1998). Phytoestrogens: The biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 68:1333–46
   PubMed Web of Science ®Google Scholar
• Shah A, Passacquale G, Gkaliagkousi E, et al. (2011). Platelet nitric oxide signalling in heart failure: Role of oxidative stress. Cardiovasc Res 91:625–31
   PubMed Web of Science ®Google Scholar
• Shahidi F, Chandrasekara A. (2010). Hydroxycinnamates and their in vitro and in vivo antioxidant activities. Phytochem Rev 9:147–70
   Web of Science ®Google Scholar
• Stochmal A, Piacente S, Pizza C, et al. (2001). Alfalfa (Medicago sativa L.) flavonoids. 1. Apigenin and luteolin glycosides from aerial parts. J Agric Food Chem 49:753–8
   PubMed Web of Science ®Google Scholar
• Tousoulis D, Briasoulis A, Papageorgiou N, et al. (2011). Oxidative stress and endothelial function: Therapeutic interventions. Recent Pat Cardiovasc Drug Discov 6:103–14
   PubMedGoogle Scholar
• Weseler AR, Bast A. (2010). Oxidative stress and vascular function: Implications for pharmacologic treatments. Curr Hypertens Rep 12:154–61
   PubMed Web of Science ®Google Scholar
• Wu Q, Wang M, Simon JE. (2003). Determination of isoflavones in red clover and related species by high-performance liquid chromatography combined with ultraviolet and mass spectrometric detection. J Chromatogr A 1016:195–209
   PubMed Web of Science ®Google Scholar