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Research Article

6-Gingerol inhibits Vibriocholerae-induced proinflammatory cytokines in intestinal epithelial cells via modulation of NF-κB

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Pages 1606-1615 | Received 08 May 2015, Accepted 14 Oct 2015, Published online: 18 Mar 2016

References

  • Ahmed RS, Seth V, Banerjee BD. 2000. Influence of dietary ginger (Zingiber officinales Rosc) on antioxidant defense system in rat: comparison with ascorbic acid. Indian J Exp Biol. 38:604–606.
  • Bandyopadhaya A, Sarkar M, Chaudhuri K. 2007. Transcriptional upregulation of inflammatory cytokines in human intestinal epithelial cells following Vibrio cholerae infection. FEBS J. 274:4631–4642.
  • Bandyopadhaya A, Sarkar M, Chaudhuri K. 2008. IL-1beta expression in Int407 is induced by flagellin of Vibrio cholerae through TLR5 mediated pathway. Microb Pathog. 44:524–536.
  • Caffrey DR, O'Neill LA, Shields DC. 1999. The evolution of the MAP kinase pathways: coduplication of interacting proteins leads to new signaling cascades. J Mol Evol. 49:567–582.
  • Chakrabarti SR, Chaudhuri K, Sen K, Das J. 1996. Porins of Vibrio cholerae: purification and characterization of OmpU. J Bacteriol. 178:524–530.
  • Chrubasik S, Pittler MH, Roufogalis BD. 2005. Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 12:684–701.
  • Fullner KJ, Boucher JC, Hanes MA, Haines III GK, Meehan BM, Walchle C, Sansonetti PJ, Mekalanos JJ. 2002. The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model. J Exp Med. 195:1455–1462.
  • Jang CH, Kim YH. 2002. Characterization of cytokines present in pediatric otitis media with effusion: comparison of allergy positive and negative. Int J Pediatr Otorhinolaryngol. 66:37–40.
  • Jolad SD, Lantz RC, Chen GJ, Bates RB, Timmermann BN. 2005. Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production. Phytochemistry 66:1614–1635.
  • Kaper JB, Morris JG Jr, Levine MM. 1995. Cholera. Clin Microbiol Rev. 8:48–86.
  • Kim SO, Kundu JK, Shin YK, Park JH, Cho MH, Kim TY, Surh YJ. 2005. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene 24:2558–2567.
  • Kuhad A, Tirkey N, Pilkhwal S, Chopra K. 2006. 6-Gingerol prevents cisplatin-induced acute renal failure in rats. Biofactors 26:189–200.
  • Lee E, Surh Y-J. 1998. Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol. Cancer Lett. 134:163–168.
  • Lu X, Rasco BA, Jabal JMF, Aston DE, Lin M, Konkel ME. 2011. nvestigating antibacterial effects of garlic (Allium sativum) concentrate and garlic-derived organosulfur compounds on Campylobacter jejuni by using Fourier Transform Infrared Spectroscopy, Raman Spectroscopy, and Electron Microscopy. Anal Chem. 83:4137–4146.
  • Naik E, Dixit VM. 2011. Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med. 208:417–420.
  • Park YJ, Wen J, Bang S, Park SW, Song SY. 2006. [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. Yonsei Med J. 47:688–697.
  • Qadri F, Raqib R, Ahmed F, Rahman T, Wenneras C, Das SK, Alam NH, Mathan MM, Svennerholm AM. 2002. Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139. Clin Diagn Lab Immunol. 9:221–229.
  • Rimoldi M, Chieppa M, Salucci V, Avogadri F, Sonzogni A, Sampietro GM, Nespoli A, Viale G, Allavena P, Rescigno M. 2005. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol. 6:507–514.
  • Rodríguez BL, Rojas A, Campos J, Ledon T, Valle E, Toledo W, Fando R. 2001. Differential interleukin-8 response of intestinal epithelial cell line to reactogenic and nonreactogenic candidate vaccine strains of Vibrio cholerae. Infect Immun. 69:613–616.
  • Ruiz PA, Braune A, Hölzlwimmer G, Quintanilla-Fend L, Haller D. 2007. Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J Nutr. 137:1208–1215.
  • Saha DR, Niyogi SK, Nair GB, Manna B, Bhattacharya SK. 2000. Detection of faecal leucocytes & erythrocytes from stools of cholera patients suggesting an evidence of an inflammatory response in cholera. Indian J Med Res. 112:5–8.
  • Saha P, Das B, Chaudhuri K. 2013. Role of 6-gingerol in reduction of cholera toxin activity in vitro and in vivo. Antimicrob Agents Chemother. 57:4373–4380.
  • Sarkar M, Chaudhuri K. 2004. Association of adherence and motility in interleukin 8 induction in human intestinal epithelial cells by Vibrio cholerae. Microbes Infect. 6:676–685.
  • Sears CL, Kaper JB. 1996. Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion. Microbiol Rev. 60:167–215.
  • Speelman P, Rabbani GH, Bukhave K, Rask-Madsen J. 1985. Increased jejunal prostaglandin E2 concentrations in patients with acute cholera. Gut. 26:188–193.
  • Srivastava KC, Mustafa T. 1992. Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypotheses. 39:342–348.
  • Surh Y-J. 1999. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat Res. 428:305–327.
  • Tjendraputra E, Tran VH, Liu-Brennan D, Roufogalis BD, Duke CC. 2001. Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorg Chem. 29:156–163.
  • Wang BS, Huang GJ, Lu YH, Chang LW. 2007. Anti-inflammatory effects of an aqueous extract of Welsh onion green leaves in mice. Food Chem. 138:751–756.
  • Wolfe KL, Liu RH. 2007. Cellular antioxidant activity (CAA) assay for assessing antioxidants, foods, and dietary supplements. J Agric Food Chem. 55:8896–8907.
  • Young HY, Luo YL, Cheng HY, Hsieh WC, Liao JC, Peng WH. 2005. Analgesic and anti-inflammatory activities of [6]-gingerol. J Ethnopharmacol. 96:207–210.
  • Zhou X, Gao DQ, Michalski J, Benitez JA, Kaper JB. 2004. Induction of interleukin-8 in T84 cells by Vibrio cholerae. Infect Immun. 72:389–397.

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