Advanced search
Publication Cover
Pharmaceutical Biology Volume 54, 2016 - Issue 9
Submit an article Journal homepage
1,062
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Molecular mechanism of inhibition of the abnormal proliferation of human umbilical vein endothelial cells by hydroxysafflor-yellow A

Ji WangSchool of Basic Medicine, Beijing University of Chinese Medicine, Beijing, China;
,
Jingjing WangSchool of Basic Medicine, Beijing University of Chinese Medicine, Beijing, China;
,
Xixi WangSchool of Basic Medicine, Beijing University of Chinese Medicine, Beijing, China;
,
Li LiuSchool of Basic Medicine, Beijing University of Chinese Medicine, Beijing, China;
,
Jinghong HuSchool of Basic Medicine, Beijing University of Chinese Medicine, Beijing, China;
,
Xue YuSchool of Basic Medicine, Beijing University of Chinese Medicine, Beijing, China;
,
Yingying XuSchool of Basic Medicine, Beijing University of Chinese Medicine, Beijing, China;
,
Xuyan NiuInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China;
,
Zong LinZhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, China
,
Yan ZhangSchool of Basic Medicine, Beijing University of Chinese Medicine, Beijing, China;
,
Xin ZhangSchool of Basic Medicine, Beijing University of Chinese Medicine, Beijing, China;
&
Qian ZhangSchool of Basic Medicine, Beijing University of Chinese Medicine, Beijing, China; Correspondence[email protected]
 show all
Pages 1800-1807 | Received 30 Jun 2015, Accepted 03 Dec 2015, Published online: 05 Jan 2016

References

  • Caraglia M, Tassone P, Marra M, Budillon A, Venuta S, Tagliaferri P. 2006. Targeting Raf-kinase: molecular rationales and translational issues. Ann Oncol. 17(Suppl 7):vii124–vii127.
  • Clauss M. 2000. Molecular biology of the VEGF and the VEGF receptor family. Semin Thromb Hemost. 26:561–569.
  • Huang F, Cao J, Liu Q, Zou Y, Li H, Yin T. 2013. MAPK/ERK signal pathway involved expression of COX-2 and VEGF byIL-1β induced in human endometriosis stromal cells in vitro. Int J Clin Exp Pathol. 6:2129–2136.
  • Grothey A, Ellis LM. 2008. Targeting angiogenesis driven by vascular endothelial growth factors using antibody-based therapies. Cancer J. 14:170–177.
  • Lau ST, Leung PS. 2011. Role of the RAS in pancreatic cancer. Curr Cancer Drug Targets. 11:412–420.
  • Li X, Gu F, Niu C, Wang Y, Liu Z, Li N, Pan B, He D, Kong J, Zhang S, et al. 2015. VEGF111b, a C-terminal splice variant of VEGF-A and induced by mitomycin C, inhibits ovarian cancer growth. J Transl Med. 13:164.
  • Rask-Madsen C, King GL. 2008. Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arterioscler Thromb Vasc Biol. 28:919–924.
  • Relf M, LeJeune S, Scott PA, Fox S, Smith K, Leek R, Moghaddam A, Whitehouse R, Bicknell R, Harris AL. 1997. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res. 57:963–969.
  • Reuter CW, Morgan MA, Grunwald V, Herrmann TR, Burchardt M, Ganser A. 2007. Targeting vascular endothelial growth factor (VEGF)-receptor-signaling in renal cell carcinoma. World J Urol. 25:59–72.
  • Rivera LB, Bergers G. 2015. CANCER. Tumor angiogenesis, from foe to friend. Science. 349:694–695.
  • Shibuya M, Claesson-Welsh L. 2006. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res. 312:549–560.
  • Su CH, He YL, Chen ZG, Lei YY, Zou JY, Zhong FT, Luo HH. 2009. Notch1 expression in esophageal squamous carcinoma and its relationship with the capillaries. J Southern Med Univ. 29:2255–2258.
  • Szewezyk NJ, Peterson BK, Jaeobson LA. 2002. Activation of Ras and the mitogen-activated protein kinase pathway promotes protein degradation in muscle cells of Caenorhabditis elegans. Mol Cell Biol. 22:4181–4188.
  • Wang J, Zhang Q, Gu LG, Cui W, Xie H, Niu XY. 2008. Effect of hydroxy safflor yellow A on the cell cycle and apoptosis of human umbilical vein endothelial cells with the stimulus of tumor cell conditioned medium. J Beijing Univ Trad Chinese Med. 31:741–744.
  • Wang J, Zhang Q, Xie H, Gu LG, Niu XY, Liu LT. 2009. Effect of hydroxy safflor Yellow A on the proliferation of human umbilical vein endothelial cells with the stimulus of tumor cell conditioned medium. CJTCMP. 24:572–575.
  • Zarkada G, Heinolainen K, Makinen T, Kubota Y, Alitalo K. 2015. VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proc Natl Acad Sci USA. 112:761–766.
  • Xu J, Liu X, Jiang Y, Chu L, Hao H, Liua Z, Verfaillie C, Zweier J, Gupta K, Liu Z. 2008. MAPK/ERK signalling mediates VEGF-induced bone marrow stem cell differentiation into endothelial cell. J Cell Mol Med. 12:2395–2406.
  • Yamaguchi R, Yano H, Nakashima Y, Ogasawara S, Higaki K, Akiba J, Hicklin DJ, Kojiro M. 2000. Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues. Oncol Rep. 7:725–729.
  • Yan B, Huang H. 2015. Perioperative serum and urine of bladder cancer patients HA, bFGF and VEGF change research. China's Clin Res. 3:348–350.
  • Yang X, Zhang Y, Hosaka K, Andersson P, Wang J, Tholander F, Cao Z, Morikawa H, Tegnér J, Yang Y. 2015. VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients. Proc Natl Acad Sci USA. 112:2900–2909.
  • Zhang Q, Niu X, Yan Y, Jin M, Yang XZ, Li JR. 2004. Research on the mechanism of hydroxysafflor Yellow A in inhibiting angiogenesis. J Beijing Univ Trad Chinese Med. 27:25–29.
  • Zhao JF, Xu M, Zhao FZ, Hu PH, Quan Q, Xiang JJ, Wang H. 2015. BFGF expression in malignant tumor and its clinical pathological significance. Chinese J Pathophysiol. 4:590–596.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.