Low concentration of formononetin stimulates the proliferation of nasopharyngeal carcinoma cell line CNE2 by upregulating bcl-2 and p-ERK1/2 expression

References

• Berthois Y, Katzenellenbogen JA, Katzenellenbogen BS. 1986. Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc Natl Acad Sci USA. 83:2496–2500.
   PubMed Web of Science ®Google Scholar
• Bogoyevitch MA, Court NW. 2004. Counting on mitogen-activated proteinkinases-ERKs 3, 4, 5, 6, 7 and 8. Cell Signal. 16:1345–1354.
   PubMed Web of Science ®Google Scholar
• Chen J, Hou R, Zhang X, Ye Y, Wang Y, Tian J. 2014. Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. PLoS One. 9:e91245.
   PubMed Web of Science ®Google Scholar
• Chen J, Liu L, Hou R, Shao Z, Wu Y, Chen X, Zhou L. 2011. Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo. Cancer Lett. 308:144–151.
   PubMed Web of Science ®Google Scholar
• Chen J, Xiong WB, Xiong Y, Wu YY, Chen XJ, Shao ZJ, Liu LT, Kuang WJ, Tan XS, Zhou LM. 2011. Calycosin stimulates proliferation of estrogen receptor-positive human breast cancer cells through downregulation of Bax gene expression and upregulation of Bcl-2 gene expression at low concentrations. J Parenter Enteral Nutr. 35:763–769.
   PubMed Web of Science ®Google Scholar
• Chen J, Zhao X, Ye Y, Wang Y, Tian J. 2013. Estrogen receptor beta-mediated proliferative inhibition and apoptosis in human breast cancer by calycosin and formononetin. Cell Physiol Biochem. 32:1790–1797.
   PubMed Web of Science ®Google Scholar
• Fang CY, Wu CC, Hsu HY, Chuang HY, Huang SY, Tsai CH, Chang Y, Tsao GS, Chen CL, Chen JY. 2015. EGCG inhibits proliferation, invasiveness and tumor growth by up-regulation of adhesion molecules, suppression of gelatinases activity, and induction of apoptosis in nasopharyngeal carcinoma cells. Int J Mol Sci. 16:2530–2558.
   PubMed Web of Science ®Google Scholar
• Guo J, Zhou X, Chen Y, Bai M, Yang X, Zhao K, Hao W, Wei W, Zhang Y. 2014. mGluR3 promotes proliferation of human embryonic cortical neural progenitor cells by activating ERK1/2 and JNK2 signaling pathway in vitro. Cell Mol Biol (Noisy-le-Grand). 60:42–49.
   PubMed Web of Science ®Google Scholar
• Gustafsson AB, Gottlieb RA. 2007. Bcl-2 family members and apoptosis, taken to heart. Am J Physiol Cell Physiol. 292:C45–C51.
   PubMed Web of Science ®Google Scholar
• Huang C, Wu M, Tang Y, Li X, Ouyang J, Xiao L, Li D, Li G. 2009. NAG7 promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up-regulation of JNK2/AP-1/MMP1 pathways. J Cell Physiol. 221:394–401.
   PubMed Web of Science ®Google Scholar
• Huang WJ, Bi LY, Li ZZ, Zhang X, Ye Y. 2014. Formononetin induces the mitochondrial apoptosis pathway in prostate cancer cells via downregulation of the IGF-1/IGF-1R signaling pathway. Pharm Biol. 52:466–470.
   Web of Science ®Google Scholar
• Jia WC, Liu G, Zhang CD, Zhang SP. 2014. Formononetin attenuates hydrogen peroxide (H2O2)-induced apoptosis and NF-κB activation in RGC-5 cells. Eur Rev Med Pharmacol Sci. 18:2191–2197.
   PubMed Web of Science ®Google Scholar
• Liu Y, He J, Chen X, Li J, Shen M, Yu W, Yang Y, Xiao Z. 2014. The proapoptotic effect of formononetin in human osteosarcoma cells: involvement of inactivation of ERK and Akt pathways. Cell Physiol Biochem. 34:637–645.
   PubMed Web of Science ®Google Scholar
• Mo L, Kuang G, Luo Y, Yang R. 2006. Relationship between the expression of estrogen and progestogen receptors in distant metastasis of nasopharyngeal carcinoma. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 20:494–495.
   PubMedGoogle Scholar
• Mu H, Bai YH, Wang ST, Zhu ZM, Zhang YW. 2009. Research on antioxidant effects and estrogenic effect of formononetin from Trifolium pratense (red clover). Phytomedicine. 16:314–319.
   PubMed Web of Science ®Google Scholar
• Pan LL, Wang AY, Huang YQ, Luo Y, Ling M. 2014. Mangiferin induces apoptosis by regulating Bcl-2 and Bax expression in the CNE2 nasopharyngeal carcinoma cell line. Asian Pac J Cancer Prev. 15:7065–7068.
   PubMedGoogle Scholar
• Peng C, Liu HY, Zhou M, Zhang LM, Li XL, Shen SR, Li GY. 2007. BRD7 suppresses the growth of Nasopharyngeal carcinoma cells (HNE1) through negatively regulating beta-catenin and ERK pathways. Mol Cell Biochem. 303:141–149.
   PubMed Web of Science ®Google Scholar
• Poluzzi E, Piccinni C, Raschi E, Rampa A, Recanatini M, De Ponti F. 2014. Phytoestrogens in postmenopause: the state of the art from a chemical, pharmacological and regulatory perspective. Curr Med Chem. 21:417–436.
   PubMed Web of Science ®Google Scholar
• Razak AR, Siu LL, Liu FF, Ito E, O’Sullivan B, Chan K. 2010. Nasopharyngeal carcinoma: the next challenges. Eur J Cancer 46:1967–1978.
   PubMed Web of Science ®Google Scholar
• Tsujimoto Y, Shimizu S. 2000. Bcl-2 family: life-or-death switch. FEBS Lett. 466:6–10.
   PubMed Web of Science ®Google Scholar
• Tulalamba W, Janvilisri T. 2012. Nasopharyngeal carcinoma signaling pathway: an update on molecular biomarkers. Int J Cell Biol. 2012:594681.
   PubMedGoogle Scholar
• Wang M, Lu X, Dong X, Hao F, Liu Z, Ni G, Chen D. 2015. pERK1/2 silencing sensitizes pancreatic cancer BXPC-3 cell to gemcitabine-induced apoptosis via regulating Bax and Bcl-2 expression. World J Surg Oncol. 13:66.
   PubMed Web of Science ®Google Scholar
• Xie M, Yi X, Wang R, Wang L, He G, Zhu M, Qi C, Liu Y, Ye Y, Tan S, et al. 2014. 14-Thienyl methylene matrine (YYJ18), the derivative from matrine, induces apoptosis of human nasopharyngeal carcinoma cells by targeting MAPK and PI3K/Akt pathways in vitro. Cell Physiol Biochem. 33:1475–1483.
   PubMed Web of Science ®Google Scholar
• Xu T, Tang J, Gu M, Liu L, Wei W, Yang H. 2013. Recurrent nasopharyngeal carcinoma: a clinical dilemma and challenge. Curr Oncol. 20:e406–e419.
   PubMed Web of Science ®Google Scholar
• Xue WQ, Qin HD, Ruan HL, Shugart YY, Jia WH. 2013. Quantitative association of tobacco smoking with the risk of nasopharyngeal carcinoma: a comprehensive meta-analysis of studies conducted between 1979 and 2011. Am J Epidemiol. 178:325–338.
   PubMed Web of Science ®Google Scholar
• Zhang X, Bi L, Ye Y, Chen J. 2014. Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt pathway. Nutr Cancer. 66:656–661.
   PubMed Web of Science ®Google Scholar