Lophirones B and C prevent aflatoxin B₁-induced oxidative stress and DNA fragmentation in rat hepatocytes

References

• Adeleye AO, Ajiboye TO, Iliasu GA, Abdussalam FA, Balogun A, Ojewuyi OB, Yakubu MT. 2014. Phenolic extract of Dialium guineense pulp enhances reactive oxygen species detoxification in aflatoxin B1 hepatocarcinogenesis. J Med Food. 17:875–885.
   PubMed Web of Science ®Google Scholar
• Aebi H. 1984. Catalase in vitro. Methods Enzymol. 105:121–126.
   PubMed Web of Science ®Google Scholar
• Ajiboye TO, Yakubu MT, Salau AK, Oladiji AT, Akanji MA, Okogun JI. 2010. Antioxidant and drug detoxification potential of aqueous extract of Annona senegalensis leaves in carbon tetrachloride-induced hepatocellular damage. Pharm Biol. 48:1361–1370.
   PubMed Web of Science ®Google Scholar
• Ajiboye TO. 2011. In vivo antioxidant potentials of Piliostigma thonningii (Schum) leaves: studies on hepatic marker enzyme, antioxidant system, drug detoxifying enzyme and lipid peroxidation. Human Exp Toxicol. 30:55–62.
   PubMed Web of Science ®Google Scholar
• Ajiboye TO. 2015. Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation and DNA fragmentation in acetaminophen-induced hepatotoxicity. J Ethnopharmacol. 164:273–282.
   PubMed Web of Science ®Google Scholar
• Ajiboye TO, Salau AK, Yakubu MT, Oladiji AT, Akanji MA, Okogun JI. 2010. Aqueous extract of Securidaca longepedunculata root induce redox imbalance in male rat liver and kidney. Hum Exp Toxicol. 29:679–688.
   PubMed Web of Science ®Google Scholar
• Ajiboye TO, Raji HO, Muritala HF, Ojewuyi OB, Yakubu MT. 2013. Anthocyanin extract of Lannea microcarpa fruits stall Aflatoxin B1-mediated oxidative rout on cellular proteins, lipids and DNA. Food Bioscience. 4:58–67.
   Google Scholar
• Ajiboye TO, Naibi AM, Abdulazeez IO, Alege IO, Mohammed AO, Bello SA, Yusuf II, Ibitoye OB, Muritala HF. 2016. Involvement of oxidative stress in bactericidal activity of 2-(2-nitrovinyl) furan against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Microbial Pathogen. 91:107–114.
   PubMed Web of Science ®Google Scholar
• Ajiboye TO, Yakubu MT, Oladiji AT. 2014a. Cytotoxic, antimutagenic, and antioxidant activities of methanolic extract and chalcone dimers (lophirones B and C) derived from Lophira alata (Van Tiegh. Ex Keay) stem bark. J Evid Based Complement Altern Med. 19:20–30.
   PubMedGoogle Scholar
• Ajiboye TO, Yakubu MT, Oladiji AT. 2014b. Electrophilic and reactive oxygen species detoxification potentials of chalcone dimers is mediated by redox transcription factor Nrf-2. J Biochem Mol Toxicol. 28:11–22.
   PubMed Web of Science ®Google Scholar
• Ajiboye TO, Yakubu MT, Oladiji AT. 2014c. Lophirones B and C extenuate AFB1-mediated oxidative onslaught on cellular proteins, lipids, and DNA through Nrf-2 expression. J Biochem Mol Toxicol. 28:558–567.
   PubMed Web of Science ®Google Scholar
• Bankole S, Schollenberger M, Drochner W. 2006. Mycotoxins in food systems in sub-Saharan Africa: a review. Mycotoxin Res. 22:163–169.
   PubMedGoogle Scholar
• Bergmeyer HU, Hørder M, Rej R. 1986a. International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 2. IFCC method for aspartate aminotransferase. J Clin Chem Clin Biochem. 24:497–510.
   PubMedGoogle Scholar
• Bergmeyer HU, Hørder M, Rej R. 1986b. International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 3. IFCC method for alanine aminotransferase. J Clin Chem Clin Biochem. 24:481–495.
   PubMedGoogle Scholar
• Burton K. 1956. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J. 62:315–323.
   PubMed Web of Science ®Google Scholar
• Doumas BT, Watson WA, Biggs HG. 1997. Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta. 258:21–30.
   PubMed Web of Science ®Google Scholar
• Duan XX, Ou JS, Li Y, Su JJ, Ou C, Yang C, Yue HF, Ban KC. 2005. Dynamic expression of apoptosis-related genes during development of laboratory hepatocellular carcinoma and its relation to apoptosis. World J Gastroenterol. 11:4740–4744.
   PubMed Web of Science ®Google Scholar
• Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB. 2000. Diagnosis and monitoring of hepatic injury I. Perform Charact Lab Tests 2068:2050–68.
   Google Scholar
• Eaton DL, Gallagher EP. 1994. Mechanisms of aflatoxin carcinogenesis. Annu Rev Pharmacol Toxicol. 34:135–172.
   PubMed Web of Science ®Google Scholar
• Ellinger-Ziegelbauer H, Stuart B, Wahle B, Bomann W, Ahr HJ. 2004. Characteristic expression profiles induced by genotoxic carcinogens in rat liver. Toxicol Sci. 77:19–34.
   PubMed Web of Science ®Google Scholar
• Ellman GL. 1959. Tissue sulfhydryl groups. Arch Biochem Biophys. 82:70–77.
   PubMed Web of Science ®Google Scholar
• Fry JR. 1981. Preparation of mammalian hepatocytes. Methods Enzymol. 77:130–137.
   PubMedGoogle Scholar
• Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. 1982. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem. 126:131–138.
   PubMed Web of Science ®Google Scholar
• Hissin PJ, Hilf R. 1976. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem. 74:214–226.
   PubMed Web of Science ®Google Scholar
• Janicke RU. 1998. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem. 73:9357–9360.
   Web of Science ®Google Scholar
• Jennen DGJ, Magkoufopoulou C, Ketelslegers HB, van Herwijnen MHM, Kleinjans JCS, van Delft JHM. 2010. Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 115:66–79.
   PubMed Web of Science ®Google Scholar
• Josse R, Dumont J, Fautrel A, Robin MA, Guillouzo A. 2012. Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds. Toxicol Appl Pharmacol. 258:176–187.
   PubMed Web of Science ®Google Scholar
• Kolb JP. 2000. Mechanisms involved in the pro- and anti-apoptotic role of NO in human leukemia. Leukemia. 14:1685–1694.
   PubMed Web of Science ®Google Scholar
• Lee J, Hye E, Lee K, Sook H. 2005. Alleviation of aflatoxin B1-induced oxidative stress in HepG2 cells by volatile extract from Allii fistulosi bulbus. Life Sci. 77:2896–2910.
   PubMed Web of Science ®Google Scholar
• Levine RL, Garland D, Oliver CN, Amici A, Clement I. 1990. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186:464–478.
   PubMed Web of Science ®Google Scholar
• Li Y, Wan DF, Su JJ, Cao J, Ou C, Qiu XK, Ban KC, Yang C, Qin LL, Luo D, et al. 2004. Differential expression of genes during aflatoxin B(1)-induced hepatocarcinogenesis in tree shrews. World J Gastroenterol. 10:497–504.
   PubMed Web of Science ®Google Scholar
• Meki AR, Abdel-Ghaffar SK, El-Gibaly I. 2001. Aflatoxin B1 induces apoptosis in rat liver: protective effect of melatonin. Neuro Endocrinol Lett. 22:417–426.
   PubMed Web of Science ®Google Scholar
• Meki ARMA, Esmail EEDF, Hussein AA, Hassanein HM. 2004. Caspase-3 and heat shock protein-70 in rat liver treated with aflatoxin B1: effect of melatonin. Toxicon. 43:93–100.
   PubMed Web of Science ®Google Scholar
• Misra HP, Fridovich I. 1972. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 247:3170–3175.
   PubMed Web of Science ®Google Scholar
• National Research Council (NRC). 2010. Guide for the care and use of laboratory animals. Laboratory animals. Available from: http://grants.nih.gov/grants/olaw/Guide-for-the-care-and-use-of-Laboratory-animals.pdf.
   Google Scholar
• Niki E. 2009. Lipid peroxidation: physiological levels and dual biological effects. Free Radic Biol Med. 47:469–484.
   PubMed Web of Science ®Google Scholar
• Oloyede HOB, Ajiboye TO, Komolafe YO, Salau AK. 2013. Polyphenolic extract of Blighia sapida arilli prevents N-nitrosodiethylamine-mediated oxidative onslaught on microsomal protein, lipid and DNA. Food Biosci. 1:48–56.
   Google Scholar
• Pryor WA, Squadrito GL. 1995. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol. 268:L699–L722.
   PubMed Web of Science ®Google Scholar
• Rastogi R, Srivastava AK, Srivastava M, Rastogi AK. 2000. Hepatocurative effect of picroliv and silymarin against aflatoxin B1 induced hepatotoxicity in rats. Planta Med. 66:709–713.
   PubMed Web of Science ®Google Scholar
• Rastogi R, Srivastava AK, Rastogi AK. 2001. Long term effect of aflatoxin B(1) on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin. Phytother Res. 15:307–310.
   PubMed Web of Science ®Google Scholar
• Reddy L, Odhav B, Bhoola K. 2006. Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage. Biol Chem. 387:87–93.
   PubMed Web of Science ®Google Scholar
• Reilly CA, Aust SD. 2001. Measurement of lipid peroxidation. Curr Protoc Toxicol. Chapter 2, Unit 2.4.
   PubMedGoogle Scholar
• Ribeiro DHB, Ferreira FL, da Silva VN, Aquino S, Correa B. 2010. Effects of aflatoxin B1 and fumonisin B1 on the viability and induction of apoptosis in rat promary hepatocytes. Int J Mol Sci. 11:1944–1955.
   PubMed Web of Science ®Google Scholar
• Sanchez A, Alvarez AM, Benito M, Fabregat I. 1997. Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor beta in fetal rat hepatocytes in primary culture. Hepatology. 26:935–943.
   PubMed Web of Science ®Google Scholar
• Scholl PF, Musser SM, Groopman JD. 1997. Synthesis and characterization of aflatoxin B1 mercapturic acids and their identification in rat urine. Chem Res Toxicol. 10:1144–1151.
   PubMed Web of Science ®Google Scholar
• Shen HM, Ong CN. 1996. Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis. Mutat Res. 366:23–44.
   PubMed Web of Science ®Google Scholar
• Shen HM, Shi CY, Lee HP, Ong CN. 1994. Aflatoxin B1-induced lipid peroxidation in rat liver. Toxicol Appl Pharmacol. 127:145–150.
   PubMed Web of Science ®Google Scholar
• Shen HM, Ong CN, Shi CY. 1995. Involvement of reactive oxygen species in aflatoxin B1-induced cell injury in cultured rat hepatocytes. Toxicology. 99:115–123.
   PubMed Web of Science ®Google Scholar
• Shen HM, Shi CY, Shen Y, Ong CN. 1996. Detection of elevated reactive oxygen species level in cultured rat hepatocytes treated with aflatoxin B1. Free Radic Biol Med. 21:139–146.
   PubMed Web of Science ®Google Scholar
• Souza MF, Tomé AR, Rao VS. 1999. Inhibition by the bioflavonoid ternatin of aflatoxin B1-induced lipid peroxidation in rat liver. J Pharm Pharmacol. 51:125–129.
   PubMed Web of Science ®Google Scholar
• Theumer MG, Cánepa MC, López AG, Mary VS, Dambolena JS, Rubinstein HR. 2010. Subchronic mycotoxicoses in Wistar rats: assessment of the in vivo and in vitro genotoxicity induced by fumonisins and aflatoxin B(1), and oxidative stress biomarkers status. Toxicology. 268:104–110.
   PubMed Web of Science ®Google Scholar
• Tilton SC, Gerwick LG, Hendricks JD, Rosato CS, Corley-Smith G, Givan SA, Bailey GS, Bayne CJ, Williams DE. 2005. Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liver. Toxicol Sci. 88:319–330.
   PubMed Web of Science ®Google Scholar
• Towner RA, Mason RP, Reinke LA. 2002. In vivo detection of aflatoxin-induced lipid free radicals in rat bile. Biochim Biophys Acta. 1573:55–62.
   PubMed Web of Science ®Google Scholar
• Van Vleet TR, Watterson TL, Klein PJ, Coulombe RA. 2006. Aflatoxin B1 alters the expression of p53 in cytochrome P450-expressing human lung cells. Toxicol Sci. 89:399–407.
   PubMed Web of Science ®Google Scholar
• Wright PJ, Leathwood PD, Plummer DT. 1972. Enzymes in rat urine: alkaline phosphatase. Enzymologia. 42:317–327.
   PubMedGoogle Scholar