2,665
Views
46
CrossRef citations to date
0
Altmetric
Research Article

Asiatic acid exerts anticancer potential in human ovarian cancer cells via suppression of PI3K/Akt/mTOR signalling

, , , &
Pages 2377-2382 | Received 15 Oct 2015, Accepted 16 Feb 2016, Published online: 17 Mar 2016

References

  • Bunbupha S, Prachaney P, Kukongviriyapan U, Kukongviriyapan V, Welbat JU, Pakdeechote P. 2015. Asiatic acid alleviates cardiovascular remodelling in rats with L-NAME-induced hypertension. Clin Exp Pharmacol Physiol. 42:1189–1197.
  • Chen JY, Chen JY, Xu QW, Xu H, Huang ZH. 2014. Asiatic acid promotes p21(WAF1/CIP1) protein stability through attenuation of NDR1/2 dependent phosphorylation of p21(WAF1/ CIP1) in HepG2 human hepatoma cells. Asian Pac J Cancer Prev. 15:963–967.
  • Cho CW, Choi DS, Cardone MH, Kim CW, Sinskey AJ, Rha C. 2006. Glioblastoma cell death induced by asiatic acid. Cell Biol Toxicol. 22:393–408.
  • Clarke-Pearson DL. 2009. Clinical practice. Screening for ovarian cancer. N Engl J Med. 361:170–177.
  • Gao X, Liu Y, Deeb D, Arbab AS, Gautam SC. 2014. Anticancer activity of pristimerin in ovarian carcinoma cells is mediated through the inhibition of prosurvival Akt/NF-κB/mTOR signaling. J Exp Ther Oncol. 10:275–283.
  • He F, Wu HN, Cai MY, Li CP, Zhang X, Wan Q, Tang SB, Cheng JD. 2014. Inhibition of ovarian cancer cell proliferation by Pien Tze Huang via the AKT-mTOR pathway. Oncol Lett. 7:2047–2052.
  • Hsu YL, Kuo PL, Lin LT, Lin CC. 2005. Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells. J Pharmacol Exp Ther. 313:333–344.
  • Jew SS, Yoo CH, Lim DY, Kim H, Mook-Jung I, Jung MW, Choi H, Jung YH, Kim H, Park HG. 2000. Structure–activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity. Bioorg Med Chem Lett. 10:119–121.
  • Kim A, Ueda Y, Naka T, Enomoto T. 2012. Therapeutic strategies in epithelial ovarian cancer. J Exp Clin Cancer Res. 31:14.
  • Kvansakul M, Hinds MG. 2015. The Bcl-2 family: structures, interactions and targets for drug discovery. Apoptosis. 20:136–150.
  • Li MX, Dewson G. 2015. Mitochondria and apoptosis: emerging concepts. F1000Prime Rep. 7:42.
  • Mabuchi S, Kuroda H, Takahashi R, Sasano T. 2015. The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. Gynecol Oncol. 137:173–179.
  • Masamha CP, Benbrook DM. 2009. Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells. Cancer Res. 69:6565–6572.
  • Nam EJ, Kim YT. 2008. Alteration of cell-cycle regulation in epithelial ovarian cancer. Int J Gynecol Cancer. 18:1169–1182.
  • Pang Y, Si M, Sun B, Niu L, Xu X, Lu T, Yuan H, Lou H. 2014. DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway. Food Chem Toxicol. 69:163–174.
  • Park BC, Bosire KO, Lee ES, Lee YS, Kim JA. 2005. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 218:81–90.
  • Ramachandran V, Saravanan R. 2015. Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic acid in diabetic rats. Hum Exp Toxicol. 34:884–893.
  • Sayal K, Gounaris I, Basu B, Freeman S, Moyle P, Hosking K, Iddawela M, Jimenez-Linan M, Abraham J, Brenton J. 2015. Epirubicin, cisplatin, and capecitabine for primary platinum-resistant or platinum-refractory epithelial ovarian cancer: results of a retrospective, single-institution study. Int J Gynecol Cancer. 25:977–984.
  • Siegel R, Naishadham D, Jemal A. 2013. Cancer statistics, 2013. CA Cancer J Clin. 63:11–30.
  • Soo Lee Y, Jin DQ, Beak SM, Lee ES, Kim JA. 2003. Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes. Eur J Pharmacol. 476:173–178.
  • Tang XL, Yang XY, Jung HJ, Kim SY, Jung SY, Choi DY, Park WC, Park H. 2009. Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade. Biol Pharm Bull. 32:1399–1405.
  • Wright JD, Chen L, Tergas AI, Patankar S, Burke WM, Hou JY, Neugut AI, Ananth CV, Hershman DL 2015. Trends in relative survival for ovarian cancer from 1975 to 2011. Obstet Gynecol. 125:1345–1352.
  • Wu Q, Lv T, Chen Y, Wen L, Zhang J, Jiang X, Liu F. 2015. Apoptosis of HL-60 human leukemia cells induced by asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway. Mol Med Rep. 12:1429–1434.
  • Zhang J, Ai L, Lv T, Jiang X, Liu F. 2013. Asiatic acid, a triterpene, inhibits cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells. Oncol Lett. 6:1762–1766.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.