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Research Article

Preclinical Studies and Optimization of Specific Tumor Delivery for 741F8 sFv, an Anti-c-erbB-2 Single-Chain Species

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Pages 75-91 | Published online: 20 Oct 2008

References

  • Adams G. P, McCartney J. E, Tai M-S., Oppermann H., Huston J. S, Stafford W. F, Bookman M. A, Fand I., Houston L. L, Weiner L. M. Highly specific in vivo, tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2, single-chain Fv. Cancer Res. 1993; 53: 4026–4034
  • Adams G. P, DeNardo S. J, Amin A., Kroger L. A, De-Nardo G. L, Hellstrom I., Hellstrom K. E. Comparison of the pharmacokinetics in mice and the biological activity of murine L6 and human-mouse chimeric ch-L6 antibody. Antibody, Immunoconj. Radiopharm. 1992; 5: 81–95
  • Adams G. P, McCartney J. E, Wolf E. I, Eisenberg J., Tai M.-S., Huston J. S, Stafford I W.F., II, Bookman M. A, Houston L. L, Weiner L. M. Optimization of in vivo, tumor targeting with divalent forms of 741F8 single-chain Fv: Effects of dose escalation and repeated i.v. administration. Cancer Immunol. Immunother. 1995a, In press
  • Adams G. P, Tai M.-S., Wolf E. J, Eisenberg J., Huston J. S, Bookman M. A, Moldofsky P., Stafford I W.F., II, Houston L. L, Weiner L. M. Enhanced tumor specificity with stably iodinated 741F8-2 (sFv')2, an anti-c-erbB-2 single-chain Fv dimer. J. Nuc. Med. 1995b, In press
  • Bindon C. I, Hale G., Bruggemann M., Waldmann H. Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q. J. Exper. Med. 1988; 168: 127–142
  • Blakey D. C, Valcaccia B. E, East S., Wright A. F, Boyle F. T, Springer C. J, Burke P. J, Melton R. G, Bag-Shawe K. D. Antitumor effects of an antibody-carboxypeptidase G2 conjugate in combination with a benzoic acid mustard prodrug. Cell Biophy. 1993; 22: 1–8
  • Brinkmann U., Pai L. H, Fitzgerald D. J, Willingham M., Pastan I. B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice. Proc. Natl. Acad. Sci. USA 1991; 88: 8616–8620
  • Brinkmann U., Gallo M., Brinkmann E., Kunwar S., Pastan I. A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin. Proc. Natl. Acad. Sci. USA 1993; 90: 547–551
  • Brown L., Miller R. A, Horning S. J, Czerwinski D., Hart S. M, McElderry R., Basham T., Warnke R. A, Merigan T. C, Levy R. Treatment of B-cell lymphomas with anti-idiotype antibodies alone and in combination with cc-interferon. Blood 1989; 72: 651–661
  • Cheung N. K, Burch L., Kushner B. H, Munn D. H. Monoclonal antibody 3F8 can effect durable remissions in neuroblastoma patients refractory to chemotherapy: a phase II trial. Progress Clin. Biol. Res. 1991; 366: 395–400
  • Clackson T., Hoogenboom H. R, Griffiths A. D, Winter G. Making antibody fragments using phage display libraries. Nature 1991; 352: 624–628
  • Colcher D., Minelli F. M., Roselli M., Muraro R., Simp-son-Milenic D., Schlom J. Radioimmu-nolocalization of human carcinoma xenografts with B72.3 second generation monoclonal antibodies. Cancer Res. 1988; 48: 4597–4603
  • Colcher D., Bird R., Roselli M., Hardman K. D, Johnson S., Pope S., Dodd S. W, Pantoliano M. W, Milenic D. E, Schlom J. In vivo, tumor targeting of a recombinant single-chain antigen-binding protein. J. Natl. Cancer Inst. 1990; 82: 1191–1197
  • DeNardo S. J, Peng J. S, DeNardo G. L, Mills S. M, Epstein A. L. Immunochemical aspects of monoclonal antibodies important for radiopharmaceutical development. Nucl. Med. Biol. 1986; 13: 303–310
  • Dorai H., McCartney J. E, Hudziak R. M, Tai M.-S., Laminet A. A, Houston L. L, Huston J. S, Oppermann H. Mammalian cell expression of single-chain Fv (sFv) antibody proteins and their C-terminal fusions with interleukin-2 and other effector domains. Bio/Technology 1994; 12: 890–897
  • Fand I., Sharkey R. M., Grundy P., Goldenberg D. M. Localization by whole-body autoradiography of intact and fragmented radiolabeled antibodies in a metastatic human colonic cancer model. Int. J. Rad. Appl. Instr. - Part B, Nucl. Med. Biol. 1992; 19: 87–99
  • Frankel A. E, Ring D. B, Tringale F., Hsieh-Ma S. T. Tissue distribution of breast cancer-associated antigens defined by monoclonal antibodies. J. Biol. Response Modifiers 1985; 4: 273–286
  • Friedman P. N, McAndrew S. J, Gawlak S. L, Chace D., Trail P. A, Brown J. P, Siegall C. B. BR96 sFv-PE40, a potent cingle-chain immunotoxin that selectively kills carcinoma cells. Cancer Res. 1993; 53: 334–339
  • Fujimori K., Covell D. G, Fletcher J. E, Weinstein J. N. Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors. Cancer Res. 1989; 49: 5656–5663
  • Gallinger S., Reilly R. M, Kirsh J. C, Odze R. D, Hay K., Polihronis J., Damani M. T, Shpitz B., Stern H. S. Comparative dual label study of first and second generation antitumor-associated glycoprotein-72 monoclonal antibodies in colorectal cancer patients. Cancer Res. 1993; 53: 271–278
  • George A. JT., Titus J. A, Jost C. R, Kurucz I., Perez P., Andrew S. M, Nicholls P. J, Huston J. S, Segal D. M. Redirection of T cell-mediated cytotoxicity by a recombinant single-chain Fv molecule. J. Immunol. 1994; 152: 1802–1811
  • George A. JT., Jamar F., Tai M.-S., Heelan B. T, Adams G. P, McCartney J. E, Houston L. L, Weiner L. W, Oppermann H., Peters A. M, Huston J. S. Radiometal labeling of recombinant proteins by a genetically engineered, minimal chelation site: coordination of technetium-99m by single-chain Fv antibody fusion proteins through a carboxyl-terminal cysteinyl peptide. Proc. Natl. Acad. Sci. USA . 1995, In press
  • Handgretinger R., Baader P., Dopfer R., Klingebiel T., Reuland P., Treuner J., Reisfeld R. A, Nietham-Mer D. A phase I study of neuroblastoma with the anti-ganglioside GD2 antibody 14.G2a. Cancer Immunol. Immunother. 1992; 35: 199–204
  • Herlyn D., Ross A. H, Iliopoulos D., Koprowski H. Induction of specific immunity to human colon carcinoma by anti-idiotypic antibodies to monoclonal antibody C017-1 A. Eur. J. Immunol. 1987; 17: 1649–1652
  • The collected papers of Paul Ehrlich, B. Himmleweit. Pergamon Press, Elmsford, NY 1975
  • Holton O. D, Black C D., Parker R. J, Covell D. G, Barbet J., Sieber S. M, Talley M. J, Weinstein J. N. Biodistribution of monoclonal IgGl, F(ab')2, and Fab' in mice after intravenous injection. Comparison between anti-B cell (anti-Lyb8.2) and irrelevant (MOPC-21) antibodies. J. Immunol. 1987; 139: 3041–3049, 3d.
  • Huse W. D, Sastry L., Iverson S. A, Kang A. S, Alting-Mees M., Burton D. R, Benkovic S. J, Lerner R. A. Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 1989; 246: 1275–1281
  • Huston J. S, Levinson D., Mudgett-Hunter M., Tai M.-S., Novotny J., Margolies M. N, Ridge R. J, Bruccol-Eri R. E., Haber E., Crea R., Oppermann H. Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced. Escherichia coli. Proc. Natl. Acad. Sci. USA 1988; 85: 5879–5883
  • Huston J. S., Mudgett-Hunter M., Tai M.-S., McCartney J., Warren F., Haber E., Oppermann H. Protein engineering of single-chain Fv analogues and fusion proteins. Meth. Enzymol. 1991; 203: 46–88
  • Molecular Design and Modeling: Concepts and Applications, J. J. Langone. Academic Press, San Diego, Part B
  • Huston J. S, McCartney J. E, Tai M.-S., Mottola-Hart-Shorn C, Jin D., Warren F., Keck P., Oppermann H. Medical applications of single-chain antibodies. Intern. Rev. Immunol. 1993a; 10: 195–217
  • Huston J. S, Tai M.-S., McCartney J., Keck P., Oppermann H. Antigen recognition and targeted delivery by the single-chain Fv. Cell Biophysics 1993b; 22: 189–224
  • Huston J. S, Adams G. P, McCartney J. E, Tai M.-S., Oppermann H., Liu S., Stafford I W.F., II, Bookman M. A, Fand I., Apell G., Laminet A, Houston L. L, Weiner L. M. Tumor targeting in a tumor xenograft model with the (sFv')2 divalent form of anti-c-erbB-2, single-chain Fv. Cell Biophysics 1994; 24/25: 249–257
  • Huston J. S, George A. JT., Tai M.-S., McCartney J. E, Jin D., Segal D. M, Oppermann H. Single-chain Fv design and production by preparative folding. Antibody Engineering2nd edition, C. Borre-Baeck. Oxford University Press, New York and Oxford 1995; 185–225
  • Hylarides M. D, Wilbur D. S, Reed M. W, Hadley S. W, Schroeder J. R, Grant L. M. Preparation and in vivo, evaluation of an N-(p-[125I]Iodophenethyl) maleimide-antibody conjugate. Bioconjugate Client 1991; 2: 435–440
  • Jain R. K. Physiological resistance to the treatment of solid tumors. Fourth Annual JBC International Conference on Antibody Engineering 1993; 4: 87–105
  • Junghans R. P, Waldmann T. A., Landolfi N. F, Avdalovic N. M, Schneider W. P, Queen C. Anti-Tac-H, a humanized antibody to the interleukin 2 receptor with new features for immunotherapy in malignant and immune disorders. Cancer Res. 1990; 50: 1495–502
  • Juweid M., Neumann R., Paik C, Perez-Bacete M. J, Sato J., van Osdol W., Weinstein J. N. Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res. 1992; 52: 5144–5153
  • Kaminski M. S., Zasady K. R, Francis I. R, Milik A. W, Ross C. W, Moon S. D, Crawford S. M, Burgess J. M, Petry N. A, Butchko G. M, et al. Radioimmu-notherapy of B-cell lymphoma with 131I-anti-Bl (anti-CD20) antibody. New Eng. J. Med. 1993; 329: 459–65
  • Kohler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975; 256: 495–497
  • Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–685
  • LoBuglio A. F, Wheeler R. H, Trang J., Haynes A., Rogers K., Harvey E. B, Sun L., Ghrayeb J., Khaz-Aeli M. B. Mouse/human chimeric monoclonal antibody in man: Kinetics and immune response. Proc. Natl. Acad. Sci. USA 1989; 86: 4220–4224
  • LoBuglio A. F, Saleh M. N, Lee J., Khazaeli M. B, Car-Rano R., Holden H., Wheeler R. H. Phase I trial of multiple large doses of murine monoclonal antibody C017-1A. I. Clinical aspects. J. Natl. Cancer Inst. 1988; 80: 932–936
  • Lowder J. N, Meeker T. C., Campbell M., Garcia C. F, Gralow J., Miller R. A, Warnke R., Levy R. Studies on B lymphoid tumors treated with monoclonal anti-idiotype antibodies: correlation with clinical responses. Blood 1987; 69: 199–210
  • Marks J. D, Hoogenboom H. R, Bonnert T. P, McCaf-Ferty J., Griffiths A. D, Winter G. Bypassing immunization. Human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 1991; 222: 581–97
  • Mendelsohn J. Anti-epidermal growth factor receptor monoclonal antibodies as potential anti-cancer agents. J. Steroid Biochem. Mol. Biol. 1990; 37: 889–892
  • Mendelsohn J. Epidermal growth factor receptor as a target for therapy with antireceptor monoclonal antibodies. Monographs - NCI 1992; 13: 125–131
  • Miller R. A, Maloney D. G, Warnke R., Levy R. Treatment of B-cell lymphoma with monoclonal antiidiotype antibody. Medical Intelligence 1982; 306: 517–522
  • McCabe R. P, Peters L. C, Haspel M. V., Pomato N., Carrasquillo J. A, Hanna M. G., Jr. Preclinical studies on the pharmacokinetic properties of human monoclonal antibodies to colorectal cancer and their use for detection of tumors. Cancer Res. 1988; 48: 4348–4353
  • McCartney J. E, Tai M.-S., Hudziak R. M, Adams G. P, Weiner L. M, Jin D., Stafford I W.F., II, Liu S., Bookman M. A, Laminet A. A, Fand I., Houston L. L, Oppermann H., Huston J. S. Engineering disulfide-linked single-chain Fv dimers [(sFv')2] with improved solution and targeting properties. Anti-dig-oxin 26–10 (sFv')2 and emii-c-erbB-2, 741F8 (sFv')2 made by protein folding and bonded through carboxyl-termi-nal cysteinyl peptides. Protein Engineering 1995; 8, In press
  • Milenic D. E, Yokota T., Filpula D. R, Finkelman M. AJ., Dodd S. W, Wood J. F, Whitlow M., Snoy P., Schlom J. Construction, binding properties, metabolism, and targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49. Cancer Res. 1991; 51: 6363–6371
  • Morrison S. L. Transfectomas provide novel chimeric antibodies. Science 1985; 229: 1202–1207
  • Press O. W, Eary J. F, Appelbaum F. R, Martin P. J, Badger C. C, Nelp W. B, Glenn S., Butchko G., Fisher D., Porter B., Matthews D. C, Fischer L. D, Bernstein I. D. Radiolabeled-antibody therapy of B-cell lymphoma with autologous bone marrow support. New Eng. J. Med. 1993; 329: 1219–1224
  • Pressman D., Korngold L. The in vivo, localization of anti-Wagner osteogenic sarcoma antibodies. Cancer 1953; 6: 619–623
  • Pressman D., Day E. D, Blau M. The use of paired labeling in the determination of tumor-localizing antibodies. Cancer Res. 1957; 17: 845–850
  • Ring D., Clark B. R., Saxena A. Identity of BCA200 and c-erbB-2 indicated by reactivity of monoclonal antibodies with recombinant c-erbB-2. Mol. Immunol. 1991; 28: 915–917
  • Savage P., So A., Spooner R. A, Epenetos A. A. A recombinant single chain antibody interleukin-2 fusion protein. Br. J. Cancer 1993; 67: 304–310
  • Scheinberg D. A, Lovett D., Divgi C. R., Graham M. C, Berman E., Pentlow K., Feirt N., Finn R. D, Clark-Son B. D., Gee T. S, et al. A phase I trial of monoclonal antibody M195 in acute myelogenous leukemia: specific bone marrow targeting and internalization of radionuclide. J. Clin. Oncol. 1991; 9: 478–490
  • Schier R., Marks J. D, Wolf E. J, Apell G., Wong C, McCartney J. E, Bookman M. A, Huston J. S, Houston L. L, Weiner L. M, Adams G. P. In vitro, and in vivo, characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library. Immunotechnology 1995; 1, In press
  • Schott M. E, Milenic D. E, Yokota T., Whitlow M., Wood J. F, Fordyce W. A, Cheng R. C, Schlom J. Differential metabolic patterns of iodinated versus radiometal chelated anticarcinoma single-chain Fv molecules. Cancer Res. 1992; 52: 6413–6417
  • Sharkey R. M, Gold D. V, Aninipot R., Vagg R., Bal-Lance C, Newman E. S, Ostella F., Hansen H. J, Goldenberg D. M. Comparison of tumor targeting in nude mice by murine monoclonal antibodies directed against different human colorectal cancer antigens. Cancer Res. 1990; 50: 828s–834s
  • Shaw D. R, Khazaeli M. B, LoBuglio A. F. Mouse/human chimeric antibodies to a tumor-associated antigen1, biologic activity of the four human IgG subclasses. J. Natl. Cancer Inst. 1988; 80: 1553–1559
  • Springer C. J, Poon G. K, Sharma S. K, Bagshawe K. D. Identification of prodrug, active drug, and metabolites in an ADEPT clinical study. Cell Biophysics 1993; 22: 9–26
  • Tai M. S, Mudgett-Hunter M., Levinson D., Wu G. M, Haber E., Oppermann H., Huston J. S. A Afunctional fusion protein containing Fc-binding fragment B of staphylococcal protein A amino terminal to antidigoxin single-chain Fv. Biochem. 1990; 29: 8024–8030
  • Trail P. A, Willner D., Lasch S. J, Henderson A. J, Hof-Stead S., Casazza A. M, Firestone R. A, Hellstrom 1., Hellstrom K. E. Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. Science 1993; 261: 212–215
  • Vadhan-Raj S., Cordon-Cardo C, Carswell E., Mintzer D., Dantis L., Duteau C, Templeton M. A, Oettgen H. F, Old L. J, Houghton A. N. Phase I trial of a mouse monoclonal antibody against GD3 ganglio-side in patients with melanoma: induction of inflammatory responses at tumor sites. J. Clin. Oncol. 1988; 6: 1636–1648
  • Vitetta E. S, Stone M., Amlot P., Fay J., May R., Till M., Newman J., Clark P., Collins R., Cunningham D., et al. Phase I immunotoxin trial in patients with B-cell lymphoma. Cancer Res. 1991; 51: 4052–4058
  • Weiner L. M, Harvey E., Padavic-Shaller K., Willson J. K, Walsh C, LaCreta F., Khazaeli M. B, Kirkwood J. M., Haller D. G. Phase II multicenter evaluation of prolonged murine monoclonal antibody 17–1A therapy in pancreatic carcinoma. J. Immunotherapy 1993; 13: 110–116
  • Weiner L. M, Houston L. L, Huston J. S, McCartney J., Tai M.-S., Appel G., Stafford I W.F., II, Bookman M. A, Gallo J., Adams G. P. Improving the tumor-selective delivery of single-chain Fv molecules. Tumor Targeting 1995; 1: 51–60
  • Weiner L. M, O'Dwyer P. J, Kitson J., Comis R. L, Fran-Kel A. E., Bauer R. J, Konrad M. S, Groves E. S. A phase I evaluation of an anti-breast carcinoma monoclonal antibody 260F9-recombinant ricin A chain immunoconjugate. Cancer Res. 1989; 49: 4062–4067
  • Weiner L. M, Moldofsky P. J, Gatenby R. A, O'Dwyer J., O'Brian J., Litwin S., Comis R. L. Antibody delivery and effector cell activation in a phase II trial of recombinant gamma-interferon and murine monoclonal antibody C017–1A in advanced colorectal carcinoma. Cancer Res. 1988; 48: 2568–2573
  • Wels W., Harwerth I. M, Mueller M., Groner B., Hynes N. E. Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the erbB-2 receptor. Cancer Res. 1992; 52: 6310–6317
  • Wolf E. A, Schreiber G. J, Cosand W. L, Raff H. V. Monoclonal antibody homodimers: enhanced antitumor activity in nude mice. Cancer Res. 1993; 53: 2560–2565
  • Yokota T., Milenic D. E, Whitlow M., Schlom J. Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res. 1992; 52: 3402–3408
  • Yokota T., Milenic D. E, Whitlow M., Wood J. F, Hubert S. L, Schlom J. Microautoradiograph-ic analysis of the normal organ distribution of radioiod-inated single-chain Fv and other immunoglobulin forms. Cancer Res. 1993; 53: 3776–3783

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