Relaxin: A missing link in the pathomechanisms of Systemic Lupus Erythematosus?

References

• Rahman A, Isenberg DA. Systemic lupus erythematosus. N Engl J Med. 2008;358(9):929–39.
   PubMed Web of Science ®Google Scholar
• Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity. 2005;23(4):344–6.
   PubMed Web of Science ®Google Scholar
• Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011;11(11):723–37.
   PubMed Web of Science ®Google Scholar
• Gordon S. Alternative activation of macrophages. Nat Rev Immunol. 2003;3(1):23–35.
   PubMed Web of Science ®Google Scholar
• Liu G, Ma H, Qiu L, Li L, Cao Y, Ma J, Zhao Y. Phenotypic and functional switch of macrophages induced by regulatory CD4+ CD25+ T cells in mice. Immunol Cell Biol. 2011;89(1):130–42.
   PubMed Web of Science ®Google Scholar
• Silvertown1 JD, Summerlee AJ, Klonisch T. Relaxin-like peptides in cancer. Int J Cancer. 2003;107:513–9.
   PubMed Web of Science ®Google Scholar
• Sherwood OD. Relaxin's physiological roles and other diverse actions. Endocr Rev. 2004;25(2):205–34.
   PubMed Web of Science ®Google Scholar
• Bryant-Greenwood GD, Schwabe C. Human relaxins: chemistry and biology. Endocr Rev. 1994;15(1):5–26.
   PubMed Web of Science ®Google Scholar
• Evans BA, Fu P, Tregear GW. Characterization of two relaxin genes in the chimpanzee. J Endocrinol. 1994;140(3):385–92.
   PubMed Web of Science ®Google Scholar
• Tanaka M. Relaxin-3/insulin-like peptide 7, a neuropeptide involved in the stress response and food intake. FEBS J. 2010;277(24):4990–7.
   PubMed Web of Science ®Google Scholar
• Van Der Westhuizen1 ET, Summers1 RJ, Halls1 ML, Bathgate RAD, Sexton PM. Relaxin receptors–new drug targets for multiple disease states. Curr Drug Targets. 2007;8(1):91–104.
   PubMed Web of Science ®Google Scholar
• Figueiredo KA, Rossi G, Cox ME. Relaxin promotes clustering, migration, and activation states of mononuclear myelocytic cells. Ann N Y Acad Sci. 2009;1160:353–60.
   PubMed Web of Science ®Google Scholar
• Shi C, Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol. 2011;11(11):762–74.
   PubMed Web of Science ®Google Scholar
• Unemori EN, Lewis M, Constant J, Arnold G, Grove BH, Normand J, et al. Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites. Wound Repair Regen. 2000;8(5):361–70.
   PubMed Web of Science ®Google Scholar
• Piccinni MP, Bani D, Beloni L, Manuelli C, Mavilia C, Vocioni F, et al. Relaxin favors the development of activated human T cells into Th1-like effectors. Eur J Immunol. 1999;29(7):2241–7.
   PubMed Web of Science ®Google Scholar
• Masini E, Nistri S, Vannacci A, Bani Sacchi T, Novelli A, Bani D. Relaxin inhibits the activation of human neutrophils: involvement of the nitric oxide pathway. Endocrinology. 2004;145(3):1106–12.
   PubMed Web of Science ®Google Scholar
• Bani D, Baronti R, Vannacci A, Bigazzi M, Sacchi TB, Mannaioni PF, Masini E. Inhibitory effects of relaxin on human basophils activated by stimulation of the Fc epsilon receptor. The role of nitric oxide. Int Immunopharmacol. 2002;2(8):1195–204.
   PubMed Web of Science ®Google Scholar
• Bond CP, Parry LJ, Samuel CS, Gehring HM, Lederman FL, Rogers PA, Summers RJ. Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle. Ann N Y Acad Sci. 2005;1041:136–43.
   PubMed Web of Science ®Google Scholar
• Garibay-Tupas JL, Okazaki KJ, Tashima LS, Yamamoto S, Bryant-Greenwood GD. Regulation of the human relaxin genes H1 and H2 by steroid hormones. Mol Cell Endocrinol. 2004;30: 219(1–2):115–25.
   Web of Science ®Google Scholar
• Peters CA, Maizels ET, Robertson MC, Shiu RPC, Soloff MS, Hunzicker-Dunn M. Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C δ signaling. Mol Endocrinol. 2000;14(4):576–90.
   PubMed Web of Science ®Google Scholar
• Arici A, Senturk LM, Seli E, Bahtiyar MO, Kim G. Regulation of monocyte chemotactic protein-1 expression in human endometrial stromal cells by estrogen and progesterone. Biol Reprod. 1999; 61(1):85–90.
   PubMed Web of Science ®Google Scholar
• Tseng L, Zhu HH, Mazella J, Koistinen H, Seppälä M. Relaxin stimulates glycodelin mRNA and protein concentrations in human endometrial glandular epithelial cells. Mol Hum Reprod. 1999;5(4):372–5.
   PubMed Web of Science ®Google Scholar
• Alok A, Karande AA. The role of glycodelin as an immune-modulating agent at the feto-maternal interface. J Reprod Immunol. 2009; 83(1–2):124–7.
   PubMed Web of Science ®Google Scholar
• McMurray RW, May W. Sex hormones and systemic lupus erythematosus: review and meta-analysis. Arthritis Rheum. 2003; 48(8):2100–10.
   PubMed Web of Science ®Google Scholar
• Urowitz MB, Ibañez D, Jerome D, Gladman DD. The effect of menopause on disease activity in systemic lupus erythematosus. J Rheumatol. 2006;33(11):2192–8.
   PubMed Web of Science ®Google Scholar
• Mok CC, Wong RW, Lau CS. Ovarian failure and flares of systemic lupus erythematosus. Arthritis Rheum. 1999;42(6):1274–80.
   PubMed Web of Science ®Google Scholar
• Petri M, Kim MY, Kalunian KC, Grossman J, Hahn BH, Sammaritano LR, et al;OC-SELENA Trial. Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med. 2005;353(24):2550–8.
   PubMed Web of Science ®Google Scholar
• Buyon JP, Petri MA, Kim MY, Kalunian KC, Grossman J, Hahn BH, et al. The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Ann Intern Med. 2005;142(12 Pt 1):953–62.
   PubMed Web of Science ®Google Scholar
• Namjou B, Scofield RH, Kelly JA, Goodmon E, Aberle T, Bruner GR, Harley JB. The effects of previous hysterectomy on lupus. Lupus. 2009;18(11):1000–5.
   PubMed Web of Science ®Google Scholar
• Mok CC, Wong RW. Pregnancy in systemic lupus erythematosus. Postgrad Med J. 2001;77(905):157–65.
   PubMed Web of Science ®Google Scholar
• Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol. 1998;179(5):1359–75.
   PubMed Web of Science ®Google Scholar
• Klonisch T, Hombach-Klonisch S. Review: Relaxin expressed at the feto–maternal interface. Reprod Dom Anim. 2000;35(3–5): 149–52.
   Web of Science ®Google Scholar
• Wang YQ, Li J, Yang Z. [Expression of relaxin receptor in placental tissues of normal pregnancy and pre-eclampsia]. Zhonghua Fu Chan Ke Za Zhi. 2008;43(4):269–7
   PubMedGoogle Scholar
• Klonisch T, Mathias S, Cambridge G, Hombach-Klonisch S, Ryan PL, Allen WR. Placental localization of relaxin in the pregnant mare. Placenta. 1997;18(2–3):121–8.
   PubMed Web of Science ®Google Scholar
• Linker-Israeli M, Quismorio FP Jr, Wong DK, Friou GJ. Serum antibodies to human fetal antigens in patients with systemic lupus erythematosus (SLE). J Immunol. 1980;124(3):1154–9.
   PubMed Web of Science ®Google Scholar
• Adams WC, Frieden EH. Inhibition of postpartum uterine involution in the rat by relaxin. Biol Reprod. 1985;33(5):1168–75.
   PubMed Web of Science ®Google Scholar
• Kim WU, Min JK, Lee SH, Park SH, Cho CS, Kim HY. Causes of death in Korean patients with systemic lupus erythematosus: a single centre retrospective study. Clin Exp Rheumatol. 1999; 17(5):539–45.
   PubMed Web of Science ®Google Scholar
• Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. 1999;274(16):10689–92.
   Google Scholar
• Bernatsky S, Ramsey-Goldman R, Foulkes WD, Gordon C, Clarke AE. Breast, ovarian, and endometrial malignancies in systemic lupus erythematosus: a meta-analysis. Br J Cancer. 2011;104(9):1478–81.
   PubMed Web of Science ®Google Scholar
• Santana IU, Gomes Ado N, Lyrio LD, Rios Grassi MF, Santiago MB. Systemic lupus erythematosus, human papillomavirus infection, cervical pre-malignant and malignant lesions: a systematic review. Clin Rheumatol. 2011;30(5):665–72.
   PubMed Web of Science ®Google Scholar
• Bernatsky S, Ramsey-Goldman R, Gordon C, Clarke AE. Prostate cancer in systemic lupus erythematosus. Int J Cancer. 2011;129(12):2966–9.
   PubMed Web of Science ®Google Scholar
• Thompson VC, Morris TG, Cochrane DR, Cavanagh J, Wafa LA, Hamilton T, et al. Relaxin becomes upregulated during prostate cancer progression to androgen independence and is negatively regulated by androgens. Prostate. 2006;66(16):1698–709.
   PubMed Web of Science ®Google Scholar