192
Views
8
CrossRef citations to date
0
Altmetric
Original Article

Decreased expression of thymic stromal lymphopoietin in salivary glands of patients with primary Sjögren’s syndrome is associated with increased disease activity

, , , , , , & show all
Pages 105-109 | Received 13 Mar 2015, Accepted 15 May 2015, Published online: 23 Sep 2015

References

  • Fox RI. Sjögren's syndrome. Lancet. 2005;366:321–31.
  • Voulgarelis M, Tzioufas AG. Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome. Nat Rev Rheumatol. 2010;6:529–37.
  • Watanabe N, Hanabuchi S, Soumelis V, Yuan W, Ho S, de Waal Malefyt R, et al. Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion. Nat Immunol. 2004;5:426–34.
  • Liu YJ, Soumelis V, Watanabe N, Ito T, Wang YH, de Waal Malefyt R, et al. TSLP: An epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Ann Rev Immunol. 2007;25:193–219.
  • Hartgring SAY, Willis CR, Dean CE Jr., Broere F, van Eden W, Bijlsma JW, et al. Critical proinflammatory role of thymic stromal lymphopoietin and its receptor in experimental autoimmune arthritis. Arthritis Rheum. 2011;63:1878–87.
  • Moret FM, Hack CE, van der Wurff-Jacobs KMG, Radstake TRDJ, Lafeber FPJG, van Roon JAG. Thymic stromal lymphopoietin (TSLP): a novel proinflammatory mediator in rheumatoid arthritis that potently activates CD1c(+) myeloid dendritic cells to attract and stimulate T cells. Arthritis Rheum. 2014;66:1176–84.
  • Wildenberg ME, Welzen-Coppens JMC, van Helden-Meeuwsen CG, Bootsma H, Vissink A, van Rooijen N, et al. Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjögren syndrome. Ann Rheum Dis. 2009;68:420–6.
  • Jagtap P, McGowan T, Bandhakavi S, Tu ZJ, Seymour S, Griffin TJ, et al. Deep metaproteomic analysis of human salivary supernatant. Proteomics. 2012;12:992–1001.
  • Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American–European Consensus Group. Ann Rheum Dis. 2002;61:554–8.
  • Seror R, Ravaud P, Bowman SJ, Baron G, Tzioufas A, Theander E, et al. EULAR Sjögren’s syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjögren’s syndrome. Ann Rheum Dis. 2010;69:1103–9.
  • Bikker A, Kruize AA, Wenting M, Versnel MA, Bijlsma JW, Lafeber FPJG, et al. Increased interleukin (IL)-7R expression in salivary glands of patients with primary Sjögren's syndrome is restricted to T cells and correlates with IL-7 expression, lymphocyte numbers and activity. Ann Rheum Dis. 2012;71:1027–33.
  • Usategui A, Criado G, Izquierdo E, Del Rey MJ, Carreira PE, Ortiz P, et al. A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis. Ann Rheum Dis. 2013;72:2018–23.
  • Noble CL, Abbas AR, Lees CW, Cornelius J, Toy K, Modrusan Z, et al. Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis. Inflamm Bowel Dis. 2010;16:1717–28.
  • Rimoldi M, Chieppa M, Salucci V, Avogadri F, Sonzogni A, Sampietro GM, et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol. 2005;6:507–14.
  • van Woerkom JM, Kruize AA, Wenting-van Wijk MJ, Knol E, Bihari IC, Jacobs JW, et al. Salivary gland and peripheral blood T helper 1 and 2 cell activity in Sjögren's syndrome compared with non-Sjögren's sicca syndrome. Ann Rheum Dis. 2005;64:1474–9.
  • Maehara T, Moriyama M, Hayashida JN, Tanaka A, Shinozaki S, Kubo Y, et al. Selective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients. Clin Exp Immunol. 2012;169:89–99.
  • Crotty S. T follicular helper cell differentiation, function, and roles in disease. Immunity. 2014;41:529–42.
  • Sonesson A, Kasetty G, Olin AI, Malmsten M, Morgelin M, Sorensen OE, et al. Thymic stromal lymphopoietin exerts antimicrobial activities. Exp Dermatol. 2011;20:1004–10.
  • Bjerkan L, Scheurs O, Engen SA, Jahnsen FL, Baekkevold ES, Blox IJ, et al. The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide. Mucosal Immunol. 2015;8:49–56.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.