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Human Fertility
an international, multidisciplinary journal dedicated to furthering research and promoting good practice
Volume 13, 2010 - Issue 4
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Invited Reviews

Medical treatment of male infertility

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Pages 208-216 | Published online: 30 Nov 2010

References

  • Adamopoulos, D. A., Nicopoulou, S., Kapolla, N., Karamertzanis, M., & Andreaou, E. (1997). The combination of testosterone undecanoate with tamoxifen citrate enhances the effects of each agent given independently on seminal parameters in men with idopathic oligozoospermia. Fertility and Sterility, 67, 756–762.
  • Adamopoulos, D. A., Pappa, A., Billa, E., Nicopoulou, S., Koukkou, E., & Michopoulos, J. (2003). Effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in men with idiopathic oligozoospermia. Fertility and Sterility, 80, 914–920.
  • Agarwal, A., Saleh, R. A., & Bedaiwy, M. A. (2003). Role of reactive oxygen species in the pathophysiology of human reproduction. Fertility and Sterility, 79, 829–843.
  • Agarwal, A., & Sekhon, L. H., (2010). The role of antioxidant therapy in the treatment of male infertility. Human Fertility, 13, 217–225.
  • AinMelk, Y., Belisle, S., Kandalaft, N., McClure, D., Tetreault, L., & Elhilali, M. (1982). Bromocriptine therapy in oligozoospermic infertile men. Archives of Andrology, 8, 135–141.
  • Aitken, R. J, Clarkson, J. S., & Fischel, S. (1989). Generation of reactive oxygen species, lipid peroxidant, and human sperm function. Biology of Reproduction, 41, 183–197.
  • Aitken, R.J. (1994). A free radical theory of male infertility. Reproduction, Fertility and Development, 6, 19–24.
  • Al-Mously, N., Cross, N. A., Eley, A., & Pacey, A. A. (2009). Real-time polymerase chain reaction shows that density centrifugation does not always remove Chlamydia trachomatis from human semen. Fertility and Sterility, 92, 1606–1615.
  • Akande, V., Turner, C., Horner, P., Horne, A., & Pacey, A. A.; On Behalf of the British Fertility Society. (2010). Impact of Chlamydia trachomatis in the reproductive setting: British Fertility Society Guidelines for practice. Human Fertility, 13, 115–125.
  • Akingbemi, B. T. (2005). Estrogen regulation of testicular function. Reproductive Biology and Endocrinology, 3, 51.
  • Andreou, E., Mahmoud, A., Vermeulen, L., Schoonjans, F., & Comhaire, F. (1995). Comparison of different methods for the investigation of antisperm antibodies on spermatozoa, in seminal plasma and in sperm. Human Reproduction, 10, 125–131.
  • Anonymous. (1998). Efficacy and safety of highly purified urinary follicle-stimulating hormone with human chorionic gonadotropin for treating men with isolated hypogonadotropic hypogonadism. European Metrodin HP Study Group. Fertility and Sterility, 70, 256–262.
  • Arata de Bellabarba, G., Tortolero, I., Villarroel, V., Molina, C. Z., Bellabarba, C., & Velazquez, E. (2000). Nonsperm cells in human semen and their relationship with semen parameters. Archives of Andrology, 45, 131–136.
  • Attia, A. M., Al-Inany, H. G., & Proctol, M. L. (2007). Gonadotrophins for idiopathic male factor sub-fertility (update). Cochrane Database of Systematic Reviews, 4, CD005071.
  • Baccetti, B., Piomboni, P., Bruni, E., Capitani, S., Gambera, L., Moretti, E., et al. (2004). Effect of follicle-stimulating hormone on sperm quality and pregnancy rate. Asian Journal of Andrology, 6, 133–137.
  • Bacon, C. G., Mittleman, M. A., Kawachi, I., Giovannucci, E., Glasser, D. B., & Rimm, E.B. (2003). Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Annals of Internal Medicine, 139, 161–168.
  • Baker, H. W. G. (2001). Male infertility. Endocrinology, In: DeGroot, L.J., Jameson, J.L., (Eds.), Vol. 3. Philadelphia: W.B. Saunders, 2308–2328.
  • Barratt, C. L., Bolton, A. E., & Cooke, I. D. (1990). Functional significance of white blood cells in the male and female reproductive tract. Human Reproduction, 5, 639–648.
  • Bener, A., Al-Ansari, A. A., Zirie, M., & Al-Hamaq, A. O. A. A. (2008). Is male fertility associated with type 2 diabetes mellitus? International Urology and Nephrology, 41, 777–784.
  • Blumenfeld, Z., Frisch, L., & Conn, P. M. (1988a). Gonadotropin-releasing hormone (GnRH) antibodies formation in hypogonadotropic azoospermic men treated with pulsatile GnRH-diagnosis and possible alternative treatment. Fertility and Sterility, 50, 622–629.
  • Blumenfeld, Z., Makler, A., Frisch, L., & Brandes, J. M. (1988b). Induction of spermatogenesis and fertility in hypogonadotropic azoospermic men by intravenous pulsatile gonadotropin-rleasing hormone (GnRH). Gynecological Endocrinology, 2, 151–164.
  • Buchter, D., Behre, H. M., Kliesch, S., & Nieschlag, E. (1998). Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. European Journal of Endocrinology, 139, 298–303.
  • Burgues, S., & Calderon, M. D. (1997). Subcutanous self-administration of highly purified follicle stimulating hormone and human chorionic gonadotrophin for the treatment of male hypogonadotrophic hypogonadism. Spanish Collaborative Group on Male Hypogonadotropic Hypogonadism. Human Reproduction, 12, 980–986.
  • Carter, J. N., Tyson, J. E., Tolis, G., Van Vliet, S., Faiman, C., & Friesen, H. G. (1978). Prolactin-screening tumors and hypogonadism in 22 men. New England Journal of Medicine, 299, 847–852.
  • Cates, W., Farely, T. M, & Rowe, P. J. (1985). Worldwide patterns of infertility: is Africa different? Lancet, 2, 596–598.
  • Chapelle, P. A., Roby-Brami, A., Yakovleff, A., & Bussel, B. (1988). Neurological correlations of ejaculation and testicular size in men with a complete spinal cord section. Journal of Neurology, Neurosurgery & Psychiatry, 51, 197–202.
  • Clark, R. V. & Sherins, R. J. (1989). Treatment of men with idiopathic oligozoospermic infertility using the aromatase inhibitor, testolactone. Results of a double-blinded, randomized, placebo-controlled trial with crossover. Journal of Andrology, 10, 240–247.
  • Comhaire, F. H., Rowe, P. J., & Farley, T. M. (1986). The effect of doxycycline in infertile couples with male accessory gland infection: a double blind prospective study. International Journal of Andrology, 9, 91–98.
  • Comhaire, F. H., de Kretser, D. M., Farley, T. M., & Rowe, P. J. (1987). Towards more objectivity in diagnosis and management of male fertility. International Journal of Andrology, 7, 1–53.
  • Comhaire, F. H. (1987). Concentration of perfloxacine in split ejcaculates of patients with chronic male accessory gland infections. The Journal of Urology, 138, 828–830.
  • Crowley, W. F. Jr., Filicori, M., Spratt, D. I., & Santoro, N. R. (1985). The physiology of gonadotropin-releasing hormone (GnRH) secretion in men and women. Recent Progress in Hormone Research, 41, 473–531.
  • Davies, K. J. A. (1987). Protein damage and degradation by oxygen radicals I – general aspects. Journal of Biological Chemistry, 262, 9895–9901.
  • de Barbeyrac, B., Papaxanthos-Roche, A., Mathieu, C., Germain, C., Brun, J. L., Gachet, M., et al. (2006). Chlamydia trachomatis in subfertile couples undergoing an in vitro fertilization program: a prospective study. European Journal of Obstetrics & Genecology and Reproductive Biology, 129, 46–53.
  • Depuydt, C. E., Bosmans, E., Zalata, A., Schoonjans, F., & Comhaire, F. H. (1996). The relation between reactive oxygen species and cytokines in andrological patients with or without male accessory gland infection. Journal of Andrology, 17, 699–707.
  • Dohle, G. R., Colpi, G. M., Hargreave, T. B., Papp, G. K., Jungwirth, A., & Weidner, W. (2005). EAU Guidelines on male infertility. European Urology, 48, 703–711.
  • Dunsmuir, W. D. & Holmes, S. A. (1996). The aetiology and management of erectile, ejaculatory and fertility problems in men with DM. Diabetic Medicine, 13, 700–708.
  • Du Plessis, S., Cabler, S., McAlister, D., Saabegh, E., & Agarwal, A. (2010). The effect of obesity on sperm disorders and male infertility. Nature Reviews in Urology, 7, 153–161.
  • Eggert-Kruse, W., Huber, K., Rohr, G., & Runnebaum, B. (1993). Determination of antisperm antibodies in serum samples by means of enzyme-linked immunosorbent assay-a procedure to be recommended during infertility investigation? Human Reproduction, 8, 1405–1413.
  • Esposito, K., Giugliano, F., Di Palo, C., Giugliano, G., Marfella, R., D'Andrea, F., et al. (2004). Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. Journal of the American Medical Association, 291, 2978–2984.
  • Fedder, J. (1996). Nonsperm cells in human semen: with special reference to seminal leukocytes and their possible influence on fertility. Archives of Andrology, 36, 41–65.
  • Feldman, H. A., Johannes, C. B., Derby, C. A., Kleinman, K. P., Mohr, B. A., Araujo, A. B., et al. (2000). Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts Male Aging Study. Preventative Medicine, 30, 328–338.
  • Fink, H. M., Mac Donald, R., Rutks, I. R., Nelson, D. B., & Wilt, T. J. (2002). Sildenafil for male erectile dysfunction: a systematic review and meta-analysis. Archives of Internal Medicine, 162, 1349–1360.
  • Foresta, C., Bettella, A., Garolla, A., Ambrosini, G., & Ferlin, A. (2005). Treatment of male idiopathic infertility with recombinant human follicle-stumulation hormone: a prospective, controlled, randomized clinical study. Fertility and Sterility, 84, 654–661.
  • Gallegos, G., Ramos, B., Santiso, R., & Goyantes, V. (2008). Sperm DNA fragmentation in infertile men with genitourinary infection by Chlamydia trachomatis and mycoplasma. Fertility and Sterility, 90, 328–334.
  • Gdoura, R., Daoudi, F., Bouzid, F., Ben Salah, F., Chaigneau, C., Sueur, J. M., et al. (2001). Detection of Chlamydia trachomatis in semen and urethral specimens from male members of infertile couples in Tunisia. European Journal of Contraception & Reproductive Health Care, 6, 14–20.
  • Gdoura, R., Kchaou, W., Ammar-Keskes, L., Chakroun, N., Sallemi, A., Znazen, A., et al. (2007). Assessment of Chlamydia trachomatis, Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, and Mycoplasma genitalium in semen and first-void urine specimens of asymptomatic male partners of infertile couples. Journal of Andrology, 29, 198–206.
  • Ghanem, H., Shaeer, O., & El-Segini, A. (2010). Combination clomiphene citrate and antioxidant therapy for idiopathic male infertility: a randomized controlled trial. Fertility and Sterility, 93, 2232–2235.
  • Goldwasser, B., Madgar, I., Jonas, P., Lunenfeld, B., & Many, M. (1983). Imipramine for the treatment of sterility in patients following retroperitoneal lymph node dissection. Andrologia, 15, 588–591.
  • Greenspan, S. L., Neer, R. M., Ridgway, E. C., & Klibanski, A. (1986). Osteoporosis in men with hyperprolactinemic hypogonadism. Annals of Internal Medicine, 104, 777–782.
  • Haas, G. G. Jr., Cines, D. B., & Schreiber, A. D. (1980). Immunologic infertility: identification of patients with antisperm antibodies. New England Journal of Medicine, 303, 722–727.
  • Haas, G. G. Jr., D'Cruz, O. J., & DeBault, L. E. (1991). Comparison of the indirect immunobead, radiolabeled, and immunofluorescence assays for immunoglobulin G serum antibodies to human sperm. Fertility and Sterility, 55, 377–388.
  • Hayes, F. J., Seminara, S. B., DeCruz, S., Boepple, P. A., & Crowley, W. F. (2000). Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback. Journal of Clinical Endocrinology & Metabolism, 85, 3027–3035.
  • Hendry, W. F., Hughes, L., Scammell, G., Pryor, J. P. & Hargreave, T. B. (1990). Comparison of prednisolone and placebo in subfertile men with antibodies to spermatozoa. Lancet, 335, 85–88.
  • Hussein, L., Ozgok, Y., Ross, L., & Niederberger, C. (2005). Clomiphene administration for cases of nonobstructive azoospermia: a multicenter study. Journal of Andrology, 26, 787–791.
  • Hosseinzadeh, S., Brewis, I. A., Eley, A., & Pacey, A. A. (2001). Co-incubation of human spermatozoa with Chlamydia trachomatis serovar E causes premature sperm death. Human Reproduction, 16, 293–299.
  • Hovatta, O., Koskimies, A. I., Ranta, T., Stenman, U. H., & Seppala, M. (1979). Bromocriptine treatment of oligospermia: a double blind study. Clinical Endocrinology, 11, 377–382.
  • Hurst, T. & Lancaster, P. (2001). Assisted conception in Australia and New Zealand 1999 and 2000. Sydney: Australian Institute of Health and Welfare National Perinatal Statistics Unit.
  • Jensen, T. K., Andersson, A. M., Jorgensen, N., Andersen, A. G., Carlsen, E., Petersen, J. H., et al. (2004). Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertility and Sterility, 82, 863–870.
  • Jones, R., Mann, T., & Sherins, R. J. (1979). Peroxidative breakdown of phospholipids in human spermatozoa, spermicidal properties of fatty acid peroxides, and protective action of seminal plasma. Fertility and Sterility, 31, 531–537.
  • Kamischke, A., Behre, H. M., Bergman, M., Simoni, M., Shafer, T., & Nieschlag, E. (1998). Recombinant Follicle stimulating hormone for treatment of male idiopathic infertility: a randomized, double-blind, placebo-controlled, clinical trial. Human Reproduction, 13, 596–603.
  • Kamischke, A. & Nieschlag, E. (1999a). Analysis of medical treatment of male infertility. Human Reproduction, 14, 1–23.
  • Kamischke, A. & Nieschlag, E. (1999b). Treatment of retrograde ejaculation and anejaculation. Human Reproduction Update, 5, 448–474.
  • Kamischke, A. & Nieschlag, E. (2002) Update on medical treatment of ejaculatory disorders. International Journal of Andrology, 25, 333–344.
  • Kao, S. H., Chao, H. T., Chen, H.-W., Hwang, T. I., Liao, T. L., & Wei, Y. H. (2008). Increase in oxidative stress in human sperm with lower motility. Fertility and Sterility, 89, 1183–1190.
  • Kaukua, J., Pekkarinen, T., Sane, T., & Mustajoki, P. (2003). Sex hormones and sexual function in obese men losing weight. Obesity, 11, 689–694.
  • Kefer, J. C., Agarwal, A., & Sabenegh, E. (2009). Role of antioxidants in the treatment of male infertility. International Journal of Urology, 16, 449–457.
  • Kendirci, M. & Hellstrom, W. J. G. (2006). Retrograde ejaculation: etiology, diagnosis, and management. Current Sexual Health Reports, 3, 133–138.
  • Klibanski, A. (2010). Clinical practice: prolactinomas. New England Journal of Medicine, 362, 1219–1226.
  • Klingmuller, D. & Schweikert, H. U. (1985). Maintenance of spermatogenesis by intranasal administration of gonadotropin-releasing hormone in patients with hypothalamic hypogonadism. Journal of Clinical Endocrinology & Metabolism, 61, 868–972.
  • Knuth, U. A., Honigl, W., Bals-Pratsch, M., Schleicher, G., & Nieschlag E. (1987). Treatment of severe oligospermia with human chorionic gonadotropin/human menopausal gonadotropin: a placebo-controlled, double blind trial. Journal of Clinical Endocrinology and Metabolism, 65, 1081–1087.
  • Kort, H. I., Massey, J. B., Elsner, C. W., Mitchell-Leef, D., Shapiro, D. B., Witt, M. A., et al. (2006) Impact of body mass index values on sperm quantity and quality. Journal of Andrology, 27, 450–452.
  • Koyama, K., Kubota, K., Ikuma, K., Shigeta, M., & Isojima S. (1988). Application of the quantitative sperm immobilizing test for follow-up study of sperm immobilizing antibody in sera of sterile women. International Journal of Fertility, 33, 201–206.
  • Kriger, J. (1995). New sexually transmitted diseases treatment guidelines. Journal of Urology, 154, 209–213.
  • Lackner, J. E., Herwig, R., Schmidbauer, J., Schatzl, G., Kratzik, C., & Marberger, M. (2006). Correlation of leukocytospermia with clinical infection and the positive effect of antiinflammatory treatment on semen quality. Fertility and Sterility, 86, 601–605.
  • Linsenmeyer, T. A. & Perkash, I. (1991). Infertility in men with spinal cord injury. Archives of Physical Medicine and Rehabilitation, 72, 747–754.
  • Liu, P. Y., Baker, G., Jayadev, V., Zacharin, M., Conway, A. J., & Handelsman, D. J. (2009). Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome. Journal of Clinical Endocrinology & Metabolism, 94, 801–808.
  • Liu, P. Y., Gebski, V. J., Turner, L., Conway, A. J., Wishart, S. M., & Handelsman, D. J. (2002). Predicting pregnancy and spermatogenesis by survival analysis during gonadotropin treatment of gonadotropin deficient infertile men. Human Reproduction, 17, 625–633.
  • Liu, P. Y. & Handelsmand, D. J. (2003). The present and future state of hormonal treatment for male infertility. Human Reproduction Update, 9, 9–23.
  • Lopes, S., Jurisicova, A., Sun, J. G., & Casper, R. F. (1998). Reactive oxygen species: potential cause for DNA framentation in human spermatozoa. Human Reproduction, 13, 896–900.
  • Lunglmayr, G., Maier, U., & Spona, J. (1983). Therapie der idiopathischen Oligozoospermie mit Bromokriptin Resultate einer prospektiv kontrollierten Studie. Andrologia, 15, 548–553.
  • Magnusdottir, E. V., Thorsteinsson, T., Thorsteinsdottir, S., Heimisdottir, M., & Olafsdottir, K. (2005). Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Human Reproduction, 20, 208–215.
  • Mazumdar, S. & Levine, A. S. (1998). Antisperm antibodies: etiology, pathogenesis, diagnosis, and treatment. Fertility and Sterility, 70, 799–806.
  • Molitch, M. E. (2000). Antipsychotic drug-induced hyperprolactinemia: clinical implications. Endocrine Practice, 6, 479–481.
  • Molitch, M. E. (2002). Medical management of prolactin-secreting pituitary adenomas. Pituitary, 5, 55–65.
  • Mortimer, C. H., McNeilly, A. S., Fisher, R. A., Murray, M. A., & Besser, G. M. (1974). Gonadotrophin-releasing hormone therapy in hypogonadal males with hypothalamic or pituitary dysfunction. British Medical Journal, 4, 617–612.
  • Nguyen, R. H. N., Wilcox, A. J., Skjaerven, R., & Baird, D. D. (2007). Men's body mass index and infertility. Human Reproduction, 22, 2488–2493.
  • Nieschlag, E. (2000). Classification of andrological disorders. Andrology: male reproductive health and dysfunctionIn: Nieschlag, E., Behre, H. M., (Eds.), Vol. 1. 83–87 Springer: Berlin, New York.
  • NIH Consensus Development Panel on Impotence. (1993). NIH Consensus Conference: impotence. Journal of the American Medical Association, 270, 83–90.
  • Nip, M. M. C., Taylor, P. V., Rutherford, A. J., & Hancock, K. W. (1995). Autoantibodies and antisperm antibodies in sera and follicular fluids of infertile patients: relation to reproductive outcome after in-vitro fertilization. Human Reproduction, 10, 2564–2569.
  • Omu, A. E., al-Qattan, F., & Abdul Hamada, B. (1996). Effect of low dose continuous corticosteroid therapy in men with antisperm antibodies on spermatozoal quality and conception rate. European Journal of Obstetrics & Gynecology and Reproductive Biology, 69, 129–134.
  • Pattinson, H. A. & Mortimer, D. (1987). Prevalence of sperm surface antibodies in the male partners of infertile couples as determined by immunobead screening. Fertility and Sterility, 48, 466–469.
  • Purvis, K. & Christiansen, E. (1993). Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility. International Journal of Andrology, 16, 1–13.
  • Raman, J. D. & Schlegel, P. N. (2002). Aromatase inhibitors for male infertility. Journal of Urology, 167, 624–629.
  • Ross, C., Morriss, A., Khairy, M., Khalaf, Y., Braude, P., Coomarasamy, A., et al. (in press). A systematic review of the effect of oral antioxidants on male infertility. Reproductive BioMedicine Online, 20, 711–723.
  • Schill, W. B. (1990). Pregnancy after brompheniramine treatment of a diabetic with incomplete emission failure. Archives of Andrology, 25, 101–104.
  • Schneede, P., Tenke, P., & Hofstetter, A. G. (2003). Urinary tract infection working group of the health care office of the European association of urology. Sexually transmitted diseases (STDs) – a synoptic overview for urologist. European Urology, 44, 1–7.
  • Sharlip, I. D., Jarow, J. P., Belker, A. M., Lipshultz, L. I., Sigman, M., Thomas, A. J., et al. (2002). Best practice policies for male infertility. Fertility and Sterility, 77, 873–882.
  • Sharma, R. K. & Agarwal, A. (1996). Role of reactive oxygen species in male infertility. Urology 48, 835–850.
  • Simon, L., Brunborg, G., Stevenson, M., Lutton, D., McManus, J., & Lewis, S. E. M. (2010). Clinical significance of sperm DNA damage in assisted reproduction outcome. Human Reproduction, 25, 1594–1608.
  • Tsertsvadze, A., Fink, H. A., Yazdi, F., MacDonald, R. J., Bella, A. J., Ansari, M. T., et al. (2009). Oral phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: a systematic review and meta-analysis. Annals of Internal Medicine, 151, 1–10.
  • Vandekerckhove, P., Lilford, R., Vail, A. & Hughes, E. (2001a). Bromocriptine for idiopathic oligo/asthenospermia (Cochrane Review). Cochrane Database of Systematic Reviews. Oxford: Update Software.
  • Vandekerckhove, P., Lilford, R., Vail, A., & Hughes, E. (2001b). Androgens versus placebo or no treatment for idiopathic oligo/asthenospermia (Cochrane Review). Cochrane Database of Systematic Reviews. Oxford: Update Software.
  • Vandekerckhove P., Lilford R., Vail A., & Hughes E. (2007). Clomiphene or tamoxifen for idiopathic oligo/asthenospermia. Cochrane Database Systematic Reviews, 4, CD000151.
  • Verhelst, J., Abs, R., Maiter, D., van den Bruel, A., Vandeweghe, M., Velkeniers, B., et al. (1999). Cabergoline in the treatment of hyperprolactinemia: a study in 455 patients. Journal of Clinical Endocrinology & Metabolism, 84, 2518–2522.
  • Vernon, M., Wilson, E., Muse, K., Estes, S., & Curry, T. (1988). Successful pregnancies from men with retrograde ejaculation with the use of washed sperm and gamete intrafallopian tube transfer (GIFT). Fertility and Sterility, 50, 822–824.
  • Villegas, J., Schulz, M., Soto, L., & Sanchez, R. (2005). Bacteria induce expression of apoptosis in human spermatozoa. Apoptosis, 10, 105–110.
  • Webster, J., Piscitelli, G., Polli, A., Ferrari, C. I., Ismail, I., & Scanlon, M. F. (1994). For the Cabergoline Comparative Study Group. New England Journal of Medicine, 331, 904–909.
  • Weidner, W., Ludwig, M., & Miller, J. (1998). Therapy in male accessory gland infection-what is fact what is fiction. Andrologia, 30, 87–90.
  • Weidner, W., Krause, W., & Ludwig, M. (1999). Relevance of male accessory gland infection for subsequent fertility with special focus on prostatitis. Human Reproduction Update, 5, 421–432.
  • Witkin, S. S. (1988). Sperm-reactive antibodies as measured by enzyme linked immunosorbent assay. Perspectives in immunoreproduction: conception and contraception. In: Mathur, S., Fredricks, C. M, (Eds.), Washington: Hemisphere Publishing Company, p. 93–101.
  • Wolff, H. & Anderson, D. J. (1988). Immunohistologic characterization and quantitation of leucocyte subpopulation in human semen. Fertility and Sterility, 49, 497–504.
  • World Health Organization. (1992). WHO semen manual for the examination of human semen and cervical mucus. Cambridge: Cambridge University Press. 8–11.
  • World Health Organization. (2000). WHO Manual for the Standardised Investigation and Diagnosis of the Infertile Couple. Cambridge: Cambridge University Press.
  • World Health Organisation. (2010). WHO laboratory manual for the examination and processing of human semen,. 5th edCH: World Health Organisation.
  • Yavets, H., Yogev, L., Hauser, R., Lessing, J. B., Paz, G., & Homonnai, Z. T. (1994). Retrograde ejaculation. Human Reproduction, 9, 381–386.

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