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Research Article

Transcriptional profiling of CD133+ cells in coronary artery disease and effects of exercise on gene expression

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Pages 227-236 | Received 29 Oct 2009, Accepted 03 May 2010, Published online: 14 Jan 2011

References

  • Libby P, Willerson JT, Braunwald E. C-reactive protein and coronary heart disease. N Engl J Med. 2004;351:295–8.
  • Gill M, Dias S, Hattori K, Rivera ML, Hicklin D, Witte L, . Vascular trauma induces rapid but transient mobilization of VEGFR2(+)AC133(+) endothelial precursor cells. Circ Res. 2001;88:167–74.
  • Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, . Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood. 2000;95:952–8.
  • Gehling UM, Ergun S, Schumacher U, Wagener C, Pantel K, Otte M, . In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood. 2000; 95:3106–12.
  • Heeschen C, Lehmann R, Honold J, Assmus B, Aicher A, Walter DH, . Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation. 2004;109:1615–22.
  • Scheubel RJ, Zorn H, Silber RE, Kuss O, Morawietz H, Holtz J, Simm A. Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. J Am Coll Cardiol. 2003;42:2073–80.
  • Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, . Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res. 2001;89:E1–7.
  • Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K, . Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med. 2003;9:1370–6.
  • Laufs U, Werner N, Link A, Endres M, Wassmann S, Jurgens K, . Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation. 2004;109:220–6.
  • Paul JD, Powell TM, Thompson M, Benjamin M, Rodrigo M, Carlow A, . Endothelial progenitor cell mobilization and increased intravascular nitric oxide in patients undergoing cardiac rehabilitation. J Cardiopulm Rehabil Prev. 2007;27: 65–73.
  • Rehman J, Li J, Parvathaneni L, Karlsson G, Panchal VR, Temm CJ, . Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells. J Am Coll Cardiol. 2004;43: 2314–18.
  • Sandri M, Adams V, Gielen S, Linke A, Lenk K, Krankel N, . Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies. Circulation. 2005;111:3391–9.
  • Steiner S, Niessner A, Ziegler S, Richter B, Seidinger D, Pleiner J, . Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease. Atherosclerosis. 2005;181: 305–10.
  • Hsia D, Casaburi R, Pradhan A, Torres E, Porszasz J. Physiological responses to linear treadmill and cycle ergometer exercise in COPD. Eur Respir J. 2009;34:605–615.
  • Desai A, Glaser A, Liu D, Raghavachari N, Blum A, Zalos G, . Microarray-based characterization of a colony assay used to investigate endothelial progenitor cells and relevance to endothelial function in humans. Arterioscler Thromb Vasc Biol. 2009;29:121–7.
  • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. JR Statist Soc B. 1995;57:289–300.
  • Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, . Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med. 2005;353:999–1007.
  • Leor J, Marber M. Endothelial progenitors: a new Tower of Babel? J Am Coll Cardiol. 2006;48:1588–90.
  • Schmidt-Lucke C, Rossig L, Fichtlscherer S, Vasa M, Britten M, Kamper U, . Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation. 2005;111:2981–7.
  • Bruhl T, Urbich C, Aicher D, Acker-Palmer A, Zeiher AM, Dimmeler S. Homeobox A9 transcriptionally regulates the EphB4 receptor to modulate endothelial cell migration and tube formation. Circ Res. 2004;94:743–51.
  • Zhang J, Oh KH, Xu H, Margetts PJ. Vascular endothelial growth factor expression in peritoneal mesothelial cells undergoing transdifferentiation. Perit Dial Int. 2008;28: 497–504.
  • Miller F, Kentsis A, Osman R, Pan ZQ. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. J Biol Chem. 2005;280:7985–96.
  • Rossig L, Urbich C, Bruhl T, Dernbach E, Heeschen C, Chavakis E, . Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells. J Exp Med. 2005;201:1825–35.
  • Song MB, Yu XJ, Zhu GX, Chen JF, Zhao G, Huang L. Transfection of HGF gene enhances endothelial progenitor cell (EPC) function and improves EPC transplant efficiency for balloon-induced arterial injury in hypercholesterolemic rats. Vascul Pharmacol. 2009;51:205–13.
  • Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong le A, Cuhlmann S, . Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis. Circ Res. 2008;103:726–32.
  • Zakkar M, Van der Heiden K, Luong le A, Chaudhury H, Cuhlmann S, Hamdulay SS, . Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol. 2009;29:1851–7.
  • Grunberg E, Eckert K, Maurer HR. Prothymosin alpha1 antagonizes the inhibitory effects of transforming growth factor-beta1 on the adhesion of peripheral blood lymphocytes to human umbilical vein endothelial cells. Int J Mol Med. 1998;1:741–6.
  • Grunberg E, Eckert K, Maurer HR, Immenschuh P, Kreuser ED. Prothymosin alpha1 effects on IL-2-induced expression of LFA-1 on lymphocytes and their adhesion to human umbilical vein endothelial cells. J Interferon Cytokine Res. 1997;17:159–65.
  • Roland I, Minet E, Ernest I, Pascal T, Michel G, Remacle J, Michiels C. Identification of hypoxia-responsive messengers expressed in human microvascular endothelial cells using differential display RT-PCR. Eur J Biochem. 2000;267:3567–74.
  • Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR. A stem cell molecular signature. Science. 2002;298:601–4.
  • Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA. ‘Stemness’: transcriptional profiling of embryonic and adult stem cells. Science. 2002;298:597–600.
  • Toren A, Bielorai B, Jacob-Hirsch J, Fisher T, Kreiser D, Moran O, . CD133-positive hematopoietic stem cell ‘stemness’ genes contain many genes mutated or abnormally expressed in leukemia. Stem Cells. 2005;23:1142–53.
  • Panepucci RA, Oliveira LH, Zanette DL, Carrara RD, Araujo AG, Orellana MD, . Increased levels of NOTCH1, NF-kappaB, and other interconnected transcription factors characterize primitive sets of hematopoietic stem cells. Stem Cells Dev. 2009;19:321–32.
  • Thorsteinsdottir U, Mamo A, Kroon E, Jerome L, Bijl J, Lawrence HJ, . Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Blood. 2002;99:121–9.
  • Pirro M, Schillaci G, Menecali C, Bagaglia F, Paltriccia R, Vaudo G, . Reduced number of circulating endothelial progenitors and HOXA9 expression in CD34+ cells of hypertensive patients. J Hypertens. 2007;25:2093–9.
  • Pons D, de Vries FR, van den Elsen PJ, Heijmans BT, Quax PH, Jukema JW. Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease. Eur Heart J. 2009;30:266–77.
  • Pons D, Jukema JW. Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease. Neth Heart J. 2008;16:30–2.

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