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Commentary

Isolating cytomegalovirus-specific T cells for adoptive transfer: are we there yet?

Pages 857-858 | Published online: 13 Oct 2010

References

  • Walter EA, Greenberg PD, Gilbert MJ, Finch RJ, Watanabe KS, Thomas ED, . Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med. 1995;333:1038–44.
  • Einsele H, Roosnek E, Rufer N, Sinzger C, Riegler S, Loffler J, . Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood. 2002;99:3916–22.
  • Riddell SR, Watanabe KS, Goodrich JM, Li CR, Agha ME, Greenberg PD. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science. 1992;257:238–41.
  • Cobbold M, Khan N, Pourgheysari B, Tauro S, McDonald D, Osman H, . Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers. J Exp Med. 2005;202:379–86.
  • Peggs KS, Verfuerth S, Pizzey A, Khan N, Guiver M, Moss PA, . Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines. Lancet. 2003;362:1375–7.
  • Micklethwaite KP, Clancy L, Sandher U, Hansen AM, Blyth E, Antonenas V, . Prophylactic infusion of cytomegalovirus-specific cytotoxic T lymphocytes stimulated with Ad5f35pp65 gene-modified dendritic cells after allogeneic hemopoietic stem cell transplantation. Blood. 2008;112:3974–81.
  • Zandvliet ML, van Liempt E, Jedema I, Veltrop-Duits LA, Willemze R, Guchelaar H-J, . Co-ordinated isolation of CD8+ and CD4+ T cells recognizing a broad repertoire of cytomegalovirus pp65 and IE1 epitopes for highly specific adoptive immunotherapy. Cytotherapy. 2010;12:933–44.
  • Bunde T, Kirchner A, Hoffmeister B, Habedank D, Hetzer R, Cherepnev G, . Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells. J Exp Med. 2005;201:1031–6.
  • Rauser G, Einsele H, Sinzger C, Wernet D, Kuntz G, Assenmacher M, . Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants. Blood. 2004; 103:3565–72.
  • Leen AM, Myers GD, Sili U, Huls MH, Weiss H, Leung KS, . Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med. 2006;12: 1160–6.
  • Sili U, Huls MH, Davis AR, Gottschalk S, Brenner MK, Heslop HE, . Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocytes using lymphoblastoid cell lines for adoptive immunotherapy. J Immunother. 2003;26:241–56.
  • Melenhorst JJ, Leen AM, Bollard CM, Quigley MF, Price DA, Rooney CM, . Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects. Blood. 2010; in press.
  • Berger C, Jensen MC, Lansdorp PM, Gough M, Elliott C, Riddell SR. Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Invest. 2008;118:294–305.
  • Hanley PJ, Cruz CR, Savoldo B, Leen AM, Stanojevic M, Khalil M, . Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes. Blood. 2009;114:1958–67.
  • Savoldo B, Cubbage ML, Durett AG, Goss J, Huls MH, Liu Z, . Generation of EBV-Specific CD4(+) cytotoxic T cells from virus naive individuals. J Immunol. 2002;168: 909–18.

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