42
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Bone marrow mesenchymal stromal cells with support of bispecific antibody and ultrasound-mediated microbubbles prevent myocardial fibrosis via the signal transducer and activators of transcription signaling pathway

, , , , , , , & show all
Pages 431-440 | Received 23 Jun 2010, Accepted 03 Nov 2010, Published online: 21 Dec 2010

References

  • Battiwalla M, Hematti P. Mesenchymal stem cells in hematopoietic stem cell transplantation. Cytotherapy. 2009;11: 503–15.
  • Pereira RF, Halford KW, O'Hara MD, Leeper DB, Sokolov BP, Pollard MD, . Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc Natl Acad Sci USA. 1995;92:4857–61.
  • Morikawa S, Mabuchi Y, Kubota Y, Nagai Y, Niibe K, Hiratsu E, . Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med. 2009;206:2483–96.
  • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, . Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–7.
  • Lee RJ, Fang Q, Davol PA, Gu Y, Sievers RE, Grabert RC, . Antibody targeting of stem cells to infarcted myocardium. Stem Cells. 2007;25:712–7.
  • Sen M, Wankowski DM, Garlie NK, Siebenlist RE, Van Epps D, LeFever AV, . Use of anti-CD3 × anti-HER2/neu bispecific antibody for redirecting cytotoxicity of activated T cells toward HER2/neu+ tumors. J Hematother Stem Cell Res. 2001;10:247–60.
  • Xu YL, Gao YH, Liu Z, Tan KB, Hua X, Fang ZQ, . Myocardium-targeted transplantation of mesenchymal stem cells by diagnostic ultrasound-mediated microbubble destruction improves cardiac function in myocardial infarction of New Zealand rabbits. Int J Cardiol. 2010;138:182–95.
  • Zhang Q, Wang Z, Ran H, Fu X, Li X, Zheng Y, . Enhanced gene delivery into skeletal muscles with ultrasound and microbubble techniques. Acad Radiol. 2006;13:363–7.
  • Li X, Wang Z, Ran H, Yuan Q, Zheng Y, Ren J, . Experimental research on therapeutic angiogenesis induced by hepatocyte growth factor directed by ultrasound-targeted microbubble destruction in rats. J Ultrasound Med. 2008;27:453–60.
  • Wang ZX, Wang ZG, Ran HT, Ren JL, Zhang Y, Li Q, . The treatment of liver fibrosis induced by hepatocyte growth factor-directed, ultrasound-targeted microbubble destruction in rats. Clin Imaging. 2009;33:454–61.
  • Ren JL, Wang ZG, Zhang Y, Zheng YY, Li XS, Zhang QX, . Transfection efficiency of TDL compound in HUVEC enhanced by ultrasound-targeted microbubble destruction. Ultrasound Med Biol. 2008;34:1857–67.
  • Luo J, Zhou X, Diao L, Wang Z. Experimental research on wild-type p53 plasmid transfected into retinoblastoma cells and tissues using an ultrasound microbubble intensifier. J Int Med Res. 2010;38:1005–15.
  • Brooks WW, Conrad CH. Isoproterenol-induced myocardial injury and diastolic dysfunction in mice: structural and functional correlates. Comp Med. 2009;59:339–43.
  • Sung JH, Yang HM, Park JB, Choi GS, Joh JW, Kwon CH, . Isolation and characterization of mouse mesenchymal stem cells. Transplant Proc. 2008;40:2649–54.
  • Chamberlain G, Fox J, Ashton B, Middleton J. Concise review. Mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells. 2007;25:2739–49.
  • Lum LG, Fok H, Sievers R, Abedi M, Quesenberry PJ, Lee RJ. Targeting of Lin-Sca+ hematopoietic stem cells with bispecific antibodies to injured myocardium. Blood Cells Mol Dis. 2004;32:82–7.
  • Zhao TC, Tseng A, Yano N, Tseng Y, Davol PA, Lee RJ, . Targeting human CD34+ hematopoietic stem cells with anti-CD45 × anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction. J Appl Physiol. 2008;104:1793–800.
  • Kraitchman DL, Tatsumi M, Gilson WD, Ishimori T, Kedziorek D, Walczak P, . Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. Circulation. 2005;112:1451–61.
  • Wang Z, Liao Y, Dong J, Li S, Wang J, Fu ML. Clinical significance and pathogenic role of anti-cardiac myosin autoantibody in dilated cardiomyopathy. Chin Med J (Engl). 2003; 116:499–502.
  • Cochlovius B, Kipriyanov SM, Stassar MJ, Christ O, Schuhmacher J, Strauss G, . Treatment of human B cell lymphoma xenografts with a CD3 × CD19 diabody and T cells. J Immunol. 2000;165:888–95.
  • Weiner LM, Holmes M, Adams GP, LaCreta F, Watts P, Garcia de Palazzo I. A human tumor xenograft model of therapy with a bispecific monoclonal antibody targeting c-erbB-2 and CD16. Cancer Res. 1993;53:94–100.
  • Rossi EA, Goldenberg DM, Cardillo TM, Stein R, Chang CH. Hexavalent bispecific antibodies represent a new class of anticancer therapeutics. I. Properties of anti-CD20/CD22 antibodies in lymphoma. Blood. 2009;113:6161–71.
  • Marmottant P, Hilgenfeldt S. Controlled vesicle deformation and lysis by single oscillating bubbles. Nature. 2003;423: 153–6.
  • Stephanou A, Brar BK, Scarabelli TM, Jonassen AK, Yellon DM, Marber MS, . Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis. J Biol Chem. 2000;275:10002–8.
  • Miyahara Y, Nagaya N, Kataoka M, Yanagawa B, Tanaka K, Hao H, . Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med. 2006;12:459–65.
  • Jiang W, Ma A, Wang T, Han K, Liu Y, Zhang Y, . Homing and differentiation of mesenchymal stem cells delivered intravenously to ischemic myocardium in vivo: a time-series study. Pflugers Arch. 2006;453:43–52.
  • Gnecchi M, He H, Liang OD, Melo LG, Morello F, Mu H, . Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med. 2005;11:367–8.
  • Li L, Zhang Y, Li Y, Yu B, Xu Y, Zhao S, . Mesenchymal stem cell transplantation attenuates cardiac fibrosis associated with isoproterenol-induced global heart failure. Transpl Int. 2008;21:1181–9.
  • Molina EJ, Palma J, Gupta D, Torres D, Gaughan JP, Houser S, . Reverse remodeling is associated with changes in extracellular matrix proteases and tissue inhibitors after mesenchymal stem cell (MSC) treatment of pressure overload hypertrophy. J Tissue Eng Regen Med. 2009;3:85–91.
  • Hsu CP, Huang CY, Wang JS, Sun PC, Shih CC. Extracellular matrix remodeling attenuated after experimental postinfarct left ventricular aneurysm repair. Ann Thorac Surg. 2008;86:1243–9.
  • Dixon JA, Gorman RC, Stroud RE, Bouges S, Hirotsugu H, Gorman JH 3rd, . Mesenchymal cell transplantation and myocardial remodeling after myocardial infarction. Circulation. 2009;120:S220–9.
  • Mias C, Lairez O, Trouche E, Roncalli J, Calise D, Seguelas MH, . Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction. Stem Cells. 2009;27:2734–43.
  • Meirelles Lda S, Fontes AM, Covas DT, Caplan AI. Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev. 2009;20:419–27.
  • Guo J, Lin GS, Bao CY, Hu ZM, Hu MY. Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction. Inflammation. 2007;30:97–104.
  • Wang TL, Yang YH, Chang H, Hung CR. Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway. J Mol Cell Cardiol. 2004;37:785–94.
  • El-Adawi H, Deng L, Tramontano A, Smith S, Mascareno E, Ganguly K, . The functional role of the JAK-STAT pathway in post-infarction remodeling. Cardiovasc Res. 2003;57:129–38.
  • Wagner M, Siddiqui MA. Signaling networks regulating cardiac myocyte survival and death. Curr Opin Investig Drugs. 2009;10:928–37.
  • Scarabelli TM, Mariotto S, Abdel-Azeim S, Shoji K, Darra E, Stephanou A, . Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury. FEBS Lett. 2009;583:531–41.
  • Boengler K, Hilfiker-Kleiner D, Drexler H, Heusch G, Schulz R. The myocardial JAK/STAT pathway: from protection to failure. Pharmacol Ther. 2008;120:172–85.
  • Barry SP, Townsend PA, McCormick J, Knight RA, Scarabelli TM, Latchman DS, . STAT3 deletion sensitizes cells to oxidative stress. Biochem Biophys Res Commun. 2009;385: 324–9.
  • Harada M, Qin Y, Takano H, Minamino T, Zou Y, Toko H, . G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med. 2005;11:305–11.
  • Ng DC, Court NW, dos Remedios CG, Bogoyevitch MA. Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts. Cardiovasc Res. 2003;57:333–46.
  • Fu X, Han B, Cai S, Lei Y, Sun T, Sheng Z. Migration of bone marrow-derived mesenchymal stem cells induced by tumor necrosis factor-alpha and its possible role in wound healing. Wound Repair Regen. 2009;17:185–91.
  • Staley BK, Irvine KD. Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation. Curr Biol. 2010;20:1580–7.
  • Sze SK, de Kleijn DP, Lai RC, Khia Way Tan E, Zhao H, Yeo KS, . Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007;6:1680–9.
  • Erices A, Conget P, Rojas C, Minguell JJ. Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2002;280:24–32.
  • Furlani D, Li W, Pittermann E, Klopsch C, Wang L, Knopp A, . A transformed cell population derived from cultured mesenchymal stem cells has no functional effect after transplantation into the injured heart. Cell Transplant. 2009;18: 319–31.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.