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Research Article

Treatment of non-healing wounds with autologous bone marrow cells, platelets, fibrin glue and collagen matrix

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Pages 705-711 | Received 14 Aug 2010, Accepted 22 Dec 2010, Published online: 02 Feb 2011

References

  • Fard AS, Esmaelzadeh M, Larijani B. Assessment and treatment of diabetic foot ulcer. Int J Clin Pract. 2007;61:1931–8.
  • Brod M. Quality of life issues in patients with diabetes and lower extremity ulcers: patients and care givers. Qual Life Res. 1998;7:365–72.
  • Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA. 2005;293:217–28.
  • Center for Disease Control and Prevention. National Diabetes Fact Sheet. National Estimates on Diabetes, 2000–2001. Center for Disease Control and Prevention, Atlanta, GA. http://www.cdc.gov/diabetes/pubs/estimates.htm. Accessed 18 November 2003.
  • Mendez MV, Stanley A, Phillips T, Murphy M, Menzoian JO, Park HY. Fibroblasts cultured from distal lower extremities in patients with venous reflux display cellular characteristics of senescence. J Vasc Surg. 1998;28:1040–50.
  • Raffetto JD, Mendez MV, Phillips TJ, Park HY, Menzoian JO. The effect of passage number on fibroblast cellular senescence in patients with chronic venous insufficiency with and without ulcer. Am J Surg. 1999;178:107–12.
  • Vande Berg JS, Rudolf R, Holland C, Haywood-Reid PL. Fibroblast senescence in pressure ulcers. Wound Repair Regen. 1998;6:38–49.
  • Trengove NJ, Stacey MC, MacAuley S, Bennett N, Gibson J, Burslem F, . Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors. Wound Repair Regen. 1999;7:442–52.
  • Harding KG, Morris HL, Patel GK. Science, medicine and the future: healing chronic wounds. Br Med J. 2002;324:160–3.
  • Falanga V, Sabolinski M. A bilayered living skin construct (APLIGRAF) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen. 1999;7:201–7.
  • Badiavas EV, Falanga V. Treatment of chronic wounds with bone marrow-derived cells. Arch Dermatol. 2003;139: 510–16.
  • Knighton DR, Ciresi KF, Fiegel VD, Austin LL, Butler EL. Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg. 1986;204:322–30.
  • Laurens N, Koolwijk P, de Maat MPM. Fibrin structure and wound healing. J Thromb Haemost. 2006;4:932–9.
  • Ichioka S, Kouraba S, Sekiya N, Ohura N, Nakatsuka T. Bone marrow-impregnated collagen matrix for wound healing: experimental evaluation in a microcirculatory model of angiogenesis, and clinical experience. Br J Plast Surg. 2005;58: 1124–30.
  • Rogers LC, Bevilacqua NJ, Armstrong DG. The use of marrow-derived stem cells to accelerate healing in chronic wounds. Int Wound J. 2008;5:20–5.
  • Humpert PM, Bartsch U, Konrade I, Hammes HP, Morcos M, Kasper M, . Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient. Exp Clin Endocrinol Diabetes. 2005; 113:538–40.
  • Valbonesi M. Fibrin glues of human origin. Best Prac Res Clin Haematol. 2006;19:191–203.
  • Whitman DM, Berry RL, Green DM. Platelet gel: an autologous alternative to fibrin glue with application in oral and maxillo facial surgery. J Oral Maxillo Facial Surgery. 1997; 55:194–9.
  • Koliakos G, Alamdari DH, Tsagias N, Kouzi-Koliakos K, Michaloudi E, Karagiannis V. A novel high-yield volume-reduction method for the cryopreservation of UC blood units. Cytotherapy. 2007;9:654–9.
  • Adkins D, Johnston M, Walsh J, Spitzer G, Goodnough T. Hydroxyethylstarch sedimentation by gravity ex vivo for red cell reduction of granulocyte apheresis components. J Clin Apher. 1998;13:56–61.
  • Harding KG, Morris HL, Patel GK. Science, medicine and the future: healing chronic wounds. Br Med J. 2002;324:160–3.
  • Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, . Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 2001;105: 369–77.
  • Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, . Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–7.
  • Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366:1736–43.
  • Lorenz HP, Longaker MT. Wounds: Biology, Pathology, and Management. Stanford: Stanford University Medical Center; 2003. 77–88.
  • Wu Y, Wang J, Scott PG, Tredget EE. Bone marrow-derived stem cells in wound healing: a review. Wound Rep Reg. 2007; 15 S18–26.
  • Valbonesi M, Giannini G, Migliori F, Dalla Costa R, Dejana AM. Cord blood (CB) stem cells for wound repair. Preliminary report of 2 cases. Transfus Apher Sci. 2004;30: 153–6.
  • Badiavas EV, Ford D, Liu P, Kouttab N, Morgan J, Richards A, Maizel A. Long-term bone marrow culture and its clinical potential in chronic wound healing. Wound Repair Regen. 2007;15:856–65.
  • Bartsch T, Brehm M, Falke T, Kogler G, Wernet P, Strauer BE. Rapid healing of a therapy-refractory diabetic foot after transplantation of autologous bone marrow stem cells. Med Klin (Munich). 2005;100:676–80.
  • Yamaguchi Y, Yoshida S, Sumikawa Y, Kubo T, Hosokawa K, Ozawa K, . Rapid healing of intractable diabetic foot ulcers with exposed bones following a novel therapy of exposing bone marrow cells and then grafting epidermal sheets. Br J Dermatol. 2004;151:1019–28.
  • Nakagawa H, Akita S, Fukui M, Fujii T, Akino K. Human mesenchymal stem cells successfully improve skin-substitute wound healing. Br J Dermatol. 2005;153:29–36.
  • Medina A, Scott PG, Ghahary A, Tredget EE. Pathophysiology of chronic nonhealing wounds. J Burn Care Rehabil. 2005;26:306–19.
  • Steed DL. Modifying the wound healing response with exogenous growth factors. Clin Plast Surg. 1998;25:397–405.
  • Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg. 2004;114: 1502–8.
  • Gharaee-Kermani M, Phan SH. Role of cytokines and cytokine therapy in wound healing and fibrotic diseases. Curr Pharm Des. 2001;7:1083–103.
  • Singer AJ, Clark RAF. Cutaneous wound healing. N Engl J Med. 1999;341:738–46.
  • Ichioka S, Ohura N, Sekiya N, Shibata M, Nakatsuka T. Regenerative surgery for sacral pressure ulcers using collagen matrix substitute dermis (artificial dermis). Ann Plast Surg. 2003;51:383–9.
  • Ichioka S, Kouraba S, Sekiya N, Ohura N, Nakatsuka T. Bone marrow-impregnated collagen matrix for wound healing: experimental evaluation in a microcirculatory model of angiogenesis, and clinical experience. Br J Plast Surg. 2005;58: 1124–30.
  • Kouraba S, Sakamoto T, Yasuda M, Yamamoto Y, Kumakiri M. Wound bed regeneration with bone marrow-impregnated collagen matrix for the treatment of the leg ulcer associated with cryoglobulinemia. J Jpn Plast Reconstr Surg. 2006;26:825–30.
  • Mizuno H, Akaishi S, Koike S, Hyakusoku H, Miyamoto M. Clinical application of collagen matrix impregnated with bone marrow-derived mononuclear cells for ischemic refractory skin ulcers. J Jpn Plast Reconstr Surg. 2006;26:726–32.
  • Langer A, Rogowski W. Systematic review of economic evaluations of human cell-derived wound care products for the treatment of venous leg and diabetic foot ulcers. BMC Health Serv Res. 2009;9:115.

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