The best bone marrow stromal cell for therapy is … ‘yellow’

References

• Ren J, Jin P, Sabatino M, Balakumaran A, Feng J, Kuznetsov SA, . Global transcriptome analysis of human bone marrow stromal cells (BMSC) reveals proliferative, mobile and interactive cells that produce abundant extracellular matrix proteins, some of which may affect BMSC potency. Cytotherapy. 2011;13:661–74.
   PubMed Web of Science ®Google Scholar
• Song L, Webb NE, Song Y, Tuan RS. Identification and functional analysis of candidate genes regulating mesenchymal stem cell self-renewal and multipotency. Stem Cells. 2006;24:1707–18.
   PubMed Web of Science ®Google Scholar
• Stenderup K, Justesen J, Clausen C, Kassem M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone. 2003;33:919–26.
   PubMed Web of Science ®Google Scholar
• Kim CG, Lee JJ, Jung DY, Jeon J, Heo HS, Kang HC, . Profiling of differentially expressed genes in human stem cells by cDNA microarray. Mol Cells. 2006;21:343–55.
   PubMed Web of Science ®Google Scholar
• Igarashi A, Segoshi K, Sakai Y, Pan H, Kanawa M, Higashi Y, . Selection of common markers for bone marrow stromal cells from various bones using real-time RT-PCR: effects of passage number and donor age. Tissue Eng. 2007;13:2405–17.
   PubMedGoogle Scholar
• Covas DT, Panepucci RA, Fontes AM, Silva WAJ, Orellana MD, Freitas MC, . Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. Exp Hematol. 2008;36:642–54.
   PubMed Web of Science ®Google Scholar
• Menicanin D, Bartold PM, Zannettino AC, Gronthos S. Identification of a common gene expression signature associated with immature clonal mesenchymal cell populations derived from bone marrow and dental tissues. Stem Cells Dev. 2010;19:1501–10.
   PubMed Web of Science ®Google Scholar
• Ioannidis JP, Allison DB, Ball CA, Coulibaly I, Cui X, Culhane AC, . Repeatability of published microarray gene expression analyses. Nat Genet. 2009;41:149–55.
   PubMed Web of Science ®Google Scholar
• Chtanova T, Newton R, Liu SM, Weininger L, Young TR, Silva DG, . Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets. J Immunol. 2005;175:7837–47.
   PubMed Web of Science ®Google Scholar
• Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause DS, . Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–17.
   PubMed Web of Science ®Google Scholar
• Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, . Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 2010;4:214–22.
   PubMed Web of Science ®Google Scholar
• Gurley KA, Reimer RJ, Kingsley DM. Biochemical and genetic analysis of ANK in arthritis and bone disease. Am J Hum Genet. 2006;79:1017–29.
   PubMed Web of Science ®Google Scholar
• Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, . Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network. Diabetes. 2009;58: 609–19.
   PubMed Web of Science ®Google Scholar
• Kettunen P, Kivimae S, Keshari P, Klein OD, Cheyette BN, Luukko K. Dact1–3 mRNAs exhibit distinct expression domains during tooth development. Gene Expr Patterns. 2010;10:140–3.
   PubMed Web of Science ®Google Scholar
• Miwa HE, Gerken TA, Jamison O, Tabak LA. Isoform-specific O-glycosylation of osteopontin and bone sialoprotein by polypeptide N-acetylgalactosaminyltransferase-1. J Biol Chem. 2010;285:1208–19.
   PubMed Web of Science ®Google Scholar
• Urano T, Narusawa K, Shiraki M, Sasaki N, Hosoi T, Ouchi Y, . Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women. Eur Spine J. 2011;20:572–577.
   PubMed Web of Science ®Google Scholar
• Moffatt P, Lee ER, St-Jacques B, Matsumoto K, Yamaguchi Y, Roughley PJ. Hyaluronan production by means of Has2 gene expression in chondrocytes is essential for long bone development. Dev Dyn. 2011;240:404–12.
   PubMed Web of Science ®Google Scholar
• Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura AJ, Hirata N, . The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell. 2009; 17:800–10.
   PubMed Web of Science ®Google Scholar
• Mukherjee A, Rotwein P. Akt promotes BMP2-mediated osteoblast differentiation and bone development. J Cell Sci. 2009;122:716–26.
   PubMed Web of Science ®Google Scholar
• Steiglitz BM, Keene DR, Greenspan DS. PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. J Biol Chem. 2002;277:49820–30.
   PubMed Web of Science ®Google Scholar
• Zhu J, Gardner J, Pullinger CR, Kane JP, Thompson JF, Francone OL. Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1. J Lipid Res. 2009;50:1330–9.
   PubMed Web of Science ®Google Scholar
• Jeong IK, Cho SW, Kim SW, Choi HJ, Park KS, Kim SY, . Lipid profiles and bone mineral density in pre- and postmenopausal women in Korea. Calcif Tissue Int. 2010;87:507–12.
   PubMed Web of Science ®Google Scholar
• Larsen KH, Frederiksen CM, Burns JS, Abdallah BM, Kassem M. Identifying a molecular phenotype for bone marrow stromal cells with in vivo bone-forming capacity. J Bone Miner Res. 2010;25:796–808.
   PubMed Web of Science ®Google Scholar
• Burns JS, Rasmussen PL, Larsen KH, Schroder HD, Kassem M. Parameters in three-dimensional osteospheroids of telomerized human mesenchymal (stromal) stem cells grown on osteoconductive scaffolds that predict in vivo bone-forming potential. Tissue Eng Part A. 2010;16:2331–42.
   PubMed Web of Science ®Google Scholar