Human umbilical cord mesenchymal stromal cells mitigate chemotherapy-associated tissue injury in a pre-clinical mouse model

References

• Carelle N, Piotto E, Bellanger A, Germanaud J, Thuillier A, Khayat D. Changing patient perceptions of the side effects of cancer chemotherapy. Cancer. 2002;95:155–63.
   PubMed Web of Science ®Google Scholar
• Crawford J, Dale DC, Lyman GH. Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management. Cancer. 2004;100:228–37.
   PubMed Web of Science ®Google Scholar
• Takimoto C, Lu Z, Zhang R, Liang M, Larson L, Cantilena L, . Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency. Clin Cancer Res. 1996;2:477–81.
   PubMed Web of Science ®Google Scholar
• Vogelzang N. Nephrotoxicity from chemotherapy: prevention and management. Oncology. 1991;5:97.
   Google Scholar
• Takemura G, Fujiwara H. Doxorubicin-induced cardiomyopathy: from the cardiotoxic mechanisms to management. Prog Cardiovas Dis. 2007;49:330–52.
   PubMed Web of Science ®Google Scholar
• Hassett MJ, O’Malley AJ, Pakes JR, Newhouse JP, Earle CC. Frequency and cost of chemotherapy-related serious adverse effects in a population sample of women with breast cancer. J Natl Cancer Inst. 2006;98:1108–17.
   PubMed Web of Science ®Google Scholar
• Pittenger M, Mackay A, Beck S, Jaiswal R, Douglas R, Mosca J, . Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–47.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, . Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002; 418: 143–147.
   Google Scholar
• Conget P, Minguell J. Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells. J Cell Physiol. 1999;181:67–73.
   PubMed Web of Science ®Google Scholar
• Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, . Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2011;466:829–34.
   Google Scholar
• Lu LL, Liu YJ, Yang SG, Zhao QJ, Wang X, Gong W, . Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica. 2006;91:1017–26.
   PubMed Web of Science ®Google Scholar
• Koc ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, . Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol. 2011;18:307–16.
   Google Scholar
• Noort W, Kruisselbrink A, In't Anker P, Kruge M, van Bezooijen R, de Paus R, . Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34 + cells in NOD/SCID mice. Exp Hematol. 2002; 30:870–8.
   PubMed Web of Science ®Google Scholar
• Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK, . Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant. 2005;11:389–98.
   PubMed Web of Science ®Google Scholar
• Ball LM, Bernardo ME, Roelofs H, Lankester A, Cometa A, Egeler RM, . Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation. Blood. 2007;110:2764–7.
   PubMed Web of Science ®Google Scholar
• van Poll D, Parekkadan B, Cho CH, Berthiaume F, Nahmias Y, Tilles AW, . Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology. 2008;47:1634–43.
   PubMed Web of Science ®Google Scholar
• Urban VS, Kiss J, Kovacs J, Gocza E, Vas V, Monostori E, . Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes. Stem Cells. 2008;26:244–53.
   PubMed Web of Science ®Google Scholar
• Mias C, Lairez O, Trouche E, Roncalli J, Calise D, Seguelas MH, . Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction. Stem Cells. 2009;27:2734–43.
   PubMed Web of Science ®Google Scholar
• Semedo P, Correa-Costa M, Antonio Cenedeze M, Maria Avancini Costa Malheiros D, Antonia dos Reis M, Shimizu MH, . Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model. Stem Cells. 2009;27: 3063–73.
   PubMed Web of Science ®Google Scholar
• Khalil PN, Weiler V, Nelson PJ, Khalil MN, Moosmann S, Mutschler WE, . Nonmyeloablative stem cell therapy enhances microcirculation and tissue regeneration in murine inflammatory bowel disease. Gastroenterology. 2007;132: 944–54.
   PubMedGoogle Scholar
• Gonzalez-Rey E, Anderson P, Gonzalez MA, Rico L, Buscher D, Delgado M. Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis. Gut. 2009;58:929–39.
   PubMed Web of Science ®Google Scholar
• Semont A, Mouiseddine M, Francois A, Demarquay C, Mathieu N, Chapel A, . Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis. Cell Death Differ. 2010;17: 952–61.
   PubMed Web of Science ®Google Scholar
• Studeny M, Marini FC, Dembinski JL, Zompetta C, Cabreira-Hansen M, Bekele BN, . Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst. 2004;96:1593–603.
   PubMed Web of Science ®Google Scholar
• Sasportas LS, Kasmieh R, Wakimoto H, Hingtgen S, van de Water JA, Mohapatra G, . Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proc Natl Acad Sci USA. 2009;106: 4822–7.
   PubMed Web of Science ®Google Scholar
• Khakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira, II, . Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med. 2006;203:1235–47.
   PubMed Web of Science ®Google Scholar
• Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, . Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007;449: 557–63.
   PubMed Web of Science ®Google Scholar
• Seshareddy K, Troyer D, Weiss M. Method to isolate mesenchymal-like cells from Wharton's jelly of umbilical cord. Meth Cell Biol. 2008;86:101–19.
   Web of Science ®Google Scholar
• Oswald J, Boxberger S, Jrgensen B, Feldmann S, Ehninger G, Bornhuser M, . Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells. 2004; 22:377–84.
   PubMed Web of Science ®Google Scholar
• Park KS, Lee YS, Kang KS. In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood. J Vet Sci. 2006;7:343–8.
   Google Scholar
• Patel SA, Sherman L, Munoz J, Rameshwar P. Immunological properties of mesenchymal stem cells and clinical implications. Arch Immunol Ther Exp (Warsz). 2008;56:1–8.
   PubMed Web of Science ®Google Scholar
• Muguruma Y, Yahata T, Miyatake H, Sato T, Uno T, Itoh J, . Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment. Blood. 2006; 107:1878–87.
   PubMed Web of Science ®Google Scholar
• Friedman R, Betancur M, Boissel L, Tuncer H, Cetrulo C, Klingemann H. Umbilical cord mesenchymal stem cells: adjuvants for human cell transplantation. Biol Blood Marrow Transplant. 2007;13:1477–86.
   PubMed Web of Science ®Google Scholar
• Angelopoulou M, Novelli E, Grove J, Rinder H, Civin C, Cheng L, . Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Exp Hematol. 2003;31:413–20.
   PubMed Web of Science ®Google Scholar
• Keefe DM, Brealey J, Goland GJ, Cummins AG. Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans. Gut. 2000;47:632–7.
   PubMed Web of Science ®Google Scholar
• Paris F, Fuks Z, Kang A, Capodieci P, Juan G, Ehleiter D, . Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science. 2001;293: 293–97.
   PubMed Web of Science ®Google Scholar
• Farrell CL, Bready JV, Rex KL, Chen JN, DiPalma CR, Whitcomb KL, . Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res. 1998;58:933–9.
   PubMed Web of Science ®Google Scholar
• Huang FS, Kemp CJ, Williams JL, Erwin CR, Warner BW. Role of epidermal growth factor and its receptor in chemotherapy-induced intestinal injury. Am J Physiol Gastrointest Liver Physiol. 2002;282:G432–42.
   PubMed Web of Science ®Google Scholar
• Maj J, Paris F, Haimovitz-Friedman A, Venkatraman E, Kolesnick R, Fuks Z. Microvascular function regulates intestinal crypt response to radiation. Cancer Res. 2003;63: 4338–41.
   Google Scholar
• Tomita S, Ishida M, Nakatani T, Fukuhara S, Hisashi Y, Ohtsu Y, . Bone marrow is a source of regenerated cardiomyocytes in doxorubicin-induced cardiomyopathy and granulocyte colony-stimulating factor enhances migration of bone marrow cells and attenuates cardiotoxicity of doxorubicin under electron microscopy. J Heart Lung Transplant. 2004; 23:577–84.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Sun Z, Han Q, Liao L, Wang J, Bian C, . Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1. Leukemia. 2009;23:4338–4341.
   Google Scholar
• Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao RC, . Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Res. 2008;18:500–7.
   PubMed Web of Science ®Google Scholar
• Zhu W, Xu W, Jiang R, Qian H, Chen M, Hu J, . Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp Mol Pathol. 2006;80:267–74.
   PubMed Web of Science ®Google Scholar