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Research Article

Systematic investigation of oxygen and growth factors in clinically valid ex vivo expansion of cord blood CD34+ hematopoietic progenitor cells

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Pages 679-685 | Received 09 Oct 2011, Accepted 06 Feb 2012, Published online: 16 Mar 2012

References

  • Cohen Y, Nagler A. Hematopoietic stem cell transplantation using umbilical cord blood. Leuk Lymphoma. 2003;44: 1287–99.
  • O’Brien TA, Tiedemann K, Vowels MR. No longer a biological waste product: umbilical cord blood. Med J Australia. 2006;184:407–10.
  • Schoemans H, Theunissen K, Maertens J, Boogaerts M, Verfaillie C, Wagner J. Adult umbilical cord blood transplantation: a comprehensive review. Bone Marrow Transplant. 2006;38:83–93.
  • Ooi J. Cord blood transplantation in adults. Bone Marrow Transplant. 2009;44:661–6.
  • Hai-Jiang W, Xin-Na D, Hui-Jun D. Expansion of hematopoietic stem/progenitor cells. Am J Hematol. 2008;83:922–6.
  • Haylock DN, Nilsson SK. Expansion of umbilical cord blood for clinical transplantation. Curr Stem Cell Res Ther. 2007;2:324–35.
  • Andrade-Zaldivar H, Santos L, De Leon Rodriguez A. Expansion of human hematopoietic stem cells for transplantation: trends and perspectives. Cytotechnology. 2008;56:151–60.
  • Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med. 2010;16:232–6.
  • Kelly SS, Sola CB, de Lima M, Shpall E. Ex vivo expansion of cord blood. Bone Marrow Transplant. 2009;44:673–81.
  • Koestenbauer S, Zisch A, Dohr G, Zech NH. Protocols for hematopoietic stem cell expansion from umbilical cord blood. Cell Transplant. 2009;18:1059–68.
  • Zhang CC, Kaba M, Iizuka S, Huynh H, Lodish HF. Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood. 2008;111:3415–23.
  • Mukhopadhyay A, Madhusudhan T, Kumar R. Hematopoietic stem cells: clinical requirements and developments in ex-vivo culture. Adv Biochem Eng Biotechnol. 2004;86:215–53.
  • Ivanovic Z, Boiron JM. Ex vivo expansion of hematopoietic stem cells: concept and clinical benefit. Transfus Clin Biol. 2009;16:489–500.
  • Askmyr M, Sims NA, Martin TJ, Purton LE. What is the true nature of the osteoblastic hematopoietic stem cell niche? Trends Endocrinol Metab. 2009;20:303–9.
  • Hofmeister CC, Zhang J, Knight KL, Le P, Stiff PJ. Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche. Bone Marrow Transplant. 2007;39:11–23.
  • Wilson A, Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol. 2006;6:93–106.
  • Zhang CC, Lodish HF. Cytokines regulating hematopoietic stem cell function. Curr Opin Hematol. 2008;15:307–11.
  • Kollet O, Aviram R, Chebath J, Ben-Hur H, Nagler A, Shultz L, . The soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro maintenance and proliferation of human CD34(+)CD38(–/low) cells capable of repopulating severe combined immunodeficiency mice. Blood. 1999;94: 923–31.
  • Lyman SD, Jacobsen SE. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood. 1998;91:1101–34.
  • Chute JP. Stem cell homing. Curr Opin Hematol. 2006;13: 399–406.
  • Yin T, Li L. The stem cell niches in bone. J Clin Invest. 2006;116:1195–201.
  • Mohle R, Kanz L. Hematopoietic growth factors for hematopoietic stem cell mobilization and expansion. Semin Hematol. 2007;44:193–202.
  • Liongue C, Wright C, Russell AP, Ward AC. Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more. Int J Biochem Cell Biol. 2009;41:2372–5.
  • Hermitte F, Brunet de la Grange P, Belloc F, Praloran V, Ivanovic Z. Very low O2 concentration (0.1%) favors G0 return of dividing CD34+ cells. Stem Cells. 2006;24:65–73.
  • Shima H, Takubo K, Iwasaki H, Yoshihara H, Gomei Y, Hosokawa K, . Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice. Biochem Biophys Res Comm. 2009;378:467–72.
  • Danet GH, Pan Y, Luongo JL, Bonnet DA, Simon MC. Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest. 2003;112:126–35.
  • Ivanovic Z, Hermitte F, Brunet de la Grange P, Dazey B, Belloc F, Lacombe F, . Simultaneous maintenance of human cord blood SCID-repopulating cells and expansion of committed progenitors at low O2 concentration (3%). Stem Cells. 2004;22:716–24.
  • Ivanovic Z. Physiological, ex vivo cell oxygenation is necessary for a true insight into cytokine biology. Eur Cytokine Netw. 2009;20:7–9.
  • Kovacevic-Filipovic M, Petakov M, Hermitte F, Debeissat C, Krstic A, Jovcic G, . Interleukin-6 (IL-6) and low O(2) concentration (1%) synergize to improve the maintenance of hematopoietic stem cells (pre-CFC). J Cell Physiol. 2007;212:68–75.
  • LaIuppa JA, Papoutsakis ET, Miller WM. Oxygen tension alters the effects of cytokines on the megakaryocyte, erythrocyte, and granulocyte lineages. Exp Hematol. 1998;26:835–43.
  • Ivanovic Z. Hypoxia or in situ normoxia: the stem cell paradigm. J Cell Physiol. 2009;219:271–5.
  • Ivanovic Z, Belloc F, Faucher JL, Cipolleschi MG, Praloran V, Dello Sbarba P. Hypoxia maintains and interleukin-3 reduces the pre-colony-forming cell potential of dividing CD34(+) murine bone marrow cells. Exp Hematol. 2002;30:67–73.
  • Ross J, Li L. Recent advances in understanding extrinsic control of hematopoietic stem cell fate. Curr Opin Hematol. 2006;13:237–42.
  • McNiece IK, Almeida-Porada G, Shpall EJ, Zanjani E. Ex vivo expanded cord blood cells provide rapid engraftment in fetal sheep but lack long-term engrafting potential. Exp Hematol. 2002;30:612–6.
  • Dao MA, Creer MH, Nolta JA, Verfaillie CM. Biology of umbilical cord blood progenitors in bone marrow niches. Blood. 2007;110:74–81.
  • Cho CH, Eliason JF, Matthew HW. Application of porous glycosaminoglycan-based scaffolds for expansion of human cord blood stem cells in perfusion culture. J Biomed Mater Res A. 2008;86:98–107.
  • Koller MR, Manchel I, Brott DA, Palsson B. Donor-to-donor variability in the expansion potential of human bone marrow cells is reduced by accessory cells but not by soluble growth factors. Exp Hematol. 1996;24:1484–93.
  • Sharma S, Gurudutta GU, Satija NK, Pati S, Afrin F, Gupta P, . Stem cell c-KIT and HOXB4 genes: critical roles and mechanisms in self-renewal, proliferation, and differentiation. Stem Cells Dev. 2006;15:755–78.
  • Zhu J, Zhang Y, Joe GJ, Pompetti R, Emerson SG. NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal. Proc Natl Acad Sci USA. 2005;102:11728–33.
  • Stein MI, Zhu J, Emerson SG. Molecular pathways regulating the self-renewal of hematopoietic stem cells. Exp Hematol. 2004;32:1129–36.

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