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Original Article

Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing

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Pages 297-302 | Received 23 Nov 2012, Accepted 14 Dec 2012, Published online: 30 Jan 2013

References

  • Centers for Medicare and Medicaid Services. Guidance to surveyors for long term care facilities, 2012. Available from: http://www.cms.hhs.gov [last accessed 17 Jan 2013]
  • Londahl M, Katzman P, Nilsson A, Hammarlund C. Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes. Diabetes Care 2010;33:998–1003
  • Londahl M, Landin-Olsson M, Katzman P. Hyperbaric oxygen therapy improves health-related quality of life in patients with diabetes and chronic foot ulcer. Diabet Med 2011;28:186–90
  • Hunter S, Langemo DK, Anderson J, et al. Hyperbaric oxygen therapy for chronic wounds. Adv Skin Wound Care 2010;23:116–9
  • Gesell LB. Hyperbaric oxygen therapy indications. Committee Report. 12th ed. Durham, NC: Undersea and Hyperbaric Medical Society; 2008
  • Narkowicz CH, Vial JH, McCartney P. Hyperbaric oxygen therapy increases free radical levels in the blood of humans. Free Radic Res Commun 1993;19:71–80
  • Wells PG, McCallum GP, Chen CS, et al. Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer. Toxicol Sci 2009;108:4–18
  • Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Radic Biol Med 1995;19:227–50
  • Bustamante J, Lodge JK, Marcocci L, et al. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med 1998;24:1023–39
  • Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 1997;29:315–31
  • Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 2001;17:888–95
  • Alleva R, Nasole E, Di Donato F, et al. α-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy. Biochem Biophys Res Commun 2005;333:404–10
  • Alleva R, Tomasetti M, Sartini D, et al. Alpha-lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy. Mol Med 2008;14:175–83
  • Petersen SK, Moreau RF, Smith EJ, Hagen TM. Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB 2008;60:362–7
  • Folkman J, Brem H. Angiogenesis and inflammation. In: Gallin J, Goldstein I, Snyderman R, eds. Inflammation: basic principles and clinical correlates. 2nd ed. New York: Raven Press; 1992:821–39
  • Halliwel B, Gutteridge C, Cross CE. Free radicals, antioxidants and human disease: where are we now. J Lab Clin Med 1992;19:598–620
  • Li J, Chen J, Kirsner R. Pathophysiology of acute wound healing. Clin Dermatol 2007;25:9–18
  • Tian YW, Stacey MC. Cytokines and growth factors in keratinocytes and sweat glands in chronic venous leg ulcers: an immunohistochemical study. Wound Rep Reg 2003;11:316–25
  • Baker AE, Leaper DJ. Proteinases, their inhibitors and cytokine profiles in acute wound fluid. Wound Rep Reg 2000;8:392–8
  • Brown GL, Curtsinger L, Jurkiewicz MJ, et al. Stimulation of healing of chronic wounds by epidermal growth factor. Plast Reconstr Surg 1991;88:189–94; discussion 195–6
  • Falanga V, Eaglstein WH, Bucalo B, et al. Topical use of human recombinant epidermal growth factor (h-EGF) in venous ulcers. J Dermatol Surg Oncol 1992;18:604–6
  • Raddatz G, Bisswanger H. Receptor site and stereospecifity of dihydrolipoamide dehydrogenase for R- and S-lipoamide: a molecular modeling study. J Biotechnol 1997;58:89–100
  • Kilic F, Handelman GJ, Serbinova E, et al. Modelling cortical cataractogenesis: in vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis. Biochem Mol Biol Int 1995;37:361–70
  • Streeper RS, Henriksen EJ, Jacob S, et al. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol 1997;273:E185–91
  • Frölich L, Götz ME, Weinmüller M, et al. (r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia. J Neural Transm 2004;111:295–310
  • Wagner FW Jr. The diabetic foot. Orthopedics 1987;10:163–72
  • Schultz GS, Sibbald RG, Falanga V, et al. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen 2003;11:1–28
  • Yogaratnam JZ, Laden G, Madden LA, et al. Hyperbaric oxygen: a new drug in myocardial revascularization and protection? Cardiovasc Revasc Med 2006;7:146–154
  • Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg 2011;127:131S–41S
  • Packer L, Roy S, Sen CK. Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription. Adv Pharmacol 1997;38:79–101
  • Sen CK, Roy S, Han D, Packer L. Regulation of cellular thiols in human lymphocytes by alpha-lipoic acid: a flow cytometric analysis. Free Radic Biol Med 1997;22:1241–57
  • Pepper MS, Mandriota SJ, Jeltsch M, et al. Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity. J Cell Physiol 1998;177:439–52
  • Sheikh AY, Gibson JJ, Rollins MD, et al. Effect of hyperoxia on vascular endothelial growth factor levels in a wound model. Arch Surg 2000;135:1293–7
  • Han C, Lin L, Zhang W, et al. Hyperbaric oxygen preconditioning alleviates myocardial ischemic injury in rats. Exp Biol Med (Maywood) 2008;233:1448–53
  • Kalns JE, Dick EJ Jr, Scruggs JP, et al. Hyperbaric oxygen treatment prevents up-regulation of angiogenesis following partial-thickness skin grafts in the pig. Wound Repair Regen 2003;11:139–44
  • Lauer G, Sollberg S, Cole M, et al. Expression and proteolysis of vascular endothelial growth factor is increased in chronic wounds. J Invest Dermatol 2000;115:12–8
  • Grazul-Bilska AT, Johnson ML, Bilski JJ, et al. Wound healing: the role of growth factors. Drugs Today (Barc) 2003;39:787–800
  • Keck PJ, Hauser SD, Krivi G, et al. Vascular permeability factor: an endothelial cell mitogen related to PDGF. Science 1989;246:1309–12
  • Folkman J, Brem H. Angiogenesis and inflammation. In: Gallin J, Goldstein I, Snyderman R, eds. Inflammation: basic principles and clinical correlates. 2nd ed. New York: Raven Press; 1992:821–39
  • Pakele R, Watanabe T, Benedict CR. Induction of endothelial cell proliferation by angiogenic factors released by activated monocytes. Cardiovasc Radiat Med 2002;3:95–101

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