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Original Article

Antileishmanial activity evaluation of bis-lawsone analogs and DNA topoisomerase-I inhibition studies

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Pages 185-189 | Received 10 Sep 2012, Accepted 07 Jan 2013, Published online: 27 Mar 2013

References

  • Reithinger R, Dujardin J-C, Louzir H, et al. Cutaneous leishmaniasis. Lancet Infect Dis 2007;7:581–96
  • Zijlstra EE, Musa AM, Khalil EAG, et al. Post-kala-azar dermal leishmaniasis. Lancet Infect Dis 2003;3:87–98
  • Haldar JP, Ghose S, Saha KC, Ghose AC. Cell-mediated immune response in Indian kala-azar and post-kala-azar dermal leishmaniasis. Infect Immun 1983;42:702–7
  • Desjeux P. Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect 2004;27:305–18
  • Croft SL, Sundar S, Fairlamb AH. Drug resistance in leishmaniasis. Clin Microbiol Rev 2006;19:111–26
  • Pérez-Victoria FJ, Sánchez-Cañete MP, Seifert K, et al. Mechanisms of experimental resistance of Leishmania to miltefosine: implications for clinical use. Drug Resist Update 2006;9:26–39
  • Bjornsti MA, Wang JC. Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli. Proc Natl Acad Sci 1987;84:8971–5
  • Stewart L, Ireton GC, Champoux JJ. Reconstitution of human topoisomerase I by fragment complementation. J Molec Biol 1997;269:355–72
  • Wang JC. DNA topoisomerases: why so many? J Biol Chem 1991;266:6659–62
  • Wang JC. DNA topoisomerases. Ann Rev Biochem 1996;65:635–92
  • Mazumder A, Wang S, Neamati N, et al. Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease. J Med Chem 1996;39:2472–81
  • Ray S, Hazra B, Mittra B, et al. Diospyrin, A bisnaphthoquinone: a novel inhibitor of type I DNA topoisomerase of Leishmania donovani. Molec Pharmacol 1998;54:994–9
  • Hazra B, Golenser J, Nechemiya O, et al. Inhibitory activity of diospyrin derivatives against Leishmania major parasites in vitro. Indian J Pharmacol 2002;34:422–7
  • Ting C-Y, Hsu C-T, Hsu H-T, et al. Isodiospyrin as a novel human DNA topoisomerase I inhibitor. Biochem Pharmacol 2003;66:1981–91
  • Sen N, Das BB, Ganguly A, et al. Camptothecin-induced imbalance in intracellular cation homeostasis regulates programmed cell death in unicellular hemoflagellate Leishmania donovani. J Biol Chem 2004;279:52366–75
  • Sen N, Das BB, Ganguly A, et al. Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani. Cell Death Differ 2004;11:924–36
  • Tisseh ZN, Bazgir A. An efficient, clean synthesis of 3,3′-(arylmethylene)bis(2-hydroxynaphthalene-1,4-dione) derivatives. Dyes Pigments 2009;83:258–61
  • Das BB, Dasgupta SB, Ganguly A, et al. Leishmania donovani bisubunit topoisomerase I gene fusion leads to an active enzyme with conserved type IB enzyme function. FEBS J 2007;274:150–63
  • Mittra B, Saha A, Chowdhury AR, et al. Luteolin, an abundant dietary component is a potent antileishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis. Mol Med (N Y) 2000;6:527–41
  • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth 1983;65:55–63
  • Chowdhury S, Mukherjee T, Sengupta S, et al. Novel betulin derivatives as antileishmanial agents with mode of action targeting type IB DNA topoisomerase. Molec Pharmacol 2011;80:694–703

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