Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase

References

• Ciesek S, Manns MP. Hepatitis in 2010: the dawn of a new era in HCV therapy. Nat Rev Gastroenterol Hepatol 2011;8:69–71
   PubMed Web of Science ®Google Scholar
• Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347:975–82
   PubMed Web of Science ®Google Scholar
• Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358:958–65
   PubMed Web of Science ®Google Scholar
• Opar A. Excitement grows for potential revolution in hepatitis C virus treatment. Nat Rev Drug Discov 2010;9:501–3
   PubMedGoogle Scholar
• Lam AM, Frick DN. Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase. J Virol 2006;80:404–11
   PubMed Web of Science ®Google Scholar
• Kwong AD, Rao BG, Jeang KT. Viral and cellular RNA helicases as antiviral targets. Nat Rev Drug Discov 2005;4:845–53
   PubMed Web of Science ®Google Scholar
• Gallinari P, Brennan D, Nardi C, et al. Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus. J Virol 1998;72:6758–69
   PubMed Web of Science ®Google Scholar
• Kim DW, Gwack Y, Han JH, Choe J. C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun 1995;215:160–6
   PubMed Web of Science ®Google Scholar
• Tai CL, Chi WK, Chen DS, Hwang LH. The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3). J Virol 1996;70:8477–84
   PubMed Web of Science ®Google Scholar
• Gwack Y, Kim DW, Han JH, Choe J. Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein. Biochem Biophys Res Commun 1996;225:654–9
   PubMedGoogle Scholar
• Gwack Y, Kim DW, Han JH, Choe J. DNA helicase activity of the hepatitis C virus nonstructural protein 3. Eur J Biochem 1997;250:47–54
   PubMedGoogle Scholar
• Belon CA, Frick DN. Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C. Future Virol 2009;4:277–93
   PubMed Web of Science ®Google Scholar
• Macarron R, Banks MN, Bojanic D, et al. Impact of high-throughput screening in biomedical research. Nat Rev Drug Discov 2011;10:188–95
   PubMed Web of Science ®Google Scholar
• Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007;70:461–77
   PubMed Web of Science ®Google Scholar
• Li JW, Vederas JC. Drug discovery and natural products: end of an era or an endless frontier? Science 2009;325:161–5
   PubMed Web of Science ®Google Scholar
• Salomon CE, Magarvey NA, Sherman DH. Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery. Nat Prod Rep 2004;21:105–21
   PubMed Web of Science ®Google Scholar
• Tani H, Akimitsu N, Fujita O, et al. High-throughput screening assay of hepatitis C virus helicase inhibitors using fluorescence-quenching phenomenon. Biochem Biophys Res Commun 2009;379:1054–9
   Google Scholar
• Copeland RA. Evaluation of enzyme inhibitors in drug discovery: a guide for medicinal chemists and pharmacologists. New York: Wiley; 2005:111–40
   Google Scholar
• Salam KA, Furuta A, Noda N, et al. Inhibition of hepatitis C virus NS3 helicase by manoalide. J Nat Prod 2012;75:650–4
   Google Scholar
• Stankiewicz-Drogon A, Palchykovska LG, Kostina VG, et al. New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection. Bioorg Med Chem 2008;16:8846–52
   PubMed Web of Science ®Google Scholar
• Mikkelsen NE, Johansson K, Virtanen A, Kirsebom LA. Aminoglycoside binding displaces a divalent metal ion in a tRNA-neomycin B complex. Nat Struct Biol 2001;8:510–14
   PubMedGoogle Scholar
• Huang Y, Liu ZR. The ATPase, RNA unwinding, and RNA binding activities of recombinant p68 RNA helicase. J Biol Chem 2002;277:12810–15
   PubMedGoogle Scholar
• Frick DN, Ginzburg O, Lam AM. A method to simultaneously monitor hepatitis C virus NS3 helicase and protease activities. Methods Mol Biol 2010;587:223–33
   Google Scholar
• Dahl G, Sandström A, Akerblom E, Danielson UH. Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3. FEBS J 2007;274:5979–86
   PubMed Web of Science ®Google Scholar
• Frick DN. The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target. Curr Issues Mol Biol 2007;9:1–20
   PubMed Web of Science ®Google Scholar
• Strott CA, Higashi Y. Cholesterol sulfate in human physiology: what’s it all about? J Lipid Res 2003;44:1268–78
   PubMed Web of Science ®Google Scholar
• Iwamori M, Iwamori Y, Ito N. Sulfated lipids as inhibitors of pancreatic trypsin and chymotrypsin in epithelium of the mammalian digestive tract. Biochem Biophys Res Commun 1997;237:262–5
   Google Scholar
• Iwamori M, Iwamori Y, Ito N. Regulation of the activities of thrombin and plasmin by cholesterol sulfate as a physiological inhibitor in human plasma. J Biochem 1999;125:594–601
   Google Scholar
• Sato J, Denda M, Nakanishi J, et al. Cholesterol sulfate inhibits proteases that are involved in desquamation of stratum corneum. J Invest Dermatol 1998;111:189–93
   PubMed Web of Science ®Google Scholar
• Ito N, Iwamori Y, Hanaoka K, Iwamori M. Inhibition of pancreatic elastase by sulfated lipids in the intestinal mucosa. J Biochem 1998;123:107–14
   PubMedGoogle Scholar
• Iwamori M, Suzuki H, Kimura T, Iwamori Y. Shedding of sulfated lipids into gastric fluid and inhibition of pancreatic DNase I by cholesterol sulfate in concert with bile acids. Biochim Biophys Acta 2000;1487:268–74
   Google Scholar
• Raney KD, Sharma SD, Moustafa IM, Cameron CE. Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target. J Biol Chem 2010;285:22725–31
   PubMed Web of Science ®Google Scholar
• Suzich JA, Tamura JK, Palmer-Hill F, et al. Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. J Virol 1993;67:6152–8
   PubMed Web of Science ®Google Scholar