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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 4
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Research Article

Design, synthesis and preliminary structure–activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives

Haoran LiuCollege of Chemistry and Chemical Engineering, Hu’nan University, Changsha, China and Correspondence[email protected]
,
Haoqun FanCollege of Chemistry and Chemical Engineering, Hu’nan University, Changsha, China and
,
Xiaohui GaoCollege of Pharmacy, Hu’nan University of Chinese Medicine, Changsha, China
,
Xueqing HuangCollege of Chemistry and Chemical Engineering, Hu’nan University, Changsha, China and
,
Xianjun LiuCollege of Chemistry and Chemical Engineering, Hu’nan University, Changsha, China and
,
Linbo LiuCollege of Chemistry and Chemical Engineering, Hu’nan University, Changsha, China and
,
Chao ZhouCollege of Chemistry and Chemical Engineering, Hu’nan University, Changsha, China and
,
Jingjing TangCollege of Chemistry and Chemical Engineering, Hu’nan University, Changsha, China and
,
Qiuan WangCollege of Chemistry and Chemical Engineering, Hu’nan University, Changsha, China and
&
Wukun LiuCollege of Chemistry and Chemical Engineering, Hu’nan University, Changsha, China and
show all
Pages 580-589 | Received 21 Feb 2015, Accepted 07 May 2015, Published online: 17 Jul 2015

References

  • Anand R, Gill KD, Mahdi AA. Therapeutics of Alzheimer’s disease: past, present and future. Neuropharmacology 2014;76:27–50
  • Pivtoraiko VN, Abrahamson EE, Leurgans SE, et al. Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer's disease. Neurobiol Aging 2015;36:12–19
  • García-Alberca JM. Cognitive intervention therapy as treatment for behavior disorders in Alzheimer disease: evidence on efficacy and neurobiological correlations. Neurología (English Edition) 2015;30:8–15
  • Molinuevo JL, Gauthier S. Benefits of combined cholinesterase inhibitor and memantine treatment in moderate–severe Alzheimer’s disease. Alzheimers Dement 2013;9:326–31
  • Small G, Bullock R. Defining optimal treatment with cholinesterase inhibitors in Alzheimer’s disease. Alzheimers Dement 2011;7:177–84
  • Silva T, Reis J, Teixeira J, et al. Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes. Ageing Res Rev 2014;15:116–45
  • Mukherjee PK, Kumar V, Mal M, et al. Acetylcholinesterase inhibitors from plants. Phytomedicine 2007;14:289–300
  • Li RS, Wang XB, Hu XJ, et al. Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer’s disease. Bioorg Med Chem Lett 2013;23:2636–41
  • Asadipour A, Alipour M, Jafari M, et al. Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors. Eur J Med Chem 2013;70:623–30
  • Liew SY, Khaw KY, Murugaiyah V, et al. Natural indole butyrylcholinesterase inhibitors from Nauclea officinalis. Phytomedicine 2015;22:45–8
  • Liu HR, Liu XJ, Fan HQ, et al. Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors. Bioorg Med Chem 2014;22:6124–33
  • Liu HR, Huang XQ, Lou DH, et al. Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B. Bioorg Med Chem Lett 2014;24:4749–53
  • Konrath EL, Passos CS, Klein-Júnior LC, et al. Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer’s disease. J Pharm Pharmacol 2013;65:1701–25
  • Darras FH, Wehle S, Huang G, et al. Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with ‘inverted’ binding mode. Bioorg Med Chem 2014;22:4867–81
  • Darvesh S, Macdonald LR, Martin E. Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems. Bioorg Med Chem Lett 2013;23:3822–5
  • Sharma J, Singla AK, Dhawan S. Zinc–naproxen complex: synthesis, physicochemical and biological evaluation. Int J Pharm 2003;260:217–27
  • Ellman GL, Courtney KD, Andres VJ, et al. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961;7:88–95
  • Skrzypek A, Matysiak J, Niewiadomy A, et al. Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors. Eur J Med Chem 2013;62:311–19
  • Magedov IV, Kireev AS, Jenkins AR, et al. Structural simplification of bioactive natural products with multicomponent synthesis. 4: 4H-pyrano-[2,3-b]naphthoquinones with anticancer activity. Bioorg Med Chem Lett 2012;22:5195–8
  • Magedov IV, Manpadi M, Rozhkova E, et al. Structural simplification of bioactive natural products with multicomponent synthesis: dihydropyridopyrazole analogues of podophyllotoxin. Bioorg Med Chem Lett 2007;17:1381–5
  • Yang R, Zhao R, Chen D, et al. Discovering selective agonists of endothelial target for acetylcholine (ETA) via diversity-guided pharmacophore simplification and simulation. Bioorg Med Chem Lett 2004;14:3017–25
  • Glave WR, Hansch CJ. Relationship between lipophilic character and anesthetic activity. J Pharm SCI-US 1972;61:589–91

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