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Journal of Maternal-Fetal Medicine Volume 9, 2000 - Issue 2
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Original Article

Effect of Antenatal Exposure to Paroxetine (Paxil) on Growth and Physical Maturation of Mice Offspring

William F. Rayburn Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Department of Pharmacology/Toxicology, University of Oklahoma Health Sciences Center, Oklahoma City, OklahomaCorrespondence[email protected]
,
Christina L. Gonzalez Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Department of Pharmacology/Toxicology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
,
H. Dix Christensen Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Department of Pharmacology/Toxicology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
,
Thomas C. Kupiec Northwest Toxicology, Salt Lake City, Utah
,
Jesse A. Jacobsen Department of Pharmacology/Toxicology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
&
Jeffrey D. Stewart Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Pages 136-141 | Received 10 Apr 1999, Accepted 06 Aug 1999, Published online: 07 Jul 2009

References

  • American College of Obstetricians and Gynecologists. Depression in women. American College of Obstetricians and Gynecologists, Washington, DC 1993, ACOG technical bulletin no. 182
  • Schmidt L A, Greenberg B D, Holzman G B, Schulkin J. Treatment of depression by obstetrician-gynecologists: a survey study. Obstet Gynecol 1997; 90: 296–300
  • Baldwin J A, Davidson E J, Pritchard A L, Ridings J E. The reproductive toxicity of paroxetine. Acta Psychiatr Scand Suppl 1989; 350: 37–39
  • Paxil [package insert] Mississauga. SmithKline Beecham Pharmaceuticals, Ontario 1995
  • Dechant K L, Clissold S P. Paroxetine: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs 1991; 41: 225–253
  • Haddock R E, Johnson A M, Langley P F, Nelson D R, Pope J A, Thomas D R, Woods F R. Metabolic pathway of paroxetine in animals and man and the comparative pharmacological properties of its metabolites. Acta Psychiatr Scan Suppl 1980; 350: 24–26
  • Rayburn W, Christensen H, Sienko A, Gonzalez C, Coleman F. Antenatal betamethasone for fetal lung maturation: selection of a murine model to investigate long-term neurobehavioral effects. Neurotoxicol Teratol 1996; 18: 329–330
  • Stewart J, Sienko A, Gonzalez C, Christensen H, Rayburn W. Is a multidose of betamethasone more beneficial than a single dose in accelerating fetal lung maturity?. Am J Obstet Gynecol 1998; 179: 1241–1247
  • Christensen H, Sienko A, Gonzales C, Coleman F, Rayburn W. Neurobehavior effects from prenatal exposure to centrally-acting drugs: selection of a murine model. Neurotox Teratol 1996; 18: 329–330
  • Christensen H, Kupiec T, Jacobsen J, Stewart J, Gonzalez C, Rayburn W. Tissue concentration from consumption of paroxetine (Paxil) in mice. Teratology 1998; 20: 365
  • Altshuler L L, Szuba M P. Course of psychiatric disorders in pregnancy: dilemmas in pharmacologic management. Neurol Clin 1994; 12: 613–635
  • Goldberg H L, Nissim R. Psychotropic drugs in pregnancy and lactation. Int J Psychiatry Med 1994; 24: 129–149
  • Kuller J, Katz V, McMahon M, Wells S, Bashford R. Pharmacologic treatment of psychiatric disease in pregnancy: fetal and neonatal effects. Obstet Gynecol 1996; 87: 789–794

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