High tissue factor activity and low tissue factor pathway inhibitor concentrations in patients with preterm labor

References

• Romero R, Espinoza J, Mazor M, Chaiworapongsa T. The preterm parturition syndrome. In: Critchley H, Bennett P, Thornton S editors. Preterm Birth. London: RCOG Press; 2004. pp 28–60.
   Google Scholar
• Minkoff H. Prematurity: infection as an etiologic factor. Obstet Gynecol 1983;62:137–144.
   PubMed Web of Science ®Google Scholar
• Romero R, Mazor M, Wu YK, Sirtori M, Oyarzun E, Mitchell MD, Hobbins JC. Infection in the pathogenesis of preterm labor. Semin Perinatol 1988;12:262–279.
   PubMed Web of Science ®Google Scholar
• Romero R, Sirtori M, Oyarzun E, Avila C, Mazor M, Callahan R, Sabo V, Athanassiadis AP, Hobbins JC. Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 1989;161:817–824.
   PubMed Web of Science ®Google Scholar
• Goncalves LF, Chaiworapongsa T, Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev 2002;8:3–13.
   PubMedGoogle Scholar
• Arias F, Rodriquez L, Rayne SC, Kraus FT. Maternal placental vasculopathy and infection: two distinct subgroups among patients with preterm labor and preterm ruptured membranes. Am J Obstet Gynecol 1993;168:585–591.
   PubMed Web of Science ®Google Scholar
• Romero R, Sepulveda W, Baumann P, Yoon BH, Brandt F, Gomez R, Mazor M, Sorokin Y, Cotton D. The preterm labor syndrome: Biochemical, cytologic, immunologic, pathologic, microbiologic, and clinical evidence that preterm labor is a heterogeneous disease. Am J Obstet Gynecol 1993;168:288.
   Google Scholar
• Combs CA, Katz MA, Kitzmiller JL, Brescia RJ. Experimental preeclampsia produced by chronic constriction of the lower aorta: validation with longitudinal blood pressure measurements in conscious rhesus monkeys. Am J Obstet Gynecol 1993;169:215–223.
   PubMed Web of Science ®Google Scholar
• Ogunyemi D, Murillo M, Jackson U, Hunter N, Alperson B. The relationship between placental histopathology findings and perinatal outcome in preterm infants. J Matern Fetal Neonatal Med 2003;13:102–109.
   PubMedGoogle Scholar
• Hill LM, Breckle R, Thomas ML, Fries JK. Polyhydramnios: ultrasonically detected prevalence and neonatal outcome. Obstet Gynecol 1987;69:21–25.
   PubMed Web of Science ®Google Scholar
• Phelan JP, Park YW, Ahn MO, Rutherford SE. Polyhydramnios and perinatal outcome. J Perinatol 1990;10:347–350.
   PubMedGoogle Scholar
• Besinger R, Carlson N. The physiology of preterm labor. Obstet Gynecol Surv 1995;45:415–440.
   Google Scholar
• Romero R, Mazor M, Gomez R. Cervix, incompetence and premature labor. Fetus 1993;3:1.
   Google Scholar
• Romero R, Espinoza J, Erez O, Hassan S. The role of cervical cerclage in obstetric practice: can the patient who could benefit from this procedure be identified? Am J Obstet Gynecol 2006;194:1–9.
   PubMed Web of Science ®Google Scholar
• Romero R. The child is the father of the man. Prenat Neonat Med 1996;1:8–11.
   Google Scholar
• Heath VC, Southall TR, Souka AP, Elisseou A, Nicolaides KH. Cervical length at 23 weeks of gestation: prediction of spontaneous preterm delivery. Ultrasound Obstet Gynecol 1998;12:312–317.
   PubMed Web of Science ®Google Scholar
• Hassan SS, Romero R, Berry SM, Dang K, Blackwell SC, Treadwell MC, Wolfe HM. Patients with an ultrasonographic cervical length <or =15 mm have nearly a 50% risk of early spontaneous preterm delivery. Am J Obstet Gynecol 2000;182:1458–1467.
   PubMed Web of Science ®Google Scholar
• Holloway JA, Warner JO, Vance GH, Diaper ND, Warner JA, Jones CA. Detection of house-dust-mite allergen in amniotic fluid and umbilical-cord blood. Lancet 2000;356:1900–1902.
   PubMed Web of Science ®Google Scholar
• Jones AC, Miles EA, Warner JO, Colwell BM, Bryant TN, Warner JA. Fetal peripheral blood mononuclear cell proliferative responses to mitogenic and allergenic stimuli during gestation. Pediatr Allergy Immunol 1996;7:109–116.
   PubMed Web of Science ®Google Scholar
• Rudolph MI, Reinicke K, Cruz MA, Gallardo V, Gonzalez C, Bardisa L. Distribution of mast cells and the effect of their mediators on contractility in human myometrium. Br J Obstet Gynaecol 1993;100:1125–1130.
   PubMedGoogle Scholar
• Belt AR, Baldassare JJ, Molnar M, Romero R, Hertelendy F. The nuclear transcription factor NF-kappaB mediates interleukin-1beta-induced expression of cyclooxygenase-2 in human myometrial cells. Am J Obstet Gynecol 1999;181:359–366.
   PubMed Web of Science ®Google Scholar
• Allport VC, Pieber D, Slater DM, Newton R, White JO, Bennett PR. Human labour is associated with nuclear factor-kappaB activity which mediates cyclo-oxygenase-2 expression and is involved with the ‘functional progesterone withdrawal’. Mol Hum Reprod 2001;7:581–586.
   PubMed Web of Science ®Google Scholar
• Chaiworapongsa T, Espinoza J, Yoshimatsu J, Kim YM, Bujold E, Edwin S, Yoon BH, Romero R. Activation of coagulation system in preterm labor and preterm premature rupture of membranes. J Matern Fetal Neonatal Med 2002;11:368–373.
   PubMedGoogle Scholar
• Elovitz MA, Baron J, Phillippe M. The role of thrombin in preterm parturition. Am J Obstet Gynecol 2001;185:1059–1063.
   PubMed Web of Science ®Google Scholar
• Gervasi MT, Chaiworapongsa T, Naccasha N, Blackwell S, Yoon BH, Maymon E, Romero R. Phenotypic and metabolic characteristics of maternal monocytes and granulocytes in preterm labor with intact membranes. Am J Obstet Gynecol 2001;185:1124–1129.
   PubMed Web of Science ®Google Scholar
• Dudley DJ. Immunoendocrinology of preterm labor: the link between corticotropin-releasing hormone and inflammation. Am J Obstet Gynecol 1999;180:S251–S256.
   PubMed Web of Science ®Google Scholar
• Pitiphat W, Gillman MW, Joshipura KJ, Williams PL, Douglass CW, Rich-Edwards JW. Plasma C-reactive protein in early pregnancy and preterm delivery. Am J Epidemiol 2005;162:1108–1113.
   PubMed Web of Science ®Google Scholar
• Khoury J, Henriksen T, Seljeflot I, Morkrid L, Froslie KF, Tonstad S. Effects of an antiatherogenic diet during pregnancy on markers of maternal and fetal endothelial activation and inflammation: the CARRDIP study. BJOG 2007;114:279–288.
   PubMed Web of Science ®Google Scholar
• van der Poll T., Buller HR, ten CH, Wortel CH, Bauer KA, van Deventer SJ, Hack CE, Sauerwein HP, Rosenberg RD, ten Cate JW. Activation of coagulation after administration of tumor necrosis factor to normal subjects. N Engl J Med 1990;322:1622–1627.
   PubMed Web of Science ®Google Scholar
• Semeraro N, Lattanzio A, Montemurro P, Papanice M, De Lucia O, De Bellis G, Giordano D. Mechanisms of blood clotting activation in inflammation: the role of mononuclear phagocytes. Int J Tissue React 1985;7:313–320.
   PubMedGoogle Scholar
• Salgado A, Boveda JL, Monasterio J, Segura RM, Mourelle M, Gomez-Jimenez J, Peracaula R. Inflammatory mediators and their influence on haemostasis. Haemostasis 1994;24:132–138.
   PubMedGoogle Scholar
• Oeth P, Parry GC, Mackman N. Regulation of the tissue factor gene in human monocytic cells. Role of AP-1, NF-kappa B/Rel, and Sp1 proteins in uninduced and lipopolysaccharide-induced expression. Arterioscler Thromb Vasc Biol 1997;17:365–374.
   PubMed Web of Science ®Google Scholar
• Almdahl SM, Osterud B. Experimental gram-negative septicemia: thromboplastin generation in mononuclear phagocytes from different anatomical sites. Thromb Res 1987;47:37–46.
   PubMed Web of Science ®Google Scholar
• Heyderman RS, Klein NJ, Daramola OA, Hammerschmidt S, Frosch M, Robertson BD, Levin M, Ison CA. Induction of human endothelial tissue factor expression by Neisseria meningitidis: the influence of bacterial killing and adherence to the endothelium. Microb Pathog 1997;22:265–274.
   PubMed Web of Science ®Google Scholar
• Semeraro N, Colucci M. Tissue factor in health and disease. Thromb Haemost 1997;78:759–764.
   PubMed Web of Science ®Google Scholar
• Bouwman JJ, Visseren FL, Bosch MC, Bouter KP, Diepersloot RJ. Procoagulant and inflammatory response of virus-infected monocytes. Eur J Clin Invest 2002;32:759–766.
   PubMed Web of Science ®Google Scholar
• Gando S, Kameue T, Matsuda N, Hayakawa M, Morimoto Y, Ishitani T, Kemmotsu O. Imbalances between the levels of tissue factor and tissue factor pathway inhibitor in ARDS patients. Thromb Res 2003;109:119–124.
   PubMed Web of Science ®Google Scholar
• Levi M, van der Poll T, ten Cate H. Tissue factor in infection and severe inflammation. Semin Thromb Hemost 2006;32:33–39.
   PubMed Web of Science ®Google Scholar
• van der Poll T., Levi M, Hack CE, ten CH, van Deventer SJ, Eerenberg AJ, de Groot ER, Jansen J, Gallati H, Buller HR, et al Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees. J Exp Med 1994;179:1253–1259.
   PubMed Web of Science ®Google Scholar
• Esmon CT, Fukudome K, Mather T, Bode W, Regan LM, Stearns-Kurosawa DJ, Kurosawa S. Inflammation, sepsis, and coagulation. Haematologica 1999;84:254–259.
   PubMed Web of Science ®Google Scholar
• Esmon CT. The interactions between inflammation and coagulation. Br J Haematol 2005;131:417–430.
   PubMed Web of Science ®Google Scholar
• Levi M, ten CH, Bauer KA, van der PT, Edgington TS, Buller HR, van Deventer SJ, Hack CE, ten Cate JW, Rosenberg RD. Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. J Clin Invest 1994;93:114–120.
   PubMed Web of Science ®Google Scholar
• Levi M, van der Poll T, Buller HR. Bidirectional relation between inflammation and coagulation. Circulation 2004;109:2698–2704.
   PubMed Web of Science ®Google Scholar
• Levi M, van der Poll T. Two-way interactions between inflammation and coagulation. Trends Cardiovasc Med 2005;15:254–259.
   PubMed Web of Science ®Google Scholar
• Broze GJ Jr, Girard TJ, Novotny WF. Regulation of coagulation by a multivalent Kunitz-type inhibitor. Biochemistry 1990;29:7539–7546.
   PubMed Web of Science ®Google Scholar
• Broze GJ Jr, Warren LA, Novotny WF, Higuchi DA, Girard JJ, Miletich JP. The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action. Blood 1988;71:335–343.
   PubMed Web of Science ®Google Scholar
• Sarig G, Blumenfeld Z, Leiba R, Lanir N, Brenner B. Modulation of systemic hemostatic parameters by enoxaparin during gestation in women with thrombophilia and pregnancy loss. Thromb Haemost 2005;94:980–985.
   PubMed Web of Science ®Google Scholar
• Uszynski M, Zekanowska E, Uszynski W, Kuczynski J. Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in amniotic fluid and blood plasma: implications for the mechanism of amniotic fluid embolism. Eur J Obstet Gynecol Reprod Biol 2001;95:163–166.
   PubMed Web of Science ®Google Scholar
• Souto JC, Martinez E, Roca M, Mateo J, Pujol J, Gonzalez D, Fontcuberta J. Prothrombotic state and signs of endothelial lesion in plasma of patients with inflammatory bowel disease. Dig Dis Sci 1995;40:1883–1889.
   PubMed Web of Science ®Google Scholar
• Berrettini M, Malaspina M, Parise P, Lucarelli G, Kisiel W, Nenci GG. A simple chromogenic substrate assay of tissue factor pathway inhibitor activity in plasma and serum. Am J Clin Pathol 1995;103:391–395.
   PubMed Web of Science ®Google Scholar
• Novo G, Caplice N, Tantillo R, Bonura F, Simari R, Novo S. TFPI antigen and activity levels in patients with asymptomatic atherosclerosis and target organ acute and chronic complications. Int Angiol 2005;24:366–371.
   PubMed Web of Science ®Google Scholar
• Sandset PM, Andersson TR. Coagulation inhibitor levels in pneumonia and stroke: changes due to consumption and acute phase reaction. J Intern Med 1989;225:311–316.
   PubMed Web of Science ®Google Scholar
• Erez O, Hoppensteadt D, Than NG, Fareed J, Mazaki-Tovi S, Espinoza J, Chaiworapongsa T, Yoon BH, Hassan S, Gotsch F, et al Tissue Factor and its Natural Inhibitor in Preeclampsia and SGA. J Matern Fetal Neonatal Med 2008;21:855–859.
   PubMed Web of Science ®Google Scholar
• Erez O, Espinoza, Chaiworapongsa T, Gotsch F, Kusanovic JP, Than NG, Mazaki-Tovi S, Papp Z, Yoon BH, Hoppensteadt D, et al A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitor. J Matern Fetal Med 2008;21:732–744.
   Google Scholar
• Abdel Gader AM, Al-Mishari AA, Awadalla SA, Buyuomi NM, Khashoggi T, Al-Hakeem M. Total and free tissue factor pathway inhibitor in pregnancy hypertension. Int J Gynaecol Obstet 2006;95:248–253.
   PubMed Web of Science ®Google Scholar
• Alexander GR, Himes JH, Kaufman RB, Mor J, Kogan M. A United States national reference for fetal growth. Obstet Gynecol 1996;87:163–168.
   PubMed Web of Science ®Google Scholar
• Arias F, Victoria A, Cho K, Kraus F. Placental histology and clinical characteristics of patients with preterm premature rupture of membranes. Obstet Gynecol 1997;89:265–271.
   PubMed Web of Science ®Google Scholar
• Franco RF, de JE, Dekkers PE, Timmerman JJ, Spek CA, van Deventer SJ, van DP, van KL, van GB, ten CH, et al The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation. Blood 2000;96:554–559.
   PubMed Web of Science ®Google Scholar
• Osterud B. Cellular interactions in tissue factor expression by blood monocytes. Blood Coagul Fibrinolysis 1995;6 Suppl 1S20–S25.
   PubMed Web of Science ®Google Scholar
• Butenas S, Bouchard BA, Brummel-Ziedins KE, Parhami-Seren B, Mann KG. Tissue factor activity in whole blood. Blood 2005;105:2764–2770.
   PubMed Web of Science ®Google Scholar
• Bach RR, Moldow CF. Mechanism of tissue factor activation on HL-60 cells. Blood 1997;89:3270–3276.
   PubMed Web of Science ®Google Scholar
• Egorina EM, Sovershaev MA, Bjorkoy G, Gruber FX, Olsen JO, Parhami-Seren B, Mann KG, Osterud B. Intracellular and surface distribution of monocyte tissue factor: application to intersubject variability. Arterioscler Thromb Vasc Biol 2005;25:1493–1498.
   PubMed Web of Science ®Google Scholar
• Rivers RP, Hathaway WE, Weston WL. The endotoxin-induced coagulant activity of human monocytes. Br J Haematol 1975;30:311–316.
   PubMed Web of Science ®Google Scholar
• Romero R, Goncalves LF, Chaiworapongsa T, Kusanovic JP, Espinoza J. Mechanisms of preterm labor and preterm premature rupture of the membranes. 2006; 2nd Edition:1379–1393.
   Google Scholar
• Lockwood CJ, Krikun G, Rahman M, Caze R, Buchwalder L, Schatz F. The role of decidualization in regulating endometrial hemostasis during the menstrual cycle, gestation, and in pathological states. Semin Thromb Hemost 2007;33:111–117.
   PubMed Web of Science ®Google Scholar
• Lockwood CJ, Krikun G, Schatz F. The decidua regulates hemostasis in human endometrium. Semin Reprod Endocrinol 1999;17:45–51.
   PubMedGoogle Scholar
• Lockwood CJ, Krikun G, Schatz F. Decidual cell-expressed tissue factor maintains hemostasis in human endometrium. Ann N Y Acad Sci 2001;943:77–88.
   PubMed Web of Science ®Google Scholar
• Gervasi MT, Chaiworapongsa T, Naccasha N, Pacora P, Berman S, Maymon E, Kim JC, Kim YM, Yoshimatsu J, Espinoza J, et al Maternal intravascular inflammation in preterm premature rupture of membranes. J Matern Fetal Neonatal Med 2002;11:171–175.
   PubMedGoogle Scholar
• Chi L, Li Y, Stehno-Bittel L, Gao J, Morrison DC, Stechschulte DJ, Dileepan KN. Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha. J Interferon Cytokine Res 2001;21:231–240.
   PubMed Web of Science ®Google Scholar
• Ahamed J, Ruf W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain. J Biol Chem 2004;279:23038–23044.
   PubMed Web of Science ®Google Scholar
• Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA 2000;97:5255–5260.
   PubMed Web of Science ®Google Scholar
• Welty-Wolf KE, Carraway MS, Ortel TL, Ghio AJ, Idell S, Egan J, Zhu X, Jiao JA, Wong HC, Piantadosi CA. Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure. Am J Physiol Lung Cell Mol Physiol 2006;290:L21–L31.
   PubMed Web of Science ®Google Scholar
• Hawiger J. Formation and regulation of platelet and fibrin hemostatic plug. Hum Pathol 1987;18:111–122.
   PubMed Web of Science ®Google Scholar
• Tracy PB, Rohrbach MS, Mann KG. Functional prothrombinase complex assembly on isolated monocytes and lymphocytes. J Biol Chem 1983;258:7264–7267.
   PubMed Web of Science ®Google Scholar
• Bajaj SP, Joist JH. New insights into how blood clots: implications for the use of APTT and PT as coagulation screening tests and in monitoring of anticoagulant therapy. Semin Thromb Hemost 1999;25:407–418.
   PubMed Web of Science ®Google Scholar
• ten Cate H, Bauer KA, Levi M, Edgington TS, Sublett RD, Barzegar S, Kass BL, Rosenberg RD. The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor. J Clin Invest 1993;92:1207–1212.
   PubMed Web of Science ®Google Scholar
• Camerer E, Kolsto AB, Prydz H. Cell biology of tissue factor, the principal initiator of blood coagulation. Thromb Res 1996;81:1–41.
   PubMed Web of Science ®Google Scholar
• Butenas S, Mann KG. Blood coagulation. Biochemistry (Mosc) 2002;67:3–12.
   PubMed Web of Science ®Google Scholar
• Lu G, Broze GJ Jr, Krishnaswamy S. Formation of factors IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin III. J Biol Chem 2004;279:17241–17249.
   PubMed Web of Science ®Google Scholar
• Rodgers GM, Shuman MA. Prothrombin is activated on vascular endothelial cells by factor Xa and calcium. Proc Natl Acad Sci USA 1983;80:7001–7005.
   PubMed Web of Science ®Google Scholar
• Busch G, Seitz I, Steppich B, Hess S, Eckl R, Schomig A, Ott I. Coagulation factor Xa stimulates interleukin-8 release in endothelial cells and mononuclear leukocytes: implications in acute myocardial infarction. Arterioscler Thromb Vasc Biol 2005;25:461–466.
   PubMed Web of Science ®Google Scholar
• Daubie V, Cauwenberghs S, Senden NH, Pochet R, Lindhout T, Buurman WA, Heemskerk JW. Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation. Biochim Biophys Acta 2006;1763:860.869.
   PubMed Web of Science ®Google Scholar
• Gomez R, Athayde N, Pacora P, Mazor M, Yoon BH, Romero R. Increased Thrombin in Intrauterine Inflammation. Am J Obstet Gynecol 1998;178:S62.
   PubMed Web of Science ®Google Scholar
• Espinoza J, Kusanovic JP, Kim CJ, Kim YM, Kim JS, Hassan SS, Gotsch F, Goncalves LF, Erez O, Friel L, et al An episode of preterm labor is a risk factor for the birth of a small-for-gestational-age neonate. Am J Obstet Gynecol 2007;196:574–575.
   PubMed Web of Science ®Google Scholar
• Kim YM, Bujold E, Chaiworapongsa T, Gomez R, Yoon BH, Thaler HT, Rotmensch S, Romero R. Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am J Obstet Gynecol 2003;189:1063–1069.
   PubMed Web of Science ®Google Scholar
• Beller FK, Ebert C. The coagulation and fibrinolytic enzyme system in pregnancy and in the puerperium. Eur J Obstet Gynecol Reprod Biol 1982;13:177–197.
   PubMed Web of Science ®Google Scholar
• Stirling Y, Woolf L, North WR, Seghatchian MJ, Meade TW. Haemostasis in normal pregnancy. Thromb Haemost 1984;52:176–182.
   PubMed Web of Science ®Google Scholar
• Bremme KA. Haemostatic changes in pregnancy. Best Pract Res Clin Haematol 2003;16:153–168.
   PubMed Web of Science ®Google Scholar
• Brenner B. Haemostatic changes in pregnancy. Thromb Res 2004;114:409–414.
   PubMed Web of Science ®Google Scholar
• Erez O, Gotsch F, Mazaki-Tovi S, Vaisbuch E, Kusanovic JP, Kim CJ, Chaiwerapongsa T, Hoppensteadt D, Fareed J, Than NG, et al Evidence of Maternal Platelet Activation, Excessive Thrombin Generation, and High Amniotic Fluid Tissue Factor Immunoreactivity and Functional Activity in Patients with Fetal Death. Journal of Maternal-Fetal and Neonatal Medicine 2009.
   Web of Science ®Google Scholar
• Bilsel AS, Onaran N, Moini H, Emerk K. Long-term effect of 17beta-estradiol and thrombin on tissue factor pathway inhibitor release from HUVEC. Thromb Res 2000;99:173–178.
   PubMed Web of Science ®Google Scholar
• Salem HT, Seppala M, Chard T. The effect of thrombin on serum placental protein 5 (PP5): is PP5 the naturally occurring antithrombin III of the human placenta? Placenta 1981;2:205–209.
   PubMed Web of Science ®Google Scholar
• Jones GR, Davey MW, Sinosich M, Grudzinskas JG. Specific interaction between placental protein 5 and heparin. Clin Chim Acta 1981;110:65–70.
   PubMed Web of Science ®Google Scholar
• Iino M, Foster DC, Kisiel W. Quantification and characterization of human endothelial cell-derived tissue factor pathway inhibitor-2. Arterioscler Thromb Vasc Biol 1998;18:40–46.
   PubMed Web of Science ®Google Scholar
• Sprecher CA, Kisiel W, Mathewes S, Foster DC. Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor. Proc Natl Acad Sci USA 1994;91:3353–3357.
   PubMed Web of Science ®Google Scholar
• Udagawa K, Miyagi Y, Hirahara F, Miyagi E, Nagashima Y, Minaguchi H, Misugi K, Yasumitsu H, Miyazaki K. Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization. Placenta 1998;19:217–223.
   PubMed Web of Science ®Google Scholar
• Udagawa K, Yasumitsu H, Esaki M, Sawada H, Nagashima Y, Aoki I, Jin M, Miyagi E, Nakazawa T, Hirahara F, et al Subcellular localization of PP5/TFPI-2 in human placenta: a possible role of PP5/TFPI-2 as an anti-coagulant on the surface of syncytiotrophoblasts. Placenta 2002;23:145–153.
   PubMed Web of Science ®Google Scholar
• Kamei S, Kazama Y, Kuijper JL, Foster DC, Kisiel W. Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene. Biochim Biophys Acta 2001;1517:430–435.
   PubMed Web of Science ®Google Scholar
• Hube F, Reverdiau P, Iochmann S, Trassard S, Thibault G, Gruel Y. Demonstration of a tissue factor pathway inhibitor 2 messenger RNA synthesis by pure villous cytotrophoblast cells isolated from term human placentas. Biol Reprod 2003;68:1888–1894.
   PubMed Web of Science ®Google Scholar
• Butzow R, Virtanen I, Seppala M, Narvanen O, Stenman UH, Ristimaki A, Bohn H. Monoclonal antibodies reacting with placental protein 5: use in radioimmunoassay, Western blot analysis, and immunohistochemistry. J Lab Clin Med 1988;111:249–256.
   PubMed Web of Science ®Google Scholar
• Kisiel W, Sprecher CA, Foster DC. Evidence that a second human tissue factor pathway inhibitor (TFPI-2) and human placental protein 5 are equivalent. Blood 1994;84:4384–4385.
   PubMed Web of Science ®Google Scholar
• Aharon A, Lanir N, Drugan A, Brenner B. Placental TFPI is decreased in gestational vascular complications and can be restored by maternal enoxaparin treatment. J Thromb Haemost 2005;3:2355–2357.
   PubMed Web of Science ®Google Scholar
• Colman RW, Clowes AW, George JN, Goldhaber SZ, Marder VJ. Overview of hemostasis. Coleman RW, Marder V, Clowes AW, George JN, Goldhaber SZ, editors. Hemostatis and Thrombosis Basic Principles and Clinical Practice. 5th edition. Philadelphia: Lippincott, Williams & Wilkins; 2006. pp 3–16.
   Google Scholar
• Kusanovic JP, Espinoza J, Romero R, Hoppensteadt D, Nien JK, Kim CJ, Erez O, Soro E, Fareed J, Edwin S, et al Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor. J Matern Fetal Neonatal Med 2007;20:453–463.
   PubMed Web of Science ®Google Scholar
• Shimura M, Wada H, Wakita Y, Nakase T, Hiyoyama K, Nagaya S, Mori Y, Shiku H. Plasma tissue factor and tissue factor pathway inhibitor levels in patients with disseminated intravascular coagulation. Am J Hematol 1997;55:169–174.
   PubMed Web of Science ®Google Scholar