Pentraxin 3 in maternal circulation: An association with preterm labor and preterm PROM, but not with intra-amniotic infection/inflammation

References

• Garlanda C, Bottazzi B, Bastone A, Mantovani A. Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Annu Rev Immunol 2005;23:337–366.
   PubMed Web of Science ®Google Scholar
• Bottazzi B, Garlanda C, Cotena A, Moalli F, Jaillon S, Deban L, Mantovani A. The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: interplay with cellular innate immunity. Immunol Rev 2009;227:9–18.
   PubMed Web of Science ®Google Scholar
• Muller B, Peri G, Doni A, Torri V, Landmann R, Bottazzi B, Mantovani A. Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients. Crit Care Med 2001;29:1404–1407.
   PubMed Web of Science ®Google Scholar
• Bottazzi B, Garlanda C, Salvatori G, Jeannin P, Manfredi A, Mantovani A. Pentraxins as a key component of innate immunity. Curr Opin Immunol 2006;18:10–15.
   PubMed Web of Science ®Google Scholar
• Rovere-Querini P, Antonacci S, Dell'Antonio G, Angeli A, Almirante G, Cin ED, Valsecchi L, Lanzani C, Sabbadini MG, Doglioni C, et al Plasma and tissue expression of the long pentraxin 3 during normal pregnancy and preeclampsia. Obstet Gynecol 2006;108:148–155.
   PubMed Web of Science ®Google Scholar
• Cetin I, Cozzi V, Pasqualini F, Nebuloni M, Garlanda C, Vago L, Pardi G, Mantovani A. Elevated maternal levels of the long pentraxin 3 (PTX3) in preeclampsia and intrauterine growth restriction. Am J Obstet Gynecol 2006;194:1347–1353.
   PubMed Web of Science ®Google Scholar
• Rovere-Querini P, Castiglioni MT, Sabbadini MG, Manfredi AA. Signals of cell death and tissue turnover during physiological pregnancy, pre-eclampsia, and autoimmunity. Autoimmunity 2007;40:290–294.
   PubMed Web of Science ®Google Scholar
• Akolekar R, Casagrandi D, Livanos P, Tetteh A, Nicolaides KH. Maternal plasma pentraxin 3 at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy. Prenat Diagn 2009;29:934–938.
   PubMed Web of Science ®Google Scholar
• Cetin I, Cozzi V, Papageorghiou AT, Maina V, Montanelli A, Garlanda C, Thilaganathan B. First trimester PTX3 levels in women who subsequently develop preeclampsia and fetal growth restriction. Acta Obstet Gynecol Scand. 2009;88:846–849.
   PubMed Web of Science ®Google Scholar
• Assi F, Fruscio R, Bonardi C, Ghidini A, Allavena P, Mantovani A, Locatelli A. Pentraxin 3 in plasma and vaginal fluid in women with preterm delivery. BJOG 2007;114:143–147.
   PubMed Web of Science ®Google Scholar
• Cruciani L, Romero R, Vaisbuch E, Kusanovic JP, Chaiworapongsa T, Mazaki-Tovi S, Mittal P, Ogge' G, Gotsch F, Erez O, et al Pentraxin 3 in Amniotic Fluid: A Novel Association with Intra-amniotic Infection and Inflammation. Jounal of Perinatal Medicine 2009; PMID: 19792835.
   Google Scholar
• Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel LA, Nien JK. Inflammation in preterm and term labour and delivery. Semin Fetal Neonatal Med 2006;11:317–326.
   PubMed Web of Science ®Google Scholar
• Gibbs RS, Romero R, Hillier SL, Eschenbach DA, Sweet RL. A review of premature birth and subclinical infection. Am J Obstet Gynecol 1992;166:1515–1528.
   PubMed Web of Science ®Google Scholar
• Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med 2000;342:1500–1507.
   PubMed Web of Science ®Google Scholar
• Gomez R, Romero R, Ghezzi F, Yoon BH, Mazor M, Berry SM. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998;179:194–202.
   PubMed Web of Science ®Google Scholar
• Minkoff H. Prematurity: infection as an etiologic factor. Obstet Gynecol 1983;62:137–144.
   PubMed Web of Science ®Google Scholar
• Romero R, Mazor M. Infection and preterm labor. Clin Obstet Gynecol 1988;31:553–584.
   PubMed Web of Science ®Google Scholar
• Romero R, Mazor M, Wu YK, Sirtori M, Oyarzun E, Mitchell MD, Hobbins JC. Infection in the pathogenesis of preterm labor. Semin Perinatol 1988;12:262–279.
   PubMed Web of Science ®Google Scholar
• Romero R, Gomez R, Ghezzi F, Yoon BH, Mazor M, Edwin SS, Berry SM. A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol 1998;179:186–193.
   PubMed Web of Science ®Google Scholar
• Alexander GR, Himes JH, Kaufman RB, Mor J, Kogan M. A United States national reference for fetal growth. Obstet Gynecol 1996;87:163–168.
   PubMed Web of Science ®Google Scholar
• Gonzalez RP, Gomez RM, Castro RS, Nien JK, Merino PO, Etchegaray AB, Carstens MR, Medina LH, Viviani PG, Rojas IT [A national birth weight distribution curve according to gestational age in Chile from 1993 to 2000]. Rev Med Chil 2004;132:1155–1165.
   PubMed Web of Science ®Google Scholar
• Yoon BH, Romero R, Moon JB, Shim SS, Kim M, Kim G, Jun JK. Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Obstet Gynecol 2001;185:1130–1136.
   PubMed Web of Science ®Google Scholar
• Romero R, Emamian M, Quintero R, Wan M, Hobbins JC, Mazor M, Edberg S. The value and limitations of the Gramstain examination in the diagnosis of intraamniotic infection. Am J Obstet Gynecol 1988;159:114–119.
   PubMed Web of Science ®Google Scholar
• Romero R, Jimenez C, Lohda AK, Nores J, Hanaoka S, Avila C, Callahan R, Mazor M, Hobbins JC, Diamond MP. Amniotic fluid glucose concentration: a rapid and simple method for the detection of intraamniotic infection in preterm labor. Am J Obstet Gynecol 1990;163:968–974.
   PubMed Web of Science ®Google Scholar
• Romero R, Quintero R, Nores J, Avila C, Mazor M, Hanaoka S, Hagay Z, Merchant L, Hobbins JC. Amniotic fluid white blood cell count: a rapid and simple test to diagnose microbial invasion of the amniotic cavity and predict preterm delivery. Am J Obstet Gynecol 1991;165:821–830.
   PubMed Web of Science ®Google Scholar
• Gewurz H, Zhang XH, Lint TF. Structure and function of the pentraxins. Curr Opin Immunol 1995;7:54–64.
   PubMed Web of Science ®Google Scholar
• Coe JE, Margossian SS, Slayter HS, Sogn JA. Hamster female protein. A new Pentraxin structurally and functionally similar to C-reactive protein and amyloid P component. J Exp Med 1981;153:977–991.
   PubMed Web of Science ®Google Scholar
• Breviario F, d'Aniello EM, Golay J, Peri G, Bottazzi B, Bairoch A, Saccone S, Marzella R, Predazzi V, Rocchi M, et al Interleukin–1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. J Biol Chem 1992;267:22190–22197.
   PubMed Web of Science ®Google Scholar
• Pepys MB, Baltz ML. Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein. Adv Immunol 1983;34:141–212.
   PubMed Web of Science ®Google Scholar
• Lee GW, Lee TH, Vilcek J. TSG–14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. J Immunol 1993;150:1804–1812.
   PubMed Web of Science ®Google Scholar
• Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP. Structure of pentameric human serum amyloid P component. Nature 1994;367:338–345.
   PubMed Web of Science ®Google Scholar
• Baumann H, Gauldie J. The acute phase response. Immunol Today 1994;15:74–80.
   PubMedGoogle Scholar
• Szalai AJ, Agrawal A, Greenhough TJ, Volanakis JE. C-reactive protein: structural biology and host defense function. Clin Chem Lab Med 1999;37:265–270.
   PubMed Web of Science ®Google Scholar
• Mantovani A, Garlanda C, Bottazzi B. Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. Vaccine 2003;21 Suppl 2: S43–S47.
   Google Scholar
• Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest 2003;111:1805–1812.
   PubMed Web of Science ®Google Scholar
• Lee GW, Goodman AR, Lee TH, Vilcek J. Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins. J Immunol 1994;153:3700–3707.
   PubMed Web of Science ®Google Scholar
• Srinivasan N, White HE, Emsley J, Wood SP, Pepys MB, Blundell TL. Comparative analyses of pentraxins: implications for protomer assembly and ligand binding. Structure 1994;2:1017–1027.
   PubMedGoogle Scholar
• Bottazzi B, Vouret-Craviari V, Bastone A, De GL, Matteucci C, Peri G, Spreafico F, Pausa M, D'Ettorre C, Gianazza E, et al Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component. J Biol Chem 1997;272:32817–32823.
   PubMed Web of Science ®Google Scholar
• Peri G, Introna M, Corradi D, Iacuitti G, Signorini S, Avanzini F, Pizzetti F, Maggioni AP, Moccetti T, Metra M, et al PTX3, A prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans. Circulation 2000;102:636–641.
   PubMed Web of Science ®Google Scholar
• Mantovani A, Garlanda C, Doni A, Bottazzi B. Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3. J Clin Immunol 2008;28:1–13.
   PubMed Web of Science ®Google Scholar
• Jeannin P, Bottazzi B, Sironi M, Doni A, Rusnati M, Presta M, Maina V, Magistrelli G, Haeuw JF, Hoeffel G, et al Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors. Immunity 2005;22:551–560.
   PubMed Web of Science ®Google Scholar
• Doni A, Peri G, Chieppa M, Allavena P, Pasqualini F, Vago L, Romani L, Garlanda C, Mantovani A. Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells. Eur J Immunol 2003; 33:2886–2893.
   PubMed Web of Science ®Google Scholar
• Doni A, Michela M, Bottazzi B, Peri G, Valentino S, Polentarutti N, Garlanda C, Mantovani A. Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFN-gamma. J Leukoc Biol 2006;79:797–802.
   PubMedGoogle Scholar
• Perrier P, Martinez FO, Locati M, Bianchi G, Nebuloni M, Vago G, Bazzoni F, Sozzani S, Allavena P, Mantovani A. Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13. J Immunol 2004;172:7031–7042.
   PubMed Web of Science ®Google Scholar
• Alles VV, Bottazzi B, Peri G, Golay J, Introna M, Mantovani A. Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes. Blood 1994;84:3483–3493.
   PubMed Web of Science ®Google Scholar
• Semov A, Semova N, Lacelle C, Marcotte R, Petroulakis E, Proestou G, Wang E. Alterations in TNF- and IL-related gene expression in space-flown WI38 human fibroblasts. FASEB J 2002;16:899–901.
   PubMedGoogle Scholar
• Presta M, Camozzi M, Salvatori G, Rusnati M. Role of the soluble pattern recognition receptor PTX3 in vascular biology. J Cell Mol Med 2007;11:723–738.
   PubMed Web of Science ®Google Scholar
• Nauta AJ, de HS, Bottazzi B, Mantovani A, Borrias MC, Aten J, Rastaldi MP, Daha MR, van KC, Roos A. Human renal epithelial cells produce the long pentraxin PTX3. Kidney Int 2005;67:543–553.
   PubMed Web of Science ®Google Scholar
• Efrati P, Presentey B, Margarlith M, Rozenszajn L. Leukocytes of Normal Pregnant Women. Obstet Gynecol 1964;23:429–432.
   PubMed Web of Science ®Google Scholar
• Stirling Y, Woolf L, North WR, Seghatchian MJ, Meade TW. Haemostasis in normal pregnancy. Thromb Haemost 1984;52:176–182.
   PubMed Web of Science ®Google Scholar
• Hopkinson ND, Powell RJ. Classical complement activation induced by pregnancy: Implications for management of connective tissue diseases. J Clin Pathol 1992;45:66–67.
   PubMed Web of Science ®Google Scholar
• Comeglio P, Fedi S, Liotta AA, Cellai AP, Chiarantini E, Prisco D, Mecacci F, Parretti E, Mello G, Abbate R. Blood clotting activation during normal pregnancy. Thromb Res 1996;84:199–202.
   PubMed Web of Science ®Google Scholar
• Sacks GP, Studena K, Sargent K, Redman CW. Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol 1998;179:80–86.
   PubMed Web of Science ®Google Scholar
• Naccasha N, Gervasi MT, Chaiworapongsa T, Berman S, Yoon BH, Maymon E, Romero R. Phenotypic and metabolic characteristics of monocytes and granulocytes in normal pregnancy and maternal infection. Am J Obstet Gynecol 2001;185:1118–1123.
   PubMed Web of Science ®Google Scholar
• Luppi P, Haluszczak C, Trucco M, DeLoia JA. Normal pregnancy is associated with peripheral leukocyte activation. Am J Reprod Immunol 2002;47:72–81.
   PubMed Web of Science ®Google Scholar
• Luppi P, Haluszczak C, Betters D, Richard CA, Trucco M, DeLoia JA. Monocytes are progressively activated in the circulation of pregnant women. J Leukoc Biol 2002;72:874–884.
   PubMed Web of Science ®Google Scholar
• Sacks GP, Redman CW, Sargent IL. Monocytes are primed to produce the Th1 type cytokine IL–12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells. Clin Exp Immunol 2003;131:490–497.
   PubMed Web of Science ®Google Scholar
• Richani K, Soto E, Romero R, Espinoza J, Chaiworapongsa T, Nien JK, Edwin S, Kim YM, Hong JS, Mazor M. Normal pregnancy is characterized by systemic activation of the complement system. J Matern Fetal Neonatal Med 2005;17:239–245.
   PubMed Web of Science ®Google Scholar
• Junqueira LC, Zugaib M, Montes GS, Toledo OM, Krisztan RM, Shigihara KM. Morphologic and histochemical evidence for the occurrence of collagenolysis and for the role of neutrophilic polymorphonuclear leukocytes during cervical dilation. Am J Obstet Gynecol 1980;138:273–281.
   PubMed Web of Science ®Google Scholar
• Liggins GC. Cervical ripening as an inflammatory reaction. 1981;1–9.
   Google Scholar
• Romero R, Brody DT, Oyarzun E, Mazor M, Wu YK, Hobbins JC, Durum SK. Infection and labor. III. Interleukin-1: a signal for the onset of parturition. Am J Obstet Gynecol 1989;160:1117–1123.
   PubMed Web of Science ®Google Scholar
• Romero R, Ceska M, Avila C, Mazor M, Behnke E, Lindley I. Neutrophil attractant/activating peptide-1/interleukin-8 in term and preterm parturition. Am J Obstet Gynecol 1991;165:813–820.
   PubMed Web of Science ®Google Scholar
• Romero R, Mazor M, Sepulveda W, Avila C, Copeland D, Williams J. Tumor necrosis factor in preterm and term labor. Am J Obstet Gynecol 1992;166:1576–1587.
   PubMed Web of Science ®Google Scholar
• Opsjln SL, Wathen NC, Tingulstad S, Wiedswang G, Sundan A, Waage A, Austgulen R. Tumor necrosis factor, interleukin-1, and interleukin-6 in normal human pregnancy. Am J Obstet Gynecol 1993;169:397–404.
   PubMed Web of Science ®Google Scholar
• Saito S, Kasahara T, Kato Y, Ishihara Y, Ichijo M. Elevation of amniotic fluid interleukin 6 (IL-6), IL-8 and granulocyte colony stimulating factor (G-CSF) in term and preterm parturition. Cytokine 1993;5:81–88.
   PubMed Web of Science ®Google Scholar
• Osmers RG, Blaser J, Kuhn W, Tschesche H. Interleukin-8 synthesis and the onset of labor. Obstet Gynecol 1995;86:223–229.
   PubMed Web of Science ®Google Scholar
• Cohen J, Ghezzi F, Romero R, Ghidini A, Mazor M, Tolosa JE, Goncalves LF, Gomez R. GRO alpha in the fetomaternal and amniotic fluid compartments during pregnancy and parturition. Am J Reprod Immunol 1996;35:23–29.
   PubMed Web of Science ®Google Scholar
• Thomson AJ, Telfer JF, Young A, Campbell S, Stewart CJ, Cameron IT, Greer IA, Norman JE. Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process. Hum Reprod 1999;14:229–236.
   PubMed Web of Science ®Google Scholar
• Keski-Nisula L, Aalto ML, Katila ML, Kirkinen P. Intrauterine inflammation at term: a histopathologic study. Hum Pathol 2000;31:841–846.
   PubMed Web of Science ®Google Scholar
• Esplin MS, Romero R, Chaiworapongsa T, Kim YM, Edwin S, Gomez R, Gonzalez R, Adashi EY. Amniotic fluid levels of immunoreactive monocyte chemotactic protein-1 increase during term parturition. J Matern Fetal Neonatal Med 2003;14:51–56.
   PubMedGoogle Scholar
• Keelan JA, Blumenstein M, Helliwell RJ, Sato TA, Marvin KW, Mitchell MD. Cytokines, prostaglandins and parturition–a review. Placenta 2003;24 Suppl A:S33–46.
   PubMed Web of Science ®Google Scholar
• Osman I, Young A, Ledingham MA, Thomson AJ, Jordan F, Greer IA, Norman JE. Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Mol Hum Reprod 2003;9:41–45.
   PubMed Web of Science ®Google Scholar
• Esplin MS, Peltier MR, Hamblin S, Smith S, Fausett MB, Dildy GA, Branch DW, Silver RM, Adashi EY. Monocyte chemotactic protein-1 expression is increased in human gestational tissues during term and preterm labor. Placenta 2005;26:661–671.
   PubMed Web of Science ®Google Scholar
• Haddad R, Tromp G, Kuivaniemi H, Chaiworapongsa T, Kim YM, Mazor M, Romero R. Human spontaneous labor without histologic chorioamnionitis is characterized by an acute inflammation gene expression signature. Am J Obstet Gynecol 2006;195:394–24.
   PubMed Web of Science ®Google Scholar
• Shynlova O, Tsui P, Dorogin A, Lye SJ. Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor. J Immunol 2008;181:1470–1479.
   PubMed Web of Science ®Google Scholar
• Gervasi MT, Chaiworapongsa T, Naccasha N, Blackwell S, Yoon BH, Maymon E, Romero R. Phenotypic and metabolic characteristics of maternal monocytes and granulocytes in preterm labor with intact membranes. Am J Obstet Gynecol 2001;185:1124–1129.
   PubMed Web of Science ®Google Scholar
• Gervasi MT, Chaiworapongsa T, Naccasha N, Pacora P, Berman S, Maymon E, Kim JC, Kim YM, Yoshimatsu J, Espinoza J, et al Maternal intravascular inflammation in preterm premature rupture of membranes. J Matern Fetal Neonatal Med 2002;11:171–175.
   PubMedGoogle Scholar
• Romero R, Gotsch F, Pineles B, Kusanovic JP. Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutr Rev 2007;65:S194–S202.
   PubMed Web of Science ®Google Scholar
• Chevillard G, Derjuga A, Devost D, Zingg HH, Blank V. Identification of interleukin-1beta regulated genes in uterine smooth muscle cells. Reproduction 2007;134:811–822.
   PubMed Web of Science ®Google Scholar