Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth

References

• Di Renzo GC, Cabero RL, the European Association of Perinatal Medicine – Study Group on “Preterm Birth”. Guidelines for the management of spontaneous preterm labor. J Perinat Med 2006;34:359–366.
   PubMed Web of Science ®Google Scholar
• Honest H, Forbes CA, Durée KH, Norman G, Duffy SB, Tsourapas A, Roberts TE, Barton PM, Jowett SM, Hyde CJ, et al. Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modeling. Health Technol Assess 2009;13:1–627. Review.
   PubMed Web of Science ®Google Scholar
• Lamont RF. Setting up a preterm prevention clinic: a practical guide. BJOG 2006;113(Suppl 3):86–92. Review.
   PubMedGoogle Scholar
• Lockwood CJ, Senyei AE, Dische MR, Casal D, Shah KD, Thung SN, Jones L, Deligdisch L, Garite TJ. Fetal fibronectin in cervical and vaginal secretions defines a patient population at high risk for preterm delivery. N Engl J Med 1991;325:669–674.
   PubMed Web of Science ®Google Scholar
• Gomez R, Galasso M, Romero R, Mazor M, Sorokin Y, Gonçalves L, Treadwell M. Ultrasonographic examination of the uterine cervix is better than cervical digital examination as a predictor of the likelihood of premature delivery in patients with preterm labor and intact membranes. Am J Obstet Gynecol 1994;171:956–964.
   PubMed Web of Science ®Google Scholar
• Berghella V, Hayes E, Visintine J, Baxter JK. Fetal fibronectin testing for reducing the risk of preterm birth. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD006843. Review.
   Google Scholar
• Da Fonseca Eb, Celik E, Parra M, Singh M, Nicolaides KH. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med 2007;357:462–469.
   PubMed Web of Science ®Google Scholar
• Mella MT, Berghella V. Prediction of preterm birth: cervical sonography. Semin Perinatol 2009;33:317–324. Review.
   PubMed Web of Science ®Google Scholar
• Espinoza J, Romero R, Goncalvez LF, Kusanovic JP, Nien JK. Assessment of risk for preterm birth in aymptomatic patients and those with preterm labor. Textbook for the perinatal medicine. Taylor and Francis, Oxford, UK; 2006. Chapter 133In: Kurjak A, Chervenak F, editors. 1417–1430.
   Google Scholar
• Di Renzo GC. The great obstetrical syndromes. J Matern Fetal Neonatal Med 2009;22:633–635.
   PubMed Web of Science ®Google Scholar
• Gomez R, Romero R, Nien JK, Chaiworapongsa T, Medina L, Kim YM, Yoon BH, Carstens M, Espinoza J, Iams JD, et al. A short cervix in women with preterm labor and intact membranes: a risk factor for microbial invasion of the amniotic cavity. Am J Obstet Gynecol 2005;192:678–689.
   PubMed Web of Science ®Google Scholar
• Reichmann JP. Home uterine activity monitoring: the role of medical evidence. Obstet Gynecol 2008;112(2 Part 1):325–327.
   Google Scholar
• Conde-Agudelo A, Romero R. Cervicovaginal fetal fibronectin for the prediction of spontaneous preterm birth in multiple pregnancy: a systematic review and meta-analysis. J Matern Fet Neonat Med. 2010 Dec;23(12):1365–76.
   PubMed Web of Science ®Google Scholar
• Ness A. Prevention of preterm birth based on short cervix: symptomatic women with preterm labor or premature prelabor rupture of membranes. Semin Perinatol 2009;33:343–351. Review.
   PubMed Web of Science ®Google Scholar
• Smith V. A systematic review and quality assessment of systematic reviews of fetal fibronectin and transvaginal length for predicting preterm birth. Eur J Obstet Gynecol Reprod Biol 2007;133:134–142.
   PubMed Web of Science ®Google Scholar
• Rahkonen L, Unkila-Kallio L, Rutanen EM, Paavonen J. Factors affecting decidual IGFBP-1 levels in the vagina and cervix in the first and mid-second trimester of pregnancy. BJOG 2009;116:45–54.
   PubMed Web of Science ®Google Scholar
• Mercer BM. Preterm premature rupture of the membranes. Obstet Gynecol 2003;101:178–193.
   PubMed Web of Science ®Google Scholar
• Alexander JM, Cox SM. Clinical course of premature rupture of membranes. Semin Perinatol 1996;20:369–374.
   PubMed Web of Science ®Google Scholar
• ACOG Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin no. 80: premature rupture of membranes. Clinical management guidelines for obstetrician-gynecologists. Obstet Gynecol 2007;109:1007–1019.
   PubMedGoogle Scholar
• Duff P. Premature rupture of the membranes in term patients. Semin Perinatol 1996;20:401–408.
   PubMed Web of Science ®Google Scholar
• Mercer BM. Preterm premature rupture of the membranes: current approaches to evaluation and management. Obstet Gynecol Clin North Am 2005;32:411–428.
   PubMed Web of Science ®Google Scholar
• Caughey AB, Robinson JN, Norwitz ER. Contemporary diagnosis and management of preterm premature rupture of membranes. Rev Obstet Gynecol 2008;1:11–22.
   PubMedGoogle Scholar
• Maymon E, Chaim W, Sheiner E, Mazor M. A review of randomized clinical trials of antibiotic therapy in preterm premature rupture of the membranes. Arch Gynecol Obstet 1998;261:173–181.
   PubMedGoogle Scholar
• Pasquier JC, Rabilloud M, Picaud JC, Ecochard R, Claris O, Gaucherand P, Collet F, Chabert P, Mellier G; DOMINOS Group. A prospective population-based study of 598 cases of PPROM between 24 and 34 weeks'gestation: description, management and mortality (DOMINOS cohort). Eur J Obstet Gynecol Reprod Biol 2005;121:164–170.
   PubMed Web of Science ®Google Scholar
• Ramsey PS, Lieman JM, Brumfield CG, Carlo W. Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes. Am J Obstet Gynecol 2005;192:1162–1166.
   PubMed Web of Science ®Google Scholar
• Neil PRL, Wallace EM. Is AmniSure® useful in the management of women with prelabor rupture of the membranes? Aust N Z J Obstet Gynaecol. 2010 Dec;50(6):534–8. Epub 2010 Oct 22.
   Google Scholar
• Reece EA, Chervenak FA, Moya FR, Hobbins JC. Amniotic fluid arborization: effect of blood, meconium, and pH alterations. Obstet Gynecol 1984;64:248–250.
   PubMed Web of Science ®Google Scholar
• Ladfors L, Mattson LA, Eriksson M, Fall O. Is a speculum examination sufficient for excluding the diagnosis of ruptured fetal membranes? Acta Obstet Gynecol Scand 1997;76:739–742.
   Web of Science ®Google Scholar
• Bornstein J, Geva A, Solt I, Fait V, Schoenfeld A, Shoham HK, Sobel J. Nonintrusive diagnosis of premature ruptured amniotic membranes using a novel polymer. Am J Perinatol 2006;23:351–354.
   Google Scholar
• Mulhair L, Carter J, Poston L, Seed P, Briley A. Prospective cohort study investigating the reliability of the AmnioSense method for detection of spontaneous rupture of membranes. BJOG 2009;116:313–318.
   Google Scholar
• El-Messidi A, Cameron A. Diagnosis of premature rupture of membranes: inspiration from the past and insights for the future. J Obstet Gynaecol Can 2010;32:561–569.
   PubMedGoogle Scholar
• Gorodeski IG, Haimovitz L, Bahari CM. Reevaluation of the pH, ferning and Nile blue sulphate staining methods in pregnant women with premature rupture of the fetal membranes. J Perinat Med 1982;10:286–292.
   PubMed Web of Science ®Google Scholar
• Friedman ML, McElin TW. Diagnosis of ruptured fetal membranes. Am J Obstet Gynecol 1969;104:544–550.
   PubMed Web of Science ®Google Scholar
• de Haan HH, Offermans PM, Smits F, Schouten HJ, Peeters LL. Value of the fern test to confirm or reject the diagnosis of ruptured membranes in modest in nonlaboring women presenting with nonspecific vaginal fluid loss. Am J Perinatol 1994;11:46–50.
   PubMed Web of Science ®Google Scholar
• Rosemond RL, Lombardi SJ, Boehm FH. Ferning of amniotic fluid contaminated with blood. Obstet Gynecol 1990;75:338–340.
   PubMedGoogle Scholar
• Shahin M, Raslan H. Comparative study of three amniotic fluid markers in premature rupture of membranes: prolactin, β subunit of human chorionic gonadotropin, and α-fetoprotein. Gynecol Obstet Invest 2006;63:195–199.
   Google Scholar
• Bon C, Bon V, Vaudoyer F, Roubille M, Pichot J. Rapid detection of insulin-like growth factor-binding protein-1 in cervico-vaginal secretions: comparison with the diamine-oxidase test to diagnose premature membrane rupture. Immuno-analyse Biol Spéc 2002;17:387–394.
   Google Scholar
• Chen Franck CK, Dudenhausen JW. Comparison of two rapid strip tests based on IGFBP-1 and PAMG-1 for the detection of amniotic fluid. Am J Perinatol 2008;25:243–246.
   Google Scholar
• Cousins LM, Smok DP, Lovett SM, Poeltler DM. Amnisure placental α microglobulin-1 rapid immunoassay versus standard diagnostic methods for detection of rupture of membranes. Am J Perinatol 2005;22:317–320.
   PubMed Web of Science ®Google Scholar
• Gravett MG, Thomas A, Schneider KA, Reddy AP, Dasari S, Jacob T, Lu X, Rodland M, Pereira L, Sadowsky DW. Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection. J Proteome Res 2007;6:89–96.
   PubMed Web of Science ®Google Scholar
• Gaucherand P, Salle B, Sergeant P, Guibaud S, Brun J, Bizollon CA, Rudigoz RC. Comparative study of three vaginal markers of the premature rupture of membranes. Insulin like growth factor binding protein 1 diamine-oxidase pH. Acta Obstet Gynecol Scand 1997;76:536–540.
   PubMed Web of Science ®Google Scholar
• Rutanen EM, Kärkkäinen TH, Lehtovirta J, Uotila JT, Hinkula MK, Hartikainen AL. Evaluation of a rapid strip test for insulin-like growth factor-binding protein-1 in the diagnosis of ruptured of fetal membrane. Clin Chim Acta 1996;253:91–101.
   PubMed Web of Science ®Google Scholar
• Lee SE, Park JS, Norwitz ER, Kim KW, Park HS, Jun JK. Measurement of placental α-microglobulin-1 in cervicovaginal discharge to diagnose rupture of membranes. Obstet Gynecol 2007;109:634–640.
   PubMed Web of Science ®Google Scholar
• Kishida T, Yamada H, Negishi H, et al. Diagnosis of premature rupture of the membranes in preterm patients, using an improved AFP kit: comparison with ROM-check and/or Nitrazine test. Eur J Obstet Gynecol Reprod Biol 1996;69:77–82.
   PubMed Web of Science ®Google Scholar
• Erdemoglu E, Mungan T. Significance of detecting insulin-like growth factor binding protein-1 in cervicovaginal secretions: comparison with nitrazine test and amniotic fluid volume assessment. Acta Obstet Gynecol Scand 2004;83:622–626.
   PubMed Web of Science ®Google Scholar
• Jeurgens-Borst AJ, Bekkers RL, Sporken JM, van der Berg PP. Use of insulin like growth factor binding protein-1 in the diagnosis of ruptured fetal membranes. Eur J Obstet Gynecol Reprod Biol 2002;102:11–14.
   PubMedGoogle Scholar
• Mittal P, Romero R, Soto E, Cordoba M, Chang CL, Vaisbuch E, Bieda J, Chaiworapongsa T, Kusanovic JP, Yeo L, et al. A role for placental α-microglobulin-1 in the identification of women with a sonographic short cervix at risk for spontaneous rupture of membranes. Am J Obstet Gynecol, Supplement to December 2009. Vol 201, n°6, pp S196–197.
   Google Scholar
• Lee SM, Lee J, Seong HS, Lee SE, Park JS, Romero R, Yoon BH. The clinical significance of a positive Amnisure test™ in women with term labor with intact membranes. J Matern Fetal Neonatal Med 2009;22:305–310.
   PubMed Web of Science ®Google Scholar
• Lee SM. Comment and reply on: the clinical significance of a positive Amnisure test in women with term labor with intact membranes. J Matern Fetal Neonatal Med 2010; early online 1–3.
   Google Scholar
• Wilfong L. Effects of maternal blood on the readability and reliability of the amnisure rapid immunoassay. Med Educ Foundation Am Coll Osteopathic Obstet Gynecol Winter Newslett 2009;30:11–12.
   Google Scholar
• Silva E, Martinez JC. Diagnosing ROM: a comparison of the gold standard, indigo carmine amnioinfusion, to the rapid immunoassay, the AmniSure ROM test. J Perinat Med 2009;37:956.
   Google Scholar
• Tagore S, Kwek K. Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental α-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy. J Perinat Med. 2010 Nov;38(6):609–12. Epub 2010 Aug 13.
   PubMed Web of Science ®Google Scholar
• Romero R, Espinoza J, Erez O, Hassan S. The role of cervical cerclage in obstetric practice: can the patient who could benefit from this procedure be identified? Am J Obstet Gynecol 2006;194:1–9. Review.
   PubMed Web of Science ®Google Scholar
• To MS, Alfirevic Z, Heath VC, Cicero S, Cacho AM, Williamson PR, Nicolaides KH; Fetal Medicine Foundation Second Trimester Screening Group. Cervical cerclage for prevention of preterm delivery in women with short cervix: randomised controlled trial. Lancet 2004;363:1849–1853.
   PubMed Web of Science ®Google Scholar
• Berghella V, Odibo AO, To MS, Rust OA, Althuisius SM. Cerclage for short cervix on ultrasonography: meta-analysis of trials using individual patient-level data. Obstet Gynecol 2005;106:181–189.
   PubMed Web of Science ®Google Scholar
• Hassan SS, Romero R, Maymon E, Berry SM, Blackwell SC, Treadwell MC, Tomlinson M. Does cervical cerclage prevent preterm delivery in patients with a short cervix? Am J Obstet Gynecol 2001;184:1325–1329; discussion 1329–1331.
   PubMed Web of Science ®Google Scholar
• Rush R W. Isaacs S, McPherson K, Lesley J, Chalmers I, Grant A. A randomized controlled trial of cervical cerclage in women at high risk of spontaneous preterm delivery. Br J Obstet Gynaecol 1984;91:724.
   PubMedGoogle Scholar
• Lazar P, Gueguen S, Dreyfus J, Renaud R, Pontonnier G, Papiernik E. Multicentre controlled trial of cervical cerclage in women at moderate risk of preterm delivery. Br J Obstet Gynaecol 1984;91:731–735.
   PubMedGoogle Scholar
• MRC/RCOG Working Party on Cervical Cerclage. Final report of the Medical Research Council/Royal College of Obstetricians and Gynaecologists multicentre randomized trial of cervical cerclage. Br J Obstet Gynecol 1993;100:516–523.
   PubMedGoogle Scholar
• Berghella V, Odibo AO, Tolosa JE. Cerclage for prevention of preterm birth in women with a short cervix found on transvaginal ultrasound examination: a randomized trial. Am J Obstet Gynecol 2004;191:1311–1317.
   PubMed Web of Science ®Google Scholar
• Daskalakis GJ. Prematurity prevention: the role of cerclage. Curr Opin Obstet Gynecol 2009;21:148–152. Review.
   PubMed Web of Science ®Google Scholar
• Mancuso MS, Owen J. Prevention of preterm birth based on a short cervix: cerclage. Semin Perinatol 2009;33:325–333. Review.
   PubMed Web of Science ®Google Scholar
• Dor J, Shalev J, Mashiach S, Blankstein J, Serr DM. Elective cervical suture of twin pregnancies diagnosed ultrasonically in the first trimester following induced ovulation. Gynecol Obstet Invest 1982;13:55–60.
   PubMed Web of Science ®Google Scholar
• Simcox R, Shennan A. Cervical cerclage: a review. Int J Surg 2007;5:205–209.
   PubMedGoogle Scholar
• Althuisius SM, Dekker GA, Hummel P, Van Geijn HP; Cervical incompetence prevention randomized cerclage trial. Cervical incompetence prevention randomized cerclage trial: emergency cerclage with bed rest versus bed rest alone. Am J Obstet Gynecol 2003;189:907–910.
   PubMed Web of Science ®Google Scholar
• Cockwell HA, Smith GN. Cervical incompetence and the role of emergency cerclage. J Obstet Gynaecol Can 2005;27:123–129.
   PubMedGoogle Scholar
• Rust OA, Roberts WE. Does cerclage prevent preterm birth? Obstet Gynecol Clin North Am 2005;32:441–456. Review.
   PubMed Web of Science ®Google Scholar
• Odibo AO, Berghella V, To MS, Rust OA, Althuisius SM, Nicolaides KH. Shirodkar versus McDonald cerclage for the prevention of preterm birth in women with short cervical length. Am J Perinatol 2007;24:55–60.
   PubMed Web of Science ®Google Scholar
• Cabero L, Saldivar D. Incompetencia cervical. Operatoria Obstétrica. MadridCabero Ed Editorial Medica Panamericana2009. p. 33.
   Google Scholar
• Walsh J, Allen VM, Colford D, Allen AC. Preterm prelabor rupture of membranes with cervical cerclage: a review of perinatal outcomes with cerclage retention. J Obstet Gynaecol Can 2010;32:448–452.
   Google Scholar
• Iams JD, Johnson FF, Sonek J, Sachs L, Gebauer C, Samuels P. Cervical incompetence as a continuum: a study of ultrasonographic cervical length and obstetric performance. Am J Obstet Gynecol 1995;172:1097–1106.
   PubMed Web of Science ®Google Scholar
• Dijkstra K, Funai EF, O'Neill L, Rebarber A, Paidas MJ, Young BK. Change in cervical length after cerclage as a predictor of preterm delivery. Obstet Gynecol 2000;96:346–350.
   PubMed Web of Science ®Google Scholar
• Oster S, Javer JC. Treatment of the incompetent cervix with the Hodge pessary. Obstet Gynecol 1966;28:206–208.
   Google Scholar
• Arabin B, Halbesma JR, Vork F, Hübener M, Van Eyck J. Is treatment with vaginal pessaries an option in patients with a sonographically detected short cervix? J Perinat Med 2003;31:122–133.
   PubMed Web of Science ®Google Scholar
• Acharya G, Eschler B, Grønberg M, Hentemann M, Ottersen T, Maltau JM. Non invasive cerclage for the management of cervical incompetence: a prospective study. Arch Gynecol Obstet 2006;273:283–287.
   PubMedGoogle Scholar
• Goya M, Pratcorona L, Rodo C, Merced C, Bello JC, Carreras E, Cabero L. RCT on prevention of preterm birth with cervical pessary. Commun Rodas, in press.
   Google Scholar
• Dharan VB, Ludmir J. Alternative treatment for a short cervix: the cervical pessary. Semin Perinatol 2009;33:338–342.
   PubMed Web of Science ®Google Scholar
• Zondek B. Die Hormone Des Ovariums Und Des Hypophysenvorderlappens. BerlinSpringer Verlag1931.
   Google Scholar
• Smith R. Parturition. N Eng J Med 2007;356:271–283.
   PubMed Web of Science ®Google Scholar
• Csapo AI, Pohanca O, Kaihola HL. Progesterone deficiency and premature labor. Br Med J 1974;1:137–140.
   PubMedGoogle Scholar
• Keirse MJ. Progestogen administration in pregnancy may prevent preterm delivery. Br J Obstet Gynaecol 1990;97:149–154.
   PubMedGoogle Scholar
• Cunningham G, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstrom KD. Williams obstetrics. 21st edMac Graw-Hill2001.
   Google Scholar
• Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH, et al. Prevention of recurrent preterm delivery by 17 α-hydroxyprogesterone caproate. National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network. N Engl J Med 2003;348:2379–2385.
   PubMed Web of Science ®Google Scholar
• Di Renzo GC, Rosati A, Mattei A, Gojnic M, Gerli S. The changing role of progesterone in preterm labor. Br J Obstet Gynaecol 2005;112:57–60.
   Google Scholar
• Ruddock NK, Shi S-Q, Jain S, Moore G, Hankins GDV, Romero R, Garfield RE. Progesterone, but not 17-α-hydroxyprogesterone caproate, inhibits human myometrial contractions. Am J Obstet Gynecol 2008;199:391.e1–391.e7.
   Web of Science ®Google Scholar
• Facchinetti F, Vaccaro V. Pharmacological use of progesterone and 17-α-hydroxyprogesterone caproate in the prevention of preterm delivery. Minerva Med 2009;61:401–409.
   Google Scholar
• Dodd JM, Flenady VJ, Cincotta R, Crowther CA. Progesterone for the prevention of preterm birth: a systematic review. Obstet Gynecol 2008;112:127–134.
   PubMed Web of Science ®Google Scholar
• Di Renzo GC, Mattei A, Gojnic M, Gerli S. Progesterone and pregnancy. Curr Opin Obstet Gynecol 2005;17:598–600.
   PubMed Web of Science ®Google Scholar
• Berghella V, Figueroa D, Szychowski JM, Owen J, Hankins GDV, Iams JD, Sheffield JS, Perez-Delboy A, Wing DA, Guzman ER, for the Vaginal Ultrasound Trial Consortium. 17-α-Hydroxyprogesterone caproate for the prevention of preterm birth in women with prior preterm birth and short cervical length. Am J Obstet Gynecol 2010;202:351.e1–351.e6.
   Web of Science ®Google Scholar
• Borna S, Sahabi N. Progesterone for maintenance tocolytic therapy after threatened preterm labor: a randomized controlled trial. Aust N Z J Obstet Gynaecol 2008;48:58–63.
   PubMed Web of Science ®Google Scholar
• Christian MS, Brent RL, Calda P. Embryo–fetal toxicity signals for 17α-hydroxyprogesterone caproate in high-risk pregnancies: a review of the non-clinical literature for embryo–fetal toxicity with progestins. J Matern Fetal Neonatal Med 2007;20:89–112.
   PubMed Web of Science ®Google Scholar
• Rebarber A, Fox NS, Klauser CK, Istwan NB, Rhea DJ, Stanziano GJ, Saltzman DH. Using 17 α-hydroxyprogesterone caproate to impact rates of recurrent preterm delivery in clinical practice. J Matern Fetal Neonatal Med 2010;23:1139–1142.
   PubMed Web of Science ®Google Scholar
• Johnstone EE, Franklin RR. Assay for fetal virilising properties using the mouse. Obstet Gynecol 1964;23:359–362.
   PubMed Web of Science ®Google Scholar
• Courtney KD, Valerio DA. Teratology in the Macaca mulatta. Teratology 1968;1:163–172.
   PubMedGoogle Scholar
• Carbone JP, Brent RL. Genital and nongenital teratogenesis of prenatal progestogen therapy: the effects of 17 α-hydroxyprogesterone caproate on embryonic and fetal development and endochondral ossification in the C57B1/6J mouse. Am J Obstet Gynecol 1993;169:1292–1298.
   PubMedGoogle Scholar
• Seegmiller RE, Nelson GW, Johnson CK. Evaluation of the teratogenic potential of delalutin (17 α-hydroxyprogesterone caproate) in mice. Teratology 1983;28:201–208.
   PubMedGoogle Scholar
• Calda P. Safety signals of 17-OHP-C use in pregnancy and efficacy in the prevention of preterm birth. J Matern Fetal Neonatal Med 2009;22:540–542.
   PubMed Web of Science ®Google Scholar
• da Fonseca EB, Bittar RE, Carvalho MH, Zugaib M. Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study. Am J Obstet Gynecol 2003;188:419–424.
   PubMed Web of Science ®Google Scholar
• Sexton DJ, O'Reilly MW, Friel AM, Morrison JJ. Functional effects of 17α -hydroxyprogesterone caproate (17P) on human myometrial contractility in vitro. Reprod Biol Endocrinol 2004;2:80.
   PubMedGoogle Scholar
• Csapo AI. The ‘see-saw’ theory of parturition. Ciba Found Symp 1977;(47):159–210.
   Google Scholar
• Crinone package insert. Internet. pdf, revised 2006. Electronic Citation. http://www.crinoneusa.com/professionals/Prescribing_ Information.
   Google Scholar
• O'Brien JM, Adair CD, Lewis DF, Hall DR, Defranco EA, Fusey S, Soma-Pillay P, Porter K, How H, Schackis R, et al. Progesterone vaginal gel for the reduction of recurrent preterm birth: primary results from a randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 2007;30: 687–696.
   PubMed Web of Science ®Google Scholar
• Hendrickx AG, Korte R, Leuschner F, Neumann BW, Poggel A, Binkerd P, Prahalada S, Günzel P. Embryotoxicity of sex steroidal hormones in nonhuman primates. II. Hydroxyprogesterone caproate, estradiol valerate. Teratology 1987;35:129–136.
   PubMedGoogle Scholar
• Rebarber A, Istwan NB, Russo-Stieglitz K, Cleary-Goldman J, Rhea DJ, Stanziano GJ, Saltzman DH. Increased incidence of gestational diabetes in women receiving prophylactic 17α-hydroxyprogesterone caproate for prevention of recurrent preterm delivery. Diabetes Care 2007;30:2277–2280.
   PubMed Web of Science ®Google Scholar
• Johnson JW, Austin KL, Jones GS, Davis GH, King TM. Efficacy of 17α hydroxyprogesterone caproate in the prevention of premature labor. N Engl J Med 1975;293:695–680.
   Google Scholar
• Papiernik-Berkhauer E. Etude en double aveugle d'un medicament prevenant la survenue prematurée de l'accouchement chez les femmes a risque elevé d'accouchement prematuré. Edition Schering Serie IV 1970;3:65–68.
   Google Scholar
• Yemini M, Borenstein R, Dreazen E, Apelman Z, Mogilner BM, Kessler I, Lancet M. Prevention of premature labor by 17α hydroxyprogesterone caproate. Am J Obstet Gynecol 1985;151: 574–577.
   PubMed Web of Science ®Google Scholar
• Hauth JC, Gilstrap LC III, Brekken AL, Hauth JM. The effect of 17 α hydroxyprogesterone caproate on pregnancy outcome in an active-duty military population. Am J Obstet Gynecol 1983;146:187–190.
   PubMed Web of Science ®Google Scholar
• DeFranco EA, O'Brien JM, Adair CD, Lewis DF, Hall DR, Fusey S, Soma-Pillay P, Porter K, How H, Schakis R, et al. Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a secondary analysis from a randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 2007;30:697–705.
   PubMed Web of Science ®Google Scholar
• Facchinetti F, Paganelli S, Comitini G, Dante G, Volpe A. Cervical length changes during preterm cervical ripening: effects of 17 α hydoxyprogesterone caproate. Am J Obstet Gynecol 2007;196:453.e1–453.e4.
   PubMed Web of Science ®Google Scholar
• Combs CA, Garite T, Maurel K, Das A, Porto M; Obstetrix Collaborative Research Network. Failure of 17-hydroxyprogesterone to reduce neonatal morbidity or prolong triplet pregnancy: a double-blind, randomized clinical trial. Am J Obstet Gynecol 2010;203:248.e1–248.e9.
   Web of Science ®Google Scholar
• Hartikainen-Sorri AL, Kauppila A, Tuimala R. Inefficacy of 17α hydroxyprogesterone caproate in the prevention of prematurity in twin pregnancy. Obstet Gynecol 1980;56: 692–695.
   PubMed Web of Science ®Google Scholar
• Rouse DJ, Caritis SN, Peaceman AM, Sciscione A, Thom EA, Spong CY, Varner M, Malone F, Iams JD, Mercer BM, A trial of 17 α-hydroxyprogesterone caproate to prevent prematurity in twins. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. N Engl J Med 2007;357:454–461.
   PubMed Web of Science ®Google Scholar
• Norman JE, MacKenzie F, Owen P, Mactier H, Hanretty K, Cooper S, Calder A, Mires G, Danielian P, Sturgiss S. Progesterone for the prevention of preterm in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis. Lancet 2009;373: 2034–2040.
   PubMed Web of Science ®Google Scholar
• ACOG Committee Opinion number 419 October 2008 (replaces n°291, November 2003). Use of progesterone to reduce preterm birth. Society for Maternal Fetal Medicine Publications Committee. Obstet Gynecol. 2008 Oct;112(4):963–5.
   Google Scholar
• Northern AT, Norman GS, Anderson K, Moseley L, Divito M, Cotroneo M, Swain M, Bousleiman S, Johnson F, Dorman K. Follow-up of children exposed in utero to 17 α-hydroxyprogesterone caproate compared with placebo. National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Obstet Gynecol 2007;110:865–872.
   Google Scholar