Umbilical cord blood concentration of soluble scavenger receptor for hemoglobin, but not pentraxin 3, is of value for the early postpartum identification of the presence of histological chorioamnionitis

References

• Salafia CM, Weigl C, Silberman L. The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies. Obstet Gynecol 1989;73:383–389.
   PubMed Web of Science ®Google Scholar
• De Felice C, Toti P, Laurini RN, Stumpo M, Picciolini E, Todros T, et al. Early neonatal brain injury in histologic chorioamnionitis. J Pediatr 2001;138:101–104
   Google Scholar
• Mestan K, Yu Y, Thorsen P, Skogstrand K, Matoba N, Liu X, Kumar R, et al. Cord blood biomarkers of the fetal inflammatory response. J Matern Fetal Neonatal Med 2009;22:379–387.
   PubMed Web of Science ®Google Scholar
• Yoon BH, Romero R, Park JS, Kim M, Oh SY, Kim CJ, Jun JK. The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol 2000;183:1124–1129.
   PubMed Web of Science ®Google Scholar
• Døllner H, Vatten L, Halgunset J, Rahimipoor S, Austgulen R. Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine inhibitors. BJOG 2002;109:534–539.
   PubMed Web of Science ®Google Scholar
• Satar M, Turhan E, Yapicioglu H, Narli N, Ozgunen FT, Cetiner S. Cord blood cytokine levels in neonates born to mothers with prolonged premature rupture of membranes and its relationship with morbidity and mortality. Eur Cytokine Netw 2008;19:37–41.
   PubMed Web of Science ®Google Scholar
• von Minckwitz G, Grischke EM, Schwab S, Hettinger S, Loibl S, Aulmann M, Kaufmann M. Predictive value of serum interleukin-6 and -8 levels in preterm labor or rupture of the membranes. Acta Obstet Gynecol Scand 2000;79:667–672.
   PubMed Web of Science ®Google Scholar
• Medzhitov R, Janeway CA Jr. Decoding the patterns of self and nonself by the innate immune system. Science 2002;296:298–300.
   PubMed Web of Science ®Google Scholar
• Rovere-Querini P, Antonacci S, Dell’Antonio G, Angeli A, Almirante G, Cin ED, Valsecchi L, et al. Plasma and tissue expression of the long pentraxin 3 during normal pregnancy and preeclampsia. Obstet Gynecol 2006;108:148–155.
   PubMed Web of Science ®Google Scholar
• Bottazzi B, Garlanda C, Salvatori G, Jeannin P, Manfredi A, Mantovani A. Pentraxins as a key component of innate immunity. Curr Opin Immunol 2006;18:10–15.
   PubMed Web of Science ®Google Scholar
• Nauta AJ, de Haij S, Bottazzi B, Mantovani A, Borrias MC, Aten J, Rastaldi MP, et al. Human renal epithelial cells produce the long pentraxin PTX3. Kidney Int 2005;67:543–553.
   PubMed Web of Science ®Google Scholar
• Buechler C, Ritter M, Orsó E, Langmann T, Klucken J, Schmitz G. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. J Leukoc Biol 2000;67:97–103.
   PubMed Web of Science ®Google Scholar
• Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, Moestrup SK. Identification of the haemoglobin scavenger receptor. Nature 2001;409:198–201.
   PubMed Web of Science ®Google Scholar
• Droste A, Sorg C, Högger P. Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family. Biochem Biophys Res Commun 1999;256:110–113.
   PubMed Web of Science ®Google Scholar
• Weaver LK, Pioli PA, Wardwell K, Vogel SN, Guyre PM. Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptors. J Leukoc Biol 2007;81:663–671.
   PubMed Web of Science ®Google Scholar
• Muller B, Peri G, Doni A, Torri V, Landmann R, Bottazzi B, Mantovani A. Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients. Crit Care Med 2001;29:1404–1407.
   PubMed Web of Science ®Google Scholar
• Møller HJ, Moestrup SK, Weis N, Wejse C, Nielsen H, Pedersen SS, Attermann J, et al. Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163. Crit Care Med 2006;34:2561–2566.
   PubMed Web of Science ®Google Scholar
• Gaïni S, Pedersen SS, Koldkaer OG, Pedersen C, Moestrup SK, Møller HJ. New immunological serum markers in bacteraemia: anti-inflammatory soluble CD163, but not proinflammatory high mobility group-box 1 protein, is related to prognosis. Clin Exp Immunol 2008;151:423–431.
   PubMed Web of Science ®Google Scholar
• Mauri T, Bellani G, Patroniti N, Coppadoro A, Peri G, Cuccovillo I, Cugno M, et al. Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality. Intensive Care Med 2010;36:621–629.
   PubMed Web of Science ®Google Scholar
• Sprong T, Peri G, Neeleman C, Mantovani A, Signorini S, van der Meer JW, van Deuren M. Pentraxin 3 and C-reactive protein in severe meningococcal disease. Shock 2009;31:28–32.
   PubMed Web of Science ®Google Scholar
• Kacerovsky M, Tosner J, Drahosova M, Hornychova H, Andrys C. Pentraxin 3 in amniotic fluid as a marker of intra-amniotic inflammation in women with preterm premature rupture of membranes. Int J Gynaecol Obstet 2010;108:203–206.
   PubMed Web of Science ®Google Scholar
• Cruciani L, Romero R, Vaisbuch E, Kusanovic JP, Chaiworapongsa T, Mazaki-Tovi S, Mittal P, et al. Pentraxin 3 in amniotic fluid: a novel association with intra-amniotic infection and inflammation. J Perinat Med 2010;38:161–171.
   PubMed Web of Science ®Google Scholar
• Kacerovsky M, Drahosova M, Andrys C, Hornychova H, Tambor V, Lenco J, Tosner J, Krejsek J. Amniotic fluid concentrations of soluble scavenger receptor for hemoglobin (sCD163) in pregnancy complicated by preterm premature rupture of the membranes and histologic chorioamnionitis. J Matern Fetal Neonatal Med 2011;24:995–1001.
   PubMed Web of Science ®Google Scholar
• Vogel I, Grove J, Thorsen P, Moestrup SK, Uldbjerg N, Møller HJ. Preterm delivery predicted by soluble CD163 and CRP in women with symptoms of preterm delivery. BJOG 2005;112:737–742.
   PubMed Web of Science ®Google Scholar
• Cruciani L, Romero R, Vaisbuch E, Kusanovic JP, Chaiworapongsa T, Mazaki-Tovi S, Dong Z, et al. Pentraxin 3 in maternal circulation: an association with preterm labor and preterm PROM, but not with intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2010;23:1097–1105.
   PubMed Web of Science ®Google Scholar
• Assi F, Fruscio R, Bonardi C, Ghidini A, Allavena P, Mantovani A, Locatelli A. Pentraxin 3 in plasma and vaginal fluid in women with preterm delivery. BJOG 2007;114:143–147.
   PubMed Web of Science ®Google Scholar
• Vogel I, Goepfert AR, Møller HJ, Cliver S, Thorsen P, Andrews WW. Early mid-trimester serum relaxin, soluble CD163, and cervical length in women at high risk for preterm delivery. Am J Obstet Gynecol 2006;195:208–214.
   PubMed Web of Science ®Google Scholar
• Moestrup SK, Møller HJ. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Ann Med 2004;36:347–354.
   PubMed Web of Science ®Google Scholar
• Mantovani A, Garlanda C, Doni A, Bottazzi B. Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3. J Clin Immunol 2008;28:1–13.
   PubMed Web of Science ®Google Scholar
• Yoon BH, Romero R, Shim JY, Shim SS, Kim CJ, Jun JK. C-reactive protein in umbilical cord blood: a simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis. J Matern Fetal Neonatal Med 2003;14:85–90.
   PubMedGoogle Scholar
• Wloch S, Palasz A, Kaminski M. Active and passive transport of drugs in the human placenta. Ginekol Pol 2009;80:772–777.
   PubMedGoogle Scholar