Impact of inherited thrombophilias on first and second trimester maternal serum markers for aneuploidy

References

• Paidas MJ, Ku DH, Lee MJ, Manish S, Thurston A, Lockwood CJ, Arkel YS. Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications. J Thromb Haemost 2005;3:497–501.
   PubMed Web of Science ®Google Scholar
• Said JM, Higgins JR, Moses EK, Walker SP, Borg AJ, Monagle PT, Brennecke SP. Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women. Obstet Gynecol 2010;115:5–13.
   PubMedGoogle Scholar
• Wu O, Robertson L, Twaddle S, Lowe G, Clark P, Walker I, Brenkel I, et al.; Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study. Screening for thrombophilia in high-risk situations: a meta-analysis and cost-effectiveness analysis. Br J Haematol 2005;131:80–90.
   PubMed Web of Science ®Google Scholar
• Cohen D, Berger SP, Steup-Beekman GM, Bloemenkamp KW, Bajema IM. Diagnosis and management of the antiphospholipid syndrome. BMJ 2010;340:2541.
   Google Scholar
• Giannakopoulos B, Passam F, Ioannou Y, Krilis SA. How we diagnose the antiphospholipid syndrome. Blood 2009;113:985–994.
   PubMed Web of Science ®Google Scholar
• Di Simone N, Marana R, Castellani R, Di Nicuolo F, D’Alessio MC, Raschi E, Borghi MO, et al. Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation. Arthritis Rheum 2010;62:1504–1512.
   PubMed Web of Science ®Google Scholar
• Crowther MA, Ginsberg JS, Julian J, Denburg J, Hirsh J, Douketis J, Laskin C, et al. A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome. N Engl J Med 2003;349:1133–1138.
   PubMed Web of Science ®Google Scholar
• Dugoff L; Society for Maternal-Fetal Medicine. First- and second-trimester maternal serum markers for aneuploidy and adverse obstetric outcomes. Obstet Gynecol 2010;115:1052–1061.
   PubMed Web of Science ®Google Scholar
• Gagnon A, Wilson RD, Audibert F, Allen VM, Blight C, Brock JA, Désilets VA, et al.; Society of Obstetricians and Gynaecologists of Canada Genetics Committee. Obstetrical complications associated with abnormal maternal serum markers analytes. J Obstet Gynaecol Can 2008;30:918–949.
   PubMedGoogle Scholar
• Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003;361:901–908.
   PubMed Web of Science ®Google Scholar
• Roqué H, Paidas MJ, Funai EF, Kuczynski E, Lockwood CJ. Maternal thrombophilias are not associated with early pregnancy loss. Thromb Haemost 2004;91:290–295.
   PubMed Web of Science ®Google Scholar
• Jauniaux E, Gulbis B, Burton GJ. The human first trimester gestational sac limits rather than facilitates oxygen transfer to the foetus–a review. Placenta 2003;24 Suppl A:S86–S93.
   PubMedGoogle Scholar
• Jauniaux E, Poston L, Burton GJ. Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution. Hum Reprod Update 2006;12:747–755.
   PubMed Web of Science ®Google Scholar
• Irwin JC, Suen LF, Martina NA, Mark SP, Giudice LC. Role of the IGF system in trophoblast invasion and pre-eclampsia. Hum Reprod 1999;14 Suppl 2:90–96.
   PubMedGoogle Scholar
• Spencer K, Yu CK, Cowans NJ, Otigbah C, Nicolaides KH. Prediction of pregnancy complications by first-trimester maternal serum PAPP-A and free beta-hCG and with second-trimester uterine artery Doppler. Prenat Diagn 2005;25:949–953.
   PubMed Web of Science ®Google Scholar
• Dugoff L, Hobbins JC, Malone FD, Porter TF, Luthy D, Comstock CH, Hankins G, et al. First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial). Am J Obstet Gynecol 2004;191:1446–1451.
   PubMed Web of Science ®Google Scholar
• Rissanen A, Niemimaa M, Suonpää M, Ryynänen M, Heinonen S. Pregnancy-associated plasma protein A, free human chorionic gonadotrophin and nuchal translucency as predictors of miscarriage. Clin Genet 2006;69:287–289.
   PubMedGoogle Scholar
• Ong S, Lash G, Baker PN. Angiogenesis and placental growth in normal and compromised pregnancies. Baillieres Best Pract Res Clin Obstet Gynaecol 2000;14:969–980.
   PubMed Web of Science ®Google Scholar
• Bose P, Black S, Kadyrov M, Bartz C, Shlebak A, Regan L, Huppertz B. Adverse effects of lupus anticoagulant positive blood sera on placental viability can be prevented by heparin in vitro. Am J Obstet Gynecol 2004;191:2125–2131.
   PubMed Web of Science ®Google Scholar
• Hills FA, Abrahams VM, González-Timón B, Francis J, Cloke B, Hinkson L, Rai R, et al. Heparin prevents programmed cell death in human trophoblast. Mol Hum Reprod 2006;12:237–243.
   PubMedGoogle Scholar
• Quenby S, Mountfield S, Cartwright JE, Whitley GS, Vince G. Effects of low-molecular-weight and unfractionated heparin on trophoblast function. Obstet Gynecol 2004;104:354–361.
   PubMed Web of Science ®Google Scholar
• Ganapathy R, Whitley GS, Cartwright JE, Dash PR, Thilaganathan B. Effect of heparin and fractionated heparin on trophoblast invasion. Hum Reprod 2007;22:2523–2527.
   PubMed Web of Science ®Google Scholar
• Yaron Y, Cherry M, Kramer RL, O’Brien JE, Hallak M, Johnson MP, Evans MI. Second-trimester maternal serum marker screening: maternal serum alpha-fetoprotein, beta-human chorionic gonadotropin, estriol, and their various combinations as predictors of pregnancy outcome. Am J Obstet Gynecol 1999;181:968–974.
   PubMed Web of Science ®Google Scholar
• Shenhav S, Gemer O, Sassoon E, Volodarsky M, Peled R, Segal S. Mid-trimester triple test levels in early and late onset severe pre-eclampsia. Prenat Diagn 2002;22:579–582.
   PubMed Web of Science ®Google Scholar
• Kagan KO, Wright D, Valencia C, Maiz N, Nicolaides KH. Screening for trisomies 21, 18 and 13 by maternal age, fetal nuchal translucency, fetal heart rate, free beta-hCG and pregnancy-associated plasma protein-A. Hum Reprod 2008;23:1968–1975.
   PubMed Web of Science ®Google Scholar