282
Views
14
CrossRef citations to date
0
Altmetric
Reviews

Mending a growth-restricted fetal heart: should we use glucocorticoids?

&
Pages 2149-2153 | Received 01 Oct 2011, Accepted 01 May 2012, Published online: 06 Jul 2012

References

  • Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 2008;359:61–73.
  • When do obstetricians recommend delivery for a high-risk preterm growth-retarded fetus? The GRIT Study Group. Growth Restriction Intervention Trial. Eur J Obstet Gynecol Reprod Biol 1996;67:121–126.
  • Prefumo F, Muiesan ML, Perini R, Paini A, Bonzi B, Lojacono A, Agabiti-Rosei E, Frusca T. Maternal cardiovascular function in pregnancies complicated by intrauterine growth restriction. Ultrasound Obstet Gynecol 2008;31:65–71.
  • Crispi F, Hernandez-Andrade E, Pelsers MM, Plasencia W, Benavides-Serralde JA, Eixarch E, Le Noble F, et al. Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses. Am J Obstet Gynecol 2008;199:254.e1–254.e8.
  • Bukowski R. Stillbirth and fetal growth restriction. Clin Obstet Gynecol 2010;53:673–680.
  • Baschat AA. Doppler application in the delivery timing of the preterm growth-restricted fetus: another step in the right direction. Ultrasound Obstet Gynecol 2004;23:111–118.
  • Rueda-Clausen CF, Morton JS, Lopaschuk GD, Davidge ST. Long-term effects of intrauterine growth restriction on cardiac metabolism and susceptibility to ischaemia/reperfusion. Cardiovasc Res 2011;90:285–294.
  • Crispi F, Bijnens B, Figueras F, Bartrons J, Eixarch E, Le Noble F, Ahmed A, Gratacós E. Fetal growth restriction results in remodeled and less efficient hearts in children. Circulation 2010;121:2427–2436.
  • Ojeda NB, Grigore D, Alexander BT. Intrauterine growth restriction: fetal programming of hypertension and kidney disease. Adv Chronic Kidney Dis 2008;15:101–106.
  • Stocker CJ, Arch JR, Cawthorne MA. Fetal origins of insulin resistance and obesity. Proc Nutr Soc 2005;64:143–151.
  • Barker DJ. Intrauterine programming of adult disease. Mol Med Today 1995;1:418–423.
  • Barker DJ. Intrauterine programming of coronary heart disease and stroke. Acta Paediatr Suppl 1997;423:178–82; discussion 183.
  • Gardosi J. Intrauterine growth restriction: new standards for assessing adverse outcome. Best Pract Res Clin Obstet Gynaecol 2009;23:741–749.
  • Crowley P. Prophylactic corticosteroids for preterm birth. Cochrane Database Syst Rev 2000; CD000065.
  • Trudinger BJ, Cook CM, Giles WB, Ng S, Fong E, Connelly A, Wilcox W. Fetal umbilical artery velocity waveforms and subsequent neonatal outcome. Br J Obstet Gynaecol 1991;98:378–384.
  • Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2006;CD004454.
  • U.S. Department of Health and Human Services PHSNPN-, 1994. Report on the Consensus Development Conference on the effect of corticosteroids for fetal maturation on perinatal outcomes; 1994.
  • Torrance HL, Derks JB, Scherjon SA, Wijnberger LD, Visser GH. Is antenatal steroid treatment effective in preterm IUGR fetuses? Acta Obstet Gynecol Scand 2009;88:1068–1073.
  • Bernstein IM, Horbar JD, Badger GJ, Ohlsson A, Golan A. Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. The Vermont Oxford Network. Am J Obstet Gynecol 2000;182:198–206.
  • Elimian A, Verma U, Canterino J, Shah J, Visintainer P, Tejani N. Effectiveness of antenatal steroids in obstetric subgroups. Obstet Gynecol 1999;93:174–179.
  • Schaap AH, Wolf H, Bruinse HW, Smolders-De Haas H, Van Ertbruggen I, Treffers PE. Effects of antenatal corticosteroid administration on mortality and long-term morbidity in early preterm, growth-restricted infants. Obstet Gynecol 2001;97:954–960.
  • Baschat AA, Harman CR. Antenatal assessment of the growth restricted fetus. Curr Opin Obstet Gynecol 2001;13:161–168.
  • Morrow RJ, Adamson SL, Bull SB, Ritchie JW. Effect of placental embolization on the umbilical arterial velocity waveform in fetal sheep. Am J Obstet Gynecol 1989;161:1055–1060.
  • Nicolaides KH, Bilardo CM, Soothill PW, Campbell S. Absence of end diastolic frequencies in umbilical artery: a sign of fetal hypoxia and acidosis. BMJ 1988;297:1026–1027.
  • Veille JC, Hanson R, Sivakoff M, Hoen H, Ben-Ami M. Fetal cardiac size in normal, intrauterine growth retarded, and diabetic pregnancies. Am J Perinatol 1993;10:275–279.
  • Gagnon R. Placental insufficiency and its consequences. Eur J Obstet Gynecol Reprod Biol 2003;110 Suppl 1:S99–107.
  • Baschat AA, Güclü S, Kush ML, Gembruch U, Weiner CP, Harman CR. Venous Doppler in the prediction of acid-base status of growth-restricted fetuses with elevated placental blood flow resistance. Am J Obstet Gynecol 2004;191:277–284.
  • Baschat AA, Gembruch U, Gortner L, Reiss I, Weiner CP, Harman CR. Coronary artery blood flow visualization signifies hemodynamic deterioration in growth-restricted fetuses. Ultrasound Obstet Gynecol 2000;16:425–431.
  • Alfirevic Z, Stampalija T, Roberts D, Jorgensen AL. Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database Syst Rev 2012;4:CD008991.
  • Naujorks AA, Zielinsky P, Beltrame PA, Castagna RC, Petracco R, Busato A, Nicoloso AL, et al. Myocardial tissue Doppler assessment of diastolic function in the growth-restricted fetus. Ultrasound Obstet Gynecol 2009;34:68–73.
  • Rizzo G, Capponi A, Pietrolucci ME, Boccia C, Arduini D. The significance of visualising coronary blood flow in early onset severe growth restricted fetuses with reverse flow in the ductus venosus. J Matern Fetal Neonatal Med 2009;22:547–551.
  • Levent E, Atik T, Darcan S, Ulger Z, Göksen D, Ozyürek AR. The relation of arterial stiffness with intrauterine growth retardation. Pediatr Int 2009;51:807–811.
  • Larsen LU, Petersen OB, Sloth E, Uldbjerg N. Color Doppler myocardial imaging demonstrates reduced diastolic tissue velocity in growth retarded fetuses with flow redistribution. Eur J Obstet Gynecol Reprod Biol 2011;155:140–145.
  • Rizzo G, Capponi A, Cavicchioni O, Vendola M, Arduini D. Fetal cardiac stroke volume determination by four-dimensional ultrasound with spatio-temporal image correlation compared with two-dimensional and Doppler ultrasonography. Prenat Diagn 2007;27:1147–1150.
  • Cruz-Martinez R, Figueras F, Benavides-Serralde A, Crispi F, Hernandez-Andrade E, Gratacos E. Sequence of changes in myocardial performance index in relation to aortic isthmus and ductus venosus Doppler in fetuses with early-onset intrauterine growth restriction. Ultrasound Obstet Gynecol 2011;38:179–184.
  • Hernandez-Andrade E, Crispi F, Benavides-Serralde JA, Plasencia W, Diesel HF, Eixarch E, Acosta-Rojas R, et al. Contribution of the myocardial performance index and aortic isthmus blood flow index to predicting mortality in preterm growth-restricted fetuses. Ultrasound Obstet Gynecol 2009;34:430–436.
  • Baschat AA, Cosmi E, Bilardo CM, Wolf H, Berg C, Rigano S, Germer U, et al. Predictors of neonatal outcome in early-onset placental dysfunction. Obstet Gynecol 2007;109:253–261.
  • Comas M, Crispi F, Cruz-Martinez R, Martinez JM, Figueras F, Gratacós E. Usefulness of myocardial tissue Doppler vs conventional echocardiography in the evaluation of cardiac dysfunction in early-onset intrauterine growth restriction. Am J Obstet Gynecol 2010;203:45.e1–45.e7.
  • Larsen LU, Petersen OB, Sloth E, Uldbjerg N. Color Doppler myocardial imaging demonstrates reduced diastolic tissue velocity in growth retarded fetuses with flow redistribution. Eur J Obstet Gynecol Reprod Biol 2011;155:140–145.
  • Comas M, Crispi F, Cruz-Martinez R, Figueras F, Gratacos E. Tissue Doppler echocardiographic markers of cardiac dysfunction in small-for-gestational age fetuses. Am J Obstet Gynecol 2011;205:57.e1–57.e6.
  • Tintu A, Rouwet E, Verlohren S, Brinkmann J, Ahmad S, Crispi F, van Bilsen M, et al. Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences. PLoS ONE 2009;4:e5155.
  • Barker DJ, Osmond C, Golding J, Kuh D, Wadsworth ME. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 1989;298:564–567.
  • Cosmi E, Visentin S, Fanelli T, Mautone AJ, Zanardo V. Aortic intima media thickness in fetuses and children with intrauterine growth restriction. Obstet Gynecol 2009;114:1109–1114.
  • Schwab M, Roedel M, Anwar MA, Müller T, Schubert H, Buchwalder LF, Walter B, Nathalielsz W. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol (Lond) 2000;528:619–632.
  • Derks JB, Giussani DA, Jenkins SL, Wentworth RA, Visser GH, Padbury JF, Nathanielsz PW. A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol (Lond) 1997;499 (Pt 1):217–226.
  • Jellyman JK, Gardner DS, Fowden AL, Giussani DA. Effects of dexamethasone on the uterine and umbilical vascular beds during basal and hypoxemic conditions in sheep. Am J Obstet Gynecol 2004;190:825–835.
  • Bennet L, Kozuma S, McGarrigle HH, Hanson MA. Temporal changes in fetal cardiovascular, behavioural, metabolic and endocrine responses to maternally administered dexamethasone in the late gestation fetal sheep. Br J Obstet Gynaecol 1999;106:331–339.
  • Koenen SV, Mecenas CA, Smith GS, Jenkins S, Nathanielsz PW. Effects of maternal betamethasone administration on fetal and maternal blood pressure and heart rate in the baboon at 0.7 of gestation. Am J Obstet Gynecol 2002;186:812–817.
  • Kari MA, Hallman M, Eronen M, Teramo K, Virtanen M, Koivisto M, Ikonen RS. Prenatal dexamethasone treatment in conjunction with rescue therapy of human surfactant: a randomized placebo-controlled multicenter study. Pediatrics 1994;93:730–736.
  • Moïse AA, Wearden ME, Kozinetz CA, Gest AL, Welty SE, Hansen TN. Antenatal steroids are associated with less need for blood pressure support in extremely premature infants. Pediatrics 1995;95:845–850.
  • Doyle LW, Ford GW, Davis NM, Callanan C. Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children. Clin Sci 2000;98:137–142.
  • Dalziel SR, Walker NK, Parag V, Mantell C, Rea HH, Rodgers A, Harding JE. Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial. Lancet 2005;365:1856–1862.
  • Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 1972;50:515–525.
  • Wallace EM, Baker LS. Effect of antenatal betamethasone administration on placental vascular resistance. Lancet 1999;353:1404–1407.
  • Edwards A, Baker LS, Wallace EM. Changes in umbilical artery flow velocity waveforms following maternal administration of betamethasone. Placenta 2003;24:12–16.
  • Edwards A, Baker LS, Wallace EM. Changes in fetoplacental vessel flow velocity waveforms following maternal administration of betamethasone. Ultrasound Obstet Gynecol 2002;20:240–244.
  • Barkehall-Thomas A, Thompson M, Baker LS, Edwards A, Wallace EM. Betamethasone associated changes in umbilical artery flow velocity waveforms in multiple pregnancies with umbilical artery absent end diastolic flow. Aust N Z J Obstet Gynaecol 2003;43:360–363.
  • Clifton VL, Wallace EM, Smith R. Short-term effects of glucocorticoids in the human fetal-placental circulation in vitro. J Clin Endocrinol Metab 2002;87:2838–2842.
  • Potter SM, Dennedy MC, Morrison JJ. Corticosteroids and fetal vasculature: effects of hydrocortisone, dexamethasone and betamethasone on human umbilical artery. BJOG 2002;109:1126–1131.
  • Miller SL, Supramaniam VG, Jenkin G, Walker DW, Wallace EM. Cardiovascular responses to maternal betamethasone administration in the intrauterine growth-restricted ovine fetus. Am J Obstet Gynecol 2009;201:613.e1–613.e8.
  • Jackson JR, Kleeman S, Doerzbacher M, Lambers DS. The effect of glucocorticosteroid administration on fetal movements and biophysical profile scores in normal pregnancies. J Matern Fetal Neonatal Med 2003;13:50–53.
  • Derks JB, Mulder EJ, Visser GH. The effects of maternal betamethasone administration on the fetus. Br J Obstet Gynaecol 1995;102:40–46.
  • Mulder EJ, Derks JB, Visser GH. Antenatal corticosteroid therapy and fetal behaviour: a randomised study of the effects of betamethasone and dexamethasone. Br J Obstet Gynaecol 1997;104:1239–1247.
  • Miller SL, Chai M, Loose J, Castillo-Meléndez M, Walker DW, Jenkin G, Wallace EM. The effects of maternal betamethasone administration on the intrauterine growth-restricted fetus. Endocrinology 2007;148:1288–1295.
  • Walker DM, Marlow N, Upstone L, Gross H, Hornbuckle J, Vail A, Wolke D, Thornton JG. The Growth Restriction Intervention Trial: long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction. Am J Obstet Gynecol 2011;204:34.e1–34.e9.
  • Baschat AA, Odibo AO. Timing of delivery in fetal growth restriction and childhood development: some uncertainties remain. Am J Obstet Gynecol 2011;204:2–3.
  • Robertson MC, Murila F, Tong S, Baker LS, Yu VY, Wallace EM. Predicting perinatal outcome through changes in umbilical artery Doppler studies after antenatal corticosteroids in the growth-restricted fetus. Obstet Gynecol 2009;113:636–640.
  • Piazze J, Dillon KC, Cerekja A. Betamethasone effects on umbilical arteries and ductus venosus waveforms in growth-restricted fetuses. J Matern Fetal Neonatal Med 2011. [Epub ahead of print October 20, 2011; doi:10.3109/14767058.2011.624216].
  • Doyle LW, Crowther CA, Middleton P, Marret S, Rouse D. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev 2009; CD004661.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.