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Original Article

Asymmetric dimethylarginine and l-arginine levels in neonatal sepsis and septic shock

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Pages 977-982 | Received 29 Jan 2014, Accepted 26 Jun 2014, Published online: 22 Jul 2014

References

  • Haque KN. Definitions of bloodstream infection in the newborn. Pediatr Crit Care Med 2005;6:45–9
  • Kermorvant-Duchemin E, Laborie S, Rabilloud M, et al. Outcome and prognostic factors in neonates with septic shock. Pediatr Crit Care Med 2008;9:186–91
  • Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003;101:3765–7
  • Pohl U, Wagner K, de Wit C. Endothelium-derived nitric oxide in the control of tissue perfusion and oxygen supply: physiological and pathophysiological implications. Eur Heart J 1993;14:93–8
  • Moncada S, Higgs A. The l-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002–12
  • Vincent JL, Zhang H, Szabo C, Preiser JC. Effects of nitric oxide in septic shock. Am J Respir Crit Care Med 2000;161:1781–5
  • De Cruz SJ, Kenyon NJ, Sandrock CE. Bench-to-bedside review: the role of nitric oxide in sepsis. Expert Rev Respir Med 2009;3:511–21
  • Kilbourn R. The discovery of nitric oxide as a key mediator in septic shock. Sepsis 1998;1:85–91
  • López A, Lorente JA, Steingrub J, et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 2004;32:21–30
  • Vallance P, Leone A, Calver A, et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992;339:572–5
  • O'Dwyer MJ, Dempsey F, Crowley V, et al. Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study. Crit Care 2006;10:139
  • Davis JS, Darcy CJ, Yeo TW, et al. Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis. PLoS One 2011;6:17260
  • Argaman Z, Young VR, Noviski N, et al. Arginine and nitric oxide metabolism in critically ill septic pediatric patients. Crit Care Med 2003;31:591–7
  • Davis JS, Anstey NM. Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysis. Crit Care Med 2011;39:380–5
  • Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005;6:2–8
  • Cardounel AJ, Cui H, Samouilov A, et al. Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function. J Biol Chem 2007;282:879–87
  • Böger RH, Sullivan LM, Schwedhelm E, et al. Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community. Circulation 2009;119:1592–600
  • Goonasekera CD, Rees DD, Woolard P, et al. Nitric oxide synthase inhibitors and hypertension in children and adolescents. J Hypertens 1997;15:901–9
  • Brooks ER, Langman CB, Wang S, et al. Methylated arginine derivatives in children and adolescents with chronic kidney disease. Pediatr Nephrol 2009;24:129–34
  • Tain YL, Huang LT. Asymmetric dimethylarginine: clinical applications in pediatric medicine. J Formos Med Assoc 2011;110:70–7
  • Alfiero Bordigato M, Piva D, Di Gangi IM, et al. Asymmetric dimethylarginine in ELBW newborns exposed to chorioamnionitis. Early Hum Dev 2011;87:143–5
  • Weiss SL, Haymond S, Ralay Ranaivo H, et al. Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis. Pediatr Crit Care Med 2012;13:210–18
  • Leiper J, Murray-Rust J, McDonald N, Vallance P. S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proc Natl Acad Sci U S A 2002;99:13527–32
  • Richir MC, Siroen MP, van Elburg RM, et al. Low plasma concentrations of arginine and asymmetric dimethylarginine in premature infants with necrotizing enterocolitis. Br J Nutr 2007;97:906–11
  • Nijveldt RJ, Teerlink T, van Leeuwen PA. The asymmetrical dimethylarginine (ADMA)-multiple organ failure hypothesis. Clin Nutr 2003;22:99–104
  • Leiper J, Vallance P. The synthesis and metabolism of asymmetric dimethyarginine (ADMA). Eur J Clin Pharmacol 2006;62:33–8
  • Druml W, Heinzel G, Kleinberger G. Amino acid kinetics in patients with sepsis. Am J Clin Nutr 2001;73:908–13
  • Luiking YC, Poeze M, Ramsay G, Deutz NE. Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production. Am J Clin Nutr 2009;89:142–52
  • Oladipo OO, Weindel AL, Saunders AN, Dietzen DJ. Impact of premature birth and critical illness on neonatal range of plasma amino acid concentrations determined by LC-MS/MS. Mol Genet Metab 2011;104:476–9

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