Infants at risk of cerebral palsy: a systematic review of outcomes used in Cochrane studies of pregnancy, childbirth and neonatology

References

• Stanley F, Blair E, Alberman E. Cerebral palsies: epidemiology and causal pathways. Clinics in developmental medicine. No. 151. London: Mac Keith Press; 2000
   Google Scholar
• Novak I, Hines M, Goldsmith S, Barclay R. Clinical prognostic messages from a systematic review on cerebral palsy. Pediatrics 2012;130:e1285–312
   PubMed Web of Science ®Google Scholar
• van Haastert IC, Groenendaal F, Uiterwaal CS, et al. Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 2011;159:86–91 e81
   PubMed Web of Science ®Google Scholar
• Blair E, Watson L. Epidemiology of cerebral palsy. Semin Fetal Neonatal Med 2006;11:117–25
   PubMed Web of Science ®Google Scholar
• Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2006;(3):CD004454
   PubMedGoogle Scholar
• Doyle LW, Crowther CA, Middleton P, Marret S. Antenatal magnesium sulfate and neurologic outcome in preterm infants: a systematic review. Obstet Gynecol 2009;113:1327–33
   PubMed Web of Science ®Google Scholar
• Higgins JP, Green S, eds. Cochrane handbook for systematic reviews of interventions: Cochrane Book Series. Chichester, UK: John Wiley & Sons, Ltd; 2008
   Google Scholar
• Soll RF. Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. Cochrane Database Syst Rev 1999;(4):CD001456
   Google Scholar
• Pfister RH, Soll RF, Wiswell T. Protein containing synthetic surfactant versus animal derived surfactant extract for the prevention and treatment of respiratory distress syndrome. Cochrane Database Syst Rev 2007;(4):CD006069
   PubMedGoogle Scholar
• El Shahed AI, Dargaville P, Ohlsson A, Soll RF. Surfactant for meconium aspiration syndrome in full term/near term infants. Cochrane Database Syst Rev 2007;(3):CD002054
   PubMed Web of Science ®Google Scholar
• Crowther CA, McKinlay CJ, Middleton P, Harding JE. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes. Cochrane Database Syst Rev 2011;(6):CD003935
   PubMed Web of Science ®Google Scholar
• Ward M, Sinn J. Steroid therapy for meconium aspiration syndrome in newborn infants. Cochrane Database Syst Rev 2003;(4):CD003485
   PubMedGoogle Scholar
• Gortner L, Wauer RR, Hammer H, et al. Early versus late surfactant treatment in preterm infants of 27 to 32 weeks' gestational age: a multicenter controlled clinical trial. Pediatrics 1998;102:1153–60
   PubMed Web of Science ®Google Scholar
• Konishi M, Fujiwara T, Chida S, et al. A prospective, randomized trial of early versus late administration of a single dose of surfactant-TA. Early Hum Dev 1992;29:275–82
   PubMed Web of Science ®Google Scholar
• OSIRIS Collaborative Group. Early versus delayed neonatal administration of a synthetic surfactant – the judgment of OSIRIS. The OSIRIS Collaborative Group (open study of infants at high risk of or with respiratory insufficiency – the role of surfactant. Lancet 1992;340:1363–9
   PubMedGoogle Scholar
• Moya FR, Gadzinowski J, Bancalari E, et al. A multicenter, randomized, masked, comparison trial of lucinactant, colfosceril palmitate, and beractant for the prevention of respiratory distress syndrome among very preterm infants. Pediatrics 2005;115:1018–29
   PubMed Web of Science ®Google Scholar
• Sinha SK, Lacaze-Masmonteil T, Valls i Soler A, et al. A multicenter, randomized, controlled trial of lucinactant versus poractant alfa among very premature infants at high risk for respiratory distress syndrome. Pediatrics 2005;115:1030–8
   PubMed Web of Science ®Google Scholar
• Chinese Collaborative Study Group for Neonatal Respiratory Diseases. Treatment of severe meconium aspiration syndrome with porcine surfactant: a multicentre, randomized, controlled trial. Acta Pædiatrica 2005;94:896–902
   PubMed Web of Science ®Google Scholar
• Findlay R, Taeusch H, Walther F. Surfactant replacement therapy for meconium aspiration syndrome. Pediatrics 1996;97:48–52
   PubMed Web of Science ®Google Scholar
• Lotze A, Mitchell B, Bulas D, et al. Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure. J Pediatr 1998;132:40–7
   PubMed Web of Science ®Google Scholar
• Crowther CA, Haslam RR, Hiller JE, et al. Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomised controlled trial. Lancet 2006;367:1913–19
   PubMed Web of Science ®Google Scholar
• Garite TJ, Kurtzman J, Maurel K, Clark R. Impact of a ‘rescue course' of antenatal corticosteroids: a multicenter randomized placebo-controlled trial. Am J Obstet Gynecol 2009;200:248 e241–9
   Google Scholar
• Guinn DA, Atkinson MW, Sullivan L, et al. Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: a randomized controlled trial. JAMA 2001;286:1581–7
   PubMed Web of Science ®Google Scholar
• Mazumder P, Dutta S, Kaur J, Narang A. Single versus multiple courses of antenatal betamethasone and neonatal outcome: a randomized controlled trial. Indian Pediatr 2008;45:661–7
   PubMed Web of Science ®Google Scholar
• McEvoy C, Schilling D, Peters D, et al. Respiratory compliance in preterm infants after a single rescue course of antenatal steroids: a randomized controlled trial. Am J Obstet Gynecol 2010;202:544 e541–9
   Google Scholar
• McEvoy C, Bowling S, Williamson K, et al. The effect of a single remote course versus weekly courses of antenatal corticosteroids on functional residual capacity in preterm infants: a randomized trial. Pediatrics 2002;110:280–4
   PubMed Web of Science ®Google Scholar
• Murphy KE, Hannah ME, Willan AR, et al. Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet 2008;372:2143–51
   PubMed Web of Science ®Google Scholar
• Peltoniemi OM, Kari MA, Tammela O, et al. Randomized trial of a single repeat dose of prenatal betamethasone treatment in imminent preterm birth. Pediatrics 2007;119:290–8
   PubMed Web of Science ®Google Scholar
• Wapner RJ, Sorokin Y, Thom EA, et al. Single versus weekly courses of antenatal corticosteroids: evaluation of safety and efficacy. Am J Obstet Gynecol 2006;195:633–42
   PubMed Web of Science ®Google Scholar
• Amorim MM, Santos LC, Faundes A. Corticosteroid therapy for prevention of respiratory distress syndrome in severe preeclampsia. Am J Obstet Gynecol 1999;180:1283–8
   PubMed Web of Science ®Google Scholar
• Block MF, Kling OR, Crosby WM. Antenatal glucocorticoid therapy for the prevention of respiratory distress syndrome in the premature infant. Obstet Gynecol 1977;50:186–90
   PubMed Web of Science ®Google Scholar
• Collaborative Group on Antenatal Steroid Therapy. Effect of antenatal dexamethasone administration on the prevention of respiratory distress syndrome. Am J Obstet Gynecol 1981;141:276–87
   PubMed Web of Science ®Google Scholar
• Pattinson RC, Makin JD, Funk M, et al. The use of dexamethasone in women with preterm premature rupture of membranes – a multicentre, double-blind, placebo-controlled, randomised trial. Dexiprom Study Group. S Afr Med J 1999;89:865–70
   PubMed Web of Science ®Google Scholar
• Doran TA, Swyer P, MacMurray B, et al. Results of a double-blind controlled study on the use of betamethasone in the prevention of respiratory distress syndrome. Am J Obstet Gynecol 1980;136:313–20
   PubMed Web of Science ®Google Scholar
• Gamsu HR, Mullinger BM, Donnai P, Dash CH. Antenatal administration of betamethasone to prevent respiratory distress syndrome in preterm infants: report of a UK multicentre trial. Br J Obstet Gynaecol 1989;96:401–10
   PubMedGoogle Scholar
• Garite TJ, Rumney PJ, Briggs GG, et al. A randomized, placebo-controlled trial of betamethasone for the prevention of respiratory distress syndrome at 24 to 28 weeks' gestation. Am J Obstet Gynecol 1992;166:646–51
   PubMed Web of Science ®Google Scholar
• Kari MA, Hallman M, Eronen M, et al. Prenatal dexamethasone treatment in conjunction with rescue therapy of human surfactant: a randomized placebo-controlled multicenter study. Pediatrics 1994;93:730–6
   PubMed Web of Science ®Google Scholar
• Lewis DF, Brody K, Edwards MS, et al. Preterm premature ruptured membranes: a randomized trial of steroids after treatment with antibiotics. Obstet Gynecol 1996;88:801–5
   PubMed Web of Science ®Google Scholar
• Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 1972;50:515–25
   PubMed Web of Science ®Google Scholar
• Morales WJ, Angel JL, O'Brien WF, Knuppel RA. Use of ampicillin and corticosteroids in premature rupture of membranes: a randomized study. Obstet Gynecol 1989;73:721–6
   PubMed Web of Science ®Google Scholar
• Nelson LH, Meis PJ, Hatjis CG, et al. Premature rupture of membranes: a prospective, randomized evaluation of steroids, latent phase, and expectant management. Obstet Gynecol 1985;66:55–8
   PubMed Web of Science ®Google Scholar
• Qublan HS, Malkawi HY, Hiasat MS, et al. The effect of antenatal corticosteroid therapy on pregnancies complicated by premature rupture of membranes. Clin Exp Obstet Gynecol 2001;28:183–6
   PubMedGoogle Scholar
• Schutte MF, Treffers PE, Koppe JG, Breur W. The influence of betamethasone and orciprenaline on the incidence of respiratory distress syndrome in the newborn after preterm labor. Br J Obstet Gynaecol 1980;87:127–31
   PubMedGoogle Scholar
• Silver RK, Vyskocil C, Solomon SL, et al. Randomized trial of antenatal dexamethasone in surfactant-treated infants delivered before 30 weeks' gestation. Obstet Gynecol 1996;87:683–91
   PubMed Web of Science ®Google Scholar
• Taeusch Jr HW, Frigoletto F, Kitzmiller J, et al. Risk of respiratory distress syndrome after prenatal dexamethasone treatment. Pediatrics 1979;63:64–72
   PubMed Web of Science ®Google Scholar
• Teramo K, Hallman M, Raivio KO. Maternal glucocorticoid in unplanned premature labor. Controlled study on the effects of betamethasone phosphate on the phospholipids of the gastric aspirate and on the adrenal cortical function of the newborn infant. Pediatr Res 1980;14:326–9
   PubMed Web of Science ®Google Scholar
• Wu JM, Yeh TF, Wang JY, et al. The role of pulmonary inflammation in the development of pulmonary hypertension in newborn with meconium aspiration syndrome (MAS). Pediatr Pulmonol Suppl 1999;18:205–8
   PubMedGoogle Scholar
• King J, Flenady V, Murray L. Prophylactic antibiotics for inhibiting preterm labor with intact membranes. Cochrane Database Syst Rev 2002;(4):CD000246
   PubMedGoogle Scholar
• King JF, Flenady VJ, Papatsonis DN, et al. Calcium channel blockers for inhibiting preterm labor. Cochrane Database Syst Rev 2003;(1):CD002255
   PubMedGoogle Scholar
• Cox SM, Bohman VR, Sherman ML, Leveno KJ. Randomized investigation of antimicrobials for the prevention of preterm birth. Am J Obstet Gynecol 1996;174:206–10
   PubMed Web of Science ®Google Scholar
• Gordon M, Samuels P, Shubert P, et al. A randomized, prospective study of adjunctive ceftizoxime in preterm labor. Am J Obstet Gynecol 1995;172:1546–52
   PubMed Web of Science ®Google Scholar
• Kenyon SL, Taylor DJ, Tarnow-Mordi W. Broad-spectrum antibiotics for preterm, prelabor rupture of fetal membranes: the ORACLE I randomised trial. Lancet 2001;357:979–88
   PubMed Web of Science ®Google Scholar
• McGregor JA, French JI, Seo K. Adjunctive clindamycin therapy for preterm labor: results of a double-blind, placebo-controlled trial. Am J Obstet Gynecol 1991;165:867–75
   PubMed Web of Science ®Google Scholar
• Newton E, Shields L, Ridgway L, et al. Combination antibiotics and indomethacin in idiopathic preterm labor: a randomized double-blind clinical trial. Am J Obstet Gynecol 1991;165:1753–9
   PubMed Web of Science ®Google Scholar
• Newton ER, Dinsmoor MJ, Gibbs RS. A randomized, blinded, placebo-controlled trial of antibiotics in idiopathic preterm labor. Obstet Gynecol 1989;74:562–6
   PubMed Web of Science ®Google Scholar
• Norman K, Pattinson RC, de Souza J, et al. Ampicillin and metronidazole treatment in preterm labor: a multicentre, randomised controlled trial. BJOG 1994;101:404–8
   Web of Science ®Google Scholar
• Oyarzún E, Gómez R, Rioseco A, et al. Antibiotic treatment in preterm labor and intact membranes: a randomized, double-blinded, placebo-controlled trial. J Matern Fetal Neonatal Med 1998;7:105–10
   Google Scholar
• Romero R, Sibai B, Caritis S, et al. Antibiotic treatment of preterm labor with intact membranes: a multicenter, randomized, double-blinded, placebo-controlled trial. Am J Obstet Gynecol 1993;169:764–74
   PubMed Web of Science ®Google Scholar
• Svare J, Langhoff-Roos J, Andersen LF, et al. Ampicillin-metronidazole treatment in idiopathic preterm labor: a randomised controlled multicentre trial. BJOG 1997;104:892–7
   Web of Science ®Google Scholar
• Watts H, Krohn M, Hillier S, Eschenbach D. Randomized trial of antibiotics in addition to tocolytic therapy to treat preterm labor. Infect Dis Obstet Gynecol 1994;1:220–7
   PubMedGoogle Scholar
• Bracero LA, Leikin E, Kirshenbaum N, Tejani N. Comparison of nifedipine and ritodrine for the treatment of preterm labor. Am J Perinatol 1991;8:365–9
   PubMed Web of Science ®Google Scholar
• Ferguson J, Dyson D, Schutz T, Stevenson D. A comparison of tocolysis with nifedipine or ritodrine: analysis of efficacy and maternal, fetal, and neonatal outcome. Am J Obstet Gynecol 1990;163:105–11
   PubMed Web of Science ®Google Scholar
• García-Velasco JA, González González A. A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor. Int J Gynecol Obstetr 1998;61:239–44
   PubMed Web of Science ®Google Scholar
• Glock J, Morales W. Efficacy and safety of nifedipine versus magnesium sulfate in the management of preterm labor: a randomized study. Am J Obstet Gynecol 1993;169:960–4
   PubMed Web of Science ®Google Scholar
• Jannet D, Abankwa A, Guyard B, et al. Nicardipine versus salbutamol in the treatment of premature labor. A prospective randomized study. Eur J Obstetr Gynecol Reprod Biol 1997;73:11–16
   PubMed Web of Science ®Google Scholar
• Koks CAM, Brölmann HAM, de Kleine MJK, Manger PA. A randomized comparison of nifedipine and ritodrine for suppression of preterm labor. Eur J Obstetr Gynecol Reprod Biol 1998;77:171–6
   PubMed Web of Science ®Google Scholar
• Kupferminc M, Lessing JB, Yaron Y, Peyser MR. Nifedipine versus ritodrine for suppression of preterm labor. BJOG 1993;100:1090–4
   Web of Science ®Google Scholar
• Larmon JE, Ross BS, May WL, Dickerson GA, Fischer RG, Morrison JC. Oral nicardipine versus intravenous magnesium sulfate for the treatment of preterm labor. Am J Obstet Gynecol 1999; 181:1432–7
   PubMed Web of Science ®Google Scholar
• Papatsonis DNM, Dekker GA. Nifedipine and ritodrine in the management of preterm labor: a randomized multicenter trial. Obstet Gynecol 1997;90:230–4
   PubMed Web of Science ®Google Scholar
• Read MD, Wellby DE. The use of a calcium antagonist (nifedipine) to suppress preterm labor. BJOG 1986;93:933–7
   Web of Science ®Google Scholar
• Weerakul W, Chittacharoen A, Suthutvoravut S. Nifedipine versus terbutaline in management of preterm labor. Int J Gynaecol Obstet 2002;76:311–13
   PubMed Web of Science ®Google Scholar
• Dodd JM, McLeod A, Windrim RC, Kingdom J. Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction. Cochrane Database Syst Rev 2010;(6):CD006780
   PubMed Web of Science ®Google Scholar
• Duley L, Matar HE, Almerie MQ, Hall DR. Alternative magnesium sulphate regimens for women with pre-eclampsia and eclampsia. Cochrane Database Syst Rev 2010;(8):CD007388
   PubMed Web of Science ®Google Scholar
• Duley L, Henderson-Smart DJ, Meher S, King JF. Antiplatelet agents for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev 2007;(2):CD004659
   PubMed Web of Science ®Google Scholar
• Hofmeyr GJ, Lawrie TA, Atallah AN, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2010;(8):CD001059
   PubMed Web of Science ®Google Scholar
• Kincaid-Smith P, North RA, Fairley KF, et al. Prevention of pre-eclampsia in high risk women with renal disease: a prospective randomized trial of heparin and dipyridamole. Nephrology 1995;1:297–300
   Google Scholar
• Mello G, Parretti E, Fatini C, et al. Low-molecular-weight heparin lowers the recurrence rate of preeclampsia and restores the physiological vascular changes in angiotensin-converting enzyme DD women. Hypertension 2005;45:86–91
   PubMed Web of Science ®Google Scholar
• Rey E, Garneau P, David M, et al. Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia: a pilot randomized controlled trial. J Thromb Haemost 2009;7:58–64
   PubMed Web of Science ®Google Scholar
• Begum MR, Begum A, Quadir E. Loading dose versus standard regime of magnesium sulfate in the management of eclampsia: a randomized trial. J Obstet Gynaecol Res 2002;28:154–9
   PubMed Web of Science ®Google Scholar
• Shilva, Saha SC, Kalra J, Prasad R. Safety and efficacy of low-dose MgSO4 in the treatment of eclampsia. Int J Gynaecol Obstet 2007;97:150–1
   PubMed Web of Science ®Google Scholar
• Chissell S, Botha J, Moodley J, McFadyen L. Intravenous and intramuscular magnesium sulphate regimens in severe pre-eclampsia. S Afr Med J 1994;84:607–10
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang Y, Canzoneri BJ, et al. Prostacyclin and thromboxane levels in women with severe preeclampsia undergoing magnesium sulfate therapy during antepartum and postpartum periods. Hypertens Pregnancy 2008;27:17–27
   PubMed Web of Science ®Google Scholar
• Ehrenberg HM, Mercer BM. Abbreviated postpartum magnesium sulfate therapy for women with mild preeclampsia: a randomized controlled trial. Obstet Gynecol 2006;108:833–8
   PubMed Web of Science ®Google Scholar
• CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Group. CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet 1994;343:619–29
   PubMed Web of Science ®Google Scholar
• Ebrashy A, Ibrahim M, Marzook A, Yousef D. Usefulness of aspirin therapy in high-risk pregnant women with abnormal uterine artery Doppler ultrasound at 14–16 weeks pregnancy: randomized controlled clinical trial. Croat Med J 2005;46:826–31
   PubMed Web of Science ®Google Scholar
• Gallery ED, Ross MR, Hawkins M, et al. Low-dose aspirin in high-risk pregnancy? Hypertens Pregnancy 1997;16:229–38
   Web of Science ®Google Scholar
• Grab D, Paulus WE, Erdmann M, et al. Effects of low-dose aspirin on uterine and fetal blood flow during pregnancy: results of a randomized, placebo-controlled, double-blind trial. Ultrasound Obstet Gynecol 2000;15:19–27
   PubMed Web of Science ®Google Scholar
• Morris JM, Fay RA, Ellwood DA, et al. A randomized controlled trial of aspirin in patients with abnormal uterine artery blood flow. Obstet Gynecol 1996;87:74–8
   PubMed Web of Science ®Google Scholar
• Newnham JP, Godfrey M, Walters BJ, et al. Low dose aspirin for the treatment of fetal growth restriction: a randomized controlled trial. Aust N Z J Obstet Gynaecol 1995;35:370–4
   PubMed Web of Science ®Google Scholar
• Rogers MS, Fung HY, Hung CY. Calcium and low-dose aspirin prophylaxis in women at high risk of pregnancy-induced hypertension. Hypertens Pregnancy 1999;18:165–72
   PubMed Web of Science ®Google Scholar
• Rotchell YE, Cruickshank JK, Gay MP, et al. Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications. Br J Obstet Gynaecol 1998;105:286–92
   PubMedGoogle Scholar
• Roy UK, Pan S. A study of use of low dose aspirin in prevention of pregnancy induced hypertension. J Indian Med Assoc 1994;92:188–91
   PubMedGoogle Scholar
• Schrocksnadel H, Sitte B, Alge A, et al. Low-dose aspirin in primigravidae with positive roll-over test. Gynecol Obstet Invest 1992;34:146–50
   PubMed Web of Science ®Google Scholar
• Subtil D, Goeusse P, Puech F, et al. Aspirin (100 mg) used for prevention of pre-eclampsia in nulliparous women: the Essai Regional Aspirine Mere-Enfant study (Part 1). BJOG 2003;110:475–84
   PubMed Web of Science ®Google Scholar
• Trudinger BJ, Cook CM, Thompson RS, et al. Low-dose aspirin therapy improves fetal weight in umbilical placental insufficiency. Am J Obstet Gynecol 1988;159:681–5
   PubMed Web of Science ®Google Scholar
• Tulppala M, Marttunen M, Soderstrom-Anttila V, et al. Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production. Hum Reprod 1997;12:1567–72
   PubMed Web of Science ®Google Scholar
• Uzan S, Beaufils M, Breart G, et al. Prevention of fetal growth retardation with low-dose aspirin: findings of the EPREDA trial. Lancet 1991;337:1427–31
   PubMed Web of Science ®Google Scholar
• Vainio M, Kujansuu E, Iso-Mustajarvi M, Maenpaa J. Low dose acetylsalicylic acid in prevention of pregnancy-induced hypertension and intrauterine growth retardation in women with bilateral uterine artery notches. BJOG 2002;109:161–7
   PubMed Web of Science ®Google Scholar
• Viinikka L, Hartikainen-Sorri AL, Lumme R, et al. Low dose aspirin in hypertensive pregnant women: effect on pregnancy outcome and prostacyclin-thromboxane balance in mother and newborn. BJOG 1993;100:809–15
   Web of Science ®Google Scholar
• Wang Z, Li W. A prospective randomized placebo-controlled trial of low-dose aspirin for prevention of intra-uterine growth retardation. Chin Med J (Engl) 1996;109:238–42
   PubMed Web of Science ®Google Scholar
• Zimmermann P, Eirio V, Koskinen J, et al. Effect of low-dose aspirin treatment on vascular resistance in the uterine, uteroplacental, renal and umbilical arteries – a prospective longitudinal study on a high risk population with persistent notch in the uterine arteries. Eur J Ultrasound 1997;5:17–30
   Google Scholar
• Belizán JM, Villar J, Gonzalez L, et al. Calcium supplementation to prevent hypertensive disorders of pregnancy. N Engl J Med 1991;325:1399–405
   PubMed Web of Science ®Google Scholar
• Crowther CA, Hiller JE, Pridmore B, et al. Calcium supplementation in nulliparous women for the prevention of pregnancy-induced hypertension, preeclampsia and preterm birth: an Australian randomized trial. Aust NZ J Obstet Gynaecol 1999;39:12–18
   PubMed Web of Science ®Google Scholar
• Kumar A, Devi SG, Batra S, et al. Calcium supplementation for the prevention of pre-eclampsia. Int J Gynaecol Obstet 2009;104:32–6
   PubMed Web of Science ®Google Scholar
• Levine RJ, Hauth JC, Curet LB, et al. Trial of calcium to prevent preeclampsia. N Engl J Med 1997;337:69–77
   PubMed Web of Science ®Google Scholar
• López-Jaramillo P, Delgado F, Jácome P, et al. Calcium supplementation and the risk of preeclampsia in ecuadorian pregnant teenagers. Obstet Gynecol 1997;90:162–7
   PubMed Web of Science ®Google Scholar
• López-Jaramillo P, Narváez M, Wetgel RM, Yépez R. Calcium supplementation reduces the risk of pregnancy-induced hypertension in an Andes population. BJOG 1989;96:648–55
   Web of Science ®Google Scholar
• Niromanesh S, Laghaii S, Mosavi-Jarrahi A. Supplementary calcium in prevention of pre-eclampsia. Int J Gynecol Obstetr 2001;74:17–21
   PubMed Web of Science ®Google Scholar
• Purwar M, Kulkarni H, Motghare V, Dhole S. Calcium supplementation and prevention of pregnancy induced hypertension. Asia Oceania J Obstet Gynaecol 1996;22:425–30
   Google Scholar
• Sanchez-Ramos L, Briones DK, Kaunitz AM, et al. Prevention of pregnancy-induced hypertension by calcium supplementation in angiotensin II-sensitive patients. Obstet Gynecol 1994;84:349–53
   PubMed Web of Science ®Google Scholar
• Villar J, Abdel-Aleem H, Merialdi M, et al. World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women. Am J Obstet Gynecol 2006;194:639–49
   PubMed Web of Science ®Google Scholar
• Villar J, Repke J, Belizan JM, Pareja G. Calcium supplementation reduces blood pressure during pregnancy: results of a randomized controlled clinical trial. Obstet Gynecol 1987;70:317–22
   PubMed Web of Science ®Google Scholar
• Villar J, Repke JT. Calcium supplementation during pregnancy may reduce preterm delivery in high-risk populations. Am J Obstet Gynecol 1990;163:1124–31
   PubMed Web of Science ®Google Scholar
• McDonald HM, Brocklehurst P, Gordon A. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev 2007;(1):CD000262
   PubMed Web of Science ®Google Scholar
• Ohlsson A, Lacy J. Intravenous immunoglobulin for suspected or subsequently proven infection in neonates. Cochrane Database Syst Rev 2010;(3):CD001239
   PubMed Web of Science ®Google Scholar
• Ohlsson A, Lacy JB. Intravenous immunoglobulin for preventing infection in preterm and/or low-birth-weight infants. Cochrane Database Syst Rev 2004;(1):CD000361
   PubMedGoogle Scholar
• Siriwachirachai T, Sangkomkamhang US, Lumbiganon P, Laopaiboon M. Antibiotics for meconium-stained amniotic fluid in labor for preventing maternal and neonatal infections. Cochrane Database Syst Rev 2010;(12):CD007772
   PubMed Web of Science ®Google Scholar
• Carey JC, Klebanoff MA, Hauth JC, et al. Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med 2000;342:534–40
   PubMed Web of Science ®Google Scholar
• Duff P, Lee ML, Hillier SL, et al. Amoxicillin treatment of bacterial vaginosis during pregnancy. Obstet Gynecol 1991;77:431–5
   PubMed Web of Science ®Google Scholar
• Guaschino S, Ricci E, Franchi M, et al. Treatment of asymptomatic bacterial vaginosis to prevent pre-term delivery: a randomised trial. Eur J Obstetr Gynecol Reprod Biol 2003;110:149–52
   PubMed Web of Science ®Google Scholar
• Hauth JC, Goldenberg RL, Andrews WW, et al. Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. N Engl J Med 1995;333:1732–6
   PubMed Web of Science ®Google Scholar
• Joesoef MR, Hillier SL, Wiknjosastro G, et al. Intravaginal clindamycin treatment for bacterial vaginosis: effects on preterm delivery and low birth weight. Am J Obstet Gynecol 1995;173:1527–31
   PubMed Web of Science ®Google Scholar
• Kekki M, Kurki T, Pelkonen J, et al. Vaginal clindamycin in preventing preterm birth and peripartal infections in asymptomatic women with bacterial vaginosis: a randomized, controlled trial. Obstet Gynecol 2001;97:643–8
   PubMed Web of Science ®Google Scholar
• Kiss H, Petricevic L, Husslein P. Prospective randomised controlled trial of an infection screening programme to reduce the rate of preterm delivery. BMJ 2004;329:371
   PubMed Web of Science ®Google Scholar
• Klebanoff MA, Carey JC, Hauth JC, et al. Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection. N Engl J Med 2001;345:487–93
   PubMed Web of Science ®Google Scholar
• Lamont RF, Duncan SL, Mandal D, Bassett P. Intravaginal clindamycin to reduce preterm birth in women with abnormal genital tract flora. Obstet Gynecol 2003;101:516–22
   PubMed Web of Science ®Google Scholar
• McDonald HM, O'Loughlin JA, Vigneswaran R, et al. Impact of metronidazole therapy on preterm birth in women with bacterial vaginosis flora (Gardnerella vaginalis): a randomised, placebo controlled trial. Br J Obstet Gynaecol 1997;104:1391–7
   PubMedGoogle Scholar
• Odendaal HJ, Popov I, Schoeman J, et al. Preterm labor – is bacterial vaginosis involved? S Afr Med J 2002;92:231–4
   PubMed Web of Science ®Google Scholar
• Ugwumadu A, Manyonda I, Reid F, Hay P. Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomised controlled trial. Lancet 2003;361:983–8
   PubMed Web of Science ®Google Scholar
• Vermeulen GM, Bruinse HW. Prophylactic administration of clindamycin 2% vaginal cream to reduce the incidence of spontaneous preterm birth in women with an increased recurrence risk: a randomised placebo-controlled double-blind trial. BJOG 1999;106:652–7
   Web of Science ®Google Scholar
• Ahmed SS, Chowdhury MA, Hoque MM, et al. Role of intravenous immunoglobulin (IVIG) as an adjuvant in the treatment of neonatal sepsis in preterm babies. J Bangladesh Coll Phys Surg 2006;24:97–104
   Google Scholar
• Chen JY. Intravenous immunoglobulin in the treatment of full-term and premature newborns with sepsis. J Formos Med Assoc 1996;95:839–44
   PubMed Web of Science ®Google Scholar
• Christensen RD, Brown MS, Hall DC, et al. Effect on neutrophil kinetics and serum opsonic capacity of intravenous administration of immune globulin to neonates with clinical signs of early-onset sepsis. J Pediatr 1991;118:606–14
   PubMed Web of Science ®Google Scholar
• Erdem G, Yurdakok M, Tekinalp G, Ersoy F. The use of IgM-enriched intravenous immunoglobulin for the treatment of neonatal sepsis in preterm infants. Turk J Pediatr 1993;35:277–81
   PubMed Web of Science ®Google Scholar
• Haque KN, Zaidi MH, Bahakim H. IgM-enriched intravenous immunoglobulin therapy in neonatal sepsis. Arch Pediatr Adolesc Med 1988;142:1293–6
   Google Scholar
• Shenoi A, Nagesh NK, Maiya PP, et al. Multicenter randomized placebo controlled trial of therapy with intravenous immunoglobulin in decreasing mortality due to neonatal sepsis. Indian Pediatr 1999;36:1113–18
   PubMedGoogle Scholar
• Sidiropoulos D, Bohme U, von Muralt G, et al. Immunoglobulin substitution in the treatment of neonatal septicemia. Schweizerische Medizinische Wochenschrift 1981;111:1649–55
   PubMedGoogle Scholar
• Weisman LE, Stoll BJ, Kueser TJ, et al. Intravenous immune globulin therapy for early-onset sepsis in premature neonates. J Pediatr 1992;121:434–43
   PubMed Web of Science ®Google Scholar
• Atici A, Satar M, Karabay A, Yilmaz M. Intravenous immunoglobulin for prophylaxis of nosocomial sepsis. Indian J Pediatr 1996;63:517–21
   PubMedGoogle Scholar
• Baker CJ, Melish ME, Hall RT, et al. Intravenous immune globulin for the prevention of nosocomial infection in low-birth-weight neonates. The Multicenter Group for the Study of Immune Globulin in Neonates. N Engl J Med 1992;327:213–19
   PubMed Web of Science ®Google Scholar
• Bussel JB. Intravenous gammaglobulin in the prophylaxis of late sepsis in very-low-birth-weight infants: preliminary results of a randomized, double-blind, placebo-controlled trial. Clin Infect Dis 1990;12:S457–62
   Google Scholar
• Chirico G, Rondini G, Plebani A, et al. Intravenous gammaglobulin therapy for prophylaxis of infection in high-risk neonates. J Pediatr 1987;110:437–42
   PubMed Web of Science ®Google Scholar
• Conway SP, Ng PC, Howel D, et al. Prophylactic intravenous immunoglobulin in pre-term infants: a controlled trial. Vox Sang 1990;59:6–11
   PubMed Web of Science ®Google Scholar
• Didato MA, Gioeli R, Priolisi A. The use of intravenous gamma-globulin for prevention of sepsis in pre-term infants. A controlled clinical trial. Helv Paediatr Acta 1989;43:283–94
   PubMedGoogle Scholar
• Fanaroff AA, Korones SB, Wright LL, et al. A controlled trial of intravenous immune globulin to reduce nosocomial infections in very-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. N Engl J Med 1994;330:1107–13
   PubMed Web of Science ®Google Scholar
• Haque KN, Zaidi MH, Haque SK, et al. Intravenous immunoglobulin for prevention of sepsis in preterm and low birth weight infants. Pediatr Infect Dis 1986;5:622–5
   PubMedGoogle Scholar
• Magny JF, Bremard-Oury C, Brault D, et al. Intravenous immunoglobulin therapy for prevention of infection in high-risk premature infants: report of a multicenter, double-blind study. Pediatrics 1991;88:437–43
   PubMed Web of Science ®Google Scholar
• Ratrisawadi V, Srisuwanporn T, Puapondh Y. Intravenous immunoglobulin prophylaxis for infection in very low birth-weight infants. J Med Assoc Thai 1991;74:14–18
   PubMedGoogle Scholar
• Sandberg K, Fasth A, Berger A, et al. Preterm infants with low immunoglobulin G levels have increased risk of neonatal sepsis but do not benefit from prophylactic immunoglobulin G. J Pediatr 2000;137:623–8
   PubMed Web of Science ®Google Scholar
• Stabile A, Miceli Sopo S, Romanelli V, et al. Intravenous immunoglobulin for prophylaxis of neonatal sepsis in premature infants. Arch Dis Child 1988;63:441–3
   PubMed Web of Science ®Google Scholar
• Tanzer F, Yazar N, Hakgudener Y, Kafali G. Intravenous immunoglobulin for sepsis prevention in preterm infants. Turk J Pediatr 1997;39:341–5
   PubMed Web of Science ®Google Scholar
• van Overmeire B, Bleyaert S, van Reempts PJ, van Acker KJ. The use of intravenously administered immunoglobulins in the prevention of severe infection in very low birth weight neonates. Biol Neonate 1993;64:110–15
   PubMedGoogle Scholar
• Weisman LE, Stoll BJ, Kueser TJ, et al. Intravenous immune globulin prophylaxis of late-onset sepsis in premature neonates. J Pediatr 1994;125:922–30
   PubMed Web of Science ®Google Scholar
• Adair CD, Ernest JM, Sanchez-Ramos L, et al. Meconium-stained amniotic fluid-associated infectious morbidity: a randomized, double-blind trial of ampicillin-sulbactam prophylaxis. Obstet Gynecol 1996;88:216–20
   PubMed Web of Science ®Google Scholar
• Evans DJ, Levene MI, Tsakmakis M. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. Cochrane Database Syst Rev 2007;(3):CD001240
   PubMed Web of Science ®Google Scholar
• Jacobs S, Hunt R, Tarnow-Mordi W, et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2007;(4):CD003311
   PubMed Web of Science ®Google Scholar
• Whitelaw A, Odd D. Postnatal phenobarbital for the prevention of intraventricular hemorrhage in preterm infants. Cochrane Database Syst Rev 2007;(4):CD001691
   PubMed Web of Science ®Google Scholar
• Goldberg RN, Moscoso P, Bauer CR, et al. Use of barbiturate therapy in severe perinatal asphyxia: a randomized controlled trial. J Pediatr 1986;109:851–6
   PubMed Web of Science ®Google Scholar
• Hall RT, Hall FK, Daily DK. High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia: a randomized, prospective study with three-year follow-up. J Pediatr 1998;132:345–8
   PubMed Web of Science ®Google Scholar
• Kuzemko JA, Hartley S. Treatment of cerebral irritation in the newborn: double-blind trial with chloral hydrate and diazepam. Dev Med Child Neurol 1972;14:740–6
   PubMed Web of Science ®Google Scholar
• Singh D, Kumar P, Majumdar S, Narang A. Effect of phenobarbital on free radicals in neonates with hypoxic ischemic encephalopathy – a randomized controlled trial. J Perinat Med 2004;32:278–81
   PubMed Web of Science ®Google Scholar
• Akisu M, Huseyinov A, Yalaz M, et al. Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. Prostaglandins Leukot Essent Fatty Acids 2003;69:45–50
   PubMed Web of Science ®Google Scholar
• Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy: efficacy outcomes. Pediatr Neurol 2005;32:11–17
   PubMed Web of Science ®Google Scholar
• Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005;365:663–70
   PubMed Web of Science ®Google Scholar
• Lin ZL, Yu HM, Lin J, et al. Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit. J Perinatol 2006;26:180–4
   PubMed Web of Science ®Google Scholar
• Shankaran S, Laptook A, Wright LL, et al. Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants. Pediatrics 2002;110:377–85
   PubMed Web of Science ®Google Scholar
• Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic–ischemic encephalopathy. N Engl J Med 2005;353:1574–84
   PubMed Web of Science ®Google Scholar
• Anwar M, Kadam S, Hiatt IM, Hegyi T. Phenobarbitone prophylaxis of intraventricular haemorrhage. Arch Dis Child 1986;61:196–7
   PubMed Web of Science ®Google Scholar
• Bedard MP, Shankaran S, Slovis TL, et al. Effect of prophylactic phenobarbital on intraventricular hemorrhage in high-risk infants. Pediatrics 1984;73:435–9
   PubMed Web of Science ®Google Scholar
• Donn SM, Roloff DW, Goldstein GW. Prevention of intraventricular haemorrhage in preterm infants by phenobarbitone. A controlled trial. Lancet 1981;2:215–17
   PubMed Web of Science ®Google Scholar
• Kuban KC, Leviton A, Krishnamoorthy KS, et al. Neonatal intracranial hemorrhage and phenobarbital. Pediatrics 1986;77:443–50
   PubMed Web of Science ®Google Scholar
• Morgan ME, Massey RF, Cooke RW. Does phenobarbitone prevent periventricular hemorrhage in very low-birth-weight babies?: A controlled trial. Pediatrics 1982;70:186–9
   PubMed Web of Science ®Google Scholar
• Ruth V, Virkola K, Paetau R, Raivio KO. Early high-dose phenobarbital treatment for prevention of hypoxic-ischemic brain damage in very low birth weight infants. J Pediatr 1988;112:81–6
   PubMed Web of Science ®Google Scholar
• Whitelaw A, Placzek M, Dubowitz L, et al. Phenobarbitone for prevention of periventricular haemorrhage in very low birth-weight infants. A randomised double-blind trial. Lancet 1983;322:1168–70
   Google Scholar
• Neilson JP. Fetal electrocardiogram (ECG) for fetal monitoring during labor. Cochrane Database Syst Rev 2006;3:CD000116
   PubMedGoogle Scholar
• Amer-Wahlin I, Hellsten C, Noren H, et al. Cardiotocography only versus cardiotocography plus ST analysis of fetal electrocardiogram for intrapartum fetal monitoring: a Swedish randomised controlled trial. Lancet 2001;358:534–8
   PubMed Web of Science ®Google Scholar
• Ojala K, Vaarasmaki M, Makikallio K, et al. A comparison of intrapartum automated fetal electrocardiography and conventional cardiotocography – a randomised controlled study. Br J Obstet Gynaecol 2006;113:419–23
   Google Scholar
• Strachan BK, van Wijngaarden WJ, Sahota D, et al. Cardiotocography only versus cardiotocography plus PR-interval analysis in intrapartum surveillance: a randomised, multicentre trial. Lancet 2000;355:456–9
   PubMed Web of Science ®Google Scholar
• Vayssiere C, David E, Meyer N, et al. A French randomized controlled trial of ST-segment analysis in a population with abnormal cardiotocograms during labor. Am J Obstet Gynecol 2007;197:299 e291–6
   Google Scholar
• Westgate J, Harris M, Curnow JS, Greene KR. Plymouth randomized trial of cardiotocogram only versus ST waveform plus cardiotocogram for intrapartum monitoring in 2400 cases. Am J Obstet Gynecol 1993;169:1151–60
   PubMed Web of Science ®Google Scholar
• Rabe H, Reynolds G, Diaz-Rossello J. Early versus delayed umbilical cord clamping in preterm infants. Cochrane Database Syst Rev 2004;(4):CD003248
   PubMedGoogle Scholar
• Tubman TR, Thompson SW, McGuire W. Glutamine supplementation to prevent morbidity and mortality in preterm infants. Cochrane Database Syst Rev 2008;(1):CD001457
   PubMed Web of Science ®Google Scholar
• Hofmeyr GJ, Bolton KD, Bowen DC, Govan JJ. Periventricular/intraventricular haemorrhage and umbilical cord clamping. Findings and hypothesis. S Afr Med J 1988;73:104–6
   PubMed Web of Science ®Google Scholar
• Kinmond S, Aitchison TC, Holland BM, et al. Umbilical cord clamping and preterm infants: a randomised trial. BMJ 1993;306:172–5
   PubMed Web of Science ®Google Scholar
• McDonnell M, Henderson-Smart DJ. Delayed umbilical cord clamping in preterm infants: a feasibility study. J Paediatr Child Health 1997;33:308–10
   PubMed Web of Science ®Google Scholar
• Nelle M, Fisher S, Conze S, et al. Effects of late cord clamping on circulation in prematures (VLBWI). Pediatr Res 1998;44:454
   Google Scholar
• Rabe H, Wacker A, Hulskamp G, et al. A randomised controlled trial of delayed cord clamping in very low birth weight preterm infants. Eur J Pediatr 2000;159:775–7
   PubMed Web of Science ®Google Scholar
• Lacey JM, Crouch JB, Benfell K, et al. The effects of glutamine-supplemented parenteral nutrition in premature infants. J Parenter Enter Nutr 1996;20:74–80
   PubMedGoogle Scholar
• Neu J, Roig JC, Meetze WH, et al. Enteral glutamine supplementation for very low birth weight infants decreases morbidity. J Pediatr 1997;131:691–9
   PubMed Web of Science ®Google Scholar
• Poindexter BB, Ehrenkranz RA, Stoll BJ, et al. Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants. Pediatrics 2004;113:1209–15
   PubMed Web of Science ®Google Scholar
• Thompson SW, McClure BG, Tubman TR. A randomized, controlled trial of parenteral glutamine in ill, very low birth-weight neonates. J Pediatr Gastroenterol Nutr 2003;37:550–3
   PubMed Web of Science ®Google Scholar
• van den Berg A, van Elburg RM, Westerbeek EA, et al. Glutamine-enriched enteral nutrition in very-low-birth-weight infants and effects on feeding tolerance and infectious morbidity: a randomized controlled trial. Am J Clin Nutr 2005;81:1397–404
   PubMed Web of Science ®Google Scholar
• Vaughn P, Thomas P, Clark R, Neu J. Enteral glutamine supplementation and morbidity in low birth weight infants. J Pediatr 2003;142:662–8
   PubMed Web of Science ®Google Scholar
• Sinha I, Jones L, Smyth RL, Williamson PR. A systematic review of studies that aim to determine which outcomes to measure in clinical trials in children. PLoS Med 2008;5:e96
   PubMed Web of Science ®Google Scholar
• Thornley B, Adams C. Content and quality of 2000 controlled trials in schizophrenia over 50 years. BMJ 1998;317:1181–4
   PubMed Web of Science ®Google Scholar
• Ruggeri M, Fortuna S, Rodeghiero F. Heterogeneity of terminology and clinical definitions in adult idiopathic thrombocytopenic purpura: a critical appraisal from a systematic review of the literature. Haematologica 2008;93:98–103
   PubMed Web of Science ®Google Scholar
• Tugwell P, Boers M, Brooks P, et al. OMERACT: an international initiative to improve outcome measurement in rheumatology. Trials 2007;8:38
   PubMed Web of Science ®Google Scholar
• Zeitlin J, Wildman K, Bréart G, et al. PERISTAT: indicators for monitoring and evaluating perinatal health in Europe. Eur J Public Health 2003;13:29–37
   PubMed Web of Science ®Google Scholar
• WOMBAT Collaboration Advisory Committee. [Internet] Standard outcomes. Available from: http://wombatcollaboration.net/modules.php?name=Content&pa=showpage&pid=36 [last accessed 12 Jun 2013]
   Google Scholar
• Shatrov JG, Birch SCM, Lam LT, et al. Chorioamnionitis and cerebral palsy: a meta-analysis. Obstet Gynecol 2010;116:387–92
   PubMed Web of Science ®Google Scholar
• McIntyre S, Novak I, Cusick A. Consensus research priorities for cerebral palsy: a Delphi survey of consumers, researchers, and clinicians. Dev Med Child Neurol 2010;52:270–5
   PubMed Web of Science ®Google Scholar
• Hasson F, Keeney S, McKenna H. Research guidelines for the Delphi survey technique. J Adv Nurs 2000;32:1008–15
   PubMed Web of Science ®Google Scholar