The Role of Palliative External Beam Radiation Therapy in Boney Metastases Pain Management

REFERENCES

• Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer. 2002;2(8):584–593.
   PubMed Web of Science ®Google Scholar
• Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 2006;12(20 Pt 2).
   Google Scholar
• Decroisette C, Monnet I, Berard H, Epidemiology and treatment costs of bone metastases from lung cancer: a French prospective, observational, multicenter study (GFPC 0601). J Thorac Oncol. 2011;6(3):576–582.
   PubMed Web of Science ®Google Scholar
• Sher DJ. Cost-effectiveness studies in radiation therapy. Expert Rev Pharmacoecon Outcomes Res. 2010;10(5):567–582.
   PubMed Web of Science ®Google Scholar
• Greco C, Forte L, Erba P, Mariani G. Bone metastases, general and clinical issues. Q J Nucl Med Mol Imaging. 2011;55(4):337–352.
   Google Scholar
• Gralow JR, Biermann JS, Farooki A, NCCN task force report: bone health in cancer care. J Natl Compr Canc Netw. 2009;7(Suppl 3):S1–S32; quiz S33–S35.
   PubMedGoogle Scholar
• Yu HH, Tsai YY, Hoffe SE. Overview of diagnosis and management of metastatic disease to bone. Cancer Control. 2012;19(2):84–91.
   PubMed Web of Science ®Google Scholar
• Smith HS. Painful osseous metastases. Pain Physician. 2011;14(4):E373–E403.
   PubMed Web of Science ®Google Scholar
• Fitch M, Maxwell C, Ryan C, Lothman H, Drudge-Coates L, Costa L. Bone metastases from advanced cancers: clinical implications and treatment options. Clin J Oncol Nurs. 2009;13(6):701–710.
   PubMed Web of Science ®Google Scholar
• Lipton A. Treatment of bone metastases and bone pain with bisphosphonates. Support Cancer Ther. 2007;4(2):92–100.
   Google Scholar
• Janjan NA, Payne R, Gillis T, Presenting symptoms in patients referred to a multidisciplinary clinic for bone metastases. J Pain Symptom Manage. 1998;16(3):171–178.
   PubMed Web of Science ®Google Scholar
• Zeng L, Chow E, Bedard G, Quality of life after palliative radiation therapy for patients with painful bone metastases: results of an international study validating the EORTC QLQ-BM22. Int J Radiat Oncol Biol Phys. 2012;84(3):e337–e342.
   PubMed Web of Science ®Google Scholar
• Delea T, McKiernan J, Brandman J, Retrospective study of the effect of skeletal complications on total medical care costs in patients with bone metastases of breast cancer seen in typical clinical practice. J Support Oncol. 2006;4(7):341–347.
   PubMedGoogle Scholar
• Lage MJ, Barber BL, Harrison DJ, Jun S. The cost of treating skeletal-related events in patients with prostate cancer. Am J Manag Care. 2008;14(5):317–322.
   PubMed Web of Science ®Google Scholar
• Delea T, Langer C, McKiernan J, The cost of treatment of skeletal-related events in patients with bone metastases from lung cancer. Oncology. 2004;67(5–6):390–396.
   PubMed Web of Science ®Google Scholar
• Janjan N. Bone metastases: approaches to management. Semin Oncol. 2001;28(4 Suppl 11):28–34.
   PubMed Web of Science ®Google Scholar
• Rolfs RT, Johnson E, Williams NJ, Sundwall DN. Utah clinical guidelines on prescribing opioids for treatment of pain. J Pain Pall Care Pharmacother. 2010;24(3):219–235.
   PubMedGoogle Scholar
• McNicol E. Opioid side effects and their treatment in patients with chronic cancer and noncancer pain. J. Pain Pall Care Pharmacother. 2008;22(4):270–281.
   PubMedGoogle Scholar
• Eustice C. The facts of analgesics (painkillers). 2008; Available at: http://arthritis.about.com/od/analgesic/a/factsanalgesics. htm.
   Google Scholar
• Cleeland CS, Gonin R, Hatfield AK, Pain and its treatment in outpatients with metastatic cancer. N Engl J Med. 1994;330(9):592–596.
   PubMed Web of Science ®Google Scholar
• Aapro M, Saad F, Costa L. Optimizing clinical benefits of bisphosphonates in cancer patients with bone metastases. Oncologist. 2010;15(11):1147–1158.
   PubMed Web of Science ®Google Scholar
• Burkiewicz JS, Scarpace SL, Bruce SP. Denosumab in osteoporosis and oncology. Ann Pharmacother. 2009;43(9): 1445–1455.
   Google Scholar
• Groot MT, Boeken Kruger CG, Pelger RC, Uyl-de Groot CA. Costs of prostate cancer, metastatic to the bone, in the Netherlands. Eur Urol. 2003;43(3):226–232.
   PubMed Web of Science ®Google Scholar
• Lutz S, Berk L, Chang E, Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline. Int J Radiat Oncol Biol Phys. 2011;79(4):965–976.
   PubMed Web of Science ®Google Scholar
• Bese NS, Kiel K, El-Gueddari Bel K, Campbell OB, Awuah B, Vikram B. Radiotherapy for breast cancer in countries with limited resources: program implementation and evidence-based recommendations. Breast J. 2006;12(Suppl 1):S96–S102.
   Google Scholar
• Sejpal SV, Bhate A, Small W. Palliative radiation therapy in the management of brain metastases, spinal cord compression, and bone metastases. Semin Intervent Radiol. 2007;24(4):363–374.
   Google Scholar
• Di Lorenzo G, Autorino R, Ciardiello F, External beam radiotherapy in bone metastatic prostate cancer: impact on patients’ pain relief and quality of life. Oncol Rep. 2003;10(2):399–404.
   PubMed Web of Science ®Google Scholar
• Mandoliti G, Polico C, Capirci C, Radiation therapy of bone metastases in the elderly: a multicentric survey of the Italian “Geriatric Radiation Oncology Group.” Rays. 1997;22(1 Suppl):57–60.
   Google Scholar
• Chow E, Davis L, Holden L, A comparison of radiation therapy outcomes of bone metastases employing international consensus endpoints and traditional endpoints. Supportive Cancer Therapy. 2004;1(3):173–178.
   Google Scholar
• Falkmer U, Jarhult J, Wersall P, Cavallin-Stahl E. A systematic overview of radiation therapy effects in skeletal metastases. Acta Oncol. 2003;42(5–6):620–633.
   PubMed Web of Science ®Google Scholar
• Huisman M, van den Bosch MA, Wijlemans JW, van Vulpen M, van der Linden YM, Verkooijen HM. Effectiveness of reirradiation for painful bone metastases: a systematic review and meta-analysis. Int J Radiat Oncol Biol Phys. 2012;84(1):8–14.
   Google Scholar
• Hayashi S, Hoshi H, Iida T, Kajiura Y. Multi-fractionated wide-field radiation therapy for palliation of multiple symptomatic bone metastases from solid tumors. Radiat Med. 1999;17(6):411–416.
   Google Scholar
• Haley ML, Gerszten PC, Heron DE, Chang YF, Atteberry DS, Burton SA. Efficacy and cost-effectiveness analysis of external beam and stereotactic body radiation therapy in the treatment of spine metastases: a matched-pair analysis. J Neurosurg Spine. 2011;14(4):537–542.
   PubMed Web of Science ®Google Scholar
• Chow E, Hruby G, Davis L, Quality of life after local external beam radiation therapy for symptomatic bone metastases: a prospective evaluation. Support Cancer Ther. Apr 1 2004;1(3):179–184.
   Google Scholar
• Culleton S, Kwok S, Chow E. Radiotherapy for pain. Clin Oncol (R Coll Radiol). 2011;23(6):399–406.
   Google Scholar
• Lutz S, Lo SS, Chow E, Sahgal A, Hoskin P. Radiotherapy for metastatic bone disease: current standards and future prospectus. Expert Rev Anticancer Ther. 2010;10(5):683–695.
   PubMed Web of Science ®Google Scholar
• Caissie A, Zeng L, Nguyen J, Assessment of health-related quality of life with the European organization for research and treatment of cancer QLQ-C15-PAL after palliative radiotherapy of bone metastases. Clin Oncol (R Coll Radiol). Mar 2012;24(2):125–133.
   Google Scholar
• Caissie A, Culleton S, Nguyen J, EORTC QLQ-C15-PAL quality of life scores in patients with advanced cancer referred for palliative radiotherapy. Support Care Cancer. 2012;20(4):841–848.
   PubMed Web of Science ®Google Scholar
• Tharmalingam S, Chow E, Harris K, Hird A, Sinclair E. Quality of life measurement in bone metastases: a literature review. J Pain Res. 2008;1:49–58.
   PubMedGoogle Scholar
• Donato V, Cianciulli M, Crescenzi M, Monaco A, Caruso C, Morrone A. Rapid palliative radiotherapy unit: multidisciplinary management of bone metastases. Radiol Med. 2012;117(6):1071–8.
   PubMed Web of Science ®Google Scholar
• Andrade RS, Proctor JW, Slack R, Marlowe U, Ashby KR, Schenken LL. A simple and effective daily pain management method for patients receiving radiation therapy for painful bone metastases. Int J Radiat Oncol Biol Phys. 2010;78(3):855–859.
   Google Scholar
• Bruera E, Kuehn N, Miller MJ, Selmser P, Macmillan K. The Edmonton Symptom Assessment System (ESAS): a simple method for the assessment of palliative care patients. J Palliat Care. 1991;7(2):6–9.
   PubMedGoogle Scholar
• Nielsen OS, Bentzen SM, Sandberg E, Gadeberg CC, Timothy AR. Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases. Radiother Oncol. 1998;47(3):233–240.
   Google Scholar
• Rasmusson B, Vejborg I, Jensen AB, Irradiation of bone metastases in breast cancer patients: a randomized study with 1 year follow-up. Radiother Oncol. 1995;34(3):179–184.
   Google Scholar
• Chow E. Update on radiation treatment for cancer pain. Curr Opin Support Palliat Care. 2007;1(1):11–15.
   Google Scholar
• Amouzegar-Hashemi F, Behrouzi H, Kazemian A, Zarpak B, Haddad P. Single versus multiple fractions of palliative radiotherapy for bone metastases: a randomized clinical trial in Iranian patients. Curr Oncol. 2008;15(3):36–39.
   Google Scholar
• Foro Arnalot P, Fontanals AV, Galceran JC, Randomized clinical trial with two palliative radiotherapy regimens in painful bone metastases: 30 Gy in 10 fractions compared with 8 Gy in single fraction. Radiother Oncol. 2008;89(2):150–155.
   PubMed Web of Science ®Google Scholar
• Kaasa S, Brenne E, Lund JA, Prospective randomised multicenter trial on single fraction radiotherapy (8 Gy x 1) versus multiple fractions (3 Gy x 10) in the treatment of painful bone metastases. Radiother Oncol. 2006;79(3):278–284.
   PubMed Web of Science ®Google Scholar
• Steenland E, Leer JW, van Houwelingen H, The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch bone metastasis study. Radiother Oncol. 1999;52(2):101–109.
   PubMedGoogle Scholar
• Kal HB. Single fraction radiotherapy is as effective as multiple fractions for palliating painful bone metastases. Cancer Treat Rev. 2003;29(4):345–347.
   Google Scholar
• Arcangeli G, Giovinazzo G, Saracino B, D'Angelo L, Giannarelli D, Micheli A. Radiation therapy in the management of symptomatic bone metastases: the effect of total dose and histology on pain relief and response duration. Int J Radiat Oncol Biol Phys. 1998;42(5):1119–1126.
   Google Scholar
• Hartsell WF, Scott CB, Bruner DW, Randomized trial of short- versus long-course radiotherapy for palliation of painful bone metastases. J Natl Cancer Inst. 2005;97(11):798–804.
   PubMedGoogle Scholar
• Konski A, Desilvio M, Hartsell W, Continuing evidence for poorer treatment outcomes for single male patients: retreatment data from RTOG 97-14. Int J Radiat Oncol Biol Phys. 2006;66(1):229–233.
   Google Scholar
• Wu JS, Wong R, Johnston M, Bezjak A, Whelan T. Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiat Oncol Biol Phys. 2003;55(3):594–605.
   PubMed Web of Science ®Google Scholar
• Sze WM, Shelley MD, Held I, Wilt TJ, Mason MD. Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy—a systematic review of randomised trials. Clin Oncol (R Coll Radiol). 2003;15(6):345–352.
   PubMed Web of Science ®Google Scholar
• Gripp S, Mjartan S, Boelke E, Willers R. Palliative radiotherapy tailored to life expectancy in end-stage cancer patients: reality or myth? Cancer. 2010;116(13):3251–3256.
   Web of Science ®Google Scholar
• Fujino M, Suzuki K, Nishio M, Nishiyama N, Osaka Y. Strategy of radiation therapy for bone metastases and MSCC in breast cancer patients. Breast Cancer. 2011;18(4): 238–243.
   Google Scholar
• van den Hout WB, van der Linden YM, Steenland E, Single- versus multiple-fraction radiotherapy in patients with painful bone metastases: cost-utility analysis based on a randomized trial. J Natl Cancer Inst. 2003;95(3): 222–229.
   Google Scholar
• Konski A. Radiotherapy is a cost-effective palliative treatment for patients with bone metastasis from prostate cancer. Int J Radiat Oncol Biol Phys. 2004;60(5):1373–1378.
   Web of Science ®Google Scholar
• Konski A, James J, Hartsell W, Economic analysis of radiation therapy oncology group 97-14: multiple versus single fraction radiation treatment of patients with bone metastases. Am J Clin Oncol. 2009;32(4):423–428.
   Google Scholar
• Shakespeare TP, Lu JJ, Back MF, Liang S, Mukherjee RK, Wynne CJ. Patient preference for radiotherapy fractionation schedule in the palliation of painful bone metastases. J Clin Oncol. 2003;21(11):2156–2162.
   Google Scholar