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Research Article

A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice

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Pages 241-245 | Received 06 Aug 2010, Accepted 24 Oct 2010, Published online: 10 Dec 2010

References

  • Bajgar J. 2004. Organophosphate/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Adv Clin Chem 38:151–216.
  • Cabal J, Bajgar J. 1999. Tabun – reappearance 50 years later. Chem Listy 93:27–31 [in Czech].
  • Cabal J, Kuca K, Kassa J. 2004. Specification of the structure of oximes able to reactivate tabun-inhibited acetylcholinesterase. Pharmacol Toxicol 95:81–86.
  • Clement JG, Hansen AS, Boulet CA. 1992. Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice. Arch Toxicol 66:216–219.
  • Ekström F, Akfur C, Tunemalm AK, Lundberg S. 2006. ářčáářStructural changes of phenylalanine 338 and histidine 447 revealed by the crystal structures of tabun-inhibited murine acetylcholinesterase. Biochemistry 45:74–81.
  • Ellman GL, Courtney DK, Andres V, Jr Feartherstone, RM. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–93.
  • Jokanovic M, Prostran M. 2009. Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. Curr Med Chem 16:2177–2188.
  • Kassa J. 2002. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol Clin Toxicol 40:803–816.
  • Kassa J, Cabal J. 1999a. A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods. Toxicology 132:111–118.
  • Kassa J, Cabal J. 1999b. A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with presently used oximes and H oximes against sarin by in vitro and in vivo methods. Hum Exp Toxicol 18:560–565.
  • Kassa J, Cabal J. 1999c. A comparison of the efficacy of acetylcholinesterase reactivators against cyclohexylmethylphosphonofluoridate (GF agent) by in vitro and in vivo methods. Pharmacol Toxicol 84:41–45.
  • Kassa J, Karasova J, Musilek K, Kuca K. 2008. An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology 243:311–316.
  • Kassa J, Karasova J, Vasina L, Bajgar J, Kuca K, Musilek K. 2009. A comparison of neuroprotective efficacy of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in tabun-poisoned rats. Drug Chem Toxicol 32:128–138.
  • Kovarik Z, Vrdoljak AL, Berend S, Catalinic M, Kuca K, Musilek K, Radic B. 2009. Evaluation of oxime K203 as antidote in tabun poisoning. Arh Hig Rada Toksikol 60:19–26.
  • Kuca K, Jun D, Musilek K. 2006. Structural requirements of acetylcholinesterase reactivators. Mini-Rev Med Chem 6:109–120.
  • Laufer R, Kalasz H, Musilek K, Szegi P, Darvas F, Kuca K, Tekes K. 2010. Synthesis, antidotal effects and HPLC behavior of some novel pyridinium aldoximes. Curr Org Chem 14:447–456.
  • Lotti M. 2000. Organophosphorus compounds. In: Spencer PS, Schaumburg HH, editors. Experimental and clinical neurotoxicology. New York: Oxford University Press. pp 898–925.
  • Lundy PM, Raveh L, Amitai G. 2006. Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol Rev 25:231–243.
  • Marrs TC. 1993. Organophosphate poisoning. Pharmacol Ther 58:51–66.
  • Marrs TC, Rice P, Vale JA. 2006. The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicol Rev 25:297–323.
  • Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M. 2008. Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase. J Enzyme Inhib Med Chem 23:70–76.
  • Musilek K, Kuca K, Jun D, Dolezal M. 2007. Progress in synthesis of new acetylcholinesterase reactivators during the period 1990–2004. Curr Org Chem 11:229–238.
  • Schoene K, Oldiges H. 1973. Efficacy of pyridinium salts in tabun and sarin poisoning. Arch Int Pharmacodyn Ther 204:110–123.
  • Tallarida RJ, Murray RB. 1987. Manual of pharmacological calculation with computer programs. New York: Springer-Verlag.
  • Worek F, Widmann R, Knopff O, Szinicz L. 1998. Reactivating potency of obidoxime, pralidoxime, HI-6 and HLö-7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Arch Toxicol 72:237–243.

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