81
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Attenuation of sulfur mustard toxicity by S-2(2-aminoethylamino)ethyl phenyl sulfide (DRDE-07) in mouse liver

, , , &
Pages 596-605 | Received 04 Nov 2010, Accepted 27 Mar 2011, Published online: 09 May 2011

References

  • Anand T, Vijayaraghavan R, Bansal I, Bhattacharya BK. 2009. Role of inflammatory cytokines and DNA damage repair proteins in sulfur mustard exposed mice liver. Toxicol Mech Methods 19:356–362.
  • Arroyo CM, Schafer RJ, Kurt EM, Broomfield CA, Carmichael AJ. 1999. Response of normal human keratinocytes to sulfur mustard (HD): cytokine release using a non-enzymatic detachment procedure. Hum Exp Toxicol 18:1–11.
  • Atkins KB, Lodhi IJ, Hurley LL, Hinshaw DB. 2000. N-acetylcysteine and endothelial cell injury by sulfur mustard. J Appl Toxicol 20 Suppl 1:S125–S128.
  • Bhattacharya R, Rao PV, Pant SC, Kumar P, Tulsawani RK, Pathak U, Kulkarni A, Vijayaraghavan R. 2001. Protective effects of amifostine and its analogues on sulfur mustard toxicity in vitro and in vivo. Toxicol Appl Pharmacol 176:24–33.
  • Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege FC, Kim IF, Markowitz V, Matese JC, Parkinson H, Robinson A, Sarkans U, Schulze-Kremer S, Stewart J, Taylor R, Vilo J, Vingron M. 2001. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet 29:365–371.
  • Clarke HT. 1912. Synthesis of 4-alkyl-1,4-thiazans. J Chem Soc 101:1583–1590.
  • Dacre JC, Goldman M. 1996. Toxicology and pharmacology of the chemical warfare agent sulfur mustard. Pharmacol Rev 48:289–326.
  • Dillman JF 3rd, Hege AI, Phillips CS, Orzolek LD, Sylvester AJ, Bossone C, Henemyre-Harris C, Kiser RC, Choi YW, Schlager JJ, Sabourin CL. 2006. Microarray analysis of mouse ear tissue exposed to bis-(2-chloroethyl) sulfide: gene expression profiles correlate with treatment efficacy and an established clinical endpoint. J Pharmacol Exp Ther 317:76–87.
  • Dillman JF 3rd, McGary KL, Schlager JJ. 2003. Sulfur mustard induces the formation of keratin aggregates in human epidermal keratinocytes. Toxicol Appl Pharmacol 193:228–236.
  • Dillman JF 3rd, Phillips CS, Dorsch LM, Croxton MD, Hege AI, Sylvester AJ, Moran TS, Sciuto AM. 2005. Genomic analysis of rodent pulmonary tissue following bis-(2-chloroethyl) sulfide exposure. Chem Res Toxicol 18:28–34.
  • Gautam A, Gupta A, Lomash V, Pant SC, Vijayaraghavan R. 2010. Prophylactic efficacy of combination of DRDE-07 and its analogues with amifostine against sulphur mustard induced systemic toxicity. Indian J Exp Biol 48:752–761.
  • Gerecke DR, Chen M, Isukapalli SS, Gordon MK, Chang YC, Tong W, Androulakis IP, Georgopoulos PG. 2009. Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect. Toxicol Appl Pharmacol 234:156–165.
  • Gray PJ. 1989. A Literature Review on the Mechanism of Action of Sulphur and Nitrogen Mustard. Defence Science and Technology Organisation (DSTO), Australia. MRL-TR-89-24.
  • Greenberg S, Kamath P, Petrali J, Hamilton T, Garfield J, Garlick JA. 2006. Characterization of the initial response of engineered human skin to sulfur mustard. Toxicol Sci 90:549–557.
  • Gross CL, Innace JK, Hovatter RC, Meier HL, Smith WJ. 1993. Biochemical manipulation of intracellular glutathione levels influences cytotoxicity to isolated human lymphocytes by sulfur mustard. Cell Biol Toxicol 9:259–267.
  • Kehe K, Balszuweit F, Steinritz D, Thiermann H. 2009. Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering. Toxicology 263:12–19.
  • Kulkarni AS, Vijayaraghavan R, Anshoo G, Satish HT, Pathak U, Raza SK, Pant SC, Malhotra RC, Prakash AO. 2006. Evaluation of analogues of DRDE-07 as prophylactic agents against the lethality and toxicity of sulfur mustard administered through percutaneous route. J Appl Toxicol 26:115–125.
  • Kumar P, Gautam A, Prakash CJ, Kumar A, Ganeshan K, Pathak U, Vijayaraghavan R. 2010. Ameliorative effect of DRDE 07 and its analogues on the systemic toxicity of sulphur mustard and nitrogen mustard in rabbit. Hum Exp Toxicol 29:747–755.
  • Kumar P, Vijayaraghavan R, Kulkarni AS, Pathak U, Raza SK, Jaiswal DK. 2002. In vivo protection by amifostine and DRDE-07 against sulphur mustard toxicity. Hum Exp Toxicol 21:371–376.
  • Lardot C, Dubois V, Lison D. 1999. Sulfur mustard upregulates the expression of interleukin-8 in cultured human keratinocytes. Toxicol Lett 110:29–33.
  • Lindsay CD, Hambrook JL. 1997. Protection of A549 cells against the toxic effects of sulphur mustard by hexamethylenetetramine. Hum Exp Toxicol 16:106–114.
  • Mazumder PK, Sugendran K, Vijayaraghavan R. 1998. Protective efficacy of calcium channel blockers in sulphur mustard poisoning. Biomed Environ Sci 11:363–369.
  • Meier HL, Johnson JB. 1992. The determination and prevention of cytotoxic effects induced in human lymphocytes by the alkylating agent 2,2’-dichlorodiethyl sulfide (sulfur mustard, HD). Toxicol Appl Pharmacol 113:234–239.
  • Monteiro-Riviere NA, Inman AO, Babin MC, Casillas RP. 1999. Immunohistochemical characterization of the basement membrane epitopes in bis(2-chloroethyl) sulfide-induced toxicity in mouse ear skin. J Appl Toxicol 19:313–328.
  • Om Kumar Sugendran, K, Vijayaraghavan R. 2001. Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous route. Chem Biol Interact 134:1–12.
  • Papirmeister B, Feister AJ, Robinson SI, Ford RD. (1991a). Medical Defence Against Mustard Gas: Toxic Mechanism and Pharmacological Implications. Boca Raton, Fl: CRC Press, 43–46.
  • Papirmeister B, Feister AJ, Sabina IR, Ford RD. 1991b. Chemistry of sulfur mustard (Chapter 5); Genotoxicity and related cellular effects of sulfur mustard (Chapter 6) in Medical Defence against Mustard Gas. Boca Raton: CRC Press Fl, 91–154.
  • Rao PVL, Vijayaraghavan R, Bhaskar AS. 1999. Sulphur mustard induced DNA damage in mice after dermal and inhalation exposure. Toxicology 139:39–51.
  • Ricketts KM, Santai CT, France JA, Graziosi AM, Doyel TD, Gazaway MY, Casillas RP. 2000. Inflammatory cytokine response in sulfur mustard-exposed mouse skin. J Appl Toxicol 20 Suppl 1:S73–S76.
  • Rogers JV, Choi YW, Kiser RC, Babin MC, Casillas RP, Schlager JJ, Sabourin CL. 2004. Microarray analysis of gene expression in murine skin exposed to sulfur mustard. J Biochem Mol Toxicol 18:289–299.
  • Rosenthal DS, Simbulan-Rosenthal CM, Iyer S, Smith WJ, Ray R, Smulson ME. 2000. Calmodulin, poly(ADP-ribose)polymerase and p53 are targets for modulating the effects of sulfur mustard. J Appl Toxicol 20 Suppl 1:S43–S49.
  • Rosenthal DS, Simbulan-Rosenthal CM, Iyer S, Spoonde A, Smith W, Ray R, Smulson ME. 1998. Sulfur mustard induces markers of terminal differentiation and apoptosis in keratinocytes via a Ca2+-calmodulin and caspase-dependent pathway. J Invest Dermatol 111:64–71.
  • Sabourin CL, Danne MM, Buxton KL, Casillas RP, Schlager JJ. 2002. Cytokine, chemokine, and matrix metalloproteinase response after sulfur mustard injury to weanling pig skin. J Biochem Mol Toxicol 16:263–272.
  • Sabourin CLK, Danne MM, Buxton KL, Rogers JV, Niemuth NA, Blank JA, Babin MC, Casillas RP. 2003. Modulation of sulfur mustard-induced inflammation and gene expression by olvanil in the hairless mouse vesicant model. J Toxicol Cutaneous Ocul Toxicol 22:125–136.
  • Sabourin CL, Petrali JP, Casillas RP. 2000. Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin. J Biochem Mol Toxicol 14:291–302.
  • Sabourin CL, Rogers JV, Choi YW, Kiser RC, Casillas RP, Babin MC, Schlager JJ. 2004. Time- and dose-dependent analysis of gene expression using microarrays in sulfur mustard-exposed mice. J Biochem Mol Toxicol 18:300–312.
  • Sawyer TW, Risk D. 2000. Effects of selected arginine analogues on sulphur mustard toxicity in human and hairless guinea pig skin keratinocytes. Toxicol Appl Pharmacol 163:75–85.
  • Sawyer TW, Lundy PM, Weiss MT. 1996. Protective effect of an inhibitor of nitric oxide synthase on sulphur mustard toxicity in vitro. Toxicol Appl Pharmacol 141:138–144.
  • Sawyer TW. 1998. Modulation of sulfur mustard toxicity by arginine analogues and related nitric oxide synthase inhibitors in vitro. Toxicol Sci 46:112–123.
  • Sawyer TW. 1998. Characterization of the protective effects of L-nitroarginine methyl ester (L-NAME) against the toxicity of sulphur mustard in vitro. Toxicology 131:21–32.
  • Schlager JJ, Hart BW. 2000. Stress gene activity in HepG2 cells after sulfur mustard exposure. J Appl Toxicol 20:395–405.
  • Shakarjian MP, Heck DE, Gray JP, Sinko PJ, Gordon MK, Casillas RP, Heindel ND, Gerecke DR, Laskin DL, Laskin JD. 2010. Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure. Toxicol Sci 114:5–19.
  • Sharma M, Vijayaraghavan R, Pathak U, Ganesan K. 2009. Prophylactic efficacy of Amifostine, DRDE-07, and their Analogues against percutaneously administered Nitrogen and sulphur mustard. Def Sci J 59:512–516.
  • Sidell FR, Urbanetti JS, Smith WJ, Hurst CG. (1997). Vesicants. In: Sidell FR, Takafuji ET, Franz DR., eds. Textbook of military medicine, warfare, weaponry, and the casualty. Medical Aspects of Chemical And Biological Warfare. Washington, DC: TMM Publications, 197–228.
  • Smith KJ, Graham JS, Hamilton TA, Skelton HG, Petrali JP, Hurst CG. 1997. Immunohistochemical studies of basement membrane proteins and proliferation and apoptosis markers in sulfur mustard induced cutaneous lesions in weanling pigs. J Dermatol Sci 15:173–182.
  • Sugendran K, Jeevaratnam K, Vijayaraghavan R, Das Gupta S. 1994. Therapeutic efficacy of saline and glucose-saline against dermally applied sulphur mustard intoxication in mice. Def Sci J 44:21–23.
  • Tsuruta J, Sugisaki K, Dannenberg AM Jr, Yoshimura T, Abe Y, Mounts P. 1996. The cytokines NAP-1 (IL-8), MCP-1, IL-1 beta, and GRO in rabbit inflammatory skin lesions produced by the chemical irritant sulfur mustard. Inflammation 20:293–318.
  • Uma Devi P, Nagarathnam A, Satish Rao BS. (2000). Chemical modifiers of radiosensitivity. In: Uma Devi P, Nagarathnam A, and Satish Rao, BS, eds. Introduction to Radiation Biology. Churchill Livingstone publishers, New Delhi. p. 2, line No. 25–26.
  • van der Schans GP, Noort D, Mars-Groenendijk RH, Fidder A, Chau LF, de Jong LP, Benschop HP. 2002. Immunochemical detection of sulfur mustard adducts with keratins in the stratum corneum of human skin. Chem Res Toxicol 15:21–25.
  • Vijayaraghavan R, Kulkarni A, Pant SC, Kumar P, Rao PV, Gupta N, Gautam A, Ganesan K. 2005. Differential toxicity of sulfur mustard administered through percutaneous, subcutaneous, and oral routes. Toxicol Appl Pharmacol 202:180–188.
  • Vijayaraghavan R, Kumar P, Joshi U, Raza SK, Lakshmana Rao PV, Malhotra RC, Jaiswal DK. 2001. Prophylactic efficacy of amifostine and its analogues against sulphur mustard toxicity. Toxicology 163:83–91.
  • Vijayaraghavan R, Sugendran K, Pant SC, Husain K, Malhotra RC. 1991. Dermal intoxication of mice with bis(2-chloroethyl)sulphide and the protective effect of flavonoids. Toxicology 69:35–42.
  • Vojvodic V, Milosavljevic Z, Boskovic B, Bojanic N. 1985. The protective effect of different drugs in rats poisoned by sulfur and nitrogen mustards. Fundam Appl Toxicol 5:S160–S168.
  • Wan Y, Wang Z, Shao Y, Xu Y, Voorhees J, Fisher G. 2000. UV-induced expression of GADD45 is mediated by an oxidant sensitive pathway in cultured human keratinocytes and in human skin in vivo. Int J Mol Med 6:683–688.
  • Werrlein RJ, Madren-Whalley JS. 2000. Effects of sulfur mustard on the basal cell adhesion complex. J Appl Toxicol 20 Suppl 1:S115–S123.
  • Werrlein RJ, Madren-Whalley JS. 2003. Multiphoton microscopy: an optical approach to understanding and resolving sulfur mustard lesions. J Biomed Opt 8:396–409.
  • Wormser U, Brodsky B, Proscura E, Foley JF, Jones T, Nyska A. 2005. Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodine. Arch Toxicol 79:660–670.
  • Zhang Z, Peters BP, Monteiro-Riviere NA. 1995. Assessment of sulfur mustard interaction with basement membrane components. Cell Biol Toxicol 11:89–101.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.