Advanced search
Publication Cover
Toxicology Mechanisms and Methods Volume 23, 2013 - Issue 2
Submit an article Journal homepage
172
Views
12
CrossRef citations to date
0
Altmetric
Research Article

Determination of LCt50s in anesthetized rats exposed to aerosolized nerve agents

Jennifer L. Collins27 SOCES/CEAN Cannon Air Force Base, NM 88103, USA
,
Xinqi PengUnited States Army Medical Research Institute of Chemical Defense Analytical Toxicology Division, Medical Toxicology Branch, Aberdeen Proving Ground, MD 21010, USA
,
Robyn LeeUnited States Army Medical Research Institute of Chemical Defense Analytical Toxicology Division, Medical Toxicology Branch, Aberdeen Proving Ground, MD 21010, USA
,
Alicia WitriolUnited States Army Medical Research Institute of Chemical Defense Analytical Toxicology Division, Medical Toxicology Branch, Aberdeen Proving Ground, MD 21010, USA
,
Zdenka PierreUnited States Army Medical Research Institute of Chemical Defense Analytical Toxicology Division, Medical Toxicology Branch, Aberdeen Proving Ground, MD 21010, USA
&
Alfred M. SciutoUnited States Army Medical Research Institute of Chemical Defense Analytical Toxicology Division, Medical Toxicology Branch, Aberdeen Proving Ground, MD 21010, USACorrespondence[email protected]
Pages 127-133 | Received 27 Jul 2012, Accepted 12 Sep 2012, Published online: 19 Oct 2012

References

  • Asai Y, Arnold JL. 2003. Terrorism in Japan. Prehosp Disaster Med 18:106–114.
  • Boskovic B, Kovacevic V, Jovanovic D. 1984. PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning. Fundam Appl Toxicol 4:S106–S115.
  • Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254.
  • Brimblecombe RW, Green DM, Stratton JA, Thompson PB. 1970. The protective actions of some anticholinergic drugs in sarin poisoning. Br J Pharmacol 39:822–830.
  • Chang FC, Hoffman BE, DeBus S. 2002. Pharmacological antagonism of lethal effects induced by O-isobutyl S-[2-(diethylamino)ethyl]methylphosphonothioate. Drug Chem Toxicol 25:321–337.
  • Doctor BP, Toker L, Roth E, Silman I. 1987. Microtiter assay for acetylcholinesterase. Anal Biochem 166:399–403.
  • Ellman GL, Courtney KD, Andres V Jr, Feather-Stone RM. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95.
  • Feder PI, Hobson DW, Olson CT, Joiner RL, Matthews MC. 1991a. Stagewise, adaptive dose allocation for quantal response dose-response studies. Neurosci Biobehav Rev 15:109–114.
  • Feder PI, Olson CT, Hobson DW, Matthews MC, Joiner RL. 1991b. Stagewise, group sequential experimental designs for quantal responses. one-sample and two-sample comparisons. Neurosci Biobehav Rev 15:129–133.
  • Feder PI, Olson CT, Hobson DW, Mathews MC. 1991c. Statistical analysis of dose-response experiments by maximum likelihood analysis and iteratively reweighted nonlinear least squares techniques. Drug Information J 25:323–334.
  • Finney DJ. 1971. Statisical logic in the monitoring of reactions to therapeutic drugs. Methods Inf Med 10:237–245.
  • Fleisher JH, Harris LW, Prudhomme C, Bursel J. 1963. Effects of ethyl p-nitrophenyl thionobenzene phosphonate (EPN) on the toxicity of isopropyl methyl phosphonofluoridate (GB). J Pharmacol Exp Ther 139:390–396.
  • Gates MR, Renshaw BC. 1946. Fluorophosphates and other phospphorus containing compounds. In: Summary Technical Report of Division 9. Washington, DC: Office of Scientific Research and Development.
  • Maynard RL, Chilcott RP. 2009. Toxciology of chemical warfare agents. In: Ballantyne B, Marrs TC, Syversen T, eds. General and Applied Toxicology,3rd edition. Wiley and Sons.
  • Maynard RL, Beswick FW. 1992. Organophosphorus compounds as checmical warfare agents. In: Ballantyne B, Marrs TC, eds. Clinical and Experimental Toxicology of Organophosphates and Carbamates. Oxford: Butterworth-Heinemann Ltd.
  • Morris JB, Hubbs AF. 2009. Inhalation dosimetry of diacetyl and butyric acid, two components of butter flavoring vapors. Toxicol Sci 108:173–183.
  • Munro N. 1994. Toxicity of the organophosphate chemical warfare agents GA, GB, and VX: implications for public protection. Environ Health Perspect 102:18–38.
  • Pazdernik TL, Cross R, Nelson S, Samson F, McDonough J Jr. 1983. Soman-induced depression of brain activity in TAB-pretreated rats: 2-deoxyglucose study. Neurotoxicology 4:27–34.
  • Tuorinsky S. 2008. Textbooks of Military Medicine – Medical Aspects of Chemical Warfare. Baltimore: Office of the Surgeon General, Department of the Army United States of America.
  • United Nations. 1987. Reports: S/16433[1984], S/17911[1986], S/18852[1987]. New York: United Nations Organization.
  • United Nations Security Council. 1984. Report of the specialists appointed by the secretary-general to investigate allegations by the Islamic Republic of Iran concerning the use of chemical weapons. New York: United Nations.
  • United Nations Security Council. 1986. Report of the mission dispatched by the secretary-general to investigate allegations of the use of chemical weapons in the conflict between the Islamic Republic of Iran and Iraq. New York: United Nations.
  • United Nations Security Council. 1987. Report of the mission dispatched by the secretary-general to investigate allegations of the use of chemical weapons in the conflict between the Islamic Republic of Iran and Iraq. New York: United Nations.
  • Von Lohs K. 1960. Zur Toxicologie und Pharmacologie Organischer Phosphosäurester. Deutsche Gesundheitwesen 15:2133–2179.
  • Weston RE, Karel L. 1946. An application of the dosimetric method for biologically assaying inhaled substances; the determination of the retained median lethal dose, percentage retention, and respiratory response in dogs exposed to different concentrations of phosgene. J Pharmacol Exp Ther 88:195–207.
  • Willems JL. 1989. Clinical management of mustard gas casualties. Ann Med Militaris (Belgicae) 3:S1–S61.
  • World Health Organization OSP. 1993. Plaguicidas y salud en las Americas. Washington, DC.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.