Pulmonary toxicity and fibrogenic response of carbon nanotubes

References

• Agostini C, Gurrieri C. (2006). Chemokine/cytokine cocktail in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 3:357–63
   PubMedGoogle Scholar
• Antonini JM. (2003). Health effects of welding. Crit Rev Toxicol 33:61–103
   PubMed Web of Science ®Google Scholar
• Azad N, Iyer AK, Wang L, et al. (2012). Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses. Nanotoxicology [Epub ahead of print]. DOI: 10.3109/17435390.2011.647929
   Google Scholar
• Beamer CA, Girtsman TA, Seaver BP, et al. (2012). IL-33 mediates multi-walled carbon nanotube (MWCNT)-induced airway hyper-reactivity via the mobilization of innate helper cells in the lung. Nanotoxicology [Epub ahead of print]. DOI: 10.3109/17435390.2012.702230
   Google Scholar
• Bergamaschi E. (2009). Occupational exposure to nanomaterials: present knowledge and future development. Nanotoxicology 3:194–201
   Web of Science ®Google Scholar
• Bonner JC. (2002). The epidermal growth factor receptor at the crossroads of airway remodeling. Am J Physiol Lung Cell Mol Physiol 283:L528–30
   PubMed Web of Science ®Google Scholar
• Bonner JC. (2007). Lung fibrotic responses to particle exposure. Toxicol Pathol 35:148–53
   PubMed Web of Science ®Google Scholar
• Bonner JC, Rice AB, Moomaw CR, Morgan DL. (2000). Airway fibrosis in rats induced by vanadium pentoxide. Am J Lung Cell Mol Physiol 278:L209–16
   PubMed Web of Science ®Google Scholar
• Borm PJ, Robbins D, Haubold S, et al. (2006). The potential risks of nanomaterials: a review carried out for ECETOC. Part Fibre Toxicol 3:11
   PubMed Web of Science ®Google Scholar
• Bottini M, Bruckner S, Nika K, et al. (2006). Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol Lett 160:121–6
   PubMed Web of Science ®Google Scholar
• British Standards Institution (BSI). (2007). Nanotechnologies Part 2: guide to safe handling and disposal of manufactured nanomaterials. BSI. PD 6699-2:2007
   Google Scholar
• Brown D, Kinloch I, Bangert U, et al. (2007). An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis. Carbon 45:1743–56
   Web of Science ®Google Scholar
• Cesta MF, Ryman-Rasmussen J, Wallace DG, et al. (2010). Bacterial lipopolysaccharide enhances PDGF signaling and pulmonary fibrosis in rats exposed to carbon nanotubes. Am J Respir Cell Mol Biol 43:142–51
   PubMed Web of Science ®Google Scholar
• Chakrabarti S, Patel KD. (2005). Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology. Exp Lung Res 31:599–621
   PubMed Web of Science ®Google Scholar
• Chang CC, Tsai ML, Huang HC, et al. (2012). Epithelial-mesenchymal transition contributes to SWCNT-induced pulmonary fibrosis. Nanotoxicology 6:600--10
   Google Scholar
• Chapman HA. (2011). Epithelial-mesenchymal interactions in pulmonary fibrosis. Ann Rev Physiol 73:413–35
   PubMed Web of Science ®Google Scholar
• Chaudhary NI, Roth GJ, Hilberg F, et al. (2007). Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis. Eur Respir J 29:976–85
   PubMed Web of Science ®Google Scholar
• Clichici S, Biris AR, Tabaran F, Filip A. (2012). Transient oxidative stress and inflammation after intraperitoneal administration of multiwalled carbon nanotubes functionalized with single strand DNA in rats. Toxicol Appl Pharmacol 259:281–92
   PubMed Web of Science ®Google Scholar
• DeMaio L, Buckley ST, Krishnaveni MS, et al. (2012). Ligand-independent transforming growth factor-β type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol 226:633–44
   PubMed Web of Science ®Google Scholar
• Donaldson K, Murphy FA, Duffin R, Poland CA. (2010). Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol 7:5
   PubMed Web of Science ®Google Scholar
• Donaldson K, Poland CA. (2012). Inhaled nanoparticles and lung cancer – what we can learn from conventional particle toxicology. Swiss Med Wkly 142:w13547
   Google Scholar
• Dong PX, Wan B, Wang ZX, et al. (2012). Exposure of single-walled carbon nanotubes impairs the functions of primarily cultured murine peritoneal macrophages. Nanotoxicology [Epub ahead of print]. DOI: 10.3109/17435390.2012.694487
   Google Scholar
• DuPont™. (2008). Nano risk framework output worksheet for: DuPont™ Crystar® 6920 PET poly-(ethylene terephthalate) resin with sepiolite clay, Pangel S-9 as an encapsulated nanodispersed filler. Available from: http://www.epa.gov/opptintr/nano/dupont2.pdf [last accessed 2 Jan 2013]
   Google Scholar
• Elgrabli D, Floriani M, Abella-Gallart S, et al. (2008). Biodistribution and clearance of instilled carbon nanotubes in rat lung. Part Fibre Toxicol 5:20
   PubMed Web of Science ®Google Scholar
• Fenoglio I, Aldieri E, Gazzano E, et al. (2012). Thickness of multiwalled carbon nanotubes affects their lung toxicity. Chem Res Toxicol 25:74–82
   PubMed Web of Science ®Google Scholar
• Ferrari G, Cook BD, Terushkin V, et al. (2009). Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis. J Cell Physiol 219:449–58
   PubMed Web of Science ®Google Scholar
• He X, Young S, Schwegler-Berry D, et al. (2011). Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-κB signaling, and promoting fibroblast-to-myofibroblast transformation. Chemical Res Toxicol 24:2237–48
   PubMed Web of Science ®Google Scholar
• Hubbard R, Venn A, Lewis S, Britton J. (2000). Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study. Am J Respir Crit Care Med 161:5–8
   PubMed Web of Science ®Google Scholar
• Inghilleri S, Morbini P, Oggionni T, et al. (2006). In situ assessment of oxidant and nitrogenic stress in bleomycin pulmonary fibrosis. Histochem Cell Biol 125:661–9
   PubMed Web of Science ®Google Scholar
• Inoue K, Koike E, Yanagisawa R, et al. (2009). Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model. Toxicol Appl Pharmacol 237:306–16
   PubMed Web of Science ®Google Scholar
• Jain S, Thakare VS, Das M, et al. (2011). Toxicity of multiwalled carbon nanotubes with end defects critically depends on their functionalization density. Chem Res Toxicol 24:2028–39
   PubMed Web of Science ®Google Scholar
• Jaurand MC. (1997). Mechanisms of fiber-induced genotoxicity. Environ Health Perspect 105:1073–84
   PubMed Web of Science ®Google Scholar
• Jaurand MF, Renier A, Daubriac, J. (2009). Mesothelioma: do asbestos and carbon nanotubes pose the same health risk? Particle Fibre Toxicol 6:16
   PubMed Web of Science ®Google Scholar
• Jia G, Wang H, Yan L, et al. (2005). Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene. Environ Sci Technol 39:1378–83
   PubMed Web of Science ®Google Scholar
• Kagan VE, Konduru NV, Feng W, et al. (2010). Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nature Nanotechnol 5:354–9
   PubMed Web of Science ®Google Scholar
• Kagan VE, Tyurina YY, Tyurin VA, et al. (2006). Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron. Toxicol Lett 165:88–100
   PubMed Web of Science ®Google Scholar
• Kang S, Herzberg M, Rodrigues DF, Elimelech M. (2008). Antibacterial effects of carbon nanotubes: size does matter! Langmuir 24:6409–13
   PubMed Web of Science ®Google Scholar
• Keane MP. (2004). Angiogenesis and pulmonary fibrosis: feast or famine? Am J Respir Crit Care Med 170:207–9
   PubMed Web of Science ®Google Scholar
• Khalil N, Xu YD, O'Connor R, Duronio V. (2005). Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1-induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNK. J Biol Chem 280:43000–9
   PubMed Web of Science ®Google Scholar
• Kim KK, Kugler MC, Wolters PJ, et al. (2006). Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA 103:13180–5
   PubMed Web of Science ®Google Scholar
• Kisin ER, Murray AR, Keane MJ, et al. (2007). Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells. J Toxicol Environ Health Part A 70:2071–9
   PubMed Web of Science ®Google Scholar
• Kisin ER, Murray AR, Sargent L, et al. (2011). Genotoxicity of carbon nanofibers: are they potentially more or less dangerous than carbon nanotubes or asbestos? Toxicol Appl Pharmacol 252:1–10
   PubMed Web of Science ®Google Scholar
• Knaapen AM, Borm PJ, Albrecht C, Schins RP. (2004). Inhaled particles and lung cancer. Part A: mechanisms. Int J Cancer 109:799–809
   PubMed Web of Science ®Google Scholar
• Lam C, James JT, McCluskey R, Hunter RL. (2004). Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77:126–34
   PubMed Web of Science ®Google Scholar
• Lam CW, James JT, McCluskey R, et al. (2006). A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol 36:189–217
   PubMed Web of Science ®Google Scholar
• Leask A, Abraham DJ. (2004). TGF-beta signaling and the fibrotic response. FASEB J: Off Publ Fed Am Soc Exp Biol 18:816–27
   PubMed Web of Science ®Google Scholar
• Lee JK, Sayers BC, Chun KS, et al. (2012). Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP Kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages. Particle Fibre Toxicol 9:14
   PubMed Web of Science ®Google Scholar
• Lindroos PM, Coin PG, Badgett A, et al. (1997). Alveolar macrophages stimulated with titanium dioxide, chrysotile asbestos, and residual oil fly ash upregulate the PDGF receptor-alpha on lung fibroblasts through an IL-1beta-dependent mechanism. Am J Respir Cell Mol Biol 16:283–92
   PubMed Web of Science ®Google Scholar
• Liu J, Legros S, Ma G, et al. (2012). Influence of surface functionalization and particle size on the aggregation kinetics of engineered nanoparticles. Chemosphere 87:918–24
   PubMed Web of Science ®Google Scholar
• Magrez A, Kasas S, Salicio V, et al. (2006). Cellular toxicity of carbon-based nanomaterials. Nano Lett 6:1121–5
   PubMed Web of Science ®Google Scholar
• Mangum JB, Turpin, EA, Antao-Menezes A, et al. (2006). Single-walled carbon nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ. Particle Fibre Toxicol 3:15
   PubMed Web of Science ®Google Scholar
• Manna SK, Sarkar S, Barr J, et al. (2005). Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-kappaB in human keratinocytes. Nano Lett 5:1676–84
   PubMed Web of Science ®Google Scholar
• Maynard AD, Baron PA, Foley M, et al. (2004). Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material. J Toxicol Environ Health Part A 67:87–107
   PubMed Web of Science ®Google Scholar
• Mercer RR, Hubbs AF, Scabilloni JF, et al. (2011). Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes. Particle Fibre Toxicol 8:21
   PubMed Web of Science ®Google Scholar
• Mercer RR, Scabilloni J, Wang L, et al. (2008). Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model. Am J Physiol Lung Cell Mol Physiol 294:L87–97
   PubMed Web of Science ®Google Scholar
• Mishra A, Rojanasakul Y, Chen B, et al. (2012). Assessment of pulmonary fibrogenic potential of multiwalled carbon nanotubes in human lung cells. J Nanomater [Epub ahead of print]
   Web of Science ®Google Scholar
• Mitchell LA, Gao J, Wal RV, et al. (2007). Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol Sci: Off J Soc Toxicol 100:203–14
   PubMed Web of Science ®Google Scholar
• Muller J, Decordier I, Hoet PH, et al. (2008). Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells. Carcinogenesis 29:427–33
   PubMed Web of Science ®Google Scholar
• Muller J, Huaux F, Moreau N, et al. (2005). Respiratory toxicity of multi-wall carbon nanotubes. Toxicol Appl Pharmacol 207:221–31
   PubMed Web of Science ®Google Scholar
• Murphy FA, Poland CA, Duffin R, et al. (2011). Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura. Am J Pathol 178:2587–600
   PubMed Web of Science ®Google Scholar
• Murray AR, Kisin ER, Tkach AV, et al. (2012). Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos. Particle Fibre Toxicol 9:10
   PubMed Web of Science ®Google Scholar
• Nagai H, Okazaki Y, Chew SH, et al. (2011). Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proc Natl Acad Sci USA 108:E1330–8
   PubMed Web of Science ®Google Scholar
• Oberdörster G, Maynard A, Donaldson K, et al. (2005). Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Particle Fibre Toxicol 2:8
   PubMed Web of Science ®Google Scholar
• Pacurari M, Qian Y, Fu W, et al. (2012). Cell permeability, migration, and reactive oxygen species induced by multiwalled carbon nanotubes in human microvascular endothelial cells. J Toxicol Environ Health Part A 75:129–47
   PubMed Web of Science ®Google Scholar
• Pacurari M, Yin XJ, Zhao J, et al. (2008). Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappaB, and Akt in normal and malignant human mesothelial cells. Environ Health Perspect 116:1211–17
   PubMed Web of Science ®Google Scholar
• Palomäki J, Välimäki E, Sund J, et al. (2011). Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism. ACS Nano 5:6861–70
   PubMed Web of Science ®Google Scholar
• Pardo A, Gibson K, Cisneros J, et al. (2005). Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. Plos Med 2:e251
   PubMed Web of Science ®Google Scholar
• Park E, Roh J, Kim S, et al. (2011). A single intratracheal instillation of single-walled carbon nanotubes induced early lung fibrosis and subchronic tissue damage in mice. Archiv Toxicol 85:1121–31
   PubMed Web of Science ®Google Scholar
• Patel V. (2011). Global carbon nanotubes market outlook: industry beckons. Nanotech Insights 2:31–5
   Google Scholar
• Patlolla AK, Hussain SM, Schlager JJ, et al. (2010a). Comparative study of the clastogenicity of functionalized and nonfunctionalized multiwalled carbon nanotubes in bone marrow cells of Swiss-Webster mice. Environ Toxicol 25:608–21
   PubMed Web of Science ®Google Scholar
• Patlolla A, Knighten B, Tchounwou P. (2010b). Multi-walled carbon nanotubes induce cytotoxicity, genotoxicity and apoptosis in normal human dermal fibroblast cells. Ethn Dis 20:S1-65–72
   PubMed Web of Science ®Google Scholar
• Peão MN, Aguas AP, de Sá CM, Grande NR. (1994). Neoformation of blood vessels in association with rat lung fibrosis induced by bleomycin. Anat Record 238:57–67
   PubMedGoogle Scholar
• Poland CA, Duffin R, Kinloch I, et al. (2008). Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nature Nanotechnol 3:423–8
   PubMed Web of Science ®Google Scholar
• Pulskamp K, Diabaté S, Krug HF. (2007). Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol Lett 168:58–74
   PubMed Web of Science ®Google Scholar
• Radisky DC, Kenny PA, Bissell MJ. (2007). Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem 101:830–9
   PubMed Web of Science ®Google Scholar
• Reddy AR, Krishna DR, Reddy YN, Himabindu V. (2010). Translocation and extra pulmonary toxicities of multi wall carbon nanotubes in rats. Toxicol Mech Meth 20:267–72
   PubMed Web of Science ®Google Scholar
• Rock JR, Barkauskas CE, Cronce MJ, et al. (2011). Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci USA 108:20867–8
   Web of Science ®Google Scholar
• Rotoli BM, Bussolati O, Barilli A, et al. (2009). Airway barrier dysfunction induced by exposure to carbon nanotubes in vitro: which role for fiber length? Human Exp Toxicol 28:361–8
   PubMed Web of Science ®Google Scholar
• Rotoli BM, Bussolati O, Bianchi MG, et al. (2008). Non-functionalized multi-walled carbon nanotubes alter the paracellular permeability of human airway epithelial cells. Toxicol Lett 178:95–102
   PubMed Web of Science ®Google Scholar
• Sato Y, Yokoyama A, Shibata K, et al. (2005). Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo. Mol BioSyst 1:176–82
   PubMed Web of Science ®Google Scholar
• Saxena R, Williams W, McGee J, et al. (2007). Enhanced in vitro and in vivo toxicity of polydispersed acid-functionalized single-wall carbon nanotubes. Nanotoxicology 1:291–300
   Web of Science ®Google Scholar
• Sayes CM, Liang F, Hudson JL, et al. (2006). Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro. Toxicol Lett 161:135–42
   PubMed Web of Science ®Google Scholar
• Schneeberger EE, Lynch RD. (2004). The tight junction: a multifunctional complex. Am J Physiol Cell Physiol 286:C1213–28
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Castranova V, Kisin ER, et al. (2003). Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environ Health Part A 66:1909–26
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kapralov AA, Feng WH, et al. (2012). Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice. Plos One 7:e30923
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kisin ER, Mercer R, et al. (2005). Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 289:L698–708
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kisin E, Murray AR, et al. (2008). Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. Am J Physiol Lung Cell Mol Physiol 295:L552–65
   PubMed Web of Science ®Google Scholar
• Sime PJ, Marr RA, Gauldie D, et al. (1998). Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts. Am J Pathol 153:825–32
   PubMed Web of Science ®Google Scholar
• Singh R, Pantarotto D, Lacerda L, et al. (2006). Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci USA 103:3357–62
   PubMed Web of Science ®Google Scholar
• Sinha N, Yeow JT. (2005). Carbon nanotubes for biomedical applications. IEEE Trans Nanobioscience 4:180–95
   PubMed Web of Science ®Google Scholar
• Song Y, Li X, Du X. (2009). Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma. Eur Respir J 34:559–67
   PubMed Web of Science ®Google Scholar
• Stella GM. (2011). Carbon nanotubes and pleural damage: perspectives of nanosafety in the light of asbestos experience. Biointerphases 6:P1–17
   PubMed Web of Science ®Google Scholar
• Thannickal VJ, Fanburg BL. (1995). Activation of an H2O-generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1. J Biol Chem 270:30334–8
   PubMed Web of Science ®Google Scholar
• Thannickal VJ, Toews GB, White ES, et al. (2004). Mechanisms of pulmonary fibrosis. Ann Rev Med 55:395–417
   PubMed Web of Science ®Google Scholar
• Tian F, Cui D, Schwarz H, et al. (2006). Cytotoxicity of single-wall carbon nanotubes on human fibroblasts. Toxicol In Vitro 20:1202–12
   PubMed Web of Science ®Google Scholar
• Turner-Warwick M. (1963). Precapillary Systemic-pulmonary anastomoses. Thorax 18:225–37
   PubMedGoogle Scholar
• Valko M, Rhodes CJ, Moncol J, et al. (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160:1–40
   PubMed Web of Science ®Google Scholar
• Vanhee D, Gosset P, Wallaert B, et al. (1994). Mechanisms of fibrosis in coal workers' pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity. Am J Respir Crit Care Med 150:1049–55
   PubMed Web of Science ®Google Scholar
• Wallace WAH, Fitch PM, Simpson AJ, Howie SEM. (2007). Inflammation-associated remodelling and fibrosis in the lung – a process and an end point. Int J Exp Pathol 88:103–10
   PubMed Web of Science ®Google Scholar
• Wang L, Castranova V, Mishra A, et al. (2010a). Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies. Particle Fibre Toxicol 7:31
   PubMed Web of Science ®Google Scholar
• Wang L, Luanpitpong S, Castranova V, et al. (2011a). Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells. Nano Lett 11:2796–803
   PubMed Web of Science ®Google Scholar
• Wang R, Mikoryak C, Li S, et al. (2011c). Cytotoxicity screening of single-walled carbon nanotubes: detection and removal of cytotoxic contaminants from carboxylated carbon nanotubes. Mol Pharm 8:1351–61
   PubMed Web of Science ®Google Scholar
• Wang L, Rojanasakul Y, Castranova V, et al. (2010b). Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts. J Toxicol Environ Health Part A 73:410–22
   PubMed Web of Science ®Google Scholar
• Wang X, Xia T, Ntim SA, et al. (2011b). Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung. ACS Nano 5:9772–87
   PubMed Web of Science ®Google Scholar
• Warheit DB, Laurence BR, Reed KL, et al. (2004). Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci: Off J Soc Toxicol 77:117–25
   PubMed Web of Science ®Google Scholar
• Willis BC, Borok Z. (2007). TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 293:L525–34
   PubMed Web of Science ®Google Scholar
• Willis BC, Liebler JM, Luby-Phelps K, et al. (2005). Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-[beta]1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 166:1321–32
   PubMed Web of Science ®Google Scholar
• Zhang Y, Yan B. (2012). Cell cycle regulation by carboxylated multiwalled carbon nanotubes through p53-independent induction of p21 under the control of the BMP signaling pathway. Chem Res Toxicol 25:1212–21
   PubMed Web of Science ®Google Scholar
• Zhang LW, Zeng L, Barron AR, Monteiro-Riviere NA. (2007). Biological interactions of functionalized single-wall carbon nanotubes in human epidermal keratinocytes. Int J Toxicol 26:103–13
   PubMed Web of Science ®Google Scholar
• Zhu L, Chang DW, Dai L, Hong Y. (2007). DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells. Nano Lett 7:3592–7
   PubMed Web of Science ®Google Scholar
• Zhu MT, Feng WY, Wang Y, et al. (2009). Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment. Toxicol Sci: Off J Soc Toxicol 107:342–51
   PubMed Web of Science ®Google Scholar