Hepatoprotective effects of DL-α-lipoic acid and α-Tocopherol through amelioration of the mitochondrial oxidative stress in acetaminophen challenged rats

References

• Abdel-Zaher AO, Abdel-Hady RH, Mahmoud MM, Farrag MMY. (2008). The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicology 243:261–70
   PubMed Web of Science ®Google Scholar
• Ahmed MB, Khater MR. (2001). Evaluation of the protective potential of Ambrosia maritime extract on acetaminophen-induced liver damage. J Ethnopharmacol 75:169–74
   PubMed Web of Science ®Google Scholar
• Ajith T, Hema U, Aswathy M. (2007). Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status. Food Chem Toxicol 45:2267–72
   PubMed Web of Science ®Google Scholar
• Alsalim W, Fadel M. (2003). Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Oral methionine compared with intravenous N-acetyl cysteine for paracetamol overdose. Emerg Med J 20:366–7
   PubMed Web of Science ®Google Scholar
• Arivazhagan P, Ramanathan K, Panneerselvam C. (2001). Effect of DL-(alpha)-lipoic acid on mitochondrial enzymes in aged rats. Chem Biol Interact 138:189–98
   PubMed Web of Science ®Google Scholar
• Bagh MB, Thakurta IG, Biswas M, et al. (2010). Age-related oxidative decline of mitochondrial functions in rat brain is prevented by long term oral antioxidant supplementation. Biogerontology 12:119–31
   PubMedGoogle Scholar
• Balaji Raghavendran HR, Sathivel A, Devaki T. (2005). Antioxidant effect of Sargassum polycystum (Phaeophyceae) against acetaminophen induced changes in hepatic mitochondrial enzymes during toxic hepatitis. Chemosphere 61:276–81
   PubMed Web of Science ®Google Scholar
• Belousov VV, Fradkov AF, Lukyanov KA, et al. (2006). Genetically encoded fluorescent indicator for intracellular hydrogen peroxide. Nat Methods 3:281–6
   PubMed Web of Science ®Google Scholar
• Bonini MG, Rota C, Tomasi A, Mason RP. (2006). The oxidation of 2′,7′-dichlorofluorescein to reactive oxygen species: a self-fulfilling prophesy? Free Radic Biol Med 40:968–75
   PubMed Web of Science ®Google Scholar
• Burcham PC, Harman AW. (1991). Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes. J Biol Chem 266:5049--54
   PubMed Web of Science ®Google Scholar
• Burke AS, MacMillan-Crow LA, Hinson JA. (2010). Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes. Chem Res Toxicol 23:1286–92
   PubMed Web of Science ®Google Scholar
• Capaldi RA, Marusich MF, Taanman JW. (1995). Mammalian cytochrome-c oxidase: Characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells. Methods Enzymol 260:117–32
   PubMed Web of Science ®Google Scholar
• Catal T, Bolkent S. (2008). Combination of selenium and three naturally occurring antioxidants administration protects D-galactosamine-induced liver injury in rats. Biol Trace Elem Res 122:127–36
   PubMed Web of Science ®Google Scholar
• Chow CK. (1991). Vitamin E and oxidative stress. Free Radic Biol Med 11:215–32
   PubMed Web of Science ®Google Scholar
• Clarke MW, Burnett JR, Croft KD. (2008). Vitamin E in human health and disease. Crit Rev Clin Lab Sci 45:417–50
   PubMed Web of Science ®Google Scholar
• Devi KP, Sreepriya M, Balakrishna K, Devaki T. (2005). Protective effect of Premna tomentosa extract (L. verbanacae) on acetaminophen-induced mitochondrial dysfunction in rats. Mol Cell Biochem 272:171–7
   PubMed Web of Science ®Google Scholar
• Ener G, Ehirli AÖ, Ayano lu Dülger G. (2003). Protective effects of melatonin, vitamin E and N acetylcysteine against acetaminophen toxicity in mice: a comparative study. J Pineal Res 35:61–8
   PubMedGoogle Scholar
• Fatania H, Al-Nassar KE, Sidhan V. (1993). Purification and partial characterisation of NADP+-linked isocitrate dehydrogenase from rat liver cytosol. FEBS Lett. 320:57–60
   PubMed Web of Science ®Google Scholar
• Grattagliano I, Bonfrate L, Diogo CV, et al. (2009). Biochemical mechanisms in drug-induced liver injury: certainties and doubts. World J Gastroenterol 15:4865–76
   PubMed Web of Science ®Google Scholar
• Hafeman D, Sunde R, Hoekstra W. (1974). Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J Nutr 104:580–7
   PubMed Web of Science ®Google Scholar
• Hempel SL, Buettner GR, O'Malley YQ, et al. (1999). Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5 (and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine. Free Radic Biol Med 27:146–59
   PubMed Web of Science ®Google Scholar
• Hinson JA, Roberts DW, James LP. (2010). Mechanisms of acetaminophen-induced liver necrosis. Handb Exp Pharmacol 196:369–405
   PubMedGoogle Scholar
• Jaeschke H, McGill MR, Williams CD, Ramachandran A. (2011). Current issues with acetaminophen hepatotoxicity – a clinically relevant model to test the efficacy of natural products. Life Sci 88:737–45
   PubMed Web of Science ®Google Scholar
• Janssen AJM, Trijbels FJM, Sengers RCA, et al. (2007). Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts. Clin Chem 53:729–34
   PubMed Web of Science ®Google Scholar
• Kalyanaraman B, Darley-Usmar V, Davies KJ, et al. (2012). Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med 52:1–6
   PubMed Web of Science ®Google Scholar
• Karlsson M, Kurz T, Brunk UT, et al. (2010). What does the commonly used DCF test for oxidative stress really show? Biochem J 428:183–90
   PubMed Web of Science ®Google Scholar
• Kotamraju S, Kalivendi SV, Konorev E, et al. (2004). Oxidant-induced iron signaling in doxorubicin-mediated apoptosis. Methods Enzymol 378:362–82
   PubMed Web of Science ®Google Scholar
• Krahenbuhl S, Chang M, Brass E, Hoppel C. (1991). Decreased activities of ubiquinol: ferricytochrome c oxidoreductase (complex III) and ferrocytochrome c: oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin (c-lactam)-induced methylmalonic aciduria. J Biol Chem 266:20998–1003
   PubMed Web of Science ®Google Scholar
• Lee S, Gharavi NM, Honda H, et al. (2009). A role for NADPH oxidase 4 in the activation of vascular endothelial cells by oxidized phospholipids. Free Radic Biol Med 47:145–51
   PubMedGoogle Scholar
• Lowry OH, Rosebrough NJ, Farr AL, et al. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–75
   PubMed Web of Science ®Google Scholar
• McCord JM, Fridovich I. (1969). Superoxide dismutase and enzymatic function for erythrocuprein (hemocuprein). J Biol Chem 244:6049–55
   PubMed Web of Science ®Google Scholar
• Mehler AH, Kornberg A. (1948). The enzymatic mechanism of oxidation-reductions between malate or isocitrate and pyruvate. J Biol Chem 174:961–77
   PubMed Web of Science ®Google Scholar
• Meyers LL, Beierschmitt WP, Khairallah EA, Cohen SD. (1988). Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice* 1. Toxicol Appl Pharmacol 93:378–87
   PubMed Web of Science ®Google Scholar
• Moron MS, Depierre JW, Mannervik B. (1979). Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 582:67–78
   PubMed Web of Science ®Google Scholar
• Nazareth W, Sethi JK, McLean AEM. (1991). Effect of paracetamol on mitochondrial membrane function in rat liver slices. Biochem Pharmacol 42:931–6
   PubMed Web of Science ®Google Scholar
• Nourjah P, Ahmad SR, Karwoski C, Willy M. (2006). Estimates of acetaminophen (paracetomal) associated overdoses in the United States. Pharmacoepidemiol Drug Saf 15:398–405
   PubMed Web of Science ®Google Scholar
• Nulton-Persson AC, Szweda LI. (2001). Modulation of mitochondrial function by hydrogen peroxide. J Biol Chem 276:23357–61
   PubMed Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–8
   PubMed Web of Science ®Google Scholar
• Ramsay RR, Rashed MS, Nelson SD. (1989). In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria* 1. Arch Biochem Biophys 273:449–57
   PubMed Web of Science ®Google Scholar
• Reed LJ, Mukherjee BB. (1969). (Alpha)-ketoglutarate dehydrogenase complex from Escherichia coli. Methods Enzymol 13:55–61
   Google Scholar
• Shay KP, Moreau RF, Smith EJ, et al. (2009). Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta 1790:1149–60
   PubMed Web of Science ®Google Scholar
• Shimizu S, Narita M, Tsujimoto Y. (1999). Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399:483–7
   PubMed Web of Science ®Google Scholar
• Streeter A, Dahlin D, Nelson S, Baillie T. (1984). The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro. Chem Biol Interact 48:349–66
   PubMed Web of Science ®Google Scholar
• Sudheesh NP, Ajith TA, Janardhanan KK. (2009). Ganoderma lucidum (Fr.) P. Karst enhances activities of heart mitochondrial enzymes and respiratory chain complexes in the aged rat. Biogerontology 10:627–36
   PubMed Web of Science ®Google Scholar
• Sudheesh NP, Ajith TA, Mathew J, et al. (2012). Ganoderma lucidum protects liver mitochondrial oxidative stress and improves the activity of electron transport chain in carbon tetrachloride intoxicated rats. Hepatol Res 42:181–91
   PubMed Web of Science ®Google Scholar
• Sudheesh NP, Ajith TA, Ramnath V, Janardhanan K. (2010). Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the mitochondria of post-mitotic tissues of aged mice. Clin Nutr 29:406–12
   PubMedGoogle Scholar
• Wasilewski M, Wojtczak L. (2005). Effects of N-acylethanolamines on the respiratory chain and production of reactive oxygen species in heart mitochondria. FEBS Lett 579:4724–8
   PubMedGoogle Scholar
• Yanpallewar SU, Sen S, Tapas S, et al. (2002). Effect of Azadirachta indica on paracetamol-induced hepatic damage in albino rats. Phytomedicine 9:391–6
   Google Scholar
• Zmijewski JW, Moellering DR, Le Goffe C, et al. (2005). Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells. Am J Physiol Heart Circ Physiol 289:H852–61
   PubMed Web of Science ®Google Scholar