Vanadium carcinogenic, immunotoxic and neurotoxic effects: a review of in vitro studies

References

• Afeseh Ngwa H, Kanthasamy A, Anantharam V, et al. (2009). Vanadium induces dopaminergic neurotoxicity via protein kinase C delta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease. Toxicol Appl Pharmacol 240:273–85
   PubMed Web of Science ®Google Scholar
• Amundson SA, Myers TG, Fornace AJ. (1998). Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene 17:3287–99
   PubMed Web of Science ®Google Scholar
• Assem FL, Levy LS. (2009). A review of current toxicological concerns on vanadium pentoxide and other vanadium compounds: gaps in knowledge and directions for future research. J Toxicol Environ Health B 12:289–306
   PubMed Web of Science ®Google Scholar
• ATSDR, Agency for Toxic Substances and Disease Registry, (2009). Toxicological profile for vanadium (Draft for Public Comment). Atlanta: U.S. Department of Health and Human Services, Public Health Service
   Google Scholar
• Aureliano M. (2011). Recent perspectives into biochemistry of decavanadate. World J Biol Chem 2:215–25
   PubMedGoogle Scholar
• Aureliano M, Crans DC. (2009). Decavanadate (V10O286−) and oxovanadates: oxometalates with many biological activities. J Inorg Biochem 103:536–46
   PubMed Web of Science ®Google Scholar
• Aureliano M, Gândara RMC. (2005). Decavanadate effects in biological systems. J Inorg Biochem 99:979–85
   PubMed Web of Science ®Google Scholar
• Avila-Costa MR, Colín-Barenque L, Zepeda-Rodríguez A, et al. (2005). Ependymal epithelium disruption after vanadium pentoxide inhalation, a mice experimental model. Neurosci Lett 381:21–5
   PubMed Web of Science ®Google Scholar
• Avila-Costa MR, Fortoul TI, Niño-Cabrera G, et al. (2006). Hippocampal cell alterations induced by the inhalation of vanadium pentoxide (V2O5) promote memory deterioration. NeuroToxicology 27:1007–12
   PubMed Web of Science ®Google Scholar
• Baran EJ. (2003). Model studies related to vanadium biochemistry: recent advances and perspectives. J Braz Chem Soc 14:878–88
   Web of Science ®Google Scholar
• Bishayee A, Waghray A, Patel MA, et al. (2010). Vanadium in the detection, prevention and treatment of cancer: the in vivo evidence. Cancer Lett 294:1–12
   PubMed Web of Science ®Google Scholar
• Breheny D, Oke O, Faux SP. (2011). The use of in vitro systems to assess cancer mechanisms and the carcinogenic potential of chemicals. Altern Lab Anim 39:1–23
   PubMed Web of Science ®Google Scholar
• Capella LS, Gefé MR, Silva EF, et al. (2002). Mechanisms of vanadate-induced cellular toxicity: role of cellular glutathione and NADPH. Arch Biochem Biophys 406:65–72
   PubMed Web of Science ®Google Scholar
• Carter JD, Ghio AJ, Samet JM, et al. (1997). Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent. Toxicol Appl Pharmacol 146:180–8
   PubMed Web of Science ®Google Scholar
• CCAC/CCPA. The Canadian Council on Animal Care. Available from: 3rs.ccac.ca/en/testing-and-production/alternative-test-methods/toxicity [last accessed May 2012]
   Google Scholar
• Chen F, Shi X. (2002). Intracellular signal transduction of cells in response to carcinogenic metals. Crit Rev Oncol Hematol 42:105–21
   PubMed Web of Science ®Google Scholar
• Chin LS, Murray SF, Harter DH, et al. (1999). Sodium vanadate inhibits apoptosis in malignant glioma cells: a role for Akt/PKB. J Biomed Sci 6:213–8
   PubMed Web of Science ®Google Scholar
• Cohen MD, McManus TP, Yang Z, et al. (1996). Vanadium affects macrophage interferone-γ-binding and -inducible responses. Toxicol Appl Pharmacol 138:110–20
   PubMed Web of Science ®Google Scholar
• Combes R, Balls M, Curren R, et al. (1999). Cell transformation assays as predictors of human carcinogenicity. Altern Lab Anim 27:745–67
   PubMed Web of Science ®Google Scholar
• Di Gioacchino M, Sabbioni E, Di Giampaolo L, et al. (2002). In vitro effects of vanadate on human immune functions. Ann Clin Lab Sci 32:148–54
   PubMed Web of Science ®Google Scholar
• Dong W, Simeonova PP, Gallucci R, et al. (1998). Toxic metals stimulate inflammatory cytokines in hepatocytes through oxidative stress mechanisms. Toxicol Appl Pharmacol 151:359–66
   PubMed Web of Science ®Google Scholar
• Elmore S. (2007). Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495–516
   PubMed Web of Science ®Google Scholar
• Fox L, Hegde S, Gumperz JE. (2010). Natural killer T cells: innate lymphocytes positioned as a bridge between acute and chronic inflammation. Microbes Infect 12:1125–33
   PubMed Web of Science ®Google Scholar
• Galli A, Vellosi R, Fiorio R, et al. (1991). Genotoxicity of vanadium compounds in yeast and cultured mammalian cells. Teratog Carcinog Mutagen 11:175–83
   PubMedGoogle Scholar
• Gândara RMC, Soares SS, Martins H, et al. (2005). Vanadate oligomers: in vivo effects in hepatic vanadium accumulation and stress markers. J Inorg Biochem 99:1238–44
   PubMed Web of Science ®Google Scholar
• Germolec DR, Frawley RP, Evans E. (2010). Markers of inflammation. Methods Mol Biol 598:53–73
   PubMedGoogle Scholar
• Geyikoglu F, Turkez H. (2008). Boron compounds reduce vanadium tetraoxide genotoxicity in human lymphocytes. Environ Toxicol Pharmacol 26:342–7
   PubMed Web of Science ®Google Scholar
• Gibson DP, Brauninger R, Shaffi HS, et al. (1997). Induction of micronuclei in Syrian hamster embryo cells: comparison to results in the SHE cell transformation assay for national toxicology program test chemicals. Mutat Res 392:61–70
   PubMed Web of Science ®Google Scholar
• Gomez-Mejiba SE, Zhai Z, Akram H, et al. (2009). Inhalation of environmental stressors & chronic inflammation: autoimmunity and neurodegeneration. Mutat Res 674:62–72
   PubMed Web of Science ®Google Scholar
• Grabowski GM, Paulauskis JD, Godleski JJ. (1999). Mediating phosphorylation events in the vanadium-induced respiratory burst of alveolar macrophages. Toxicol Appl Pharmacol 156:170–8
   PubMed Web of Science ®Google Scholar
• Harry GJ, Billingsley M, Bruinink A, et al. (1998). In vitro techniques for the assessment of neurotoxicity. Environ Health Perspect 106:131–58
   PubMed Web of Science ®Google Scholar
• Huang C, Ma WY, Young MR, et al. (1998). Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells. Proc Natl Acad Sci USA 95:156–61
   PubMed Web of Science ®Google Scholar
• Huang C, Zhang Z, Ding M, et al. (2000). Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis. J Biol Chem 275:32516–22
   PubMed Web of Science ®Google Scholar
• IARC, International Agency for Research on Cancer. (2006). IARC Monographs on the evaluation of carcinogenic risks to humans. Cobalt in hard metals and cobalt sulfate, gallium arsenide, indium phosphide and vanadium pentoxide. Vol. 86
   Google Scholar
• Ivancsits S, Pilger A, Diem E, et al. (2002). Vanadate induces DNA strand breaks in cultured human fibroblasts at doses relevant to occupational exposure. Mutat Res 519:25–35
   PubMed Web of Science ®Google Scholar
• Jaspers I, Samet JM, Erzurum S, et al. (2000). Vanadium-induced κB-dependent transcription depends upon peroxide-induced activation of the p38 mitogen-activated protein kinase. Am J Respir Cell Mol Biol 23:95–102
   PubMed Web of Science ®Google Scholar
• Jiang N, Dreher KL, Dye JA, et al. (2000). Residual oil fly ash induces cytotoxicity and mucin secretion by guinea pig tracheal epithelial cells via an oxidant-mediated mechanism. Toxicol Appl Pharmacol 163:221–30
   PubMed Web of Science ®Google Scholar
• Kitani S, Rajiva De Silva N, Morita Y, et al. (1998). Global environmental pollutant substance vanadium activates mast cells and basophils at the late phase in the presence of hydrogen peroxide. Environ Toxicol Pharmacol 6:1–12
   PubMed Web of Science ®Google Scholar
• Klein-Patel ME, Diamond G, Boniotto M, et al. (2006). Inhibition of β-defensin gene expression in airway epithelial cells by low doses of residual oil fly ash is mediated by vanadium. Toxicol Sci 92:115–25
   PubMed Web of Science ®Google Scholar
• Korbecki J, Baranowska-Bosiacka I, Gutowska I, et al. (2012). Biochemical and medical importance of vanadium compounds. Acta Biochim Pol 59:1–6
   PubMed Web of Science ®Google Scholar
• Laizé V, Tiago DM, Aureliano M, et al. (2009). New insights into mineralogenic effects of vanadate. Cell Mol Life Sci 66:3831–6
   PubMed Web of Science ®Google Scholar
• Lee K, Shen X, König R. (2001). Effects of cadmium and vanadium ions on antigen-induced signaling in CD4+ T cells. Toxicology 169:53–65
   PubMed Web of Science ®Google Scholar
• Lukas J, Lukas C, Bartek J. (2004). Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair 3:997–1007
   PubMed Web of Science ®Google Scholar
• Luo J, Sun Y, Lin H, et al. (2003). Activation of JNK by vanadate induces a Fas-associated death domain (FADD)-dependent death of cerebellar granule progenitors in vitro. J Biol Chem 278:4542–51
   PubMed Web of Science ®Google Scholar
• Luster MI, Simeonova PP, Germolec DR. (2008). Immunotoxicology. In ELS. Chichester: John Wiley & Sons Ltd, Available from: http://www.els.net [doi: 10.1002/9780470015902.a0000955.pub2]
   Google Scholar
• Markopoulou S, Kontargiris E, Batsi C, et al. (2009). Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin. FEBS J 276:3784–99
   PubMed Web of Science ®Google Scholar
• Moskalyk RR, Alfantazi AM. (2003). Processing of vanadium: a review. Miner Eng 16:793–805
   Web of Science ®Google Scholar
• Mukherjee B, Patra B, Mahapatra S, et al. (2004). Vanadium-an element of atypical biological significance. Toxicol Lett 150:135–43
   PubMed Web of Science ®Google Scholar
• NTP. (2002). NTP toxicology and carcinogenesis studies of vanadium pentoxide (CAS No. 1314-62-1) in F344/N rats and B6C3F1 mice (inhalation). Natl Toxicol Program Tech Rep Ser 507:1–343
   Google Scholar
• Oeckinghaus A, Ghosh S. (2009). The NF-κB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1:a000034
   PubMed Web of Science ®Google Scholar
• Parfett CLJ, Pilon R. (1995). Oxidative stress-regulated gene expression and promotion of morphological transformation induced in C3H/10T1/2 cells by ammonium metavanadate. Fd Chem Toxic 33:301–8
   PubMed Web of Science ®Google Scholar
• Piotrowska A, Iżykowska I, Podhorska-Okołów M, et al. (2008). Budowa białek z rodziny NF-κB i ich rola w procesie apoptozy. Postepy Hig Med Dosw 62:64–74
   Google Scholar
• Pucci B, Kasten M, Giordano A. (2000). Cell cycle and apoptosis. Neoplasia 2:291–9
   PubMed Web of Science ®Google Scholar
• Ramírez P, Eastmond DA, Laclette JP, et al. (1997). Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide. Mutat Res 386:291–8
   PubMed Web of Science ®Google Scholar
• Rana SVS. (2008). Metals and apoptosis: recent developments. J Trace Elem Med Biol 22:262–84
   PubMed Web of Science ®Google Scholar
• Rehder D. (2012). The potentiality of vanadium in medicinal applications. Future Med Chem 4:1823–37
   PubMed Web of Science ®Google Scholar
• Rivedal E, Roseng LE, Sanner T. (1990). Vanadium compounds promote the induction of morphological transformation of hamster embryo cells with no effect on gap junctional cell communication. Cell Biol Toxicol 6:303–14
   PubMed Web of Science ®Google Scholar
• Rizzo MT. (2011). Cyclooxygenase-2 in oncogenesis. Clin Chim Acta 412:671–87
   PubMed Web of Science ®Google Scholar
• Rodríguez-Mercado JJ, Mateos-Nava RA, Altamirano-Lozano MA. (2011). DNA damage induction in human cells exposed to vanadium oxides in vitro. Toxicol In Vitro 25:1996–2002
   PubMed Web of Science ®Google Scholar
• Rodríguez-Mercado JJ, Roldán-Reyes E, Altamirano-Lozano M. (2003). Genotoxic effects of vanadium(IV) in human peripheral blood cells. Toxicol Lett 144:359–69
   PubMed Web of Science ®Google Scholar
• Rogers DF. (2007). Physiology of airway mucus secretion and pathophysiology of hypersecretion. Respir Care 52:1134–46
   PubMed Web of Science ®Google Scholar
• Roggen EL, Kristinsen Soni N, Verheyen GR. (2006). Respiratory immunotoxicity: an in vitro assessment. Toxicol In Vitro 20:1249–64
   PubMed Web of Science ®Google Scholar
• Rojas E, Valverde M, Herrera LA, et al. (1996). Genotoxicity of vanadium pentoxide evaluate by the single cell gel electrophoresis assay in human lymphocytes. Mutat Res 359:77–84
   PubMed Web of Science ®Google Scholar
• Roldán-Reyes E, Aguilar-Morales C, Frías-Váquez, S, et al. (1997). Induction of sister chromatid exchanges in human lymphocytes by vanadium pentoxide in combination with caffeine. Med Sci Res 25:501–4
   Google Scholar
• Rondini EA, Walters DM, Bauer AK. (2010). Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner. Part Fibre Toxicol 7:9
   PubMed Web of Science ®Google Scholar
• Rooney AA, Luebke RW, Selgrade MK, et al. (2012). Immunotoxicology and its application in risk assessment. EXS 101:251–87
   PubMedGoogle Scholar
• Sabbioni E, Kuèera J, Pietra R, et al. (1996). A critical review on normal concentrations of vanadium in human blood, serum, and urine. Sci Total Environ 188:49–58
   PubMed Web of Science ®Google Scholar
• Sabbioni E, Pozzi G, Devos S, et al. (1993). The intensity of vanadium(V)-induced cytotoxicity and morphological transformation in BALB/3T3 cells is dependent on glutathione-mediated bioreduction to vanadium(IV). Carcinogenesis 14:2565–8
   PubMed Web of Science ®Google Scholar
• Sakai A. (2008). BALB/c 3T3 cell transformation assays for the assessment of chemical carcinogenicity. AATEX 14:367–73
   Google Scholar
• Sheu CW, Rodriguez I, Lee JK. (1992). Proliferation and morphological transformation of BALB/3T3 cells by a prolonged treatment with sodium orthovanadate. Fd Chem Toxic 30:307–11
   PubMed Web of Science ®Google Scholar
• Shi X, Jiang H, Mao Y, et al. (1996). Vanadium(IV)-mediated free radical generation and related 2′-deoxyguanosine hydroxylation and DNA damage. Toxicology 106:27–38
   PubMed Web of Science ®Google Scholar
• Soares SS, Gutiérrez-Merino C, Aureliano M. (2007a). Decavanadate induces mitochondrial membrane depolarization and inhibits oxygen consumption. J Inorg Biochem 101:789–96
   PubMed Web of Science ®Google Scholar
• Soares SS, Gutiérrez-Merino C, Aureliano M. (2007b). Mitochondria as a target for decavanadate toxicity in Sparus aurata heart. Aquat Toxicol 83:1–9
   PubMed Web of Science ®Google Scholar
• Soares SS, Martins H, Duarte RO, et al. (2007c). Vanadium distribution, lipid peroxidation and oxidative stress markers upon decavanadate in vivo administration. J Inorg Biochem 101:80–8
   PubMed Web of Science ®Google Scholar
• Soazo M, Garcia GB. (2007). Vanadium exposure through lactation produces behavioral alterations and CNS myelin deficit in neonatal rats. Neurotoxicol Teratol 29:503–10
   PubMed Web of Science ®Google Scholar
• Tang H, Sun Y, Xiu Q, et al. (2007). Cyclooxygenase-2 induction requires activation of nuclear factor of activated T-cells in Beas-2B cells after vanadium exposure and plays an anti-apoptotic role. Arch Biochem Biophys 468:92–9
   PubMed Web of Science ®Google Scholar
• Thompson KH, Orvig C. (2004). Vanadium compounds in the treatment of diabetes. Met Ions Biol Syst 41:221–52
   PubMedGoogle Scholar
• Thompson KH, Lichter J, LeBel C, et al. (2009). Vanadium treatment of type 2 diabetes: a view to the future. J Inorg Biochem 103:554–8
   PubMed Web of Science ®Google Scholar
• Todorich B, Olopade JO, Surguladze N, et al. (2011). The mechanism of vanadium-mediated developmental hypmyelination is related to destruction of oligodendrocyte progenitors through a relationship with ferritin and iron. Neurotox Res 19:361–73
   PubMed Web of Science ®Google Scholar
• Tsiani E, Fantus IG. (1997). Vanadium compounds biological actions and potential as pharmacological agents. Trends Endocrinol Metab 8:51–8
   PubMed Web of Science ®Google Scholar
• Wang Q, Liu TT, Fu Y, et al. (2010). Vanadium compounds discriminate hepatoma and normal hepatic cells by differential regulation of reactive oxygen species. J Biol Inorg Chem 15:1087–97
   PubMed Web of Science ®Google Scholar
• WHO. (2000). Vanadium. In: WHO air quality guidelines for Europe. European Series. 2nd ed. World Health Organization, WHO Regional Publications, Vol. 91
   Google Scholar
• Wozniak K, Blasiak J. (2004). Vanadyl sulfate can differently damage DNA in human lymphocytes and HeLa cells. Arch Toxicol 78:7–15
   PubMed Web of Science ®Google Scholar
• Yasuda M, Nishizawa T, Ohigashi H, et al. (2009). Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction. Carcinogenesis 30:1209–16
   PubMed Web of Science ®Google Scholar
• Ye J, Ding M, Leonard SS, et al. (1999a). Vanadate induces apoptosis in epidermal JB6 P+ cells via hydrogen peroxide-mediated reactions. Mol Cell Biochem 202:9–17
   PubMed Web of Science ®Google Scholar
• Ye J, Ding M, Zhang X, et al. (1999b). Induction of TNFalpha in macrophages by vanadate is dependent on activation of transcription factor NF-kappaB and free radical reactions. Mol Cell Biochem 198:193–200
   PubMed Web of Science ®Google Scholar
• Yu D, Walters DM, Zhu L, et al. (2011). Vanadium pentoxide (V2O5) induced mucin production by airway epithelium. Am J Physiol Lung Cell Mol Physiol 301:L31–9
   PubMed Web of Science ®Google Scholar
• Zhang Z, Huang C, Li J, et al. (2001). Vanadate-induced cell growth regulation and the role of reactive oxygen species. Archiv Biochem Biophys 392:311–20
   PubMed Web of Science ®Google Scholar
• Zhang Z, Chen F, Huang C, et al. (2002a). Vanadate induces G2/M phase arrest in p53-deficient mouse embryo fibroblasts. J Environ Pathol Toxicol Oncol 21:223–31
   PubMedGoogle Scholar
• Zhang Z, Huang C, Li J, et al. (2002b). Vanadate-induced cell growth arrest is p53-dependent through activation of p21 in Cl41 cells. J Inorg Biochem 89:142–8
   PubMed Web of Science ®Google Scholar
• Zhang Z, Leonard SS, Huang C, et al. (2003). Role of reactive oxygen species and MAPKs in vanadate-induced G2/M phase arrest. Free Radic Biol Med 34:1333–42
   PubMed Web of Science ®Google Scholar
• Zhong BZ, Gu ZW, Wallace WE, et al. (1994). Genotoxicity of vanadium pentoxide in Chinese hamster V79 cells. Mutat Res 321:35–42
   PubMed Web of Science ®Google Scholar
• Zwolak I. (2013). Comparison of five different in vitro assays for assessment of sodium metavanadate cytotoxicity in Chinese hamster ovary cells (CHO-K1 line). Toxicol Ind Health [Epub ahead of print]. doi:10.1177/0748233713483199
   Google Scholar