161
Views
8
CrossRef citations to date
0
Altmetric
Research Article

SAR genotoxicity and tumorigenicity predictions for 2-MI and 4-MI using multiple SAR software

, &
Pages 284-293 | Received 18 Nov 2013, Accepted 07 Jan 2014, Published online: 27 Jan 2014

References

  • Benigni R, Bossa C, Jeliazkova N, et al. (2008). The Benigni/Bossa rule base for mutagenicity and carcinogenicity – a module of Toxtree. EUR – 23241 EN, JRC Scientific and Technical Reports
  • Chan PC. (2004). NTP Technical Report on the toxicity and carcinogenicity studies of 2-methylimidazole. NTP TR 516, NIH publication 05-4456. Available from: http://ntp.niehs.nih.gov/files/516final_web.pdf [last accessed 15 Oct 2012]
  • Chan PC. (2007). NTP Technical Report on the toxicity and carcinogenicity studies of 4-methylimidazole. NTP TR 535, NIH publication 07-4471. Available from: http://ntp.niehs.nih.gov/files/535_web_final.pdf [last accessed 15 Oct 2012]
  • Chan PC, Hill GD, Kissling GE, Nyska A. (2008a). Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice. Arch Toxicol 82:45–53
  • Chan PC, Sills RC, Kissling GE, et al. (2008b). Induction of thyroid and liver tumors by chronic exposure to 2-methylimidazole in F344/N rats and B6C3F1 mice. Arch Toxicol 82:399–412
  • Contrera JF. (2013). Validation of Toxtree and SciQSAR in silico predictive software using a publicly available benchmark mutagenicity database and their applicability for the qualification of impurities in pharmaceuticals. Regul Toxicol Pharmacol 67:285–93
  • DEREK. Available from: http://www.lhasalimited.org/index.php [last accessed 15 Oct 2012]
  • Egan JW, Zlokarnik G, Grootenhuis PDJ. (2004). In silico prediction of drug safety: despite progress there is abundant room for improvement. Drug Discov Today: Technol-Lead Profile 1:381–7
  • Fuart-Gatnik M, Worth A. (2010). Review of software tools for toxicity prediction. EUR 24489 EN, JRC Scientific and Technical Reports
  • Hayashi M, Kamata E, Hirose A, et al. (2005). In silico assessment of chemical mutagenesis in comparison with results of Salmonella microsome assay on 909 chemicals. Mut Res 288:129–35
  • IARC. (2011a). 2-Methylimidazole: IARC monographs: monographs. Available from: http://monographs.iarc.fr/ENG/Monographs/vol101/mono101-014.pdf [last accessed 15 Oct 2012]
  • IARC. (2011b). 4-Methlyimidazole: IARC monographs. Available from: http://monographs.iarc.fr/ENG/Monographs/vol101/mono101-015.pdf [last accessed 15 Oct 2012]
  • IGHRC. (2013). Predictive approaches to chemical hazard identification and characterization: current use by UK department and agency. Available from: http://ieh.cranfield.ac.uk/ighrc/pdf/cr%20reports/cr16%5B1%5D.pdf [last accessed 28 Dec 2013]
  • Krishna G. (2010). Alternatives to animal experimentation in research. In Jagadeesh G, Murthy S, Gupta YK, Prakash A, eds. Research tools, Chapter 11. New Delhi, India: Wolters Kluwer Health, 155–77
  • Lapenna S, Fuart-Gatrik M, Worth A. (2010). Review of QSAR models and software tools for predicting acute and chronic toxicity. EUR – 24639 EN, JRC Scientific and Technical Reports
  • NTP. (2007). National Toxicology Program. Toxicology and carcinogenesis studies of 4-methylimidazole (CAS No. 822-36-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). National Toxicology Program. Technical Report Series No. 535. NIH Publication No. 07-4471. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health
  • OEHHA. (2011). Office of Environmental Health Hazard Assessment. No significant risk level (NSRL) for the proposition 65 carcinogen 4-methylimidazole. Available from: http://oehha.ca.gov/prop65/law/pdf_zip/010711NSRLrisk4EI.pdf [last accessed 15 March 2013]
  • OEHHA. (2012). Office of Environmental Health Hazard Assessment. 4-methylimidazole, a fact sheet. Available from: http://oehha.ca.gov/public_info/facts/4MEIfacts_021012.html [last accessed 15 Oct 2012]
  • REACH: Registration, Evaluation, Authorization and Restriction of Chemical substances (EC 1907/2006). Available from: http://ec.europa.eu/environment/chemicals/reach/reach_intro.htm [last accessed 30 Nov 2012]
  • Rothfuss A, Steger-hartmann T, Heinrich N, Wichard J. (2006). Computational prediction of the chromosomal-damaging potential of chemicals. Chem Res Toxicol 19:1313–19
  • Snyder R, Pearl G, Mandakas G, et al. (2004). Assessment of the sensitivity of the computational programs DEREK, TOPKAT, and MCASE in the prediction of the genotoxicity of pharmaceutical molecules. Environ Mol Mutagen 43:143–58
  • Worth A, Lapenna S, Piparo EL, et al. (2010). The applicability of the software tools for genotoxicity and carcinogenicity prediction: case studies relevant to assessment of pesticides. Available from: http://ihcp.jrc.ec.europa.eu/our_labs/predictive_toxicology/doc/EUR_24640_EN.pdf [last accessed 28 Dec 2013]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.