Levofloxacin increases the effect of serum deprivation on anoikis of rat nucleus pulposus cells via Bax/Bcl-2/caspase-3 pathway

References

• Ahsan R, Tajima N, Chosa E, et al. (2001). Biochemical and morphological changes in herniated human intervertebral disc. J Orthop Sci 6:510–18
   PubMedGoogle Scholar
• Alini M, Roughley PJ, Antoniou J, et al. (2002). A biological approach to treating disc degeneration: not for today, but may be for tomorrow. Eur Spine J 11:S215–20
   PubMed Web of Science ®Google Scholar
• Antoniou J, Steffen T, Nelson F, et al. (1996). The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest 98:996–1003
   PubMed Web of Science ®Google Scholar
• Barber AJ, Nakamura M, Wolpert EB, et al. (2001). Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. J Biol Chem 276:32814–21
   PubMed Web of Science ®Google Scholar
• Boos N, Weissbach S, Rohrbach H, et al. (2002). Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine 27:2631–44
   PubMed Web of Science ®Google Scholar
• Buckwalter JA. (1995). Aging and degeneration of the human intervertebral disc. Spine 20:1307–14
   PubMed Web of Science ®Google Scholar
• Chiarugi P, Giannoni E. (2008). Anoikis: a necessary death program for anchorage-dependent cells. Biochem Pharmacol 76:1352–64
   PubMed Web of Science ®Google Scholar
• Costa-Rodrigues J, Martins EG, Fernandes MH. (2012). Induced osteoclastogenesis by fluoroquinolones in unstimulated and stimulated human osteoclast precursor cells. Bone 51:17–27
   PubMed Web of Science ®Google Scholar
• Deng Y, Chen B, Qi Y, et al. (2011). The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro. Toxicol Appl Pharmacol 257:67–73
   PubMed Web of Science ®Google Scholar
• Dwivedi A, Mujtaba SF, Yadav N, et al. (2014). Cellular and molecular mechanism of ofloxacin induced apoptotic cell death under ambient UV-A and sunlight exposure. Free Radic Res 48:333–46
   PubMed Web of Science ®Google Scholar
• Fernández M, Sánchez-Franco F, Palacios N, et al. (2004). IGF-I inhibits apoptosis through the activation of the phosphatidylinositol 3-kinase/Akt pathway in pituitary cells. J Mol Endocrinol 33:155–63
   PubMed Web of Science ®Google Scholar
• Frisch SM, Francis H. (1994). Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124:619–26
   PubMed Web of Science ®Google Scholar
• Frisch SM, Screaton RA. (2001). Anoikis mechanisms. Curr Opin Cell Biol 13:555–62
   PubMed Web of Science ®Google Scholar
• Gilmore AP. (2005). Anoikis. Cell Death Differ 12:1473–7
   PubMed Web of Science ®Google Scholar
• Gruber HE, Hanley EN Jr. (1998). Analysis of aging and degeneration of the human intervertebral disc: comparison of surgical specimens with normal controls. Spine 23:751–7
   PubMed Web of Science ®Google Scholar
• Huddleston PM, Steckelberg JM, Hanssen AD, et al. (2000). Ciprofloxacin inhibition of experimental fracture healing. J Bone Joint Surg Am 82:161–73
   PubMed Web of Science ®Google Scholar
• Kimura S, Toda H, Shimabukuro Y, et al. (1991). Topical chemotherapy in human periodontitis using a new controlled-release insert containing ofloxacin. I: microbiological observation. J Periodontal Res 26:33–41
   PubMed Web of Science ®Google Scholar
• Kroeber M, Unglaub F, Guehring T, et al. (2005). Effects of controlled dynamic disc distraction on degenerated intervertebral discs: an in vivo study on the rabbit lumbar spine model. Spine 30:181–7
   PubMed Web of Science ®Google Scholar
• Le Maitre CL, Freemont AJ, Hoyland JA. (2007). Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther 9:R45
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402–8
   PubMed Web of Science ®Google Scholar
• Meredith JE Jr, Fazeli B, Schwartz MA. (1993). The extracellular matrix as a cell survival factor. Mol Biol Cell 4:953–61
   PubMed Web of Science ®Google Scholar
• Oliphant CM, Green GM. (2002). Quinolones: a comprehensive review. Am Fam Physician 65:455–64
   PubMed Web of Science ®Google Scholar
• Paoli P, Giannoni E, Chiarugi P. (2013). Anoikis molecular pathways and its role in cancer progression. Biochim Biophys Acta 1833:3481–98
   PubMed Web of Science ®Google Scholar
• Park JB, Kim KW, Han CW, Chang H. (2001). Expression of Fas receptor on disc cells in herniated lumbar disc tissue. Spine 26:142–6
   PubMed Web of Science ®Google Scholar
• Park JB, Park IC, Park SJ, et al. (2006). Anti-apoptotic effects of caspase inhibitors on rat intervertebral disc cells. J Bone Joint Surg Am 88:771–9
   PubMed Web of Science ®Google Scholar
• Perry AC, Prpa B, Rouse MS, et al. (2003). Levofloxacin and trovafloxacin inhibition of experimental fracture-healing. Clin Orthop Relat Res (414):95–100
   PubMed Web of Science ®Google Scholar
• Risbud MV, Guttapalli A, Albert TJ, Shapiro IM. (2005). Hypoxia activates MAPK activity in rat nucleus pulposus cells: regulation of integrin expression and cell survival. Spine 30:2503–9
   PubMed Web of Science ®Google Scholar
• Roberts S, Urban JP, Evans H, Eisenstein SM. (1996). Transport properties of the human cartilage endplate in relation to its composition and calcification. Spine 21:415–20
   PubMed Web of Science ®Google Scholar
• Sendzik J, Lode H, Stahlmann R. (2009). Quinolone-induced arthropathy: an update focusing on new mechanistic and clinical data. Int J Antimicrob Agents 33:194–200
   PubMed Web of Science ®Google Scholar
• Sendzik J, Shakibaei M, Schaäfer-Korting M, Stahlmann R. (2005). Fluoroquinolonescause changes in extracellular matrix, signalling proteins, metalloproteinases and caspase-3 in cultured human tendon cells. Toxicology 212:24–36
   PubMed Web of Science ®Google Scholar
• Sun JP, Shi ZY, Liu SM, et al. (2013). Trimethoxy-benzaldehyde levofloxacin hydrazone inducing the growth arrest and apoptosis of human hepatocarcinoma cells. Cancer Cell Int 13:67. doi:10.1186/1475-2867-13-67
   PubMed Web of Science ®Google Scholar
• Taddei ML, Giannoni E, Fiaschi T, Chiarugi P. (2012). Anoikis: an emerging hallmark in health and diseases. J Pathol 226:380–93
   PubMed Web of Science ®Google Scholar
• Tan Y, Lu K, Deng Y, et al. (2012). The effects of levofloxacin on rabbit fibroblast-like synoviocytes in vitro. Toxicol Appl Pharmacol 265:175–80
   PubMed Web of Science ®Google Scholar
• Teupe C, Meffert R, Winckler S, et al. (1992). Ciprofloxacin-impregnated poly-L-lactic acid drug carrier. New aspects of a resorbable drug delivery system in local antimicrobial treatment of bone infections. Arch Orthop Trauma Surg 112:33–5
   PubMed Web of Science ®Google Scholar
• Trout JJ, Buckwalter JA, Moore KC. (1982). Ultrastructure of the human intervertebral disc: II. Cells of the nucleus pulposus. Anat Rec 204:307–14
   PubMedGoogle Scholar
• Tuncay I, Ozbek H, Kosem M, Unal O. (2005). A comparison of effects of fluoroquinolones on fracture healing (an experimental study in rats). Ulus Travma Acil Cerrahi Derg 11:17–22
   PubMedGoogle Scholar
• Waddell G. (1996). Low back pain: a twentieth century health care enigma. Spine 21:2820–5
   PubMed Web of Science ®Google Scholar
• Walsh AJ, Lotz JC. (2004). Biological response of the intervertebral disc to dynamic loading. J Biomech 37:329–37
   PubMed Web of Science ®Google Scholar
• Wang L, Wu Y, Tan Y, et al. (2013). Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells. J Appl Toxicol 34:870–7
   PubMed Web of Science ®Google Scholar
• Yang SD, Ma L, Gu TX, et al. (2014a). 17β-Estradiol protects against apoptosis induced by levofloxacin in rat nucleus pulposus cells by upregulating integrin α2β1. Apoptosis 19:789–800
   PubMed Web of Science ®Google Scholar
• Yang D, Wang D, Shimer A, et al. (2014b). Glutathione protects human nucleus pulposus cells from cell apoptosis and inhibition of matrix synthesis. Connect Tissue Res 55:132–9
   PubMed Web of Science ®Google Scholar
• Zhang CC, Cui GP, Hu JG, et al. (2014). Effects of adenoviral vector expressing hIGF-1 on apoptosis in nucleus pulposus cells in vitro. Int J Mol Med 33:401–5
   PubMed Web of Science ®Google Scholar
• Zhang YH, Zhao CQ, Jiang LS, Dai LY. (2011). Substrate stiffness regulates apoptosis and the mRNA expression of extracellular matrix regulatory genes in the rat annular cells. Matrix Biol 30:135–44
   PubMed Web of Science ®Google Scholar
• Zhao CQ, Liu D, Li H, et al. (2007). Interleukin-1β enhances the effect of serum deprivation on rat annular cell apoptosis. Apoptosis 12:2155–61
   PubMed Web of Science ®Google Scholar
• Zhong X, Rescorla FJ. (2012). Cell surface adhesion molecules and adhesion-initiated signaling: understanding of anoikis resistance mechanisms and therapeutic opportunities. Cell Signal 24:393–401
   PubMed Web of Science ®Google Scholar
• Zhou GQ, Yang F, Leung VYL. (2008). Molecular and cellular biology of the intervertebral disc and the use of animal models. Curr Orthop 22:267–73
   Web of Science ®Google Scholar