374
Views
24
CrossRef citations to date
0
Altmetric
Research Articles

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid

, , , , , , , , , , , , , , , & show all
Pages 201-211 | Received 13 Dec 2014, Accepted 27 Jan 2015, Published online: 20 Apr 2015

References

  • Beauparlant P, Bedard D, Bernier C, et al. (2009). Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777. Anticancer Drugs 20:346–54
  • Bi TQ, Che XM. (2010). Nampt/PBEF/visfatin and cancer. Cancer Biol Ther 10:119–25
  • Evstatiev R, Bukaty A, Jimenez K, et al. (2014). Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin. Am J Hematol 89:524–9
  • Galli U, Ercolano E, Carraro L, et al. (2008). Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. Chem Med Chem 3:771–9
  • Holen K, Saltz LB, Hollywood E, et al. (2008). The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Invest New Drugs 26:45–51
  • Houtkooper RH, Canto C, Wanders RJ, Auwerx J. (2010). The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev 31:194–223
  • Hovstadius P, Larsson R, Jonsson E, et al. (2002). A phase I study of CHS 828 in patients with solid tumor malignancy. Clin Cancer Res 8:2843–50
  • Kenney B, Stack G. (2009). Drug-induced thrombocytopenia. Arch Pathol Lab Med 133:309–14
  • Konieczna IM, Panuganti S, DeLuca TA, et al. (2013). Administration of nicotinamide does not increase platelet levels in mice. Blood Cells Mol Dis 50:171–6
  • Lindhagen E, Hjarnaa PJV, Friberg LE, et al. (2004). Pharmacodynamic differences between species exemplified by the novel anticancer agent CHS 828. Drug Develop Res 61:218–26
  • Montecucco F, Cea M, Bauer I, et al. (2013). Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors as therapeutics: rationales, controversies, clinical experience. Curr Drug Targets 14:637–43
  • Nahimana A, Attinger A, Aubry D, et al. (2009). The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies. Blood 113:3276–86
  • Oh A, Ho YC, Zak M, et al. (2014). Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. ChemBioChem 15:1121–30
  • Olesen UH, Thougaard AV, Jensen PB, Sehested M. (2010). A preclinical study on the rescue of normal tissue by nicotinic acid in high-dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor. Mol Cancer Ther 9:1609–17
  • Pessina A, Albella B, Bayo M, et al. (2003). Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics. Toxicol Sci 75:355–67
  • Pessina A, Parent-Massin D, Albella B, et al. (2009). Application of human CFU-Mk assay to predict potential thrombocytotoxicity of drugs. Toxicol In Vitro 23:194–200
  • Pittelli M, Formentini L, Faraco G, et al. (2010). Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool. J Biol Chem 285:34106–14
  • Schou C, Ottosen ER, Petersen HJ, et al. (1997). Novel cyanoguanidines with potent oral antitumor activity. Bioorg Med Chem Lett 3:3095–100
  • Vander Heiden MG, Cantley LC, Thompson CB. (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029–33
  • von Heideman A, Berglund A, Larsson R, Nygren P. (2010). Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data. Cancer Chemother Pharmacol 65:1165–72
  • Xiao Y, Elkins K, Durieux JK, et al. (2013). Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618. Neoplasia 15:1151–60
  • Zabka TS, Singh JT, Dhawan P, et al. (2015). Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase. Toxicol Sci 144:163–72
  • Zheng X, Bair KW, Bauer P, et al. (2013a). Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett 23:5488–97
  • Zheng X, Bauer P, Baumeister T, et al. (2013b). Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. J Med Chem 56:6413–33

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.