Genotoxic and oxidative stress effects of 2-amino-9H-pyrido[2,3-b]indole in human hepatoma G2 (HepG2) and human lung alveolar epithelial (A549) cells

References

• Balendiran GK, Dabur R, Fraser D. (2004). The role of glutathione in cancer. Cell Biochem Funct 22:343–52
   PubMed Web of Science ®Google Scholar
• Castell JV, Teresa DM, Gómez-Lechón MJ, et al. (2005). Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach. Exp Toxicol Pathol 57:189–204
   PubMed Web of Science ®Google Scholar
• Dearfield KL, Jacobson-Kram D, Brown NA, et al. (1983). Evaluation of a human hepatoma cell line as a target cell in genetic toxicology. Mutat Res 108:437–49
   PubMed Web of Science ®Google Scholar
• Dumont J, Josse R, Lambert C, et al. (2010). Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells. Toxicol Appl Pharmacol 245:256–63
   PubMed Web of Science ®Google Scholar
• Evans MD, Dizdaroglu M, Cooke MS. (2004). Oxidative DNA damage and disease: induction, repair and significance. Mutat Res 567:1–61
   PubMed Web of Science ®Google Scholar
• Fenech M. (2000). The in vitro micronucleus technique. Mutat Res 455:81–95
   PubMed Web of Science ®Google Scholar
• Franco R, Schoneveld OJ, Pappa A, et al. (2007). The central role of glutathione in the pathophysiology of human diseases. Arch Physiol Biochem 113:234–58
   PubMedGoogle Scholar
• Fu YF, Zhao G, Wang S, et al. (2014). Simultaneous determination of fifteen heterocyclic aromatic amines in the urine of smokers and nonsmokers using ultra-high performance liquid chromatography-tandem mass spectrometry. J Chromatogr A 1333:45–53
   PubMed Web of Science ®Google Scholar
• IARC. (1986). Monographs on the evaluation of carcinogenic risks to humans: A-alpha-C (2-Amino-9H-pyrido [2,3-b]indole). Lyon: International Agency for Research on Cancer
   Google Scholar
• IARC. (1993). Monographs on the evaluation of carcinogenic risks to humans: some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. Lyon: International Agency for Research on Cancer
   Google Scholar
• Janssen YM, Van-Houten B, Borm PJ, et al. (1993). Cell and tissue responses to oxidative damage. Laboratory investigation. J Tech Methods Pathol 69:261–74
   Google Scholar
• Jiang L, Cao J, An Y, et al. (2007). Genotoxicity of acrylamide in human hepatoma G2 (HepG2) cells. Toxicol In Vitro 21:1486–92
   PubMed Web of Science ®Google Scholar
• Kato T, Hasegawa R, Nakae D, et al. (1996). Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline, at low dose levels. Cancer Sci 87:127–33
   Google Scholar
• King RS, Teitel CH, Kadlubar FF, et al. (2000). In vitro bioactivation of N-hydroxy-2-amino-α-carboline. Carcinogenesis 21:1347–54
   PubMed Web of Science ®Google Scholar
• King RS, Teitel CH, Shaddock JG, et al. (1999). Detoxification of carcinogenic aromatic and heterocyclic amines by enzymatic reduction of the N-hydroxy derivative. Cancer Lett 143:167–71
   PubMed Web of Science ®Google Scholar
• Knasmuller S, Mersch-Sundermann V, Kevekordes S, et al. (2004). Use of human derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge. Toxicology 198:315–28
   PubMed Web of Science ®Google Scholar
• Knasmüller S, Parzefall W, Sanyal R, et al. (1998). Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens. Mutat Res 402:185–202
   PubMed Web of Science ®Google Scholar
• Kurzawa-Zegota M, Najafzadeh M, Baumgartner A, et al. (2012). The protective effect of the flavonoids on food-mutagen-induced DNA damage in peripheral blood lymphocytes from colon cancer patients. Food Chem Toxicol 50:124–9
   PubMed Web of Science ®Google Scholar
• LeBel CP, Ischiropoulos H, Bondy SC. (1992). Evaluation of the probe 2′, 7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5:227–31
   PubMed Web of Science ®Google Scholar
• Loft S, Astrup A, Buemann B, et al. (1994). Oxidative DNA damage correlates with oxygen consumption in humans. FASEB J 8:534–7
   PubMed Web of Science ®Google Scholar
• Loft S, Vistisen K, Ewertz M, et al. (1992). Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis 13:2241–7
   PubMed Web of Science ®Google Scholar
• Majer BJ, Kassie F, Sasaki Y, et al. (2004). Investigation of the genotoxic effects of 2-amino-9H-pyrido[2,3-b] indole in different organs of rodents and in human derived cells. J Chromatogr B 802:167–73
   PubMed Web of Science ®Google Scholar
• Manabe S, Izumikawa S, Asakuno K, et al. (1991a). Detection of carcinogenic amino-α-carbolines and amino-γ-carbolines in diesel-exhaust particles. Environ Pollut 70:255–65
   PubMed Web of Science ®Google Scholar
• Manabe S, Tohyama K, Wada O, et al. (1991b). Detection of a carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) in cigarette smoke condensate. Carcinogenesis 12:1945–7
   PubMed Web of Science ®Google Scholar
• Mangal D, Vudathala D, Park JH, et al. (2009). Analysis of 7, 8-dihydro-8-oxo-2′-deoxy-guanosine in cellular DNA during oxidative stress. Chem Res Toxicol 22:788–97
   PubMed Web of Science ®Google Scholar
• Marnett LJ. (2000). Oxyradicals and DNA damage. Carcinogenesis 21:361–70
   PubMed Web of Science ®Google Scholar
• Matsumoto T, Yoshida D, Tomita H. (1981). Determination of mutagens, amino-alpha-carbolines in grilled foods and cigaretted foods and cigarette-smoke condensate. Cancer Lett 12:105–10
   PubMed Web of Science ®Google Scholar
• Mersch-Sundermann V, Knasmüller S, Wu X, et al. (2004). Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicology 198:329–40
   PubMed Web of Science ®Google Scholar
• Moriya M. (1993). Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted G·C→T·A transversions in simian kidney cells. Proc Natl Acad Sci USA 90:1122–6
   PubMed Web of Science ®Google Scholar
• Myhre O, Andersen JM, Aarnes H, et al. (2003). Evaluation of the probes 2′, 7′-dichlorofluorescindiacetate, luminol, and lucigenin as indicators of reactive species formation. Biochem Pharmacol 65:1575–82
   PubMed Web of Science ®Google Scholar
• Nagao M, Fujita Y, Wakabayashi K, et al. (1983). Ultimate forms of mutagenic and carcinogenic heterocyclic amines produced by pyrolysis. Biochem Biophys Res Commun 114:626–31
   PubMed Web of Science ®Google Scholar
• Nauwelaers G, Bessette EE, Gu D, et al. (2011). DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes. Chem Res Toxicol 24:913–25
   PubMed Web of Science ®Google Scholar
• Ohgaki H, Matsukura N, Morino K, et al. (1984). Carcinogenicity in mice of mutagenic compounds from glutamic-acid and soybean globulin pyrolysates. Carcinogenesis 5:815–19
   PubMed Web of Science ®Google Scholar
• Olive PL, Wlodek D, Durand RE, Banath J. (1992). Factors influencing DNA migration from individual cells subjected to gel electrophoresis. Exp Cell Res 198:259–67
   PubMed Web of Science ®Google Scholar
• Peng C, Arthur D, Liu F, et al. (2013). Genotoxicity of hydroquinone in A549 cells. Cell Biol Toxicol 29:213–27
   PubMed Web of Science ®Google Scholar
• Pezdirc M, Žegura B, Filipič M. (2013). Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells. Food Chem Toxicol 59:386–94
   PubMed Web of Science ®Google Scholar
• Pfau W, Martin FL, Cole KJ, et al. (1999). Heterocyclic aromatic amines induce DNA strand breaks and cell transformation. Carcinogenesis 20:545–51
   PubMed Web of Science ®Google Scholar
• Pinti M, Troiano L, Nasi M, et al. (2002). Hepatoma HepG2 cells as a model for in vitro studies on mitochondrial toxicity of antiviral drugs: which correlation with the patient? J Biol Regul Homeost Agents 17:166–71
   Web of Science ®Google Scholar
• Robbana-Barnat S, Rabache M, Rialland E, et al. (1996). Heterocyclic amines: occurrence and prevention in cooked food. Environ Health Perspect 104:280–8
   PubMed Web of Science ®Google Scholar
• Sasaki YF, Saga A, Akasaka M, et al. (1997). In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse. Mutat Res 395:57–73
   PubMed Web of Science ®Google Scholar
• Snyderwine EG, Sadrieh N, King RS, et al. (1998). Formation of DNA adducts of the food-derived mutagen 2-amino-9H-pyrido-[2,3-b]indole (A(α)C) and bioassay of mammary gland carcinogenicity in Sprague–Dawley rats. Food Chem Toxicol 36:1033–41
   Google Scholar
• Toraason M, Clark J, Dankovic D, et al. (1999). Oxidative stress and DNA damage in Fischer rats following acute exposure to trichloroethylene or perchloroethylene. Toxicology 138:43–53
   PubMed Web of Science ®Google Scholar
• Trevisan M, Browne R, Ram M, et al. (2001). Correlates of markers of oxidative status in the general population. Am J Epidemiol 154:348–56
   PubMed Web of Science ®Google Scholar
• Turesky RJ, Taylor J, Schnackenberg L, et al. (2005). Quantitation of carcinogenic heterocyclic aromatic amines and detection of novel heterocyclic aromatic amines in cooked meats and grill scrapings by HPLC/ESI-MS. J Agric Food Chem 53:3248–58
   PubMed Web of Science ®Google Scholar
• Wakata A, Oka N, Hiramoto K, et al. (1985). DNA strand cleavage in vitro by 3-hydroxyamino-1-methyl-5H-pyrido [4, 3-b]-indole, a direct-acting mutagen formed in the metabolism of carcinogenic 3-amino-1-methyl-5H-pyrido [4, 3-b] indole. Cancer Res 45:5867–71
   PubMed Web of Science ®Google Scholar
• Yamashita M, Wakabayashi K, Nagao M, et al. (1986). Detection of 2-amino-3-methylimidazo [4, 5-f] quinoline in cigarette smoke condensate. Jpn J Cancer Res 77:419–22
   PubMedGoogle Scholar
• Yoshida D, Matsumoto T. (1980). Amino-alpha-carbolines as mutagenic agents in cigarette smoke condensate. Cancer Lett 10:141–9
   PubMed Web of Science ®Google Scholar
• Yoshimi N, Sugie S, Iwata H, et al. (1988). Species and sex differences in genotoxicity of heterocyclic amine pyrolysis and cooking products in the hepatocyte primary culture/DNA repair test using rat, mouse, and hamster hepatocytes. Environ Mol Mutag 12:53–64
   PubMed Web of Science ®Google Scholar
• Zhang XB, Felton JS, Tucker JD, et al. (1996). Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and amino (alpha) carboline. Carcinogenesis 17:2259–65
   PubMed Web of Science ®Google Scholar
• Zhao G, Wang S, Fu Y, et al. (2014). Analysis of the heterocyclic aromatic amines in cigarette smoke by liquid chromatography–tandem mass spectrometry. Chromatographia 77:813–20
   Web of Science ®Google Scholar
• Zou J, Chen Q, Tang S, et al. (2009). Olaquindox-induced genotoxicity and oxidative DNA damage in human hepatoma G2 (HepG2) cells. Mutat Res 676:27–33
   PubMed Web of Science ®Google Scholar