A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice

References

• Bajgar J. (2004). Organophosphate/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis and treatment. Adv Clin Chem 38:151–216
   PubMed Web of Science ®Google Scholar
• Clement JG, Hansen AS, Boulet CA. (1992). Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice. Arch Toxicol 66:216–19
   PubMed Web of Science ®Google Scholar
• Delfino RT, Ribeiro TS, Figueroa-Villar JD. (2009). Organophosphorus compounds as chemical warfare agents: a review. J Braz Chem Soc 20:407–28
   Web of Science ®Google Scholar
• Ellman GL, Courtney DK, Andres V Jr, Featherstone RM. (1961). A new and rapid determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–93
   PubMed Web of Science ®Google Scholar
• Jokanovic M. (2012). Structure-activity relationship and efficacy of pyridinium oximes in the treatment of poisoning with organophosphorus compounds: a review of recent data. Curr Topic Med Chem 12:1775–89
   PubMed Web of Science ®Google Scholar
• Jokanovic M, Prostran M. (2009). Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. Curr Med Chem 16:2177–88
   PubMed Web of Science ®Google Scholar
• Jun D, Kuca K, Stodulka P, et al. (2007). HPLC analysis of HI-6 dichloride and dimethanesulfonate – antidotes against nerve agents and organophosphorus pesticides. Anal Lett 40:2783–7
   Web of Science ®Google Scholar
• Kassa J. (2002). Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol Clin Toxicol 40:803–16
   PubMed Web of Science ®Google Scholar
• Kassa J, Cabal J. (1999). A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with presently used oximes and H oximes against sarin by in vitro and in vivo methods. Hum Exp Toxicol 18:560–5
   PubMed Web of Science ®Google Scholar
• Kassa J, Karasova J, Musilek K, Kuca K. (2008a). An evaluation of therapeutic and reactivating efficacy of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology 243:311–16
   PubMed Web of Science ®Google Scholar
• Kassa J, Karasova J, Musilek K, et al. (2008b). A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Drug Chem Toxicol 31:371–81
   PubMed Web of Science ®Google Scholar
• Kassa J, Kuca K, Bartosova L, Kunesova G. (2007). The development of new structural analogues of oximes for the antidotal treatment of poisoning by nerve agents and the comparison of their reactivating and therapeutic efficacy with currently available oximes. Curr Org Chem 11:267–83
   Web of Science ®Google Scholar
• Kassa J, Sepsova V, Musilek K, Horova A. (2013). The evaluation of the reactivating and therapeutic efficacy of three novel bispyridinium oximes (K454, K346, K458) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice. Toxicol Mech Method 23:94–8
   PubMed Web of Science ®Google Scholar
• Kassa J, Sepsova V, Tumova M. (2014a). A comparison of the reactivating and therapeutic efficacy of two novel oximes K378 and K458 with currently available oximes in rats and mice poisoned with sarin. J Appl Biomed 12:155–60
   Web of Science ®Google Scholar
• Kassa J, Sepsova V, Tumova M, et al. (2014b). The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361, K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice. Toxicol Mech Method 24:173–8
   PubMed Web of Science ®Google Scholar
• Kassa J, Sepsova V, Tumova M, et al. (2015). A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (K727, K733) with oxime K203 and trimedoxime in tabun-poisoned rats and mice. Bas Clin Pharmacol Toxicol 116:367–71
   PubMed Web of Science ®Google Scholar
• Kassa J, Zdarova Karasova J, Sepsova V, Bajgar J. (2011). A comparison of the reactivating and therapeutic efficacy of the newly developed bispyridinium oxime K203 with currently available oximes in sarin poisoned rats and mice. J Appl Biomed 9:225–30
   Web of Science ®Google Scholar
• Kuca K, Jun D, Musilek K. (2006). Structural requirements of acetylcholinesterase reactivators. Mini Rev Med Chem 6:269–77
   PubMed Web of Science ®Google Scholar
• Kuca K, Musilek K, Jun D, et al. (2009). Could oxime HI-6 really be considered as “broad-spectrum” antidote? J Appl Biomed 7:143–9
   Web of Science ®Google Scholar
• Kuca K, Racakova V, Jun D, Bajgar J. (2007). Structure-activity relationship of acetylcholinesterase reactivators – antidotes against nerve agents. Lett Org Chem 4:212–17
   Web of Science ®Google Scholar
• Lawrence DT, Kirk MA. (2007). Chemical terrorism attacks: update on antidotes. Emerg Med Clin N Am 25:567–95
   PubMed Web of Science ®Google Scholar
• Lorke DE, Kalasz H, Petroianu GA, Tekes K. (2008). Entry of oximes into the brain. A review. Curr Med Chem 15:743–53
   PubMed Web of Science ®Google Scholar
• Lundy PM, Hamilton MG, Sawyer TW, Mikler J. (2011). Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning. Toxicology 285:90–6
   PubMed Web of Science ®Google Scholar
• Lundy PM, Raveh L, Amitai G. (2006). Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol Rev 25:231–43
   PubMedGoogle Scholar
• Marrs TC, Rice P, Vale JA. (2006). The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicol Rev 25:297–323
   PubMedGoogle Scholar
• Musilek K, Dolezal M, Gunn-Moore F, Kuca K. (2011). Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides. Med Res Rev 31:548–75
   PubMed Web of Science ®Google Scholar
• Musilek K, Kuca K, Jun D, Dolezal M. (2007). Progress in synthesis of new acetylcholinesterase reactivators during the period 1990–2004. Curr Org Chem 11:229–38
   Web of Science ®Google Scholar
• Ohtomi S, Takase M, Kumagai F. (1996). Sarin poisoning in Japan. A clinical experience in Japan Self Defense Force (JSDF) Central Hospital. Int Rev Arm Ser 69:97–102
   Google Scholar
• Szinicz L, Worek F, Thiermann H, et al. (2007). Development of antidotes: problems and strategies. Toxicology 233:23–30
   PubMed Web of Science ®Google Scholar
• Tallarida R, Murray R. (1987). Manual of pharmacological calculation with computer programs. New York: Springer-Verlag
   Google Scholar
• Voicu V, Radulescu FS, Medvedovici A. (2015). Relationship between the structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and intergration to biopharmaceutical classification. Expert Opin Drug Metab Toxicol 11:95–109
   PubMed Web of Science ®Google Scholar
• Worek F, Wille T, Koller M, Thierman H. (2012). Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase – structure–activity relationships. Biochem Pharmacol 83:1700–6
   PubMed Web of Science ®Google Scholar