Advanced search
Publication Cover
Toxicology Mechanisms and Methods Volume 26, 2016 - Issue 1
Submit an article Journal homepage
262
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Thirty-day rat toxicity study reveals reversible liver toxicity of mifepristone (RU486) and metapristone

Yingying XiaoCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China,
,
Yewei ZhuCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China,
,
Suhong YuCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China,
,
Cuicui YanCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China,
,
Rodney J. Y. HoDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA, and
,
Jian LiuCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China,
,
Tao LiCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China,
,
Jie WangCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China,
,
Liyuan WanCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China,
,
Xingtian YangCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China,
,
Huo XuCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China,
,
Jichuang WangCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China,
,
Xiaohuang TuSurgery Department, Fuzhou General Hospital, Fuzhou, China
&
Lee JiaCancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China, Correspondence[email protected]
 show all
Pages 36-45 | Received 24 Jul 2015, Accepted 08 Nov 2015, Published online: 23 Feb 2016

References

  • Chen JZ, Wang JC, Gao Y, Zeng RJ. (2014a). A novel UPLC/MS/MS method for rapid determination of metapristone in rat plasma, a new cancer metastasis chemopreventive agent derived from mifepristone (RU486). J Pharm Biomed Anal 95:158–63
  • Chen J, Wang J, Shao J, Gao Y. (2014b). The unique pharmacological characteristics of mifepristone (RU486): from terminating pregnancy to preventing cancer metastasis. Med Res Rev 34:979–1000
  • Gao Y, Shao J, Jiang Z, Chen J. (2014). Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics. Drug Discov Today 19:326–40
  • Haier J, Nasralla M, Nicolson GL. (2000). Cell surface molecules and their prognostic values in assessing colorectal carcinomas. Ann Surg 231:11
  • Heikinheimo O, Haukkamaa M, Lähteenmäki P. (1989). Distribution of RU 486 and its demethylated metabolites in humans. J Clin Endocrinol Metab 68:270–5
  • Heikinheimo O, Kontula K, Croxatto H, et al. (1987). Plasma concentrations and receptor binding of RU 486 and its metabolites in humans. J Steroid Biochem 26:279–84
  • Heikinheimo O, Tevilin M, Shoupe D, et al. (1986). Quantitation of RU 486 in human plasma by HPLC and RIA after column chromatography. Contraception 34:613–24
  • Institute of Laboratory Animal Resources (US). Committee on Care, Use of Laboratory Animals, National Institutes of Health (US). Division of Research Resources. (1985). Guide for the care and use of laboratory animals[M]. National Academies Press, 21–48
  • Jia L, Pei R, Lin M, Yang X. (2001). Acute and subacute toxicity and efficacy of S-nitrosylated captopril, an ACE inhibitor possessing nitric oxide activities. Food Chem Toxicol 39:1135–43
  • Jia L, Schweikart K, Tomaszewski J, Page JG. (2008). Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: absence of toxicity due to saturating absorption. Food Chem Toxicol 46:203–11
  • Kim K, Kim SH, Yang CW, Li C. (2003). Differentiation between acute cyclosporine nephrotoxicity and acute tubular necrosis using enalaprilat renal scintigraphy in rats. Invest Radiol 38:473–81
  • Lähteenmäki P, Heikinheimo O, Croxatto H, et al. (1987). Pharmacokinetics and metabolism of RU 486. J Steroid Biochem 27:859–63
  • Liu X, Jia L. (2007). The conduct of drug metabolism studies considered good practice (I): analytical systems and in vivo studies. Curr Drug Metab 8:815–21
  • Mei Z, Li X, Wu Q, et al. (2005). The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle. Pharmacol Res 51:345–51
  • Mukinda JT, Syce JA. (2007). Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents. J Ethnopharmacol 112:138–44
  • Porto LC, da Silva J, Ferraz Ade B, et al. (2013). Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch]. Food Chem Toxicol 59:579–85
  • Shi YE, Ye ZH, He CH, et al. (1993). Pharmacokinetic study of RU 486 and its metabolites after oral administration of single doses to pregnant and non-pregnant women. Contraception 48:133–49
  • Sitruk-Ware R, Spitz IM. (2003). Pharmacological properties of mifepristone: toxicology and safety in animal and human studies. Contraception 68:409–20
  • Tang C, Bi HC, Zhong GP, et al. (2009). Simultaneous determination of mifepristone and monodemethyl‐mifepristone in human plasma by liquid chromatography-tandem mass spectrometry method using levonorgestrel as an internal standard: application to a pharmacokinetic study. Biomed Chromatogr 23:71–80
  • Teng YN, Dong RQ, Wang BJ, Liu HJ. (2011). Determinations of mifepristone and its metabolites and their pharmacokinetics in healthy female Chinese subjects. Yao Xue Xue Bao 46:1241–5
  • Wang J, Chen J, Wan L, Shao J, Lu Y. (2014). Synthesis, spectral characterization, and in vitro cellular activities of metapristone, a potential cancer metastatic chemopreventive agent derived from mifepristone (RU486). AAPS J 16:289–98
  • Yu S, Yang X, Zhu Y, Xie F. (2015). Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex. Sci Rep 5:7830
  • Zhang F, Xue J, Shao J. (2012). Compilation of 222 drugs’ plasma protein binding data and guidance for study designs. Drug Discov Today 17:475–85

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.