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Research Article

Geraniin induces apoptosis of human breast cancer cells MCF-7 via ROS-mediated stimulation of p38 MAPK

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Pages 311-318 | Received 12 Nov 2015, Accepted 31 Dec 2015, Published online: 20 Apr 2016

References

  • Chen Y-J, Liu W-H, Kao P-H, et al. (2010). Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells. Toxicon 55:1306–16
  • Cragg GM, Newman DJ, Snader KM. (1997). Natural products in drug discovery and development. J Nat Prod 60:52–60
  • da Rocha AB, Lopes RM, Schwartsmann G. (2001). Natural products in anticancer therapy. Curr Opin Pharmacol 1:364–9
  • De Chiara G, Marcocci ME, Torcia M, et al. (2006). Bcl-2 phosphorylation by p38 MAPK: identification of target sites and biologic consequences. J Biol Chem 281:21353–61
  • Duan WJ, Li QS, Xia MY, et al. (2011). Silibinin activated ROS-p38-NF-κB positive feedback and induced autophagic death in human fibrosarcoma HT1080 cells. J Asian Nat Prod Res 13:27–35
  • Guo QS, Huang X, Li SL. (2010). Effects of matrine on apoptosis of human ovarian cancer cell line SKOV-3 and its mechanism[J]. Chin Pharmacol Bull 26:1104–7
  • Haldar S, Jena N, Croce CM. (1995). Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci USA 92:4507–11
  • Han CR, Jun DY, Kim YH, et al. (2013). Prometaphase arrest-dependent phosphorylation of Bcl-2 family proteins and activation of mitochondrial apoptotic pathway are associated with 17α-estradiol-induced apoptosis in human Jurkat T cells. Biochim Biophys Acta MolCell Res 1833:2220–32
  • Jemal A, Siegel R, Xu J, Ward E. (2010). Cancer statistics, CA-CANCER. J Clin 60:277–300
  • Kim R, Emi M, Tanabe K, Toge T. (2004). Therapeutic potential of antisense Bcl-2 as a chemosensitizer for cancer therapy. Cancer 101:2491–502
  • Klein EA, Kupelian PA. (2003). Localized prostate cancer: radiation or surgery? Urol Clin North Am 30:315–30
  • Kuo PL, Chiang LC, Lin CC. (2002). Resveratrol-induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells. Life Sci 72:23–34
  • Kwon K-B, Yoo S-J, Ryu D-G, et al. (2002). Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells. Biochem Pharmacol 63:41–7
  • Laulier C, Lopez BS. (2012). The secret life of Bcl-2: apoptosis-independent inhibition of DNA repair by Bcl-2 family members. Mutat Res Rev Mutat Res 751:247–57
  • Li DF, Wang ZH, Chen HM, et al. (2009). Isoliquiritigenin induces monocytic differentiation of HL-60 cells. Free Radic Biol Med 46:731–6
  • Li J, Xu Z, Tan M, et al. (2010). 3-(4-(Benzo[d]thiazol-2-yl)-1-phenyl-1H-pyrazol-3-yl) phenyl acetate induced HepG2 cell apoptosis through a ROS-mediated pathway. Chem Biol Interact 183:341–8
  • Liu B, Cheng Y, Zhang B, et al. (2008). Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway. Cancer Lett 275:54–60
  • Liu X, Zhao M, Wu K, et al. (2012). Immunomodulatory and anticancer activities of phenolics from emblica fruit (Phyllanthus emblica L.). Food Chem 131:685–90
  • Mingoia F, Di Sano C, Di Blasi F, et al. (2013). Exploring the anticancer potential of pyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-one derivatives: the effect on apoptosis induction, cell cycle and proliferation. Eur J Med Chem 64:345–56
  • Mojgan DM, Maneulla A, Julie M. (2007). Regulation of autophagy by NF-κB transcription factor and reactives oxygen species. Autophagy 3:390–2
  • Oh S-H, Lim S-C. (2006). A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation. Toxicol Appl Pharmacol 212:212–23
  • Palanisamy UD, Ling LT, Manaharan T, Appleton D. (2011). Rapid isolation of geraniin from Nephelium lappaceum rind waste and its anti-hyperglycemic activity. Food Chem 127:21–7
  • Sarkar FH, Li Y. (2004). Cell signaling pathways altered by natural chemopreventive agents. Mutat Res Fundam Mol Mech Mutagen 555:53–64
  • Sheridan C, Martin SJ. (2010). Mitochondrial fission/fusion dynamics and apoptosis. Mitochondrion 10:640–8
  • Skommer J, Wlodkowic D, Mättö M, et al. (2006). HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells. Leuk Res 30:322–31
  • Suzuki K, Hino M, Kutsuna H, et al. (2001). Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by IL-1 beta. J Immunol 1 67:5940–7
  • Vinatier D, Dufour P, Subtil D. (1996). Apoptosis: a programmed cell death involved in ovarian and uterine physiology. Eur J Obstet Gynecol Reprod Biol 67:85–102
  • Yang J, Wu JN, Tashiro S, et al. (2007). Critical roles of reactive oxygen species in mitochondrial permeability transition in mediating evodiamine-induced human melanoma A375-S2 cell apoptosis. Free Radic Res 41:1099–108
  • Yu ZL, Li WJ, Liu FY. (2004). Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett 215:159–66
  • Zhang Y, Gan Y, Guo Z, Xie S. (2011). Shikonin induces apoptosis of human cervical Hela cancer cells via ROS/p38 MAPK signaling pathway. Chin Pharmacol Bull 27:864–7

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