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Research Article

General Principles for in Vitro Toxicology

Pages 163-180 | Published online: 27 Sep 2008

References

  • Gad S C. A tier testing strategy incorporating in vitro testing methods for pharmaceutical safety assessment. Humane Innovations and Alternatives in Animal Experimentation 1989; 3: 75–79
  • Mehendale H M. Application of isolated organ techniques in toxicology. Principles and methods of toxicology, A W Hayes. Raven, New York 1989; 699–740
  • Acosta D, Sorensen E MB, Anufuro D C, et al. An in vitro approach to the study of target organ toxicity of drugs and chemicals. In Vitro Cell Dev Biol 1985; 21: 495–504
  • Stammati A P, Silano V, Zucco F. Toxicology investigations with cell culture system. Toxicology 1981; 20: 91–153
  • Tyson C A, Stacey N H. In vitro screens from CNS, liver and kidney for systemic toxicity. Benchmarks: alternative methods in toxicology, M Mehlman. Princeton Scientific, Princeton, NJ 1989; 111–136
  • Zbinden G. Predictive value of animal studies in toxicology. Centre for Medicines Research, CarshaltonUK 1987
  • Lijinsky W. Importance of animal experiments in carcinogenesis research. Envir Mol Mutagen 1988; 11: 307–314
  • Gad S C. Recent developments in replacing, reducing and refining animal use in toxicologic research and testing. Fundam Appl Toxicol 1990; 15(1)8–16
  • Gad S C, Changelis C P. Animal Models in Toxicology. Dekker, New York 1992
  • Singer P. Animal liberation: a new ethic for our treatment of animals. Random House, New York 1975
  • Russell W MS, Burch R L. The principles of humane experimental technique. Methuen, London 1959
  • Hooisma J. Tissue culture and neurotoxicology. Neurobehav Toxicol Teralol 1982; 4: 617–622
  • Neubert D. The use of culture techniques in studies on prenatal toxicity. Pharmacol Ther 1982; 18: 397–434
  • Williams G M, Dunkel V C, Ray V A. Cellular systems for toxicity testing. Ann NY Acad Sci 1983; 407
  • Rofe P C. Tissue culture and toxicology. Food Cosmet Toxicol 1971; 9: 685–696
  • Goldberg A M, Frazier J M. Alternatives to animals in toxicity testing. Sci Am 1989; 261: 24–30
  • American Medical Association. Public support for animals in research. Ann Med News June 9, 1989
  • Cowley G, Hager M, Drew L, et al. The battle over animal rights. Newsweek Dec 26, 1988
  • Gad S C. Handbook of product safety evaluation. Dekker, New York 1988
  • Gad S C, Changelis C P. Acute toxicology: principles and methods. Telford, Caldwell, NJ 1988
  • Gad S C. Statistical analysis of screening studies in toxicology: with special emphasis on neurotoxicity. J Am Coll Toxicol, 8: 171–183
  • Cooper J A, Saracci R, Cole P. Describing the validity of carcinogen screening test. Br J Cancer 1979; 39: 87–89
  • Bennenuto A J, Cohen R. A realistic role for non-animal tests. Pharm Exec June, 1990
  • Gad S C. Industrial application for in vitro toxicity testing methods: a tier testing strategy for product safety assessment. In vitro toxicity testing, J Frazier. Dekker, New York 1991
  • Frazier J M. Scientific criteria for validation of in vitro toxicity tests. Organization for Economic Co-Operation and Development, Brussels 1990
  • NTP Final report: NTP workshop on validation and regulatory acceptance of alternative toxicological test methods December, 1995; 11–12

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