Sildenafil for Chronic Obstructive Pulmonary Disease: A Randomized Crossover Trial

References

• O'Donnell DE, Banzett RB, Carrieri-Kohlman V, Casaburi R, Davenport PW, Gandevia SC, Gelb AF, Mahler DA, Webb KA. Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable. Proc Am Thorac Soc 2007 May; 4(2):145–168.
   PubMedGoogle Scholar
• Vonk-Noordegraaf A, Marcus JT, Holverda S, Roseboom B, Postmus PE. Early changes of cardiac structure and function in COPD patients with mild hypoxemia. Chest 2005 Jun; 127(6):1898–1903.
   PubMed Web of Science ®Google Scholar
• Kessler R, Faller M, Weitzenblum E, Chaouat A, Aykut A, Ducolone A, Ehrhart M, Oswald-Mammosser M. “Natural history” of pulmonary hypertension in a series of 131 patients with chronic obstructive lung disease. Am J Respir Crit Care Med 2001 Jul 15; 164(2):219–224.
   PubMed Web of Science ®Google Scholar
• Holverda S, Rietema H, Westerhof N, Marcus JT, Gan CT, Postmus PE, Vonk-Noordegraaf A. Stroke volume increase to exercise in chronic obstructive pulmonary disease is limited by increased pulmonary artery pressure. Heart 2009 Feb; 95(2):137–141.
   PubMed Web of Science ®Google Scholar
• Nocturnal Oxygen Therapy Trial Group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Ann Intern Med 1980 Sep; 93(3):391–398.
   PubMed Web of Science ®Google Scholar
• Report of the Medical Research Council Working Party. Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Lancet 1981 Mar 28; 1(8222):681–686.
   PubMed Web of Science ®Google Scholar
• Vestri R, Philip-Joet F, Surpas P, Arnaud A, Saadjian A. One-year clinical study on nifedipine in the treatment of pulmonary hypertension in chronic obstructive lung disease. Respiration 1988; 54(2):139–144.
   PubMed Web of Science ®Google Scholar
• Stolz D, Rasch H, Linka A, Di Valentino M, Meyer A, Brutsche M, Tamm M. A randomised, controlled trial of bosentan in severe COPD. Eur Respir J 2008 Sep; 32(3):619–628.
   PubMed Web of Science ®Google Scholar
• Kalra L, Bone MF. Effect of nifedipine on physiologic shunting and oxygenation in chronic obstructive pulmonary disease. Am J Med 1993 Apr; 94(4):419–423.
   PubMed Web of Science ®Google Scholar
• Ghofrani HA, Wiedemann R, Rose F, Schermuly RT, Olschewski H, Weissmann N, Gunther A, Walmrath D, Seeger W, Grimminger F. Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Lancet 2002 Sep 21; 360(9337):895–900.
   PubMed Web of Science ®Google Scholar
• Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED. Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation 2007 Jul 17; 116(3):238–248.
   PubMed Web of Science ®Google Scholar
• Holverda S, Rietema H, Bogaard HJ, Westerhof N, Postmus PE, Boonstra A, Vonk-Noordegraaf A. Acute effects of sildenafil on exercise pulmonary hemodynamics and capacity in patients with COPD. Pulm Pharmacol Ther 2008; 21(3):558–564.
   PubMed Web of Science ®Google Scholar
• Blanco I, Gimeno E, Munoz PA, Pizarro S, Gistau C, Rodriguez-Roisin R, Roca J, Barbera JA. Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Am J Respir Crit Care Med 2010 Feb 1; 181(3):270–278.
   PubMed Web of Science ®Google Scholar
• Vonbank K, Ziesche R, Higenbottam TW, Stiebellehner L, Petkov V, Schenk P, Germann P, Block LH. Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD. Thorax 2003 Apr; 58(4):289–293.
   PubMed Web of Science ®Google Scholar
• Galie N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D, Fleming T, Parpia T, Burgess G, Branzi A, Grimminger F, Kurzyna M, Simonneau G. Sildenafil Use in Pulmonary Arterial Hypertension Study G. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 2005 Nov 17; 353(20):2148–2157.
   PubMed Web of Science ®Google Scholar
• Simonneau G, Rubin LJ, Galie N, Barst RJ, Fleming TR, Frost AE, Engel PJ, Kramer MR, Burgess G, Collings L, Cossons N, Sitbon O, Badesch DB, Group PS. Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial. Ann Intern Med 2008 Oct 21; 149(8):521–530.
   PubMed Web of Science ®Google Scholar
• Idiopathic Pulmonary Fibrosis Clinical Research, Zisman DA, Schwarz M, Anstrom KJ, Collard HR, Flaherty KR, Hunninghake GW. A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis. N Engl J Med 2010 Aug 12; 363(7):620–628.
   PubMed Web of Science ®Google Scholar
• Alp S, Skrygan M, Schmidt WE, Bastian A. Sildenafil improves hemodynamic parameters in COPD—An investigation of six patients. Pulm Pharmacol Ther 2006; 19(6):386–390.
   PubMed Web of Science ®Google Scholar
• Rietema H, Holverda S, Bogaard HJ, Marcus JT, Smit HJ, Westerhof N, Postmus PE, Boonstra A, Vonk-Noordegraaf A. Sildenafil treatment in COPD does not affect stroke volume or exercise capacity. Eur Respir J 2008 Apr; 31(4):759–764.
   PubMed Web of Science ®Google Scholar
• Wyrwich KW, Tierney WM, Babu AN, Kroenke K, Wolinsky FD. A comparison of clinically important differences in health-related quality of life for patients with chronic lung disease, asthma, or heart disease. Health Serv Res 2005 Apr; 40(2):577–591.
   PubMed Web of Science ®Google Scholar
• Redelmeier DA, Guyatt GH, Goldstein RS. Assessing the minimal important difference in symptoms: a comparison of two techniques. J Clin Epidemiol 1996 Nov; 49(11):1215–1219.
   PubMed Web of Science ®Google Scholar
• Jones PW. Quality of life, symptoms and pulmonary function in asthma: Long-term treatment with nedocromil sodium examined in a controlled multicentre trial. Nedocromil Sodium Quality of Life Study Group. Eur Respir J 1994 Jan; 7(1):55–62.
   PubMed Web of Science ®Google Scholar