Respiratory Viral Detection and Small Airway Inflammation in Lung Tissue of Patients with Stable, Mild COPD

References

• Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet 1997; 349:1498–1504.
   PubMed Web of Science ®Google Scholar
• Kuwano K, Bosken CH, Paré PD, Bai TR, Wiggs BR, Hogg JC. Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1993; 148:1220–1225.
   PubMed Web of Science ®Google Scholar
• Hogg JC, Chu F, Utokaparch S, The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004; 350:2645–2653.
   PubMed Web of Science ®Google Scholar
• McDonough JE, Yuan R, Suzuki M, Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med 2011; 365:1567–1575.
   PubMed Web of Science ®Google Scholar
• Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol 2009; 4:435–459.
   PubMed Web of Science ®Google Scholar
• Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977; 1: 1645–1648.
   PubMed Web of Science ®Google Scholar
• Beasley V, Joshi PV, Singanayagam A, Molyneaux PL, Johnston SL, Mallia P. Lung microbiology and exacerbations in COPD. Int J COPD 2012; 7:555–569.
   Web of Science ®Google Scholar
• Erb-Downward JR, Thompson DL, Han MK, Analysis of the lung microbiome in the “healthy” smoker and in COPD. PLoS ONE 2011; 6: e16384.
   PubMed Web of Science ®Google Scholar
• Sze MA, Dimitriu PA, Hayashi S, The lung tissue microbiome in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012; 185:1073–1080.
   PubMed Web of Science ®Google Scholar
• Han MK, Huang YJ, Lipuma JJ, Significance of the microbiome in obstructive lung disease. Thorax 2012; 67:456–463.
   PubMed Web of Science ®Google Scholar
• Hogg JC, Macek V, Dakhama A, The prevalence of common respiratory viruses in human lungs. In: Marone G, Austen KF, Lichtenstein LM (Eds.) Asthma and Allergic Diseases: Physiology, Immunopharmacology, and Treatment. Academic Press, San Diego CA, 1998: 321–333.
   Google Scholar
• Seemungal T, Harper-Owen R, Bhowmik A, Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164:1618–1623.
   PubMed Web of Science ®Google Scholar
• Rohde G, Wiethege A, Borg I, Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study. Thorax 2003; 58:37–42.
   PubMed Web of Science ®Google Scholar
• Qiu Y, Zhu J, Bandi V, Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerabations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003; 168:968–975.
   PubMed Web of Science ®Google Scholar
• Tan WC, Xiang X, Qiu D, Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease. Am J Med 2003; 115:272–277.
   PubMedGoogle Scholar
• Wedzicha JA. Role of viruses in exacerbations of chronic obstructive pulmonary disease. Proc Am Thor Soc 2004; 1:115–120.
   PubMedGoogle Scholar
• Singh M, Lee SH, Porter P, Human rhinovirus 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 2012; 125:1369–1378.
   Web of Science ®Google Scholar
• Falsey AR, Formica MA, Walsh EE. Yield of sputum for viral detection by reverse transcriptase PCR in adults hospitalized with respiratory illness. J Clin Microbiol 2012; 50:21–24.
   PubMed Web of Science ®Google Scholar
• Dakhama A, Chan NG, Ahmad HY, Usefulness of bronchoalveolar lavage for diagnosis of acute and persistent respiratory syncytial virus lung infections in guinea pigs. Pediatr Pulmonol 1998; 26:396–404.
   PubMed Web of Science ®Google Scholar
• Utokaparch S, Marchant D, Gosselink JV, The relationship between respiratory viral loads and diagnosis in children presenting to a pediatric hospital emergency department. Pediatr Infect Dis J 2011; 30:e18–23.
   PubMed Web of Science ®Google Scholar
• Rabe KF, Hurd S, Anzueto A, Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007; 176:532–555.
   PubMed Web of Science ®Google Scholar
• Gosselink JV, Hayashi S, Chau E, Cooper J, Elliott WM, Hogg JC. Evaluation of small sample cDNA amplification for microdissected airway expression profiling in COPD. COPD 2007; 4:91–105.
   PubMedGoogle Scholar
• McNees AL, White ZS, Zanwar P, Vilchez RA, Butel JS. Specific and quantitative detection of human polyomaviruses BKV, JCV, and SV40 by real time PCR. J Clin Virol 2005; 34(1):52–62.
   PubMed Web of Science ®Google Scholar
• Dhanasekaran S, Doherty TM, Kenneth J; TB Trials Study Group. Comparison of different standards for real-time PCR based absolute quantification. J Immunol Meth 2010; 354(1–2): 34–39.
   PubMed Web of Science ®Google Scholar
• Young RP, Hopkins RJ, Christmas T, Black PN, Metcalf P, Gamble GD. COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur Respir J 2009; 34:380–386.
   PubMed Web of Science ®Google Scholar
• Powell HA, Iyen-Omofoman B, Baldwin DR, Hubbard RB, Tata LJ. Chronic obstructive pulmonary disease and risk of lung cancer: the importance of smoking and timing of diagnosis. J Thorac Oncol 2013; 8:6–11.
   PubMed Web of Science ®Google Scholar
• Macek V, Dakhama A, Hogg JC, Green FH, Rubin BK, Hegele RG. PCR detection of viral nucleic acid in fatal asthma: is the lower respiratory tract a reservoir for common viruses? Can Respir J 1999; 6:37–43.
   PubMedGoogle Scholar
• Falsey AR, Formica MA, Hennessey PA, Criddle MM, Sullender W, Walsh EE. Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006: 173:639–643.
   PubMed Web of Science ®Google Scholar
• Papi A, Bellettato CM, Braccioni F, Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med 2006; 173:1114–1121.
   PubMed Web of Science ®Google Scholar
• Pare PD, Hegele RG, Hogg JC. The lung pathology of acute exacerbations of COPD. Lung Biol Health Dis 1996; 92:13–22.
   Google Scholar
• Kim EY, Battalie JT, Patel AC, Persistent activation of an innate immune axis translates respiratory viral infection into chronic lung disease. Nature Med 2008; 14:633–640.
   PubMed Web of Science ®Google Scholar
• Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. New Engl J Med 2008: 359:2355–2365.
   PubMed Web of Science ®Google Scholar
• Sethi S, Mallia P, Johnston SL. New paradigms in the pathogenesis of chronic obstructive pulmonary disease II. Proc Am Thorac Soc 2009; 6:532–534.
   PubMedGoogle Scholar
• Sutton TC, Tayyari F, Khan MA, Manson HE, Hegele RG. T helper 1 background protects against airway hyperresponsiveness and inflammation in guinea pigs with persistent respiratory syncytial virus infection. Pediatr Res 2007; 61(5 Pt 1):525–529.
   PubMed Web of Science ®Google Scholar
• Churg A, Marshall CV, Sin DD, Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012; 185:34–43.
   PubMed Web of Science ®Google Scholar
• Tate MD, Ioannidis LJ, Croker B, Brown LE, Brooks AG, Reading PC. The role of neutrophils during mild and severe influenza virus infections of mice. PLoS One 2011; 6:e17618.
   PubMed Web of Science ®Google Scholar
• Mallia P, Johnston SL. Influenza infection and COPD. Int J Chron Obstruct Pulmon Dis 2007; 2:55–64.
   PubMedGoogle Scholar
• Ichinohe T, Pang IK, Kumamoto Y, Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci USA 2011; 108:5354–5359.
   PubMed Web of Science ®Google Scholar