Intravenous and Intratracheal Mesenchymal Stromal Cell Injection in a Mouse Model of Pulmonary Emphysema

References

• Mannino DM, Braman S. The epidemiology and economics of chronic obstructive pulmonary disease. Proc Amer Thorac Soc 2007; 4(7):502–506.
   PubMedGoogle Scholar
• Faulkner MA, Hilleman DE. The economic impact of chronic obstructive pulmonary disease. Exp Opin Pharmacother 2002; 3(3):219–228.
   PubMedGoogle Scholar
• Baraldo S, Turato G, Saetta M. Pathophysiology of the small airways in chronic obstructive pulmonary disease. Respir Inter Rev Thorac Dis 2012; 84(2):89–97.
   Google Scholar
• Galbán CJ, Han MK, Boes JL, Chughtai KA, Meyer CR, Johnson TD, Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression. Nature Med 2012; 18(11):1711–1715.
   PubMed Web of Science ®Google Scholar
• Bourbon JR, Boucherat O, Boczkowski J, Crestani B, Delacourt C. Bronchopulmonary dysplasia and emphysema: in search of common therapeutic targets. Trends Mol Med 2009; 15(4):169–179.
   PubMed Web of Science ®Google Scholar
• Sin DDD, McAlister FFA, Man SFP, Anthonisen NR. Contemporary management of chronic obstructive pulmonary disease: Scientific review. JAMA: J Amer Med Asso 2003; 290(17):2301–2312.
   PubMed Web of Science ®Google Scholar
• Haaften T van, Byrne R, Bonnet S. Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. Amer J Respir Crit Care Med 2009; 180:1131–1142.
   PubMed Web of Science ®Google Scholar
• Zhao F, Zhang Y, Liu Y, Zhou J, Li Z, Wu C, Therapeutic effects of bone marrow-derived mesenchymal stem cells engraftment on bleomycin-induced lung injury in rats. Transplant Proc 2008; 40:1700–1705.
   PubMed Web of Science ®Google Scholar
• Gupta N, Su X, Popov B. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 2007; 179(3):1855–1863.
   PubMed Web of Science ®Google Scholar
• Loebinger MR, Janes SM. Stem cells for lung disease. Chest 2007; 132(1):279–285.
   PubMed Web of Science ®Google Scholar
• Ortiz L a, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 2003; 100(14):8407–8411.
   PubMed Web of Science ®Google Scholar
• Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J, Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Amer J Respir Cell Mol Biol 2005; 33(2):145–152.
   PubMed Web of Science ®Google Scholar
• Kotton DN, Fabian AJ, Mulligan RC. Failure of bone marrow to reconstitute lung epithelium. Amer J Respir Cell Mol Biol 2005; 33(4):328–334.
   PubMed Web of Science ®Google Scholar
• Loi R, Beckett T, Goncz KK, Suratt BT, Weiss DJ. Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells. Amer J Respir Crit Care Med 2006; 173(2):171–179.
   PubMed Web of Science ®Google Scholar
• Yamada M, Kubo H, Kobayashi S, Ishizawa K, Numasaki M, Ueda S, Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J Immunol 2004; 172(2):1266–1272.
   PubMed Web of Science ®Google Scholar
• Wong AP, Dutly AE, Sacher A, Lee H, Hwang DM, Liu M, Targeted cell replacement with bone marrow cells for airway epithelial regeneration. American journal of physiology. Lung Cell Mol Physiol 2007; 293(3):L740–752.
   PubMed Web of Science ®Google Scholar
• Spees JL, Pociask D a, Sullivan DE, Whitney MJ, Lasky J a, Prockop DJ, Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis. American journal of respiratory and critical care medicine. 2007 Aug 15;176(4):385–94.
   Google Scholar
• Block G, Ohkouchi S, Fung F, Frenkel J, Gregory C, Pochampally R, Multipotent stromal cells are activated to reduce apoptosis in part of upregulation and secretion of stanniocalcin-1. Stem Cells 2009; 27(3):670–681.
   PubMed Web of Science ®Google Scholar
• Lee RH, Pulin A a, Seo MJ, Kota DJ, Ylostalo J, Larson BL, Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell 2009; 5(1):54–63.
   PubMed Web of Science ®Google Scholar
• Chen L, Tredget EE, Wu PYG, Wu Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PloS One 2008; 3(4):e1886.
   PubMed Web of Science ®Google Scholar
• Crisostomo PR, Wang Y, Markel T a, Wang M, Lahm T, Meldrum DR. Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism. Amer J Physiol Cell Physiol 2008; 294(3):C675–682.
   PubMed Web of Science ®Google Scholar
• Ionescu L, Byrne RN, van Haaften T, Vadivel A, Alphonse RS, Rey-Parra GJ, Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action. Amer J Physiol Lung Cell Mol Physiol 2012 Sep 28; 303:967–977.
   PubMed Web of Science ®Google Scholar
• Katsha AM, Ohkouchi S, Xin H, Kanehira M, Sun R, Nukiwa T, Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model. Mol Ther J Amer Soc Gene Ther 2011; 19(1):196–203.
   PubMed Web of Science ®Google Scholar
• Cruz FF, Antunes MA, Abreu SC, Fujisaki LC, Silva JD, Xisto DG, Protective effects of bone marrow mononuclear cell therapy on lung and heart in an elastase-induced emphysema model. Respir Physiol Neurobiol 2012; 182(1):26–36.
   PubMed Web of Science ®Google Scholar
• Osiris. Osiris Therapeutics Reports interim data for COPD stem cell study. Available from: http://investor.osiris.com/ 2012 Sep 05.
   Google Scholar
• Bouloukaki I, Tsiligianni IG, Tsoumakidou M, Mitrouska I, Prokopakis EP, Mavroudi I, Sputum and nasal lavage lung-specific biomarkers before and after smoking cessation. BMC Pulmon Med 2011; 11:35.
   PubMed Web of Science ®Google Scholar
• Foronjy RF, Mirochnitchenko O, Propokenko O, Lemaitre V, Jia Y, Inouye M, Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice. Amer J Respir Crit Care Med 2006; 173(6):623–631.
   PubMed Web of Science ®Google Scholar
• Ito S, Ingenito EP, Brewer KK, Black LD, Parameswaran H, Lutchen KR, Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling. J Appl Physiol 2005; 98(2):503–511.
   PubMed Web of Science ®Google Scholar
• Ishii M, Emami K, Xin Y, Barulic A, Kotzer CJ, Logan G a, Regional Functional-Structure Relationships in Lungs of an Elastase Murine Model of Emphysema. J Appl Physiol 2012; 112:135–148
   PubMed Web of Science ®Google Scholar
• Sung JH, Yang H-M, Park JB, Choi G-S, Joh J-W, Kwon CH, Isolation and characterization of mouse mesenchymal stem cells. Transplant Proc 2008; 40(8):2649–2654.
   PubMed Web of Science ®Google Scholar
• Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8(4):315–317.
   PubMed Web of Science ®Google Scholar
• Lama V, Smith L, Badri L. Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts. J Clin Investig 2007; 117(4):989–996.
   PubMed Web of Science ®Google Scholar
• Tibboel J, Joza S, Reiss I, Jongste JC De, Post M. Amelioration of hyperoxia-induced lung injury using a sphingolipid-based intervention. Euro Respir J 2013; 42(3):e–pub ahead of print.
   Google Scholar
• Tsuchida S, Engelberts D, Roth M, McKerlie C, Post M, Kavanagh BP. Continuous positive airway pressure causes lung injury in a model of sepsis. American journal of physiology. Lung Cell Mol Physiol 2005; 289(4):L554–564.
   PubMed Web of Science ®Google Scholar
• Ridsdale R, Roth-Kleiner M, D'Ovidio F, Unger S, Yi M, Keshavjee S, Surfactant palmitoylmyristoylphosphatidylcholine is a marker for alveolar size during disease. Amer J Respir Crit Care Med 2005; 172(2):225–232.
   PubMed Web of Science ®Google Scholar
• Emami K, Chia E, Kadlecek S, Macduffie-Woodburn JP, Zhu J, Pickup S, Regional correlation of emphysematous changes in lung function and structure: a comparison between pulmonary function testing and hyperpolarized MRI metrics. J Appl Physiol 2011; 110(1):225–235.
   PubMed Web of Science ®Google Scholar
• Vanoirbeek J a J, Rinaldi M, De Vooght V, Haenen S, Bobic S, Gayan-Ramirez G, Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases. American journal of respiratory cell and molecular biology. 2010 Jan;42(1):96–104.
   Google Scholar
• Hamakawa H, Bartolák-Suki E, Parameswaran H, Majumdar A, Lutchen KR, Suki B. Structure-function Relations in an Elastase-induced Mouse Model of Emphysema. Amer J Respir Cell Mol Biol 2010; (C):1–38.
   Google Scholar
• Glaab T, Taube C, Braun A, Mitzner W. Invasive and noninvasive methods for studying pulmonary function in mice. Respir Res 2007; 8:63.
   PubMed Web of Science ®Google Scholar
• Peták F, Habre W, Donati Y. Hyperoxia-induced changes in mouse lung mechanics: forced oscillations vs. barometric plethysmography. J Appl Physiol 2001; (90):2221–2230.
   PubMedGoogle Scholar
• De Vleeschauwer SI, Rinaldi M, De Vooght V, Vanoirbeek JA, Vanaudenaerde BM, Verbeken EK, Repeated invasive lung function measurements in intubated mice: an approach for longitudinal lung research. Lab Anim 2011; 45(2):81–89.
   PubMedGoogle Scholar
• Zhen G, Xue Z, Zhao J, Gu N, Tang Z, Xu Y, Mesenchymal stem cell transplantation increases expression of vascular endothelial growth factor in papain-induced emphysematous lungs and inhibits apoptosis of lung cells. Cytother (Informa Healthcare Stockholm) 2010; 12(5):605–614.
   PubMed Web of Science ®Google Scholar
• Shigemura N, Okumura M, Mizuno S, Imanishi Y, Nakamura T, Sawa Y. Autologous transplantation of adipose tissue-derived stromal cells ameliorates pulmonary emphysema. Amer J Transplant 2006; 6(11):2592–2600.
   PubMed Web of Science ®Google Scholar
• Bauer J, Liebisch G, Hofmann C, Huy C, Schmitz G, Obermeier F, Lipid alterations in experimental murine colitis: role of ceramide and imipramine for matrix metalloproteinase-1 expression. PloS One 2009; 4(9):e7197.
   PubMedGoogle Scholar
• Wright T, Notter R, Wang Z, Harmsen A, Gigliotti F. Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia. Infect Immun 2001; 69(2):758–764.
   PubMed Web of Science ®Google Scholar
• Enhorning G, Hohlfeld J, Krug N, Lema G, Welliver RC. Surfactant function affected by airway inflammation and cooling: possible impact on exercise-induced asthma. Euro Respir J: Euro Soc Clin Respir Physiol 2000; 15(3):532–538.
   PubMed Web of Science ®Google Scholar
• Liu M, Wang L, Enhorning G. Surfactant dysfunction develops when the immunized guinea-pig is challenged with ovalbumin aerosol. Clin Exper Allergy: J Brit Soc Allergy Clin Immunol 1995; 25(11):1053–1060.
   PubMed Web of Science ®Google Scholar
• Peinado VI, Pizarro S, Barberà JA. Pulmonary vascular involvement in COPD. Chest 2008; 134(4):808–814.
   PubMed Web of Science ®Google Scholar
• Matsuura Y, Kawata N, Yanagawa N, Sugiura T, Sakurai Y, Sato M, Quantitative assessment of cross-sectional area of small pulmonary vessels in patients with COPD using inspiratory and expiratory MDCT. Euro J Radiol 2013; 82:1804–10.
   PubMed Web of Science ®Google Scholar
• Barberà JA, Riverola A, Roca J, Ramirez J, Wagner PD, Ros D, Pulmonary vascular abnormalities and ventilation-perfusion relationships in mild chronic obstructive pulmonary disease. Amer J Respir Crit Care Med 1994; 149(2 Pt 1):423–429.
   PubMed Web of Science ®Google Scholar
• Peinado VI, Barberà JA, Abate P, Ramírez J, Roca J, Santos S, Inflammatory Reaction in Pulmonary Muscular Arteries of Patients with Mild Chronic. Am J Respir Crit Care Med 1999; 159:1605–1611.
   PubMed Web of Science ®Google Scholar
• Artaechevarria X, Blanco D, de Biurrun G, Ceresa M, Pérez-Martín D, Bastarrika G, Evaluation of micro-CT for emphysema assessment in mice: comparison with non-radiological techniques. Euro Radiol 2011; 21(5):954–962.
   PubMed Web of Science ®Google Scholar