1,619
Views
19
CrossRef citations to date
0
Altmetric
Review

Maintaining Control of Chronic Obstructive Airway Disease: Adherence to Inhaled Therapy and Risks and Benefits of Switching Devices

&

References

  • Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. 2014 [cited 2014 Nov 26]; Available from: http://www.ginasthma.org/local/uploads/files/GINA_Report_2014_Aug12.pdf.
  • Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2014 [cited 2014 Nov 26]; Available from: http://www.ginasthma.org/local/uploads/files/GINA_Report_2014_Aug12.pdf3.
  • Cazzola M, Segreti A, Bettoncelli G, Calzetta L, Cricelli C, Pasqua F, et al.Change in asthma and COPD prescribing by Italian general practitioners between 2006 and 2008. Prim Care Respir J 2011; 20(3):291–298.
  • Ciapponi A, Alison L, Agustina M, Demian G, Silvana C, Edgardo S. The epidemiology and burden of COPD in Latin America and the Caribbean: systematic review and meta-analysis. COPD 2014; 11(3):339–350.
  • Holgate S, Bisgaard H, Bjermer L, Haahtela T, Haughney J, Horne R, et al.The Brussels Declaration: the need for change in asthma management. Eur Respir J 2008; 32(6):1433–1442.
  • Allegra L, Cremonesi G, Girbino G, Ingrassia E, Marsico S, Nicolini G, et al.Real-life prospective study on asthma control in Italy: cross-sectional phase results. Respir Med 2012; 106(2):205–214.
  • Chapman KR, Boulet LP, Rea RM, Franssen E. Suboptimal asthma control: prevalence, detection and consequences in general practice. Eur Respir J 2008; 31(2):320–325.
  • Demoly P, Paggiaro P, Plaza V, Bolge SC, Kannan H, Sohier B, et al.Prevalence of asthma control among adults in France, Germany, Italy, Spain and the UK. Eur Respir Rev 2009; 18(112):105–112.
  • Partridge MR, van der Molen T, Myrseth SE, Busse WW. Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study. BMC Pulm Med 2006; 6:13.
  • Peters SP, Jones CA, Haselkorn T, Mink DR, Valacer DJ, Weiss ST. Real-world Evaluation of Asthma Control and Treatment (REACT): findings from a national Web-based survey. J Allergy Clin Immunol 2007; 119(6):1454–1461.
  • Cutler DM, Everett W. Thinking outside the pillbox–medication adherence as a priority for health care reform. N Engl J Med 2010; 362(17):1553–1555.
  • Birkhead G, Attaway NJ, Strunk RC, Townsend MC, Teutsch S. Investigation of a cluster of deaths of adolescents from asthma: evidence implicating inadequate treatment and poor patient adherence with medications. J Allergy Clin Immunol 1989; 84(4 Pt 1):484–491.
  • Harrison B, Stephenson P, Mohan G, Nasser S. An ongoing Confidential Enquiry into asthma deaths in the Eastern Region of the UK, 2001-2003. Prim Care Respir J 2005; 14(6):303–313.
  • Williams LK, Pladevall M, Xi H, Peterson EL, Joseph C, Lafata JE, et al.Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma. J Allergy Clin Immunol 2004; 114(6):1288–1293.
  • Barnes N, Calverley PM, Kaplan A, Rabe KF. Chronic obstructive pulmonary disease and exacerbations: patient insights from the global Hidden Depths of COPD survey. BMC Pulm Med 2013; 13:54.
  • Paladini L, Hodder R, Cecchini I, Bellia V, Incalzi RA. The MRC dyspnoea scale by telephone interview to monitor health status in elderly COPD patients. Respir Med 2010; 104(7):1027–1034.
  • Ágh T, Inotai A, Meszaros A. Factors associated with medication adherence in patients with chronic obstructive pulmonary disease. Respiration 2011; 82(4):328–334.
  • Bosley CM, Parry DT, Cochrane GM. Patient compliance with inhaled medication: does combining beta-agonists with corticosteroids improve compliance? Eur Respir J 1994; 7(3):504–509.
  • Vestbo J, Anderson JA, Calverley PM, Celli B, Ferguson GT, Jenkins C, et al.Adherence to inhaled therapy, mortality and hospital admission in COPD. Thorax 2009; 64(11):939–943.
  • World Health Organization. Adherence to long-term therapies: Evidence for action. Geneva, Switzerland, 2003.
  • Cheetham TC, Niu F, Green K, Scott RD, Derose SF, Vansomphone SS, et al.Primary nonadherence to statin medications in a managed care organization. J Manag Care Pharm 2013; 19(5):367–373.
  • Jackevicius CA, Mamdani M, Tu JV. Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA 2002; 288(4):462–467.
  • Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005; 353(5):487–497.
  • Simpson SH, Eurich DT, Majumdar SR, Padwal RS, Tsuyuki RT, Varney J, et al.A meta-analysis of the association between adherence to drug therapy and mortality. Br Med J 2006; 333(7557):15.
  • Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care 2005; 43(6):521–530.
  • DiMatteo MR. Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 2004; 42(3):200–209.
  • Rau JL. Determinants of patient adherence to an aerosol regimen. Respir Care 2005; 50(10):1346–1356; discussion 1357–1349.
  • Melani AS, Bonavia M, Cilenti V, Cinti C, Lodi M, Martucci P, et al.Inhaler mishandling remains common in real life and is associated with reduced disease control. Respir Med 2011; 105(6):930–938.
  • Molimard M, Raherison C, Lignot S, Depont F, Abouelfath A, Moore N. Assessment of handling of inhaler devices in real life: an observational study in 3811 patients in primary care. J Aerosol Med 2003 Fall; 16(3):249–254.
  • Rand CS, Nides M, Cowles MK, Wise RA, Connett J. Long-term metered-dose inhaler adherence in a clinical trial. The Lung Health Study Research Group. Am J Respir Crit Care Med 1995; 152(2):580–588.
  • Williams LK, Joseph CL, Peterson EL, Wells K, Wang M, Chowdhry VK, et al.Patients with asthma who do not fill their inhaled corticosteroids: a study of primary nonadherence. J Allergy Clin Immunol 2007; 120(5):1153–1159.
  • Gamble J, Stevenson M, McClean E, Heaney LG. The prevalence of nonadherence in difficult asthma. Am J Respir Crit Care Med 2009; 180(9):817–822.
  • Wilson SR, Strub P, Buist AS, Knowles SB, Lavori PW, Lapidus J, et al.Shared treatment decision making improves adherence and outcomes in poorly controlled asthma. Am J Respir Crit Care Med 2010; 181(6):566–577.
  • Bauman LJ, Wright E, Leickly FE, Crain E, Kruszon-Moran D, Wade SL, et al.Relationship of adherence to pediatric asthma morbidity among inner-city children. Pediatrics 2002; 110(1 Pt 1):e6.
  • Clatworthy J, Price D, Ryan D, Haughney J, Horne R. The value of self-report assessment of adherence, rhinitis and smoking in relation to asthma control. Prim Care Respir J 2009; 18(4):300–305.
  • Melani AS, Zanchetta D, Barbato N, Sestini P, Cinti C, Canessa PA, et al.Inhalation technique and variables associated with misuse of conventional metered-dose inhalers and newer dry powder inhalers in experienced adults. Ann Allergy Asthma Immunol 2004; 93(5):439–446.
  • Papi A, Haughney J, Virchow JC, Roche N, Palkonen S, Price D. Inhaler devices for asthma: a call for action in a neglected field. Eur Respir J 2011; 37(5):982–985.
  • Halm EA, Mora P, Leventhal H. No symptoms, no asthma: the acute episodic disease belief is associated with poor self-management among inner-city adults with persistent asthma. Chest 2006; 129(3):573–580.
  • Quittner AL, Zhang J, Marynchenko M, Chopra PA, Signorovitch J, Yushkina Y, et al.Pulmonary medication adherence and health-care use in cystic fibrosis. Chest 2014; 146(1):142–151.
  • Cecere LM, Slatore CG, Uman JE, Evans LE, Udris EM, Bryson CL, et al.Adherence to long-acting inhaled therapies among patients with chronic obstructive pulmonary disease (COPD). COPD 2012; 9(3):251–258.
  • Barnestein-Fonseca P, Leiva-Fernandez J, Vidal-Espana F, Garcia-Ruiz A, Prados-Torres D, Leiva-Fernandez F. Efficacy and safety of a multifactor intervention to improve therapeutic adherence in patients with chronic obstructive pulmonary disease (COPD): protocol for the ICEPOC study. Trials 2011; 12:40.
  • Klok T, Kaptein AA, Duiverman EJ, Brand PL. It's the adherence, stupid (that determines asthma control in preschool children)! Eur Respir J 2014; 43(3):783–791.
  • Neugaard BI, Priest JL, Burch SP, Cantrell CR, Foulis PR. Quality of care for veterans with chronic diseases: performance on quality indicators, medication use and adherence, and health care utilization. Popul Health Manag 2011; 14(2):99–106.
  • Souza-Machado A, Santos PM, Cruz AA. Adherence to treatment in severe asthma: predicting factors in a program for asthma control in Brazil. World Allergy Organ J 2010; 3(3):48–52.
  • Van Steenis M, Driesenaar J, Bensing J, Van Hulten R, Souverein P, Van Dijk L, et al.Relationship between medication beliefs, self-reported and refill adherence, and symptoms in patients with asthma using inhaled corticosteroids. Patient Prefer Adherence 2014; 8:83–91.
  • Nieuwlaat R, Wilczynski N, Navarro T, Hobson N, Jeffery R, Keepanasseril A, et al.Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2014; 11:CD000011.
  • Horne R, Chapman SC, Parham R, Freemantle N, Forbes A, Cooper V. Understanding patients' adherence-related beliefs about medicines prescribed for long-term conditions: a meta-analytic review of the Necessity-Concerns Framework. PLoS One 2013; 8(12):e80633.
  • Demonceau J, Ruppar T, Kristanto P, Hughes DA, Fargher E, Kardas P, et al.Identification and assessment of adherence-enhancing interventions in studies assessing medication adherence through electronically compiled drug dosing histories: A systematic literature review and meta-analysis. Drugs 2013; 73(6):545–562.
  • Horne R. Adherence to asthma medication: a question of ability? Prim Care Respir J 2011; 20(2):118–119.
  • Lavorini F, Magnan A, Dubus JC, Voshaar T, Corbetta L, Broeders M, et al.Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD. Respir Med 2008; 102(4):593–604.
  • McFadden ER, Jr. Improper patient techniques with metered dose inhalers: clinical consequences and solutions to misuse. J Allergy Clin Immunol 1995; 96(2):278–283.
  • Rootmensen GN, van Keimpema AR, Jansen HM, de Haan RJ. Predictors of incorrect inhalation technique in patients with asthma or COPD: a study using a validated videotaped scoring method. J Aerosol Med Pulm Drug Deliv 2010; 23(5):323–328.
  • Sestini P, Cappiello V, Aliani M, Martucci P, Sena A, Vaghi A, et al.Prescription bias and factors associated with improper use of inhalers. J Aerosol Med 2006; 19(2):127–136.
  • Goris S, Tasci S, Elmali F. The effects of training on inhaler technique and quality of life in patients with COPD. J Aerosol Med Pulm Drug Deliv 2013; 26(6):336–344.
  • Takemura M, Mitsui K, Itotani R, Ishitoko M, Suzuki S, Matsumoto M, et al.Relationships between repeated instruction on inhalation therapy, medication adherence, and health status in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2011; 6:97–104.
  • Takemura M, Kobayashi M, Kimura K, Mitsui K, Masui H, Koyama M, et al.Repeated instruction on inhalation technique improves adherence to the therapeutic regimen in asthma. J Asthma 2010; 47(2):202–208.
  • Takemura M, Mitsui K, Ido M, Matsumoto M, Koyama M, Inoue D, et al.Impact of a network system for providing proper inhalation technique by community pharmacists. J Asthma 2012; 49(5):535–541.
  • Mehuys E, Van Bortel L, De Bolle L, Van Tongelen I, Annemans L, Remon JP, et al.Effectiveness of pharmacist intervention for asthma control improvement. Eur Respir J 2008; 31(4):790–799.
  • Armour C, Bosnic-Anticevich S, Brillant M, Burton D, Emmerton L, Krass I, et al.Pharmacy Asthma Care Program (PACP) improves outcomes for patients in the community. Thorax 2007; 62(6):496–502.
  • Barbanel D, Eldridge S, Griffiths C. Can a self-management programme delivered by a community pharmacist improve asthma control? A randomised trial. Thorax 2003; 58(10):851–854.
  • Basheti IA, Reddel HK, Armour CL, Bosnic-Anticevich SZ. Improved asthma outcomes with a simple inhaler technique intervention by community pharmacists. J Allergy Clin Immunol 2007; 119(6):1537–1538.
  • Cordina M, McElnay JC, Hughes CM. Assessment of a community pharmacy-based program for patients with asthma. Pharmacotherapy 2001; 21(10):1196–1203.
  • Kritikos V, Armour CL, Bosnic-Anticevich SZ. Interactive small-group asthma education in the community pharmacy setting: A pilot study. J Asthma 2007; 44(1):57–64.
  • McLean W, Gillis J, Waller R. The BC Community Pharmacy Asthma Study: A study of clinical, economic and holistic outcomes influenced by an asthma care protocol provided by specially trained community pharmacists in British Columbia. Can Respir J 2003; 10(4):195–202.
  • Self TH, Brooks JB, Lieberman P, Ryan MR. The value of demonstration and role of the pharmacist in teaching the correct use of pressurized bronchodilators. Can Med Assoc J 1983; 128(2):129–131.
  • Takemura M, Mitsui K, Ido M, Matsumoto M, Koyama M, Inoue D, et al.Effect of a network system for providing proper inhalation technique by community pharmacists on clinical outcomes in COPD patients. Int J Chron Obstruct Pulmon Dis 2013; 8:239–244.
  • Wang KY, Chian CF, Lai HR, Tarn YH, Wu CP. Clinical pharmacist counseling improves outcomes for Taiwanese asthma patients. Pharm World Sci 2010; 32(6):721–729.
  • Wieshammer S, Dreyhaupt J. Dry powder inhalers: Which factors determine the frequency of handling errors? Respiration 2008; 75(1):18–25.
  • Hardwell A, Barber V, Hargadon T, McKnight E, Holmes J, Levy ML. Technique training does not improve the ability of most patients to use pressurised metered-dose inhalers (pMDIs). Prim Care Respir J 2011; 20(1):92–96.
  • Levy ML, Hardwell A, McKnight E, Holmes J. Asthma patients' inability to use a pressurised metered-dose inhaler (pMDI) correctly correlates with poor asthma control as defined by the global initiative for asthma (GINA) strategy: a retrospective analysis. Prim Care Respir J 2013; 22(4):406–411.
  • Wolstenholme RJ, Shettar SP, Taher F, Hatton B. Use of Haleraid in rheumatoid arthritis with obstructive lung disease. Br J Rheumatol 1986; 25(3):318.
  • Press VG, Arora VM, Shah LM, Lewis SL, Ivy K, Charbeneau J, et al.Misuse of respiratory inhalers in hospitalized patients with asthma or COPD. J Gen Intern Med 2011; 26(6):635–642.
  • O'Conor R, Wolf MS, Smith SG, Martynenko M, Vicencio DP, Sano M, et al.Health literacy, cognitive function, proper use and adherence to inhaled asthma controller medications among older adults with asthma. Chest 2014 Oct 2 [Epub ahead of print].
  • Dolovich MB, Ahrens RC, Hess DR, Anderson P, Dhand R, Rau JL, et al.Device selection and outcomes of aerosol therapy: Evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology. Chest 2005; 127(1):335–371.
  • Bjermer L. The role of small airway disease in asthma. Curr Opin Pulm Med 2014; 20(1):23–30.
  • Brand P, Hederer B, Austen G, Dewberry H, Meyer T. Higher lung deposition with Respimat Soft Mist inhaler than HFA-MDI in COPD patients with poor technique. Int J Chron Obstruct Pulmon Dis 2008; 3(4):763–770.
  • Brusselle G, Peche R, Van den Brande P, Verhulst A, Hollanders W, Bruhwyler J. Real-life effectiveness of extrafine beclometasone dipropionate/formoterol in adults with persistent asthma according to smoking status. Respir Med 2012; 106(6):811–819.
  • Hogg JC, McDonough JE, Suzuki M. Small airway obstruction in COPD: new insights based on micro-CT imaging and MRI imaging. Chest 2013; 143(5):1436–1443.
  • Mariotti F, Francesco F, Acerbi D, Meyer T, Herpich C. Lung deposition of the extra fine dry powder fixed combination beclomethasone dipropionate plus formoterol fumarate via the NEXT DPI® in healthy subjects, asthmatic and COPD patients. Eur Respir J 2011; 38(Suppl 55):139s [abstract P830].
  • Usmani OS, Biddiscombe MF, Barnes PJ. Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size. Am J Respir Crit Care Med 2005; 172(12):1497–1504.
  • De Backer W, Devolder A, Poli G, Acerbi D, Monno R, Herpich C, et al.Lung deposition of BDP/formoterol HFA pMDI in healthy volunteers, asthmatic, and COPD patients. J Aerosol Med Pulm Drug Deliv 2010; 23(3):137–148.
  • Leach CL, Bethke TD, Boudreau RJ, Hasselquist BE, Drollmann A, Davidson P, et al.Two-dimensional and three-dimensional imaging show ciclesonide has high lung deposition and peripheral distribution: a nonrandomized study in healthy volunteers. J Aerosol Med 2006; 19(2):117–126.
  • Leach CL, Colice GL. A pilot study to assess lung deposition of HFA-beclomethasone and CFC-beclomethasone from a pressurized metered dose inhaler with and without add-on spacers and using varying breathhold times. J Aerosol Med Pulm Drug Deliv 2010; 23(6):355–361.
  • Scichilone N, Spatafora M, Battaglia S, Arrigo R, Benfante A, Bellia V. Lung penetration and patient adherence considerations in the management of asthma: role of extra-fine formulations. J Asthma Allergy 2013; 6:11–21.
  • Muller V, Galffy G, Eszes N, Losonczy G, Bizzi A, Nicolini G, et al.Asthma control in patients receiving inhaled corticosteroid and long-acting beta2-agonist fixed combinations. A real-life study comparing dry powder inhalers and a pressurized metered dose inhaler extrafine formulation. BMC Pulm Med 2011; 11:40.
  • Price D, Small I, Haughney J, Ryan D, Gruffydd-Jones K, Lavorini F, et al.Clinical and cost effectiveness of switching asthma patients from fluticasone-salmeterol to extra-fine particle beclometasone-formoterol: a retrospective matched observational study of real-world patients. Prim Care Respir J 2013; 22(4):439–448.
  • Terzano C, Cremonesi G, Girbino G, Ingrassia E, Marsico S, Nicolini G, et al.1-year prospective real life monitoring of asthma control and quality of life in Italy. Respir Res 2012; 13:112.
  • Colice G, Martin RJ, Israel E, Roche N, Barnes N, Burden A, et al.Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone. J Allergy Clin Immunol 2013; 132(1):45–54.
  • Postma DS, O'Byrne PM, Pedersen S. Comparison of the effect of low-dose ciclesonide and fixed-dose fluticasone propionate and salmeterol combination on long-term asthma control. Chest 2011; 139(2):311–318.
  • Thorsson L, Edsbacker S. Lung deposition of budesonide from a pressurized metered-dose inhaler attached to a spacer. Eur Respir J 1998; 12(6):1340–1345.
  • Acerbi D, Brambilla G, Kottakis I. Advances in asthma and COPD management: delivering CFC-free inhaled therapy using Modulite technology. Pulm Pharmacol Ther 2007; 20(3):290–303.
  • Buttini F, Miozzi M, Balducci AG, Royall PG, Brambilla G, Colombo P, et al.Differences in physical chemistry and dissolution rate of solid particle aerosols from solution pressurised inhalers. Int J Pharm 2014; 465(1–2):42–51.
  • Leach CL, Davidson PJ, Hasselquist BE, Boudreau RJ. Influence of particle size and patient dosing technique on lung deposition of HFA-beclomethasone from a metered dose inhaler. J Aerosol Med 2005; 18(4):379–385.
  • Nicolini G, Scichilone N, Bizzi A, Papi A, Fabbri LM. Beclomethasone/formoterol fixed combination for the management of asthma: patient considerations. Ther Clin Risk Manag 2008; 4(5):855–864.
  • Zagà V, Mariano V, Vakeffliu Y, Ribolla R, Sini A, Coloretti I, et al.Is inhaler technique improving in Italy? [Italian] Uso scorretto degli inalatori per l'asma e la BPCO: In Italia sta cambiando qualcosa? Rassegna di Patologia dell'Apparato Respiratorio 2012; 27(4):211–218.
  • Haughney J, Price D, Barnes NC, Virchow JC, Roche N, Chrystyn H. Choosing inhaler devices for people with asthma: current knowledge and outstanding research needs. Respir Med 2010; 104(9):1237–1245.
  • Clark AR, Hollingworth AM. The relationship between powder inhaler resistance and peak inspiratory conditions in healthy volunteers–implications for in vitro testing. J Aerosol Med 1993; 6(2):99–110.
  • Shur J, Lee S, Adams W, Lionberger R, Tibbatts J, Price R. Effect of device design on the in vitro performance and comparability for capsule-based dry powder inhalers. AAPS J 2012; 14(4):667–676.
  • Corradi M, Chrystyn H, Cosio BG, Pirozynski M, Loukides S, Louis R, et al.NEXThaler, an innovative dry powder inhaler delivering an extrafine fixed combination of beclometasone and formoterol to treat large and small airways in asthma. Expert Opin Drug Deliv 2014; 11(9):1497–1506.
  • Everard ML, Devadason SG, Le Souef PN. Flow early in the inspiratory manoeuvre affects the aerosol particle size distribution from a Turbuhaler. Respir Med 1997; 91(10):624–628.
  • Chiesi, European Medicines Committee. Fostair 100/6 inhalation solution: summary of product characteristics. [cited April 3 2014 ]; Available from: http://www.medicines.org.uk/emc/medicine/21006/SPC/
  • Pasquali I, Brambilla G, Long EJ, Hargrave GK, H.K. V. A visualisation study for the aerosol generation in NEXThaler® [abstract]. Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists (AAPS); Chicago, USA, 2012.
  • Scuri M, Alfieri V, Giorgio A, Pisi R, Ferrari F, Taverna M, et al.Measurement of the inhalation profile through a novel dry powder inhaler (Nexthaler®) in asthmatic patients using acoustic monitoring [abstract]. Am J Respir Crit Care Med 2013; 187:A1931.
  • Melani AS, Canessa P, Coloretti I, DeAngelis G, DeTullio R, Del Donno M, et al.Inhaler mishandling is very common in patients with chronic airflow obstruction and long-term home nebuliser use. Respir Med 2012; 106(5):668–676.
  • Voshaar T, Spinola M, Linnane P, Campanini A, Lock D, Lafratta A, et al.Comparing usability of NEXThaler with other inhaled corticosteroid/long-acting beta-agonist fixed combination dry powder inhalers in asthma patients. J Aerosol Med Pulm Drug Deliv 2013.
  • Committee for Medicinal Products for Human Use (CHMP). Note for guidance on the clinical development of medicinal products in the treatment of asthma (CPMP/EWP/2922/01). 2002 [cited 2013 29 January]; Available from: http://www.emea.europa.eu/pdfs/human/ewp/292201en.pdf.
  • Committee for Medicinal Products for Human Use (CHMP). Concept paper on the need for revision of the CHMP note for guidance on the clinical development of medicinal products in the treatment of asthma (CPMP/EWP/2922/01). 2009 [cited 2013 29 January]; Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/10/WC500006234.pdf.
  • Rubin BK. What does it mean when a patient says, "my asthma medication is not working"? Chest 2004; 126(3):972–981.
  • Chrystyn H, Price D. Not all asthma inhalers are the same: factors to consider when prescribing an inhaler. Prim Care Respir J 2009; 18(4):243–249.
  • Giraud V, Allaert FA. Improved asthma control with breath-actuated pressurized metered dose inhaler (pMDI): the SYSTER survey. Eur Rev Med Pharmacol Sci 2009; 13(5):323–330.
  • Virchow JC, Crompton GK, Dal Negro R, Pedersen S, Magnan A, Seidenberg J, et al.Importance of inhaler devices in the management of airway disease. Respir Med 2008; 102(1):10–19.
  • Chrystyn H, Small M, Milligan G, Higgins V, Gil EG, Estruch J. Impact of patients' satisfaction with their inhalers on treatment compliance and health status in COPD. Respir Med 2014; 108(2):358–365.
  • Dolovich L, Nair K, Sellors C, Lohfeld L, Lee A, Levine M. Do patients' expectations influence their use of medications? Qualitative study. Can Fam Physician 2008; 54(3):384–393.
  • Makela MJ, Backer V, Hedegaard M, Larsson K. Adherence to inhaled therapies, health outcomes and costs in patients with asthma and COPD. Respir Med 2013; 107(10):1481–1490.
  • Johansson G, Stallberg B, Tornling G, Andersson S, Karlsson GS, Falt K, et al.Asthma treatment preference study: a conjoint analysis of preferred drug treatments. Chest 2004; 125(3):916–923.
  • Kaiser H, Parasuraman B, Boggs R, Miller CJ, Leidy NK, O'Dowd L. Onset of effect of budesonide and formoterol administered via one pressurized metered-dose inhaler in patients with asthma previously treated with inhaled corticosteroids. Ann Allergy Asthma Immunol 2008; 101(3):295–303.
  • Sovani MP, Whale CI, Oborne J, Cooper S, Mortimer K, Ekstrom T, et al.Poor adherence with inhaled corticosteroids for asthma: can using a single inhaler containing budesonide and formoterol help? Br J Gen Pract 2008; 58(546):37–43.
  • van der Palen J, Klein JJ, van Herwaarden CL, Zielhuis GA, Seydel ER. Multiple inhalers confuse asthma patients. Eur Respir J 1999; 14(5):1034–1037.
  • Doyle S, Lloyd A, Williams A, Chrystyn H, Moffat M, Thomas M, et al.What happens to patients who have their asthma device switched without their consent? Prim Care Respir J 2010; 19(2):131–139.
  • Braido F, Baiardini I, Sumberesi M, Blasi F, Canonica GW. Obstructive lung diseases and inhaler treatment: results from a national public pragmatic survey. Respir Res 2013; 14:94.
  • Thomas M, Price D, Chrystyn H, Lloyd A, Williams AE, von Ziegenweidt J. Inhaled corticosteroids for asthma: impact of practice level device switching on asthma control. BMC Pulm Med 2009; 9:1.
  • Thomas M, Williams AE. Are outcomes the same with all dry powder inhalers? Int J Clin Pract Suppl 2005; (149):33–35.
  • Williams AE, Chrystyn H. Survey of pharmacists' attitudes towards interchangeable use of dry powder inhalers. Pharm World Sci 2007; 29(3):221–227.
  • Price D. Do healthcare professionals think that dry powder inhalers can be used interchangeably? Int J Clin Pract Suppl 2005; (149):26–29.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.